LOCUS       NM_001004216            1707 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus NADPH oxidase 3 (Nox3), mRNA.
ACCESSION   NM_001004216 XM_217848
VERSION     NM_001004216.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1707)
  AUTHORS   Michihara,A., Oda,A. and Mido,M.
  TITLE     High Expression Levels of NADPH Oxidase 3 in the Cerebrum of
            Ten-Week-Old Stroke-Prone Spontaneously Hypertensive Rats
  JOURNAL   Biol Pharm Bull 39 (2), 252-258 (2016)
   PUBMED   26830484
  REMARK    GeneRIF: These results suggested that the high expression levels of
            NOX3 increased oxidative stress in stroke-prone hypertensive rat
            cerebrum.
REFERENCE   2  (bases 1 to 1707)
  AUTHORS   Mukherjea,D., Jajoo,S., Kaur,T., Sheehan,K.E., Ramkumar,V. and
            Rybak,L.P.
  TITLE     Transtympanic administration of short interfering (si)RNA for the
            NOX3 isoform of NADPH oxidase protects against cisplatin-induced
            hearing loss in the rat
  JOURNAL   Antioxid Redox Signal 13 (5), 589-598 (2010)
   PUBMED   20214492
  REMARK    GeneRIF: NOX3 regulates stress-related genes in the cochlea, such
            as TRPV1 and KIM-1, and initiates apoptosis in the cochlea.
REFERENCE   3  (bases 1 to 1707)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1707)
  AUTHORS   Mukherjea,D., Jajoo,S., Whitworth,C., Bunch,J.R., Turner,J.G.,
            Rybak,L.P. and Ramkumar,V.
  TITLE     Short interfering RNA against transient receptor potential
            vanilloid 1 attenuates cisplatin-induced hearing loss in the rat
  JOURNAL   J Neurosci 28 (49), 13056-13065 (2008)
   PUBMED   19052196
  REMARK    GeneRIF: These data provide a link between NOX3 and TRPV1 in
            cisplatin-induced hearing loss and suggest that targeting these
            proteins for knockdown by siRNA could serve as a novel approach in
            treating cisplatin ototoxicity.
REFERENCE   5  (bases 1 to 1707)
  AUTHORS   Nakano,Y., Banfi,B., Jesaitis,A.J., Dinauer,M.C., Allen,L.A. and
            Nauseef,W.M.
  TITLE     Critical roles for p22phox in the structural maturation and
            subcellular targeting of Nox3
  JOURNAL   Biochem J 403 (1), 97-108 (2007)
   PUBMED   17140397
REFERENCE   6  (bases 1 to 1707)
  AUTHORS   Banfi,B., Malgrange,B., Knisz,J., Steger,K., Dubois-Dauphin,M. and
            Krause,K.H.
  TITLE     NOX3, a superoxide-generating NADPH oxidase of the inner ear
  JOURNAL   J Biol Chem 279 (44), 46065-46072 (2004)
   PUBMED   15326186
  REMARK    GeneRIF: NOX3 is a relevant source of ROS generation in the
            cochlear and vestibular systems and that NOX3-dependent ROS
            generation might contribute to hearing loss and balance problems in
            response to ototoxic drugs.
REFERENCE   7  (bases 1 to 1707)
  AUTHORS   Fuller,P.M., Jones,T.A., Jones,S.M. and Fuller,C.A.
  TITLE     Evidence for macular gravity receptor modulation of hypothalamic,
            limbic and autonomic nuclei
  JOURNAL   Neuroscience 129 (2), 461-471 (2004)
   PUBMED   15501603
REFERENCE   8  (bases 1 to 1707)
  AUTHORS   Fuller,P.M., Jones,T.A., Jones,S.M. and Fuller,C.A.
  TITLE     Neurovestibular modulation of circadian and homeostatic regulation:
            vestibulohypothalamic connection?
  JOURNAL   Proc Natl Acad Sci U S A 99 (24), 15723-15728 (2002)
   PUBMED   12434016
REFERENCE   9  (bases 1 to 1707)
  AUTHORS   Jones,S.M., Erway,L.C., Bergstrom,R.A., Schimenti,J.C. and
            Jones,T.A.
  TITLE     Vestibular responses to linear acceleration are absent in
            otoconia-deficient C57BL/6JEi-het mice
  JOURNAL   Hear Res 135 (1-2), 56-60 (1999)
   PUBMED   10491954
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY573239.1.
            
            On Sep 10, 2004 this sequence version replaced XM_217848.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY573239.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132265,
                                           SAMD00132268 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1707
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..1707
                     /gene="Nox3"
                     /note="NADPH oxidase 3"
                     /db_xref="GeneID:292279"
                     /db_xref="RGD:1303190"
     CDS             1..1707
                     /gene="Nox3"
                     /note="superoxide producing enzyme"
                     /codon_start=1
                     /product="NADPH oxidase 3"
                     /protein_id="NP_001004216.1"
                     /db_xref="GeneID:292279"
                     /db_xref="RGD:1303190"
                     /translation="MPTCWILNESVSFVVALLWLAINIYLFIDTFCWYAEEESFFYTR
                     VILGSALAWARASAVCLNFNCMLILLPVSRNFVSLVRGTSVCCRGPWRRQLDKNLKFH
                     KLVAYGIAVNSVIHIVAHLFNLERYHLGQAKDAEGLLAALSKLGNAPNESYLNPVRTL
                     YTGTTTQLLMTVSGITGLVISLALILIMTSSTEFIRQSSYELFWYTHHIFIFLFISLA
                     IHGGGRIIRGQTPESLRLHNVTFCRDHFDEWQEAASCPVPQFSGKEPSAWKWTLGPVV
                     LYACEIIIRFWRSHQEVVITKVVSHPSAVLELHMKKRDFKMAPGQYIFIQCPSISPLE
                     WHPFTLTSAPQEDFFSVHIRASGDWTEALLKAFGAEGQAPSELCSMPRLAVDGPFGGS
                     LADVFHYPVSVCIATGIGVTPFASLLKSVWYKCCESQSLPGLSKVYFYWICRDAAAFE
                     WFADLLLSLETQMSEQGKAHLLSYHIYLTGWDEYQAIHIALHWDESLDVITGLKQKTF
                     YGRPNWNEEFKQIAYNHPSSSIGVFFCGPKAMSKTLQKMCRLYSSSDPRGVHFYYNKE
                     NF"
     exon            1..48
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            49..144
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            145..255
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            256..340
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            341..486
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            487..668
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            669..798
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            799..891
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1145
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1308
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1455
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1580
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1707
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgccgacgt gctggatttt gaacgagagt gtgtccttcg tggttgctct cttgtggctg
       61 gcaataaata tctatctgtt tattgacacg ttctgctggt atgctgaaga ggagtctttc
      121 ttttatacac gagttattct gggttccgca ttggcatggg cccgggcatc tgccgtgtgc
      181 ctgaatttta actgcatgct aattctgtta cctgtcagtc ggaacttcgt ttcactggtg
      241 agaggaacga gcgtgtgctg tagaggaccg tggagacggc aactagacaa aaacctcaag
      301 ttccacaagc tcgttgccta cgggatagct gttaattcag ttatccacat tgtggcacac
      361 ttgttcaacc tggagcgtta tcacctgggt caggccaagg atgctgaagg gctgctggct
      421 gcgctttcca aacttggcaa tgccccaaat gaaagctacc tcaatccggt ccgcaccttg
      481 tatacgggta caaccactca gctattaatg acagtctccg gaattactgg cctggtgatc
      541 tctctggctt tgatattgat catgacctct tcaactgagt ttatcaggca gtcctcttat
      601 gagctattct ggtacacaca ccatatcttc atcttcctct tcatcagtct ggccatccac
      661 ggaggaggtc gcatcattcg aggtcaaact ccagagagtc tccggctgca caatgtcacc
      721 ttctgcagag accacttcga cgaatggcag gaagctgcct cgtgccctgt acctcaattt
      781 tctggcaagg agccgtcggc ctggaaatgg actttgggcc ctgtggtctt gtatgcgtgt
      841 gaaataataa ttaggttctg gagatctcac caagaagttg tcattaccaa ggtggtgagt
      901 cacccatctg cagtcctgga acttcacatg aagaagcgtg acttcaagat ggcgcccgga
      961 cagtacatct ttatccagtg cccatccatc tccccgctgg agtggcaccc cttcactctc
     1021 acgtctgctc cccaggagga cttcttcagt gtacacatcc gagcctcagg agactggaca
     1081 gaggcgttac tgaaggcatt tggagcagag ggacaggctc ccagtgagct ctgtagcatg
     1141 ccgagactgg cagtggacgg gcccttcgga ggctctctgg cagatgtatt tcactaccct
     1201 gtgagcgtgt gcattgcaac aggaattgga gtcaccccct tcgcctctct tctgaagtct
     1261 gtgtggtata agtgttgtga atcacagagt ctgcctggac tgagcaaggt gtacttctac
     1321 tggatctgcc gggatgctgc agcctttgag tggtttgccg atctgttact ttcactggaa
     1381 acacagatga gtgaacaagg gaaggctcat ttgctgagtt accacatata tctcactggc
     1441 tgggatgaat accaggcaat tcacatagct ttacactggg atgaaagtct ggatgtgatt
     1501 acaggcttaa agcagaagac cttctatggg cgacccaact ggaatgagga attcaagcag
     1561 attgcctaca atcaccctag cagcagcatt ggcgtgttct tctgtggacc caaagccatg
     1621 tcaaagactc ttcaaaagat gtgccgtttg tactcatcct cagatcctag gggcgttcat
     1681 ttctattaca acaaggaaaa cttctag
//
