LOCUS       NM_053683               2571 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus NADPH oxidase 1 (Nox1), mRNA.
ACCESSION   NM_053683
VERSION     NM_053683.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2571)
  AUTHORS   Naser,N., Lonj,C.K., Rikard-Bell,M., Sandow,S.L. and Murphy,T.V.
  TITLE     Advanced glycated end-products inhibit dilation through
            constitutive endothelial RAGE and Nox1/4 in rat isolated skeletal
            muscle arteries
  JOURNAL   Microcirculation 31 (1), e12837 (2024)
   PUBMED   37985248
  REMARK    GeneRIF: Advanced glycated end-products inhibit dilation through
            constitutive endothelial RAGE and Nox1/4 in rat isolated skeletal
            muscle arteries.
REFERENCE   2  (bases 1 to 2571)
  AUTHORS   Park,J.M., Do,V.Q., Seo,Y.S., Kim,H.J., Nam,J.H., Yin,M.Z.,
            Kim,H.J., Kim,S.J., Griendling,K.K. and Lee,M.Y.
  TITLE     NADPH Oxidase 1 Mediates Acute Blood Pressure Response to
            Angiotensin II by Contributing to Calcium Influx in Vascular Smooth
            Muscle Cells
  JOURNAL   Arterioscler Thromb Vasc Biol 42 (5), e117-e130 (2022)
   PUBMED   35354309
  REMARK    GeneRIF: NADPH Oxidase 1 Mediates Acute Blood Pressure Response to
            Angiotensin II by Contributing to Calcium Influx in Vascular Smooth
            Muscle Cells.
REFERENCE   3  (bases 1 to 2571)
  AUTHORS   Singh,S., Bruder-Nascimento,A., Belin de Chantemele,E.J. and
            Bruder-Nascimento,T.
  TITLE     CCR5 antagonist treatment inhibits vascular injury by regulating
            NADPH oxidase 1
  JOURNAL   Biochem Pharmacol 195, 114859 (2022)
   PUBMED   34843718
  REMARK    GeneRIF: CCR5 antagonist treatment inhibits vascular injury by
            regulating NADPH oxidase 1.
REFERENCE   4  (bases 1 to 2571)
  AUTHORS   Zhu,J., Qiu,J.G., Xu,W.T., Ma,H.X. and Jiang,K.
  TITLE     Alamandine protects against renal ischaemia-reperfusion injury in
            rats via inhibiting oxidative stress
  JOURNAL   J Pharm Pharmacol 73 (11), 1491-1502 (2021)
   PUBMED   34244746
REFERENCE   5  (bases 1 to 2571)
  AUTHORS   Tan,L., Liu,L., Yao,J. and Piao,C.
  TITLE     miR-145-5p attenuates inflammatory response and apoptosis in
            myocardial ischemia-reperfusion injury by inhibiting (NADPH)
            oxidase homolog 1
  JOURNAL   Exp Anim 70 (3), 311-321 (2021)
   PUBMED   33658472
  REMARK    GeneRIF: miR-145-5p attenuates inflammatory response and apoptosis
            in myocardial ischemia-reperfusion injury by inhibiting (NADPH)
            oxidase homolog 1.
REFERENCE   6  (bases 1 to 2571)
  AUTHORS   Arbiser,J.L., Petros,J., Klafter,R., Govindajaran,B.,
            McLaughlin,E.R., Brown,L.F., Cohen,C., Moses,M., Kilroy,S.,
            Arnold,R.S. and Lambeth,J.D.
  TITLE     Reactive oxygen generated by Nox1 triggers the angiogenic switch
  JOURNAL   Proc Natl Acad Sci U S A 99 (2), 715-720 (2002)
   PUBMED   11805326
REFERENCE   7  (bases 1 to 2571)
  AUTHORS   Arnold,R.S., Shi,J., Murad,E., Whalen,A.M., Sun,C.Q.,
            Polavarapu,R., Parthasarathy,S., Petros,J.A. and Lambeth,J.D.
  TITLE     Hydrogen peroxide mediates the cell growth and transformation
            caused by the mitogenic oxidase Nox1
  JOURNAL   Proc Natl Acad Sci U S A 98 (10), 5550-5555 (2001)
   PUBMED   11331784
REFERENCE   8  (bases 1 to 2571)
  AUTHORS   Zou,A.P., Li,N. and Cowley,A.W. Jr.
  TITLE     Production and actions of superoxide in the renal medulla
  JOURNAL   Hypertension 37 (2 Pt 2), 547-553 (2001)
   PUBMED   11230333
REFERENCE   9  (bases 1 to 2571)
  AUTHORS   Banfi,B., Maturana,A., Jaconi,S., Arnaudeau,S., Laforge,T.,
            Sinha,B., Ligeti,E., Demaurex,N. and Krause,K.H.
  TITLE     A mammalian H+ channel generated through alternative splicing of
            the NADPH oxidase homolog NOH-1
  JOURNAL   Science 287 (5450), 138-142 (2000)
   PUBMED   10615049
  REMARK    Erratum:[Science. 2005 Jan 7;307(5706):44]
REFERENCE   10 (bases 1 to 2571)
  AUTHORS   Suh,Y.A., Arnold,R.S., Lassegue,B., Shi,J., Xu,X., Sorescu,D.,
            Chung,A.B., Griendling,K.K. and Lambeth,J.D.
  TITLE     Cell transformation by the superoxide-generating oxidase Mox1
  JOURNAL   Nature 401 (6748), 79-82 (1999)
   PUBMED   10485709
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053683.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF152963.1, SRR21887623.2337885.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093046, SAMN16093049
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000021.1  101595349-101595520 c
            173-268             JAXUCZ010000021.1  101591233-101591328 c
            269-379             JAXUCZ010000021.1  101585418-101585528 c
            380-464             JAXUCZ010000021.1  101585120-101585204 c
            465-613             JAXUCZ010000021.1  101584651-101584799 c
            614-795             JAXUCZ010000021.1  101584360-101584541 c
            796-928             JAXUCZ010000021.1  101584138-101584270 c
            929-1021            JAXUCZ010000021.1  101582066-101582158 c
            1022-1257           JAXUCZ010000021.1  101580791-101581026 c
            1258-1420           JAXUCZ010000021.1  101580460-101580622 c
            1421-1567           JAXUCZ010000021.1  101578812-101578958 c
            1568-1692           JAXUCZ010000021.1  101578508-101578632 c
            1693-2571           JAXUCZ010000021.1  101572342-101573220 c
FEATURES             Location/Qualifiers
     source          1..2571
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq32"
     gene            1..2571
                     /gene="Nox1"
                     /note="NADPH oxidase 1"
                     /db_xref="GeneID:114243"
                     /db_xref="RGD:620598"
     exon            1..172
                     /gene="Nox1"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1819
                     /gene="Nox1"
                     /note="MOX1; NOH-1; NOX-1; mitogenic oxidase 1; MOX-1;
                     NADH/NADPH mitogenic oxidase subunit p65-mox"
                     /codon_start=1
                     /product="NADPH oxidase 1"
                     /protein_id="NP_446135.2"
                     /db_xref="GeneID:114243"
                     /db_xref="RGD:620598"
                     /translation="MGNWLVNHWLSVLFLVSWLGLNIFLFVYVFLNYEKSDKYYYTRE
                     ILGTALALARASALCLNFNSMVILIPVCRNLLSFLRGTCSFCNHTLRKPLDHNLTFHK
                     LVAYMICIFTAIHIIAHLFNFERYSRSQQAMDGSLASVLSSLFHPEKEDSWLNPIQSP
                     NVTVMYAAFTSIAGLTGVVATVALVLMVTSAMEFIRRNYFELFWYTHHLFIIYIICLG
                     IHGLGGIVRGQTEESMSESHPRNCSYSFHEWDKYERSCRSPHFVGQPPESWKWILAPI
                     AFYIFERILRFYRSRQKVVITKVVMHPCKVLELQMRKRGFTMEIGQYIFVNCPSISFL
                     EWHPFTLTSAPEEEFFSIHIRAAGDWTENLIRTFEQQHSPMPRIEVDGPFGTVSEDVF
                     QYEVAVLVGAGIGVTPFASFLKSIWYKFQRAHNKLKTQKIYFYWICRETGAFAWFNNL
                     LNSLEQEMDELGKPDFLNYRLFLTGWDSNIAGHAALNFDRATDVLTGLKQKTSFGRPM
                     WDNEFSRIATAHPKSVVGVFLCGPPTLAKSLRKCCRRYSSLDPRKVQFYFNKETF"
     exon            173..268
                     /gene="Nox1"
                     /inference="alignment:Splign:2.1.0"
     exon            269..379
                     /gene="Nox1"
                     /inference="alignment:Splign:2.1.0"
     exon            380..464
                     /gene="Nox1"
                     /inference="alignment:Splign:2.1.0"
     exon            465..613
                     /gene="Nox1"
                     /inference="alignment:Splign:2.1.0"
     exon            614..795
                     /gene="Nox1"
                     /inference="alignment:Splign:2.1.0"
     exon            796..928
                     /gene="Nox1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1021
                     /gene="Nox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1257
                     /gene="Nox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1420
                     /gene="Nox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1567
                     /gene="Nox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1692
                     /gene="Nox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..2571
                     /gene="Nox1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttctgagtag gtgtgcattt gagtgtcata aagacatata tcttgagcta gacagaagtt
       61 cctatcctga aggatcccat cagagaaacc agattgctcc taagaggctc cagacctcca
      121 tttgacaatg ggaaactggc tggttaacca ctggctctca gttttgtttc tggtttcttg
      181 gttggggctg aacatttttc tgtttgtgta cgtcttcctg aattatgaga agtctgacaa
      241 gtactattac acgagagaaa ttctcggaac tgccttggcc ttggccagag catctgcttt
      301 gtgcctgaat tttaacagca tggtgatcct gattcctgtg tgtcgaaatc tgctctcctt
      361 cctgaggggc acctgctcat tttgcaacca cacgctgaga aagccattgg atcacaacct
      421 caccttccat aagctggtgg catatatgat ctgcatattc acagctattc atatcattgc
      481 acatctattt aactttgaac gctacagtag aagccaacag gccatggatg gatctcttgc
      541 ctctgttctc tccagcctat tccatcccga gaaagaagat tcttggctaa atcccatcca
      601 gtctccaaac gtgacagtga tgtatgcagc atttaccagt attgctggcc ttactggagt
      661 ggtcgccact gtggctttgg ttctcatggt aacttcagct atggagttta tccgcaggaa
      721 ttattttgag ctcttctggt atacacatca ccttttcatc atctatatca tctgcttagg
      781 gatccatggc ctggggggga ttgtccgggg tcaaacagaa gagagcatga gtgaaagtca
      841 tccccgcaac tgttcatact ctttccacga gtgggataag tatgaaagga gttgcaggag
      901 tcctcatttt gtggggcaac cccctgagtc ttggaagtgg atcctcgcgc cgattgcttt
      961 ttatatcttt gaaaggatcc ttcgctttta tcgctcccgg cagaaggtcg tgattaccaa
     1021 ggttgtcatg cacccatgta aagttttgga attgcagatg aggaagcggg gctttactat
     1081 ggaaatagga cagtatatat tcgtaaattg cccctcgatt tccttcctgg aatggcatcc
     1141 ctttactctg acctctgctc cagaggaaga atttttctcc attcatattc gagcagcagg
     1201 ggactggaca gaaaatctca taaggacatt tgaacaacag cactcaccaa tgcccaggat
     1261 cgaggtggat ggtccctttg gcacagtcag tgaggatgtc ttccagtacg aagtggctgt
     1321 actggttggg gcagggattg gcgtcactcc ctttgcttcc ttcttgaaat ctatctggta
     1381 caaattccag cgtgcacaca acaagctgaa aacacaaaag atctatttct actggatttg
     1441 tagagagacg ggtgcctttg cctggttcaa caacttattg aattccctgg aacaagagat
     1501 ggacgaatta ggcaaaccgg atttcctaaa ctaccgactc ttcctcactg gctgggatag
     1561 caacattgct ggtcatgcag cattaaactt tgacagagcc actgacgtcc tgacaggtct
     1621 gaaacagaaa acctcctttg ggagaccaat gtgggacaat gagttttcta gaatagctac
     1681 tgcccacccc aagtctgtgg tgggggtttt cttatgcggc cctccgactt tggcaaaaag
     1741 cctgcgcaaa tgctgtcggc ggtactcaag tctggatcct aggaaggttc aattctactt
     1801 caacaaagaa acgttctgaa ttggaggaag ccgcacagta gtacttctcc atcttccttt
     1861 tcactaacgt gtgggtcagc tactagatag tccgttgtcg cacaaggact tcactcccat
     1921 cttaaagttg actcaactcc atcattcttg ggctttggca acatgagagc tgcataactc
     1981 acaattgcaa aacacatgaa ttattattgg ggggattgta aatccttctg ggaaacctgc
     2041 ctttagctga attttgctgg ttgacacttg cacaatttaa cctcaggtgt cttggttgat
     2101 acctgataat cttccctccc acctgtccct cacagaagat ttctaagtag ggtgatttta
     2161 aaatatttat tgaatccacg acaaaacaat aatcataaat aataaacata aaattaccaa
     2221 gattcccact cccatatcat acccactaag tacatcgtta tacatgagct tatcatccag
     2281 tgtgaccaac aatttatact ttactgtgcc aaaataatct tcatctttgc ttattgaaca
     2341 attttgctga ctttccctag taatatctta agtatattaa ctggaatcaa atttgtatta
     2401 tagttagaag ccaactatat tgccagtttg tattgtttga aataactgga aaggcctgac
     2461 ctacatcgtg gggtaattta acagaagctc tttccatttt ttgttgttgt tgttaaagag
     2521 ttttgtttat gaatgtgtta taaaaagaaa ataaaaagtt ataattttga c
//
