LOCUS       NM_053524               2176 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus NADPH oxidase 4 (Nox4), mRNA.
ACCESSION   NM_053524
VERSION     NM_053524.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2176)
  AUTHORS   Li,S., Lyu,Q., Shi,Q., Bai,Y., Ren,X. and Ma,J.
  TITLE     Intermittent short-duration reoxygenation relieves high-altitude
            pulmonary hypertension via NOX4/H2O2/PPAR-gamma axis
  JOURNAL   Clin Sci (Lond) 138 (3), 103-115 (2024)
   PUBMED   38237016
  REMARK    GeneRIF: Intermittent short-duration reoxygenation relieves
            high-altitude pulmonary hypertension via NOX4/H2O2/PPAR-gamma axis.
REFERENCE   2  (bases 1 to 2176)
  AUTHORS   Naser,N., Lonj,C.K., Rikard-Bell,M., Sandow,S.L. and Murphy,T.V.
  TITLE     Advanced glycated end-products inhibit dilation through
            constitutive endothelial RAGE and Nox1/4 in rat isolated skeletal
            muscle arteries
  JOURNAL   Microcirculation 31 (1), e12837 (2024)
   PUBMED   37985248
  REMARK    GeneRIF: Advanced glycated end-products inhibit dilation through
            constitutive endothelial RAGE and Nox1/4 in rat isolated skeletal
            muscle arteries.
REFERENCE   3  (bases 1 to 2176)
  AUTHORS   Matsunaga,S., Kohda,A., Kamakura,S., Hayase,J., Miyano,K.,
            Shiose,A. and Sumimoto,H.
  TITLE     Hypoxia stabilizes the H2 O2 -producing oxidase Nox4 in
            cardiomyocytes via suppressing autophagy-related lysosomal
            degradation
  JOURNAL   Genes Cells 29 (1), 63-72 (2024)
   PUBMED   37985134
  REMARK    GeneRIF: Hypoxia stabilizes the H2 O2 -producing oxidase Nox4 in
            cardiomyocytes via suppressing autophagy-related lysosomal
            degradation.
REFERENCE   4  (bases 1 to 2176)
  AUTHORS   Zhang,Y., Shan,M., Ding,X., Sun,H., Qiu,F. and Shi,L.
  TITLE     Maternal exercise represses Nox4 via SIRT1 to prevent vascular
            oxidative stress and endothelial dysfunction in SHR offspring
  JOURNAL   Front Endocrinol (Lausanne) 14, 1219194 (2023)
   PUBMED   37501791
  REMARK    GeneRIF: Maternal exercise represses Nox4 via SIRT1 to prevent
            vascular oxidative stress and endothelial dysfunction in SHR
            offspring.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2176)
  AUTHORS   Sun,Z.H., Liu,F., Kong,L.L., Ji,P.M., Huang,L., Zhou,H.M., Sun,R.,
            Luo,J. and Li,W.Z.
  TITLE     Interruption of TRPC6-NFATC1 signaling inhibits NADPH oxidase 4 and
            VSMCs phenotypic switch in intracranial aneurysm
  JOURNAL   Biomed Pharmacother 161, 114480 (2023)
   PUBMED   37002575
  REMARK    GeneRIF: Interruption of TRPC6-NFATC1 signaling inhibits NADPH
            oxidase 4 and VSMCs phenotypic switch in intracranial aneurysm.
REFERENCE   6  (bases 1 to 2176)
  AUTHORS   Gorin,Y., Ricono,J.M., Kim,N.H., Bhandari,B., Choudhury,G.G. and
            Abboud,H.E.
  TITLE     Nox4 mediates angiotensin II-induced activation of Akt/protein
            kinase B in mesangial cells
  JOURNAL   Am J Physiol Renal Physiol 285 (2), F219-F229 (2003)
   PUBMED   12842860
  REMARK    GeneRIF: Nox4-based NAD(P)H oxidase and generation of reactive
            oxygen species mediate the effect of ANG II on Akt/PKB activation
            and protein synthesis in glomerular mesangial cells
REFERENCE   7  (bases 1 to 2176)
  AUTHORS   Lassegue,B., Sorescu,D., Szocs,K., Yin,Q., Akers,M., Zhang,Y.,
            Grant,S.L., Lambeth,J.D. and Griendling,K.K.
  TITLE     Novel gp91(phox) homologues in vascular smooth muscle cells : nox1
            mediates angiotensin II-induced superoxide formation and
            redox-sensitive signaling pathways
  JOURNAL   Circ Res 88 (9), 888-894 (2001)
   PUBMED   11348997
REFERENCE   8  (bases 1 to 2176)
  AUTHORS   Yang,S., Madyastha,P., Bingel,S., Ries,W. and Key,L.
  TITLE     A new superoxide-generating oxidase in murine osteoclasts
  JOURNAL   J Biol Chem 276 (8), 5452-5458 (2001)
   PUBMED   11098048
REFERENCE   9  (bases 1 to 2176)
  AUTHORS   Shiose,A., Kuroda,J., Tsuruya,K., Hirai,M., Hirakata,H., Naito,S.,
            Hattori,M., Sakaki,Y. and Sumimoto,H.
  TITLE     A novel superoxide-producing NAD(P)H oxidase in kidney
  JOURNAL   J Biol Chem 276 (2), 1417-1423 (2001)
   PUBMED   11032835
REFERENCE   10 (bases 1 to 2176)
  AUTHORS   Geiszt,M., Kopp,J.B., Varnai,P. and Leto,T.L.
  TITLE     Identification of renox, an NAD(P)H oxidase in kidney
  JOURNAL   Proc Natl Acad Sci U S A 97 (14), 8010-8014 (2000)
   PUBMED   10869423
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY027527.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY027527.1, AB044086.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2176
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2176
                     /gene="Nox4"
                     /note="NADPH oxidase 4"
                     /db_xref="GeneID:85431"
                     /db_xref="RGD:620600"
     exon            1..106
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1786
                     /gene="Nox4"
                     /EC_number="1.6.3.1"
                     /note="kox-1; kidney superoxide-producing NADPH oxidase;
                     kidney oxidase-1"
                     /codon_start=1
                     /product="NADPH oxidase 4"
                     /protein_id="NP_445976.1"
                     /db_xref="GeneID:85431"
                     /db_xref="RGD:620600"
                     /translation="MALSWRSWLANEGVKHLCLLVWLSLNVLLFWKTFLLYNQGPEYY
                     YIHQMLGLGLCLSRASASVLNLNCSLILLPMCRTVLAYLRGSQKVPSRRTRRLLDKSK
                     TLHITCGITICIFSGVHVAAHLVNALNFSVNYSEHFLALNAARYQNEDPRKLLFTTVP
                     GLTGVCMVVVLFLMVTASTYAIRVSNYDIFWYTHNLFFVFYMLLLLHVSGGLLKYQTN
                     LDTHPPGCISLNRTPSQNMSIADYVSEHFHGSLPGGFSKLEDHYQKTLVKICLEEPKF
                     QAHFPQTWIWISGPLCLYCAERLYRCIRSNKPVTIISVINHPSDVMELRMIKENFKAR
                     PGQYIILHCPSVSALENHPFTLTMCPTETKATFGVHFKVVGDWTERFRDLLLPPSSQD
                     SEILPFIQSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLLDDWK
                     PYKLRRLYFIWVCRDIQSFQWFADLLYVLHNKFWQENRPDFVNIQLYLSQTDGIQKII
                     GEKYHTLNSRLFIGRPRWKLLFDEIAKCNRGKTVGVFCCGPSSISKTLHNLSNRNNSY
                     GTKFEYNKESFS"
     exon            107..202
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            203..313
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            314..398
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            399..496
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            497..524
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            525..597
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            598..678
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            679..895
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1060
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1123
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1184
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1266
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1386
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1495
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1564
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1665
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..2176
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttccgtcc caagcaccga gcggagcgca gcacccccgc gccggcggta tggcgctgtc
       61 ctggaggagc tggctggcca acgaaggggt taaacacctc tgtctgcttg tttggctgtc
      121 cctaaatgtc ctgcttttct ggaaaacctt cctgctgtac aaccaagggc cagaatacta
      181 ctacatccac cagatgttgg gcctaggatt gtgtttgagc agagcttctg catctgtcct
      241 gaacctcaac tgcagcctga tccttttacc catgtgccgc acagtcctgg cttaccttcg
      301 cggatcacag aaggtcccta gcaggagaac aagaagattg ttggacaaaa gcaagactct
      361 acatatcacc tgtggcataa ctatttgtat tttctcaggt gtgcatgtag ctgcccactt
      421 ggtgaacgcc ctgaacttct cagtgaacta tagtgaacat ttccttgcac tgaatgcagc
      481 aagataccag aatgaggatc ccagaaagct tctcttcaca actgttccgg gcctgacagg
      541 tgtctgcatg gtggtggtat tgttcctcat ggttacagct tctacctatg caataagagt
      601 ttctaattat gatatcttct ggtatactca caacctcttc tttgtcttct acatgctgct
      661 gctgctgcat gtttcgggtg gcttgttgaa gtatcaaacc aatttagaca ctcaccctcc
      721 tggctgtatc agtcttaacc ggaccccatc tcagaatatg tccatagcag actacgtctc
      781 agaacatttt catggatctt tgcctggagg gttttcaaaa ttagaagatc attaccagaa
      841 aacactggtg aagatttgcc tggaagaacc caagttccaa gctcatttcc cacagacctg
      901 gatttggatt tctggacctt tgtgcctata ctgtgctgag agactttacc gatgcatccg
      961 gagcaacaaa cctgtcacca ttatctcagt aatcaatcat ccctcagatg tcatggaact
     1021 ccgtatgatc aaagaaaact ttaaagcaag acctggccag tatattattc tacattgtcc
     1081 cagtgtatca gcattagaaa accacccatt tactctcaca atgtgtccta ctgaaaccaa
     1141 agcaacattt ggtgtccact ttaaagtagt aggagactgg acagaaagat tccgagattt
     1201 actactgcct ccatcaagcc aagattctga gattctgccc ttcattcaat ctagaaacta
     1261 ccccaagtta tacattgatg gcccatttgg aagtccattt gaggagtcac tgaactatga
     1321 agttagtctg tgtgtggctg gaggcattgg ggtcactccg tttgcatcga tactaaacac
     1381 tctactggat gactggaaac catacaagct aagaagactg tattttatct gggtctgcag
     1441 agacatccaa tcattccagt ggtttgcaga cttgctctat gtgctgcata acaagttttg
     1501 gcaagaaaac agacctgact ttgtgaacat ccagctgtac ctcagtcaaa cagatgggat
     1561 acagaagata attggagaaa aataccacac attgaattct agacttttta ttgggcgtcc
     1621 tcggtggaag cttttatttg atgaaatagc aaaatgtaac agagggaaaa cagttggagt
     1681 tttctgctgt ggacccagtt ctatttccaa gactcttcat aatttgagta accggaacaa
     1741 ctcatatggg acaaaatttg aatacaataa agaatctttc agctaaaacc ttaggagact
     1801 actgggactc taaagaagga acaagtgcaa tttctaagac ttagagactc ggctgaatca
     1861 gacagctatg ctatgccaaa gaatatcaaa gttttgctat ttatgattat ttaaaatgag
     1921 aattcaaaaa gtgtggcaaa aatgacatgg ttaatctgca agccaaaggg gccctgaaga
     1981 atatttgatg tggtgattca catattgatg ggcaaattaa aagaatgctg ttagatgcac
     2041 actgttgatt tttatgggaa attcaagaac tctctaatga ggagctgaac tcactcactc
     2101 tgaagctgat agccacagcc ctctttaaat tgttttcagt cgaacaggtt caaagattga
     2161 acaaaattaa aaattc
//
