LOCUS       NM_001414916            6994 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus NOVA alternative splicing regulator 1 (Nova1),
            transcript variant 1, mRNA.
ACCESSION   NM_001414916 XM_006240069
VERSION     NM_001414916.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6994)
  AUTHORS   Liu,Z., Lou,Y., Cui,J.C., Chen,Y., Liu,J.T., Yuan,Y., Han,Y.,
            Huo,Y.L., Qi,Y.X., Jiang,Z.L. and Yao,Q.P.
  TITLE     Circular RNA UVRAG Mediated by Alternative Splicing Factor NOVA1
            Regulates Adhesion and Migration of Vascular Smooth Muscle Cells
  JOURNAL   Genes (Basel) 12 (3), 418 (2021)
   PUBMED   33799408
  REMARK    GeneRIF: Circular RNA UVRAG Mediated by Alternative Splicing Factor
            NOVA1 Regulates Adhesion and Migration of Vascular Smooth Muscle
            Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6994)
  AUTHORS   Li,H., Lv,B., Kong,L., Xia,J., Zhu,M., Hu,L., Zhen,D., Wu,Y.,
            Jia,X., Zhu,S. and Cui,H.
  TITLE     Nova1 mediates resistance of rat pheochromocytoma cells to
            hypoxia-induced apoptosis via the Bax/Bcl-2/caspase-3 pathway
  JOURNAL   Int J Mol Med 40 (4), 1125-1133 (2017)
   PUBMED   28791345
  REMARK    GeneRIF: Nova1 mediates resistance of rat pheochromocytoma cells to
            hypoxia-induced apoptosis via the Bax/Bcl-2/caspase-3 pathway.
REFERENCE   3  (bases 1 to 6994)
  AUTHORS   Vernia,S., Edwards,Y.J., Han,M.S., Cavanagh-Kyros,J., Barrett,T.,
            Kim,J.K. and Davis,R.J.
  TITLE     An alternative splicing program promotes adipose tissue
            thermogenesis
  JOURNAL   Elife 5, e17672 (2016)
   PUBMED   27635635
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6994)
  AUTHORS   Kapeli,K., Pratt,G.A., Vu,A.Q., Hutt,K.R., Martinez,F.J.,
            Sundararaman,B., Batra,R., Freese,P., Lambert,N.J., Huelga,S.C.,
            Chun,S.J., Liang,T.Y., Chang,J., Donohue,J.P., Shiue,L., Zhang,J.,
            Zhu,H., Cambi,F., Kasarskis,E., Hoon,S., Ares,M. Jr., Burge,C.B.,
            Ravits,J., Rigo,F. and Yeo,G.W.
  TITLE     Distinct and shared functions of ALS-associated proteins TDP-43,
            FUS and TAF15 revealed by multisystem analyses
  JOURNAL   Nat Commun 7, 12143 (2016)
   PUBMED   27378374
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6994)
  AUTHORS   Storchel,P.H., Thummler,J., Siegel,G., Aksoy-Aksel,A., Zampa,F.,
            Sumer,S. and Schratt,G.
  TITLE     A large-scale functional screen identifies Nova1 and Ncoa3 as
            regulators of neuronal miRNA function
  JOURNAL   EMBO J 34 (17), 2237-2254 (2015)
   PUBMED   26105073
  REMARK    GeneRIF: Nova1 and Ncoa3 stimulate miRNA function by different
            mechanisms that converge on Argonaute (Ago) proteins, core
            components of the miRNA-induced silencing complex (miRISC).
REFERENCE   6  (bases 1 to 6994)
  AUTHORS   Eom,T., Zhang,C., Wang,H., Lay,K., Fak,J., Noebels,J.L. and
            Darnell,R.B.
  TITLE     NOVA-dependent regulation of cryptic NMD exons controls synaptic
            protein levels after seizure
  JOURNAL   Elife 2, e00178 (2013)
   PUBMED   23359859
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6994)
  AUTHORS   Li,H., Sun,C., Wang,Y., Gao,Y., Liu,Y., Gao,Y., Li,X. and Zhang,C.
  TITLE     Dynamic expression pattern of neuro-oncological ventral antigen 1
            (Nova1) in the rat brain after focal cerebral ischemia/reperfusion
            insults
  JOURNAL   J Histochem Cytochem 61 (1), 45-54 (2013)
   PUBMED   23042482
  REMARK    GeneRIF: Nova1 might mediate neuronal responsiveness, and its
            expression might positively correlate with neural repair after
            ischemia-reperfusion insults in the rat brain.
REFERENCE   8  (bases 1 to 6994)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   9  (bases 1 to 6994)
  AUTHORS   Kumar,D.V., Nighorn,A. and St John,P.A.
  TITLE     Role of Nova-1 in regulating alpha2N, a novel glycine receptor
            splice variant, in developing spinal cord neurons
  JOURNAL   J Neurobiol 52 (2), 156-165 (2002)
   PUBMED   12124753
  REMARK    GeneRIF: Role of Nova-1 in regulating alpha2N, a novel glycine
            receptor splice variant, in developing spinal cord neurons.
REFERENCE   10 (bases 1 to 6994)
  AUTHORS   Jensen,K.B., Dredge,B.K., Stefani,G., Zhong,R., Buckanovich,R.J.,
            Okano,H.J., Yang,Y.Y. and Darnell,R.B.
  TITLE     Nova-1 regulates neuron-specific alternative splicing and is
            essential for neuronal viability
  JOURNAL   Neuron 25 (2), 359-371 (2000)
   PUBMED   10719891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Dec 14, 2022 this sequence version replaced XM_006240069.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.2404696.1,
                                           SRR26360172.1325082.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               JAXUCZ010000006.1  69632281-69632437   c
            158-301             JAXUCZ010000006.1  69630546-69630689   c
            302-468             JAXUCZ010000006.1  69531175-69531341   c
            469-540             JAXUCZ010000006.1  69524090-69524161   c
            541-6994            JAXUCZ010000006.1  69506983-69513436   c
FEATURES             Location/Qualifiers
     source          1..6994
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q21"
     gene            1..6994
                     /gene="Nova1"
                     /gene_synonym="Nova-1"
                     /note="NOVA alternative splicing regulator 1"
                     /db_xref="GeneID:298992"
                     /db_xref="RGD:621345"
     exon            1..157
                     /gene="Nova1"
                     /gene_synonym="Nova-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1545
                     /gene="Nova1"
                     /gene_synonym="Nova-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RNA-binding protein Nova-1; neuro-oncological ventral
                     antigen 1"
                     /codon_start=1
                     /product="RNA-binding protein Nova-1 isoform 1"
                     /protein_id="NP_001401845.1"
                     /db_xref="GeneID:298992"
                     /db_xref="RGD:621345"
                     /translation="MMAAAPIQQNGTHTGVPIDLDPPDSRKRPLEAPPEAGSTKRTNT
                     GEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKDFYPGTTERVCLI
                     QGTIEALNAVHGFIAEKIREMPQNVAKTEPVSILQPQTTVNPDRIKQTLPSSPTTTKS
                     SPSDPMTTSRANQVKIIVPNSTAGLIIGKGGATVKAIMEQSGAWVQLSQKPDGINLQE
                     RVVTVSGEPEQNRKAVELIIQKIQEDPQSGSCLNISYANVTGPVANSNPTGSPYANTA
                     EVLPTAAAAAGLLGHANLAGVAAFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGL
                     GLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTFALGSLAAAT
                     AATNGYFGAASPLAASAILGTEKSTDGSKDVVEIAVPENLVGAILGKGGKTLVEYQEL
                     TGARIQISKKGEFVPGTRNRKVTITGTPAATQAAQYLITQRITYEQGVRAANPQKVG"
     exon            158..301
                     /gene="Nova1"
                     /gene_synonym="Nova-1"
                     /inference="alignment:Splign:2.1.0"
     exon            302..468
                     /gene="Nova1"
                     /gene_synonym="Nova-1"
                     /inference="alignment:Splign:2.1.0"
     exon            469..540
                     /gene="Nova1"
                     /gene_synonym="Nova-1"
                     /inference="alignment:Splign:2.1.0"
     exon            541..6994
                     /gene="Nova1"
                     /gene_synonym="Nova-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcggcag gaactgcaag catgatggcg gcagctccca ttcagcagaa cgggacccat
       61 acgggggttc ccatagatct ggacccgccg gactcgcgga aaaggccgct tgaagcgccc
      121 cctgaagccg gcagcaccaa gaggaccaac acgggcgaag acggccagta ctttctaaag
      181 gtcctcatac ctagttatgc tgctggatct ataattggga agggaggaca gacaattgtt
      241 cagttgcaaa aggaaacggg agccacgatc aagctgtcta agtccaaaga tttttatcca
      301 ggtactactg agagggtttg cttgatccag ggaacgattg aagcactgaa tgcagttcat
      361 ggattcattg cagaaaaaat tcgagaaatg ccccaaaatg ttgccaagac agaaccagtc
      421 agtatcctgc aacctcagac caccgttaac cctgatcgca tcaaacaaac attgccatct
      481 tccccaacta ccaccaagtc ctctccatct gaccccatga ccacctccag agccaatcag
      541 gtaaagatta tagttcccaa cagcacagca ggtctgataa tagggaaggg aggtgctact
      601 gtgaaggcta taatggagca gtcaggggct tgggtgcagc tttcccagaa acctgatggg
      661 atcaacttgc aagagagggt tgtcactgtg agtggagaac ctgaacaaaa ccgaaaagct
      721 gttgaactta tcatccagaa gatacaagag gatccacaga gtggcagctg tctcaatatc
      781 agttatgcca atgtgacagg tccagtggca aattccaatc caaccggatc tccttatgca
      841 aacactgctg aagtgttacc aactgccgca gccgccgcag ggctattagg acatgctaac
      901 cttgccggtg ttgcggcctt cccagcagtt ttatctggct tcacaggcaa tgacctggtg
      961 gccatcacct ctgcacttaa tacattagcc agctatggat ataatctcaa cacattaggt
     1021 ttaggtctca gccaagcagc agcaacgggg gctttggctg ccgcagctgc cagtgccaac
     1081 ccagcagcag cagcagccaa tttgttggcc acctatgcca gtgaagcctc agccagcggc
     1141 agcacagctg gtggaacggc ggggacattt gcattaggta gcctggctgc tgctactgct
     1201 gcaaccaatg gatactttgg agctgcctca cccctagctg ccagtgccat tctagggaca
     1261 gagaaatcca cagatggatc aaaggatgta gttgaaatag cagttccaga aaacttagtt
     1321 ggtgcaatac ttggcaaagg agggaaaacc ttagtggaat accaggagtt gactggtgca
     1381 aggatacaga tctccaaaaa gggagagttc gtacctggca cacggaatcg gaaggtaacc
     1441 attactggaa caccagctgc aacacaggct gctcagtatt taattacaca gaggatcaca
     1501 tatgagcaag gagtgcgggc cgccaatcct cagaaagtgg gttgagtgcc ccgattatac
     1561 gtcagattgt tttaacccct cctttacccc attttcaaga aggatgtact gtactttgca
     1621 gaagtgaagt ttttctgtta ttaatatata attatgcaaa tgaatgcgac tatgttgaca
     1681 atgtgtatat gtaaataata tgtgttttac cagatgtttc atagaatttt ttcttgacct
     1741 gttttgttct ctatactttg cttgtgtata tttgtcagag gtgtttctag tgtaagattt
     1801 aagcctgcca ttttaccagc attattgtag tttaatgatt gaatgtagac agggatatgc
     1861 gtatagtttt cagtcttagt tctagataac actaaattaa ctactgttag gttgagtatg
     1921 gtggggtcag tgacctaaac tggagtgagg ccaaagcact gtcatgtatg tcttacttcc
     1981 tgcttagggc acagagaagt aggaaacaat attttgaaaa taagttttaa atttaaaatg
     2041 atcaaaaagc aatatagttg cataaaagca ctgtaaaata tttaaaaggt taaaactgtg
     2101 gaaaattaca ttggtaagtt tacagatcaa taaaagcacc tgttctccat ctgaactaga
     2161 caatggaaat aatgctgcat gctggccatg gcccattctt catcatttgt aagttcaaca
     2221 aaagttctca catggagtcc cacctcttca gaggtttgta cattcgtttt taagcactga
     2281 attcactact gatcccatcg cctggccagt agaacagtca ttactccatt aacatcttca
     2341 ctgtttagac acataactgt ggtacagtgt attggaaatt ttataaacaa acgtgaaagt
     2401 gccaacacat tattgatagc tgataatgtt tcattatctg caactgctgg ataagtacgt
     2461 tgcattttaa gagcttataa ttgtgtataa tttgttaaca ctagaaacct attagtattg
     2521 tgaatgtaga ttttactgtg aagctatctg tgatttagct gtttgctcca tgacggagtc
     2581 cttgcagcat ggcgctagca gccagtgcag tttctaatac tcggtaattt gcatgttttg
     2641 tggagcattt ttatgtcacc aaccagacag tatttcctgc atgcttattt agaagaggca
     2701 gtttatcttg agaggtagtg tgatctacct ttgtcaggct ttttgacagg tcatttcaga
     2761 gtaagccttt gttcccaaga cccaacaact gtcaccctct tctgtacctc tcctgagtgc
     2821 caactgtcca ggccatttga cacaccatct gttaacctct gagtttgccc gctcaaggcc
     2881 actcataggg gcatccatcc ccaagcacct cctcatgctg tgcatgcagt cttaaattca
     2941 atggacaaaa ataaaatgct ggctacctct ggatcatctg gctgagcaac tgaattacaa
     3001 aagagaatta cttccatctc aacttccgcc cattggttac gtccatccta gcaagctaaa
     3061 tggcatccca gctgctcctt tctgtgcaac caattaaaga acaatgagtg tgatgctcca
     3121 tgtctgaatt tcgtccagcc tctctctgaa ctgtgatctt tgtcctcatg aactttccct
     3181 tttgttcatt gaactatatg gactcttcat ttcatattga tttactgtgc aatttacttt
     3241 tggacattga gaacttgaaa ttatttcctg atcccttccc cttccactat taataattca
     3301 tttctgtcaa actgtaagag taggactcat tttttttttt tagtttttaa cattggactg
     3361 ttatttcatt tagagttctc tatctctaaa tatttattta gagaatgatt ttcaaaggga
     3421 atgatatgct tgtttaaatg aaagagaaaa gctgtagtaa actgtgttaa ttggtaatga
     3481 ctatttatcg tcgatactct gtagctgtgt aagttttgac aaatagtgta tctcgtggaa
     3541 tcagtggtta gcattgccgc tattatattt actcatttta tcattataaa tgtgcttagt
     3601 tcatcatgta gcatcacttg tctcccgtct cattttttcc ttgcatgtca caagtctcag
     3661 atcatttata atacattaac agtaaataat atctatgtaa atttctttca ccatgctgtc
     3721 tcagagtcag cagtgaagaa aggcaaagat tggggcccca ctcattggaa gaagggaaag
     3781 gaagcgatct aggatgtgta ttagaagcat ttcaaatgtc gggtctttaa aatgttttgt
     3841 tcagtattag caaaccttta atcttttttt caaaattcca gtagtccact gtggagccca
     3901 tacatttcat ctggaattta atgtttcttt gaagccaaac catttagcag ttatgtgtat
     3961 tttattagct agcgtggctg acagtgcact cagttcaatt ttaattgtaa atgggaattc
     4021 caaacttttc ctacttggca tggttatctg ttagttaaaa ccaaaagcta aattggagat
     4081 atttacattt taatttatgg taacaaatat gggtttgtat gcattatgtg taaatcagct
     4141 tcatgctgtt taaaaaaacg tactgaaatt tatagaccat gtagaattga tttgtgatgc
     4201 gatgctttaa tttattgcaa gaaaattagt atggcttcag actgccacag gtcggcgtgt
     4261 gacgatggct gttcagccat actgatccaa agtggggaaa actggtgaca caaggcaaaa
     4321 catctcatga aatgcaacta tttatagtct tgtttcgcta taaggaggct ggtgaacacg
     4381 ctgaatacga attacctcag ttctgcagct ttctgtgtct ttttaatgca ttctgtttca
     4441 gggtcacttt caatcaatat ttcatttact tactgagatt gaatgggcgc tctgagacac
     4501 agtgtgctgt ttatcataca gattggacac ctcattctag atccgagatc ttttcctcaa
     4561 cactgggagc tgtcctttca gcaccacaaa attactgctt gaagctgcat tgcagtttat
     4621 tttctttgtt ttggtttttg tttggttctt tgtttttgtt tttggttgtt tctttggttc
     4681 ttttgttttg ttttgttttc tgttttcact gggagctttt ctttcagcac cacattgcac
     4741 ctagactttt taacggctgc cttcctcttt gcactgaaga ccaatttcgt ctgcacttcc
     4801 agttatttgc tattacctgt aggactttca atcctacttc acctcaccca gcccactccc
     4861 aaaacagtaa atgtatctat ttctgtggaa atcatttctc attgaatgat cagaaagaat
     4921 gataagttct aacctgtaac ggctcatttc gactcattgc ttacagtaga cctaagctct
     4981 gttttcctgc ttattcgact ccttccagct tcccatcaca tctgtaacaa actctcaaaa
     5041 tgatattgcc acaccgccat gcacaagcct acctgcacag tagagataga ttattccatc
     5101 gcattcagat ggttaacaga ggttagcaag tcctgtatta tatatttata tcgctttcta
     5161 agaaagtgca tattaatgtt tactttaaga atgtgtaaat ggtgctatca agaatctgat
     5221 aaattttatc ccagtttttt gtgtaccact tctaatgtat gagatttatt tttttattgg
     5281 aaaaaataaa cagtatgaaa gcattaaatt ggtagatttt agtaatttga caatgaatgg
     5341 aatccccatg ttacaggccc tatcttttct tagaaatttt aatggtggta atagacttca
     5401 acagaggtac tggttacaac attcctttta atccattctt atggtacatt cttgattcat
     5461 ataatgattc ctcactgagt ccttaagtaa attttgttta ctgtaattct tctccaagaa
     5521 gggaattctt gctttccaag gcagcaattg aaaggagatg aaaatacaat ttaacattct
     5581 acatccacaa acacaattta agaccagtta ctctgttagt agcagaaatt cattgatcat
     5641 caaattcagg gcaagcatgg ctataagtaa taattttgag tgcaatgtaa tcttagaaat
     5701 ttaatatata cactttattt aaatgatgca aacagccata tgaaattctt tatgattaga
     5761 aaacaggatg aactcatttt gcctcctgct tggtttctca taaacatgag tacatgctat
     5821 tgttgtgcac tgttgtccat agatgtcttt ttacataaag ggtaagtatc attactttac
     5881 aattattttt ggaattttgc atgttatttt tgtttcatca gatatgtgcc cccaattaaa
     5941 taacgttttt gcgaaaaaag aaagtatcag aaacttgtgt taattttcaa aacaaagcaa
     6001 agtgtagaac attattagat aggatgtcat tccactggtc tataaaaaca aaaagcaact
     6061 gttcttgaaa attgaagcat taccttgtat aattaataaa gtacatcaaa tcagatttgt
     6121 aaataaaata ttgtttaaat ctaaagtatt caatattttg attagattat ttttttaagg
     6181 aaaatattta acgtgtatgt gctgaatttt tttttaaata gttttttata attgcgatgg
     6241 aagggcaatt gtctcattaa aagtggtgca gaggccaata cttgggttgc cattagatat
     6301 ataaacaagt gaaaactgtg gaacaagttt taagctcatt ttggaaaaaa aaacagttct
     6361 gtagaaatgc atatttgtat ttgtttctct aataaatctg caaatagctt taaacacaaa
     6421 ttagttttaa ttatttaaac atgagttctg ttaagtaact taatatctgt tttgccttac
     6481 attgtgtgaa aacattgtcc tgtggaaatg aatacaggct tatagtgaaa atcaaggtag
     6541 gtctgcattt atttgaaaaa accaagcatt tagcacttag gtgtgcttac cgctatgaaa
     6601 tcattggaga atttgcatag aagacagtac tgccccatat cacaccagct aatctactgc
     6661 tgaaatcaat agaggaccag tttgaatctg ctttaactca gtatcaagta agagacgaac
     6721 aagtaagtgc aatcacatct gaatgtttga taccggaacc ctgatggtgc cagtgctctt
     6781 cgtcaataga gcgaggaagt aatgtggctt ctcactgcag agacctggtc ttcttcaatg
     6841 tgttttacac acaattaaaa atattgtccc tggtaacatg tattccatga aatagtatga
     6901 aatgttttag gataacatac agttgtctct ctgttgttaa tatagcatct ccactttgaa
     6961 aatgcttgaa ggagataaat atacatgaaa atca
//
