LOCUS       NM_001393998            1308 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus NADPH oxidase organizer 1 (Noxo1), mRNA.
ACCESSION   NM_001393998 XM_008767566
VERSION     NM_001393998.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1308)
  AUTHORS   Yamamoto,A., Takeya,R., Matsumoto,M., Nakayama,K.I. and Sumimoto,H.
  TITLE     Phosphorylation of Noxo1 at threonine 341 regulates its interaction
            with Noxa1 and the superoxide-producing activity of Nox1
  JOURNAL   FEBS J 280 (20), 5145-5159 (2013)
   PUBMED   23957209
REFERENCE   2  (bases 1 to 1308)
  AUTHORS   Gianni,D., Diaz,B., Taulet,N., Fowler,B., Courtneidge,S.A. and
            Bokoch,G.M.
  TITLE     Novel p47(phox)-related organizers regulate localized NADPH oxidase
            1 (Nox1) activity
  JOURNAL   Sci Signal 2 (88), ra54 (2009)
   PUBMED   19755710
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1308)
  AUTHORS   Yamamoto,A., Kami,K., Takeya,R. and Sumimoto,H.
  TITLE     Interaction between the SH3 domains and C-terminal proline-rich
            region in NADPH oxidase organizer 1 (Noxo1)
  JOURNAL   Biochem Biophys Res Commun 352 (2), 560-565 (2007)
   PUBMED   17126813
REFERENCE   4  (bases 1 to 1308)
  AUTHORS   Cheng,G., Diebold,B.A., Hughes,Y. and Lambeth,J.D.
  TITLE     Nox1-dependent reactive oxygen generation is regulated by Rac1
  JOURNAL   J Biol Chem 281 (26), 17718-17726 (2006)
   PUBMED   16636067
REFERENCE   5  (bases 1 to 1308)
  AUTHORS   Banfi,B., Clark,R.A., Steger,K. and Krause,K.H.
  TITLE     Two novel proteins activate superoxide generation by the NADPH
            oxidase NOX1
  JOURNAL   J Biol Chem 278 (6), 3510-3513 (2003)
   PUBMED   12473664
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 25, 2021 this sequence version replaced XM_008767566.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1588937.1,
                                           SRR23984936.917973.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               JAXUCZ010000010.1  14228205-14228387
            184-264             JAXUCZ010000010.1  14228496-14228576
            265-340             JAXUCZ010000010.1  14228857-14228932
            341-518             JAXUCZ010000010.1  14229016-14229193
            519-700             JAXUCZ010000010.1  14229337-14229518
            701-814             JAXUCZ010000010.1  14229611-14229724
            815-932             JAXUCZ010000010.1  14229957-14230074
            933-1308            JAXUCZ010000010.1  14230166-14230541
FEATURES             Location/Qualifiers
     source          1..1308
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1308
                     /gene="Noxo1"
                     /note="NADPH oxidase organizer 1"
                     /db_xref="GeneID:302976"
                     /db_xref="RGD:1307802"
     exon            1..183
                     /gene="Noxo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1167
                     /gene="Noxo1"
                     /codon_start=1
                     /product="NADPH oxidase organizer 1"
                     /protein_id="NP_001380927.1"
                     /db_xref="GeneID:302976"
                     /db_xref="RGD:1307802"
                     /translation="MASPRHPVSAHAVALVQMERLQTFAFSVCWSDNSDTFARRSWEE
                     FRQLQKTLKKIFPVEAGLLQRSERVLPKLPDAPLLTRRGHTGRGLLRLRLLETYVRSL
                     LATSQHIVTSSTLNSFFAPKPLDLEPMLPPGSLVILPTPEEPLSQPIGSLAIHSLEAQ
                     SMRCLQPFHTLDTKDRPFHTQAKEILDILLRHPSGWWLVENKDQQTAWFPAPYLEEIA
                     TGQGQESGMAVQGSGRQFCATQAYEGSRPDELSVPSGARVHVLETSDRGWWLCRYNGQ
                     TGLLPAVLLQPEGLGSLLGRPGLPDSGGADKVTEGRTVPPVVPTRPCMSAIQSRCCSI
                     TRRAVGQEQRTQVPP"
     exon            184..264
                     /gene="Noxo1"
                     /inference="alignment:Splign:2.1.0"
     exon            265..340
                     /gene="Noxo1"
                     /inference="alignment:Splign:2.1.0"
     exon            341..518
                     /gene="Noxo1"
                     /inference="alignment:Splign:2.1.0"
     exon            519..700
                     /gene="Noxo1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..814
                     /gene="Noxo1"
                     /inference="alignment:Splign:2.1.0"
     exon            815..932
                     /gene="Noxo1"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1308
                     /gene="Noxo1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctggagtgt gaatgctttg cagggactcc acttagggca gtgttgggga attccacttc
       61 acttcttccg gatgctcgga actccttcaa gcacccggtg ggaggccatt cataatcatg
      121 gcaagtccaa gacacccagt atcagcccat gctgtagccc tggtgcagat ggaacggctc
      181 cagacgtttg ccttctctgt gtgctggtca gacaacagtg acacctttgc tcgcaggagc
      241 tgggaggagt ttaggcagct ccagaagacc cttaagaaaa tcttcccagt ggaggcaggc
      301 ctgcttcaga gatctgaacg agttcttccc aagcttcctg atgctccatt gttgacacgt
      361 cggggacata ctggccgagg cctgttacgt ttgcggctgc tggaaaccta tgtacggtca
      421 ctgctggcaa cctcacagca catagtgacg agctcaacac tcaatagctt ctttgcaccc
      481 aaacctctgg atctggagcc catgctgcct cctggcagcc tggtgatcct gcccacccca
      541 gaggagccct tatcccaacc tataggcagc cttgccattc atagcctgga ggctcagagc
      601 atgcgctgct tacagccatt ccacactctt gacacaaaag acagaccttt ccacactcag
      661 gctaaagaaa ttctggacat attactacgg catccttcag gctggtggct ggtggagaac
      721 aaggaccagc agacagcctg gtttccagct ccctacctgg aggagatagc aacaggccaa
      781 ggccaggagt cgggcatggc tgttcaagga agtgggaggc agttctgtgc tacccaggcc
      841 tatgagggca gtcgccctga tgagctatcc gtgccctcag gagcacgtgt acatgtgctg
      901 gaaacctcag accgaggctg gtggctgtgc aggtataatg gccagacagg cctgctccct
      961 gcagtgttgc tgcaacctga agggctgggt tccctcctgg gcaggccagg gctcccagac
     1021 agtggtgggg cagacaaggt gactgagggc aggactgttc cccctgtagt accaactcgc
     1081 ccctgtatga gtgccatcca gagcagatgc tgctccatca cccgcagggc agtgggacag
     1141 gaacaacgga cccaagttcc cccttgagga tttgtatggc cctgcagaga ggctgtactg
     1201 tcaaagccaa cctcaagcaa agcagggacg agggtgtggc tctatgactg gcagggccat
     1261 gggccagtca actttctatt tcctctaaat aaaactggaa tgacttca
//
