LOCUS       NM_001192014             738 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus notochord homeobox (Noto), mRNA.
ACCESSION   NM_001192014 XM_578357
VERSION     NM_001192014.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 738)
  AUTHORS   Alten,L., Schuster-Gossler,K., Beckers,A., Groos,S., Ulmer,B.,
            Hegermann,J., Ochs,M. and Gossler,A.
  TITLE     Differential regulation of node formation, nodal ciliogenesis and
            cilia positioning by Noto and Foxj1
  JOURNAL   Development 139 (7), 1276-1284 (2012)
   PUBMED   22357932
REFERENCE   2  (bases 1 to 738)
  AUTHORS   Vidigal,J.A., Morkel,M., Wittler,L., Brouwer-Lehmitz,A., Grote,P.,
            Macura,K. and Herrmann,B.G.
  TITLE     An inducible RNA interference system for the functional dissection
            of mouse embryogenesis
  JOURNAL   Nucleic Acids Res 38 (11), e122 (2010)
   PUBMED   20350929
REFERENCE   3  (bases 1 to 738)
  AUTHORS   Zizic Mitrecic,M., Mitrecic,D., Pochet,R., Kostovic-Knezevic,L. and
            Gajovic,S.
  TITLE     The mouse gene Noto is expressed in the tail bud and essential for
            its morphogenesis
  JOURNAL   Cells Tissues Organs 192 (2), 85-92 (2010)
   PUBMED   20197654
REFERENCE   4  (bases 1 to 738)
  AUTHORS   Beckers,A., Alten,L., Viebahn,C., Andre,P. and Gossler,A.
  TITLE     The mouse homeobox gene Noto regulates node morphogenesis,
            notochordal ciliogenesis, and left right patterning
  JOURNAL   Proc Natl Acad Sci U S A 104 (40), 15765-15770 (2007)
   PUBMED   17884984
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17554]
REFERENCE   5  (bases 1 to 738)
  AUTHORS   Abdelkhalek,H.B., Beckers,A., Schuster-Gossler,K., Pavlova,M.N.,
            Burkhardt,H., Lickert,H., Rossant,J., Reinhardt,R., Schalkwyk,L.C.,
            Muller,I., Herrmann,B.G., Ceolin,M., Rivera-Pomar,R. and Gossler,A.
  TITLE     The mouse homeobox gene Not is required for caudal notochord
            development and affected by the truncate mutation
  JOURNAL   Genes Dev 18 (14), 1725-1736 (2004)
   PUBMED   15231714
REFERENCE   6  (bases 1 to 738)
  AUTHORS   Mitrecic,D., Kostovic-Knezevic,L. and Gajovic,S.
  TITLE     Morphological features of tail bud development in truncate mouse
            mutants
  JOURNAL   Cells Tissues Organs 178 (1), 23-32 (2004)
   PUBMED   15550757
REFERENCE   7  (bases 1 to 738)
  AUTHORS   Dietrich,S., Schubert,F.R. and Gruss,P.
  TITLE     Altered Pax gene expression in murine notochord mutants: the
            notochord is required to initiate and maintain ventral identity in
            the somite
  JOURNAL   Mech Dev 44 (2-3), 189-207 (1993)
   PUBMED   8155581
REFERENCE   8  (bases 1 to 738)
  AUTHORS   THEILER,K.
  TITLE     Anatomy and development of the 'truncate' (boneless) mutation in
            the mouse
  JOURNAL   Am J Anat 104, 319-343 (1959)
   PUBMED   13837681
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000004.1.
            
            On Jul 17, 2010 this sequence version replaced XM_578357.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389,
                              SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-379               JAXUCZ010000004.1  119518663-119519041
            380-591             JAXUCZ010000004.1  119520022-119520233
            592-738             JAXUCZ010000004.1  119522756-119522902
FEATURES             Location/Qualifiers
     source          1..738
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..738
                     /gene="Noto"
                     /gene_synonym="RGD1562910"
                     /note="notochord homeobox"
                     /db_xref="GeneID:502857"
                     /db_xref="RGD:1562910"
     CDS             1..738
                     /gene="Noto"
                     /gene_synonym="RGD1562910"
                     /note="notochord homolog"
                     /codon_start=1
                     /product="homeobox protein notochord"
                     /protein_id="NP_001178943.1"
                     /db_xref="GeneID:502857"
                     /db_xref="RGD:1562910"
                     /translation="MSSPVPQPASSGTQVQPGDLGPCPVAVSPVVPNHLARGRLESSF
                     SVEAILARPETREHSATSLPLSTCTSLNFGSVSQYQVLPWVCSTGTWLPTYLSVGIYP
                     MCSMSCMPGLNVTHLFCQQGLRLTGSELPSCLGPLKRAPTVNLQDHNTERHQKRVRTM
                     FSEQQLGELEKVFAKQHNLVGKERAQLAARLHLTENQVRIWFQNRRVKYQKQQKLKSP
                     PPDAMEEPSNSSEGNVRNEDAEAGVGS"
     exon            1..379
                     /gene="Noto"
                     /gene_synonym="RGD1562910"
                     /inference="alignment:Splign:2.1.0"
     exon            380..591
                     /gene="Noto"
                     /gene_synonym="RGD1562910"
                     /inference="alignment:Splign:2.1.0"
     exon            592..738
                     /gene="Noto"
                     /gene_synonym="RGD1562910"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtccagcc cagtgcccca gcctgcttcc tcaggcactc aggtccagcc cggggacttg
       61 ggaccctgtc cggtggctgt ttccccagta gtcccgaacc acctagctcg gggacgcctg
      121 gagtcctcct tctctgttga ggccatcctg gcgagacccg agactcgtga gcactctgcc
      181 acgtctctgc cgctctctac ctgcaccagt ctgaactttg gctctgtgtc acagtaccag
      241 gtcctgccct gggtgtgctc cacggggact tggctgccca cctacctgag cgtaggcatc
      301 tacccgatgt gctccatgtc ctgcatgccc ggattgaatg tgactcacct cttctgccaa
      361 cagggcctca gactcacagg gtcagagcta ccttcctgtc taggccctct gaaacgggca
      421 cccactgtga accttcagga ccacaatacc gagagacacc aaaagagggt tcgcacaatg
      481 tttagcgagc agcagctggg agagttggag aaggtatttg caaagcagca caacctggtg
      541 gggaaggaga gagcccagtt ggctgccagg ctgcacttga cagagaacca ggtaaggatc
      601 tggttccaga atcgcagggt aaagtatcaa aagcagcaaa aactgaagtc acctccccct
      661 gatgccatgg aggagccctc caacagctca gagggcaacg tccggaatga agacgctgag
      721 gcaggagttg gcagttaa
//
