LOCUS       NM_001108214            4270 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus neuronal PAS domain protein 2 (Npas2), mRNA.
ACCESSION   NM_001108214 XM_001058630 XM_244089
VERSION     NM_001108214.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4270)
  AUTHORS   Herichova,I., Hasakova,K., Lukacova,D., Mravec,B., Horvathova,L.
            and Kavicka,D.
  TITLE     Prefrontal cortex and dorsomedial hypothalamus mediate food
            reward-induced effects via npas2 and egr1 expression in rat
  JOURNAL   Physiol Res 66 (Suppl 4), S501-S510 (2017)
   PUBMED   29355377
  REMARK    GeneRIF: In the prefrontal cortex, food reward induced rhythm in
            the expression of npas2.
REFERENCE   2  (bases 1 to 4270)
  AUTHORS   Ozburn,A.R., Kern,J., Parekh,P.K., Logan,R.W., Liu,Z., Falcon,E.,
            Becker-Krail,D., Purohit,K., Edgar,N.M., Huang,Y. and McClung,C.A.
  TITLE     NPAS2 Regulation of Anxiety-Like Behavior and GABAA Receptors
  JOURNAL   Front Mol Neurosci 10, 360 (2017)
   PUBMED   29163035
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4270)
  AUTHORS   Lee,S.M., Zhang,Y., Tsuchiya,H., Smalling,R., Jetten,A.M. and
            Wang,L.
  TITLE     Small heterodimer partner/neuronal PAS domain protein 2 axis
            regulates the oscillation of liver lipid metabolism
  JOURNAL   Hepatology 61 (2), 497-505 (2015)
   PUBMED   25212631
REFERENCE   4  (bases 1 to 4270)
  AUTHORS   Hwang,C.K., Chaurasia,S.S., Jackson,C.R., Chan,G.C., Storm,D.R. and
            Iuvone,P.M.
  TITLE     Circadian rhythm of contrast sensitivity is regulated by a
            dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling
            pathway in retinal ganglion cells
  JOURNAL   J Neurosci 33 (38), 14989-14997 (2013)
   PUBMED   24048828
REFERENCE   5  (bases 1 to 4270)
  AUTHORS   Soltesova,D., Monosikova,J., Koysova,L., Vesela,A., Mravec,B. and
            Herichova,I.
  TITLE     Effect of streptozotocin-induced diabetes on clock gene expression
            in tissues inside and outside the blood-brain barrier in rat
  JOURNAL   Exp Clin Endocrinol Diabetes 121 (8), 466-474 (2013)
   PUBMED   23864491
  REMARK    GeneRIF: Possible role of npas2 in locomotor activity regulation in
            diabetic animals. The most pronounced changes were observed in the
            frontal cortex, which displayed up-regulation of npas2 expression.
REFERENCE   6  (bases 1 to 4270)
  AUTHORS   Curtis,A.M., Seo,S.B., Westgate,E.J., Rudic,R.D., Smyth,E.M.,
            Chakravarti,D., FitzGerald,G.A. and McNamara,P.
  TITLE     Histone acetyltransferase-dependent chromatin remodeling and the
            vascular clock
  JOURNAL   J Biol Chem 279 (8), 7091-7097 (2004)
   PUBMED   14645221
REFERENCE   7  (bases 1 to 4270)
  AUTHORS   Dudley,C.A., Erbel-Sieler,C., Estill,S.J., Reick,M., Franken,P.,
            Pitts,S. and McKnight,S.L.
  TITLE     Altered patterns of sleep and behavioral adaptability in
            NPAS2-deficient mice
  JOURNAL   Science 301 (5631), 379-383 (2003)
   PUBMED   12843397
REFERENCE   8  (bases 1 to 4270)
  AUTHORS   Rutter,J., Reick,M., Wu,L.C. and McKnight,S.L.
  TITLE     Regulation of clock and NPAS2 DNA binding by the redox state of NAD
            cofactors
  JOURNAL   Science 293 (5529), 510-514 (2001)
   PUBMED   11441146
REFERENCE   9  (bases 1 to 4270)
  AUTHORS   Hogenesch,J.B., Gu,Y.Z., Jain,S. and Bradfield,C.A.
  TITLE     The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally
            active complexes with circadian and hypoxia factors
  JOURNAL   Proc Natl Acad Sci U S A 95 (10), 5474-5479 (1998)
   PUBMED   9576906
REFERENCE   10 (bases 1 to 4270)
  AUTHORS   Hogenesch,J.B., Chan,W.K., Jackiw,V.H., Brown,R.C., Gu,Y.Z.,
            Pray-Grant,M., Perdew,G.H. and Bradfield,C.A.
  TITLE     Characterization of a subset of the basic-helix-loop-helix-PAS
            superfamily that interacts with components of the dioxin signaling
            pathway
  JOURNAL   J Biol Chem 272 (13), 8581-8593 (1997)
   PUBMED   9079689
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Jul 27, 2021 this sequence version replaced NM_001108214.2.
            
            Summary: The protein encoded by this gene is a member of the basic
            helix-loop-helix (bHLH)-PAS family of transcription factors. A
            similar mouse protein may play a regulatory role in the acquisition
            of specific types of memory. It also may function as a part of a
            molecular clock operative in the mammalian forebrain. [provided by
            RefSeq, Feb 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2060962.1,
                                           SRR26643289.25404.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-523               JAXUCZ010000009.1  48959565-48960087
            524-577             JAXUCZ010000009.1  49034558-49034611
            578-726             JAXUCZ010000009.1  49060977-49061125
            727-818             JAXUCZ010000009.1  49066100-49066191
            819-908             JAXUCZ010000009.1  49074522-49074611
            909-1029            JAXUCZ010000009.1  49086595-49086715
            1030-1143           JAXUCZ010000009.1  49087704-49087817
            1144-1262           JAXUCZ010000009.1  49097773-49097891
            1263-1345           JAXUCZ010000009.1  49098608-49098690
            1346-1452           JAXUCZ010000009.1  49099401-49099507
            1453-1600           JAXUCZ010000009.1  49101604-49101751
            1601-1685           JAXUCZ010000009.1  49104177-49104261
            1686-1827           JAXUCZ010000009.1  49106797-49106938
            1828-1937           JAXUCZ010000009.1  49107516-49107625
            1938-2039           JAXUCZ010000009.1  49108911-49109012
            2040-2186           JAXUCZ010000009.1  49111055-49111201
            2187-2384           JAXUCZ010000009.1  49118773-49118970
            2385-2575           JAXUCZ010000009.1  49121178-49121368
            2576-2668           JAXUCZ010000009.1  49122005-49122097
            2669-2843           JAXUCZ010000009.1  49134605-49134779
            2844-4270           JAXUCZ010000009.1  49136610-49138036
FEATURES             Location/Qualifiers
     source          1..4270
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q22"
     gene            1..4270
                     /gene="Npas2"
                     /note="neuronal PAS domain protein 2"
                     /db_xref="GeneID:316351"
                     /db_xref="RGD:1309681"
     exon            1..523
                     /gene="Npas2"
                     /inference="alignment:Splign:2.1.0"
     exon            524..577
                     /gene="Npas2"
                     /inference="alignment:Splign:2.1.0"
     CDS             546..2996
                     /gene="Npas2"
                     /codon_start=1
                     /product="neuronal PAS domain-containing protein 2"
                     /protein_id="NP_001101684.2"
                     /db_xref="GeneID:316351"
                     /db_xref="RGD:1309681"
                     /translation="MDEDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLPGNTRKLD
                     KTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFVIVVTT
                     DGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEFL
                     KSDNDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRV
                     PLGKEVCFIATVRLATPQFLKEMCVADEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLP
                     FEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITY
                     HQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPTEAMHPSALKEKDSSLEPQPHF
                     NALDMGASGLTSSPSPSASSRSSHKSSHTAMSEPTSTPTKLMAENSTTALPRSATLPQ
                     ELPVQGLSQAATMPAPLLSSSSCDLAKQLLPQSLPQTVLQSPPAPVTQFSAQFSMFQT
                     IKDQLEQRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSGAQRPA
                     AQQPLQQRPSAPSQPPLVVNTPLPGQITSTQVTNQHLLRESNVMSAQGPKPIRSSQLL
                     PASSRSLSSLPSQFSSTASVLPPGLSLTTVAPTPQDTSQCQPSPDFGHDRQLRLLLSQ
                     PIQPMMPGSCDARQPSEVSRTGRQVKYAQSQVTFPSPDSHPTSSSAPTPVLLMGQAVL
                     HPGFPASQPSPLQPTQVQQQPPPYLQAPTSLHSEQPDSLLLSTFSQQPAPLGYAATQP
                     TQPQPPRPSRRVSRLSES"
     exon            578..726
                     /gene="Npas2"
                     /inference="alignment:Splign:2.1.0"
     exon            727..818
                     /gene="Npas2"
                     /inference="alignment:Splign:2.1.0"
     exon            819..908
                     /gene="Npas2"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1029
                     /gene="Npas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1143
                     /gene="Npas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1262
                     /gene="Npas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1345
                     /gene="Npas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1452
                     /gene="Npas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1600
                     /gene="Npas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1685
                     /gene="Npas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1827
                     /gene="Npas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1937
                     /gene="Npas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2039
                     /gene="Npas2"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2186
                     /gene="Npas2"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2384
                     /gene="Npas2"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2575
                     /gene="Npas2"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2668
                     /gene="Npas2"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2843
                     /gene="Npas2"
                     /inference="alignment:Splign:2.1.0"
     exon            2844..4270
                     /gene="Npas2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgccccag gcatcgggtc ctgtcgaccg ctgcagccag accgacggtg ggctcccgga
       61 gccactcacc aagggagagg actaggcacc ccgaacctcg ggattcgggg gtgctcggag
      121 ggtgctagat gagtgctgcg tgcccggaca gaatctttga agattgcccg cagcccttcc
      181 agagctccac cgcatgcatc ctgaaccttg gaagcctggg acgcctagcg agtgtggttg
      241 cccggccgtg gccctggtgt cactgcgttc ctgggtctga cttggcttag ggccggattg
      301 aaagccggat ctttgtgctt agacagctcc tgggactccc cgggttggat gctagagcac
      361 tgttttagtg ggaggtgtgc cccctcccca agtagaggag gggtgcaccc ttgacttttc
      421 taaaaagcga cttagggtgg aaagcagagg gcagggacag gtaccaagag gctcaattca
      481 aagccagcct cttccctctg cccgcctctc cttactgctt aaggcaaaac tgcatagaaa
      541 ctctaatgga cgaagatgag aaggatagag caaagagagc ctctcgaaac aagtctgaga
      601 agaagcgtcg ggaccagttc aatgttctca tcaaagagct cagctccatg ctcccaggca
      661 acactcggaa actggacaaa acaactgtgc tggagaaggt catcggattt ctgcagaaac
      721 acaatgaagt ctcagcacaa acagaaatct gtgacatcca gcaggactgg aagccttcat
      781 tcctcagtaa cgaagaattc acccagctga tgttggaggc gttagatggc ttcgtcattg
      841 ttgtgacaac ggacggcagc atcatctatg tgtccgacag catcacgcct ctcctcggac
      901 atttaccgtc ggatgtcatg gatcagaact tgttaaattt ccttccagaa caagaacatt
      961 ccgaagttta taaaatcctt tcctcccata tgcttgtgac ggattccccc tccccagaat
     1021 tcctaaaatc tgacaacgat ttagagtttt attgtcatct tctgagaggc agcttgaacc
     1081 caaaggaatt tccaacttac gaatacataa aatttgtagg aaattttcgc tcttacaaca
     1141 atgtgcctag cccctcctgt aatggctttg acaacaccct ttcaagaccc tgccgcgtgc
     1201 ccctggggaa ggaggtctgc ttcatcgcca cggtgcgcct ggcaacacca cagttcttaa
     1261 aggaaatgtg tgtagctgac gaacctttag aggaattcac ttcgaggcat agcttggaat
     1321 ggaaattttt atttctggat cacagagccc ctccaatcat aggatacctg ccctttgaag
     1381 tacttggcac gtcaggctat gactactacc acattgatga cctggagctc ctggccaggt
     1441 gccaccagca cttgatgcag tttggcaaag ggaagtcgtg ttgttaccgg tttctaacca
     1501 aaggacagca gtggatttgg ttgcaaaccc actactacat cacctaccac cagtggaact
     1561 ccaagcccga gttcatcgtg tgcacacact cggtggtcag ttacgcagat gtccgagtgg
     1621 aaaggagaca ggagctggct ctggaagatc cacccacaga agccatgcac ccctctgcac
     1681 tgaaggaaaa ggactcaagc ctagagcctc agccgcactt taatgcactt gacatgggtg
     1741 cctcaggtct taccagcagt ccttcgccat cagcatcctc gaggagttcc cacaagtcct
     1801 cacacacagc catgtcagaa cccacctcca ctccaaccaa gctgatggct gagaacagca
     1861 ccacagcttt gccaagatca gccaccctac cccaggagtt accagtgcag gggctcagcc
     1921 aggcagccac aatgccagct cctctgcttt cctcatcatc ctgtgacctt gccaagcagc
     1981 tcctgcctca gtccctgcct cagacggtcc tgcagagtcc acctgctcca gtgacacagt
     2041 tttcagcaca atttagcatg ttccagacca taaaagacca gttggagcag aggacacgga
     2101 tcctgcaggc caacattcgg tggcagcagg aagagcttca caagatccag gaacaactct
     2161 gcctggtcca ggactccaac gtccagatgt ttctacagca gccagcggtg tctctgagct
     2221 tcagcggtgc ccagagaccg gcagctcagc agccactgca acaaaggcca tctgcaccgt
     2281 ctcagccccc gcttgtggtc aacactccac tgccggggca gatcacatcc acccaagtca
     2341 caaaccagca cctgctcaga gaatcgaatg tgatgtccgc ccagggtcca aaaccaataa
     2401 gaagctccca gttgctgcct gccagcagcc gttcactgag cagcctgccg tcccagttca
     2461 gcagcacagc gtccgtgctc ccaccaggcc tgagcctcac cactgtcgct cccacccctc
     2521 aggacaccag ccagtgccag cccagccctg acttcggcca tgatcggcag ctcaggctgt
     2581 tgctgagcca acccatccag cctatgatgc ctgggtcttg tgatgccagg cagccctcag
     2641 aagtcagcag gactggacgg caagtcaaat atgcacagag ccaagtgacg tttccaagtc
     2701 ctgactccca ccccaccagc agcagcgccc ccaccccggt cctgttgatg gggcaggccg
     2761 tgctccatcc cggcttcccc gcatcccagc catcacccct gcaaccaaca caggtacaac
     2821 agcagccacc accctatcta caggcaccaa catctctgca cagtgaacag ccggactcgc
     2881 tccttctctc caccttctcc cagcagccag cacctctggg ctatgcagcc acacagccta
     2941 cacagccgca acccccacgc ccttcccgca gggtcagccg gctgtcagag tcctaaggtc
     3001 tccagcagcc atcccggtag tgccctgaca ctggagtcca gaagcaaaca gctttaacca
     3061 atggaaaacg gggttggccg tgggagatgg gaagaagcgg ttgtgtgact ttggcgcacc
     3121 ctgtgtacat ttcagaactc ctgatggtaa catgtctgaa gtgtggcact tgcagaatgg
     3181 ggaaagaaca ggattattgg ccatgatttc cttgccctgg gcttctcggg catccgctac
     3241 agccatacag acaggaacta agtgccctgt atgggcactg cttcctggtc tatttgcaga
     3301 ggtggtacct ctcgctgcct ccaggggaga gcgctccaag tactctaccg actgacacag
     3361 gtcctaagcc ctagcgggcc ttgactctct tgatggtctt tcctttacag tcaaggacta
     3421 agttaaaggt ctttggagag agtataaaga gattattttt cattattttt aaatggttgt
     3481 ttttttttta atttgcacac ctgtgcacaa gggaaataac aggcactttc gggggttttt
     3541 gtttgttcgt tcgtttgttt gtttgtttgt tttaataata aggtcccatg gcttcattgg
     3601 gaatacacaa taatagaaac agtcccacca atcagatagc gaagcctgtt attaatgaag
     3661 ctacagatcc acacccttgg cctaaaccct agcggactga ggctctcggg caccaggccc
     3721 tacaggggtg ttttccttcc taaatagaac actggactct tcctgttaat ttcgctgata
     3781 gtaactacaa aagtggattc agcaaagcac aatctcacaa tgattccgaa ttcctgagag
     3841 acatcttaga ctatgaggga agagggccca caagcagggg tactccgcag gccgaatctc
     3901 ccaggaaacc aggcatgtga tggccttcct agtgaggtag gccaccatga cttccggtat
     3961 atcttccccg atgattccga agatcggatt ttccttttca gaatgcactt tgcttttttt
     4021 ttctttatgt tttgttacat cgaggtgttt ctaaagagaa gattttatgt aattataaga
     4081 ggaagtgtag tgaattgtac agctgttgta ataatgacct atttctataa aaaaataaaa
     4141 ttgtatggat tatgtgtaaa ttattttgta tctgagagac cagttccatt cacaaatatg
     4201 aaagtataaa ggtttccttg tgtttttctg tgagtgaaac attttgtaat aaattaacaa
     4261 gtttgtacaa
//
