LOCUS       NP_001004216             568 aa            linear   ROD 03-APR-2024
DEFINITION  NADPH oxidase 3 [Rattus norvegicus].
ACCESSION   NP_001004216 XP_217848
VERSION     NP_001004216.1
DBSOURCE    REFSEQ: accession NM_001004216.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 568)
  AUTHORS   Michihara,A., Oda,A. and Mido,M.
  TITLE     High Expression Levels of NADPH Oxidase 3 in the Cerebrum of
            Ten-Week-Old Stroke-Prone Spontaneously Hypertensive Rats
  JOURNAL   Biol Pharm Bull 39 (2), 252-258 (2016)
   PUBMED   26830484
  REMARK    GeneRIF: These results suggested that the high expression levels of
            NOX3 increased oxidative stress in stroke-prone hypertensive rat
            cerebrum.
REFERENCE   2  (residues 1 to 568)
  AUTHORS   Mukherjea,D., Jajoo,S., Kaur,T., Sheehan,K.E., Ramkumar,V. and
            Rybak,L.P.
  TITLE     Transtympanic administration of short interfering (si)RNA for the
            NOX3 isoform of NADPH oxidase protects against cisplatin-induced
            hearing loss in the rat
  JOURNAL   Antioxid Redox Signal 13 (5), 589-598 (2010)
   PUBMED   20214492
  REMARK    GeneRIF: NOX3 regulates stress-related genes in the cochlea, such
            as TRPV1 and KIM-1, and initiates apoptosis in the cochlea.
REFERENCE   3  (residues 1 to 568)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (residues 1 to 568)
  AUTHORS   Mukherjea,D., Jajoo,S., Whitworth,C., Bunch,J.R., Turner,J.G.,
            Rybak,L.P. and Ramkumar,V.
  TITLE     Short interfering RNA against transient receptor potential
            vanilloid 1 attenuates cisplatin-induced hearing loss in the rat
  JOURNAL   J Neurosci 28 (49), 13056-13065 (2008)
   PUBMED   19052196
  REMARK    GeneRIF: These data provide a link between NOX3 and TRPV1 in
            cisplatin-induced hearing loss and suggest that targeting these
            proteins for knockdown by siRNA could serve as a novel approach in
            treating cisplatin ototoxicity.
REFERENCE   5  (residues 1 to 568)
  AUTHORS   Nakano,Y., Banfi,B., Jesaitis,A.J., Dinauer,M.C., Allen,L.A. and
            Nauseef,W.M.
  TITLE     Critical roles for p22phox in the structural maturation and
            subcellular targeting of Nox3
  JOURNAL   Biochem J 403 (1), 97-108 (2007)
   PUBMED   17140397
REFERENCE   6  (residues 1 to 568)
  AUTHORS   Banfi,B., Malgrange,B., Knisz,J., Steger,K., Dubois-Dauphin,M. and
            Krause,K.H.
  TITLE     NOX3, a superoxide-generating NADPH oxidase of the inner ear
  JOURNAL   J Biol Chem 279 (44), 46065-46072 (2004)
   PUBMED   15326186
  REMARK    GeneRIF: NOX3 is a relevant source of ROS generation in the
            cochlear and vestibular systems and that NOX3-dependent ROS
            generation might contribute to hearing loss and balance problems in
            response to ototoxic drugs.
REFERENCE   7  (residues 1 to 568)
  AUTHORS   Fuller,P.M., Jones,T.A., Jones,S.M. and Fuller,C.A.
  TITLE     Evidence for macular gravity receptor modulation of hypothalamic,
            limbic and autonomic nuclei
  JOURNAL   Neuroscience 129 (2), 461-471 (2004)
   PUBMED   15501603
REFERENCE   8  (residues 1 to 568)
  AUTHORS   Fuller,P.M., Jones,T.A., Jones,S.M. and Fuller,C.A.
  TITLE     Neurovestibular modulation of circadian and homeostatic regulation:
            vestibulohypothalamic connection?
  JOURNAL   Proc Natl Acad Sci U S A 99 (24), 15723-15728 (2002)
   PUBMED   12434016
REFERENCE   9  (residues 1 to 568)
  AUTHORS   Jones,S.M., Erway,L.C., Bergstrom,R.A., Schimenti,J.C. and
            Jones,T.A.
  TITLE     Vestibular responses to linear acceleration are absent in
            otoconia-deficient C57BL/6JEi-het mice
  JOURNAL   Hear Res 135 (1-2), 56-60 (1999)
   PUBMED   10491954
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY573239.1.
            
            On Sep 10, 2004 this sequence version replaced XP_217848.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY573239.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132265,
                                           SAMD00132268 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..568
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     Protein         1..568
                     /product="NADPH oxidase 3"
                     /note="superoxide producing enzyme"
                     /calculated_mol_wt=64286
     Site            13..33
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q672K1.1)"
     Site            50..70
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q672K1.1)"
     Region          95..547
                     /region_name="COG4097"
                     /note="Predicted ferric reductase [Inorganic ion transport
                     and metabolism]"
                     /db_xref="CDD:443273"
     Site            104..124
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q672K1.1)"
     Site            168..188
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q672K1.1)"
     Site            202..222
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q672K1.1)"
     Site            238
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q672K1.1)"
     Region          295..568
                     /region_name="NOX_Duox_like_FAD_NADP"
                     /note="NADPH oxidase (NOX) catalyzes the generation of
                     reactive oxygen species (ROS) such as superoxide and
                     hydrogen peroxide. ROS were originally identified as
                     bactericidal agents in phagocytes, but are now also
                     implicated in cell signaling and metabolism. NOX...;
                     cd06186"
                     /db_xref="CDD:99783"
     Site            order(322,336..339,352..354,357..360,409)
                     /site_type="other"
                     /note="FAD binding pocket [chemical binding]"
                     /db_xref="CDD:99783"
     Site            order(336,338..339)
                     /site_type="other"
                     /note="FAD binding motif [chemical binding]"
                     /db_xref="CDD:99783"
     Site            396..416
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q672K1.1)"
     Site            404..414
                     /site_type="other"
                     /note="NAD pyrophosphate binding region [chemical
                     binding]"
                     /db_xref="CDD:99783"
     Site            order(404,408..411,413)
                     /site_type="other"
                     /note="beta-alpha-beta stucture motif"
                     /db_xref="CDD:99783"
     Site            order(409..410,442..444,536..537)
                     /site_type="other"
                     /note="NAD binding pocket [chemical binding]"
                     /db_xref="CDD:99783"
     Site            order(440..441,444)
                     /site_type="other"
                     /note="NADP ribose binding motif [chemical binding]"
                     /db_xref="CDD:99783"
     CDS             1..568
                     /gene="Nox3"
                     /coded_by="NM_001004216.1:1..1707"
                     /db_xref="GeneID:292279"
                     /db_xref="RGD:1303190"
ORIGIN      
        1 mptcwilnes vsfvvallwl ainiylfidt fcwyaeeesf fytrvilgsa lawarasavc
       61 lnfncmlill pvsrnfvslv rgtsvccrgp wrrqldknlk fhklvaygia vnsvihivah
      121 lfnleryhlg qakdaeglla alsklgnapn esylnpvrtl ytgtttqllm tvsgitglvi
      181 slalilimts stefirqssy elfwythhif iflfislaih gggriirgqt peslrlhnvt
      241 fcrdhfdewq eaascpvpqf sgkepsawkw tlgpvvlyac eiiirfwrsh qevvitkvvs
      301 hpsavlelhm kkrdfkmapg qyifiqcpsi splewhpftl tsapqedffs vhirasgdwt
      361 eallkafgae gqapselcsm prlavdgpfg gsladvfhyp vsvciatgig vtpfasllks
      421 vwykccesqs lpglskvyfy wicrdaaafe wfadlllsle tqmseqgkah llsyhiyltg
      481 wdeyqaihia lhwdesldvi tglkqktfyg rpnwneefkq iaynhpsssi gvffcgpkam
      541 sktlqkmcrl ysssdprgvh fyynkenf
//
