LOCUS       NM_173299                513 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus defensin NP-4 precursor (Np4), mRNA.
ACCESSION   NM_173299
VERSION     NM_173299.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Szyk,A., Wu,Z., Tucker,K., Yang,D., Lu,W. and Lubkowski,J.
  TITLE     Crystal structures of human alpha-defensins HNP4, HD5, and HD6
  JOURNAL   Protein Sci 15 (12), 2749-2760 (2006)
   PUBMED   17088326
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Ericksen,B., Wu,Z., Lu,W. and Lehrer,R.I.
  TITLE     Antibacterial activity and specificity of the six human
            {alpha}-defensins
  JOURNAL   Antimicrob Agents Chemother 49 (1), 269-275 (2005)
   PUBMED   15616305
REFERENCE   3  (bases 1 to 513)
  AUTHORS   Hornef,M.W., Putsep,K., Karlsson,J., Refai,E. and Andersson,M.
  TITLE     Increased diversity of intestinal antimicrobial peptides by
            covalent dimer formation
  JOURNAL   Nat Immunol 5 (8), 836-843 (2004)
   PUBMED   15235601
REFERENCE   4  (bases 1 to 513)
  AUTHORS   Yount,N.Y., Wang,M.S., Yuan,J., Banaiee,N., Ouellette,A.J. and
            Selsted,M.E.
  TITLE     Rat neutrophil defensins. Precursor structures and expression
            during neutrophilic myelopoiesis
  JOURNAL   J Immunol 155 (9), 4476-4484 (1995)
   PUBMED   7594610
REFERENCE   5  (bases 1 to 513)
  AUTHORS   Wilde,C.G., Griffith,J.E., Marra,M.N., Snable,J.L. and Scott,R.W.
  TITLE     Purification and characterization of human neutrophil peptide 4, a
            novel member of the defensin family
  JOURNAL   J Biol Chem 264 (19), 11200-11203 (1989)
   PUBMED   2500436
REFERENCE   6  (bases 1 to 513)
  AUTHORS   Eisenhauer,P.B., Harwig,S.S., Szklarek,D., Ganz,T., Selsted,M.E.
            and Lehrer,R.I.
  TITLE     Purification and antimicrobial properties of three defensins from
            rat neutrophils
  JOURNAL   Infect Immun 57 (7), 2021-2027 (1989)
   PUBMED   2543629
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Oct 7, 2022 this sequence version replaced NM_173299.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U16684.1, BF290038.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680416, SAMN06680441
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                JAXUCZ010000016.1  77199568-77199642   c
            76-257              JAXUCZ010000016.1  77197837-77198018   c
            258-513             JAXUCZ010000016.1  77197065-77197320   c
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..513
                     /gene="Np4"
                     /gene_synonym="NP-4"
                     /note="defensin NP-4 precursor"
                     /db_xref="GeneID:286958"
                     /db_xref="RGD:727857"
     exon            1..75
                     /gene="Np4"
                     /gene_synonym="NP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            76..257
                     /gene="Np4"
                     /gene_synonym="NP-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..370
                     /gene="Np4"
                     /gene_synonym="NP-4"
                     /note="neutrophil antibiotic peptide NP-4; ratNP-4;
                     neutrophil defensin 4; defensin 3b; defensin alpha 4"
                     /codon_start=1
                     /product="defensin alpha 4 precursor"
                     /protein_id="NP_775421.1"
                     /db_xref="GeneID:286958"
                     /db_xref="RGD:727857"
                     /translation="MRTLTLLITLLLLALHTQAESPQERAKAAPDQDMVMEDQDIFIS
                     FGGYKGTVLQDAVVKAGQACYCRIGACVSGERLTGACGLNGRIYRLCCR"
     exon            258..513
                     /gene="Np4"
                     /gene_synonym="NP-4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctgctcct gtatcccaag gcctggaaag aagagttctg tgtctcttgc tctgctctcc
       61 ctgcatacgc caaaggagac ccacagccat gaggacactc actctgctca tcacccttct
      121 cctgctggcc ctccacaccc aggcagagtc tccccaagaa agagctaagg cggctccaga
      181 ccaggatatg gtcatggagg accaggatat tttcatatcc tttggagggt ataaaggcac
      241 tgttctccaa gatgcagttg tgaaggcagg tcaagcctgc tattgcagaa tcggagcctg
      301 tgtttctgga gaacggctca ctggggcatg tggtctcaat ggccgcatct accgtctctg
      361 ttgccgctga gcaagaagaa ggaggaggag gaagaggagg agaaggagga gaagaagcca
      421 tttgtcatat gacttgaagg agactgttac ttgtcccatg ttatgtcctt gagttttctc
      481 tttctttata tccaaataaa tttcttatag caa
//
