LOCUS       NM_001002827            6483 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus notch receptor 4 (Notch4), mRNA.
ACCESSION   NM_001002827 XM_579090
VERSION     NM_001002827.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6483)
  AUTHORS   Guo,M., Zhang,M., Cao,X., Fang,X., Li,K., Qin,L., He,Y., Zhao,J.,
            Xu,Y., Liu,X. and Li,X.
  TITLE     Notch4 mediates vascular remodeling via ERK/JNK/P38 MAPK signaling
            pathways in hypoxic pulmonary hypertension
  JOURNAL   Respir Res 23 (1), 6 (2022)
   PUBMED   35016680
  REMARK    GeneRIF: Notch4 mediates vascular remodeling via ERK/JNK/P38 MAPK
            signaling pathways in hypoxic pulmonary hypertension.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6483)
  AUTHORS   Xia,Z., Wang,J., Yang,S., Liu,C., Qin,S., Li,W., Cheng,Y., Hu,H.,
            Qian,J., Liu,Y. and Deng,C.
  TITLE     Emodin alleviates hypertrophic scar formation by suppressing
            macrophage polarization and inhibiting the Notch and TGF-beta
            pathways in macrophages
  JOURNAL   Braz J Med Biol Res 54 (8), e11184 (2021)
   PUBMED   34320121
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6483)
  AUTHORS   Yang,G.S., Zhou,X.Y., An,X.F., Liu,X.J., Zhang,Y.J. and Yu,D.
  TITLE     Mild hypothermia inhibits the Notch 3 and Notch 4 activation and
            seizure after stroke in the rat model
  JOURNAL   Pathol Res Pract 214 (7), 1008-1016 (2018)
   PUBMED   29754932
  REMARK    GeneRIF: mild hypothermia inhibits Notch 3 and Notch 4 activation
            and seizure after stroke in the rat model
REFERENCE   4  (bases 1 to 6483)
  AUTHORS   Pierscianek,D., Wolf,S., Keyvani,K., El Hindy,N., Stein,K.P.,
            Sandalcioglu,I.E., Sure,U., Mueller,O. and Zhu,Y.
  TITLE     Study of angiogenic signaling pathways in hemangioblastoma
  JOURNAL   Neuropathology 37 (1), 3-11 (2017)
   PUBMED   27388534
REFERENCE   5  (bases 1 to 6483)
  AUTHORS   Pierscianek,D., Michel,A., Hindy,N.E., Keyvani,K., Dammann,P.,
            Oezkan,N., Mueller,O., Sure,U. and Zhu,Y.
  TITLE     Activation of multiple angiogenic signaling pathways in
            hemangiopericytoma
  JOURNAL   Brain Tumor Pathol 33 (3), 200-208 (2016)
   PUBMED   26951238
REFERENCE   6  (bases 1 to 6483)
  AUTHORS   Uyttendaele,H., Ho,J., Rossant,J. and Kitajewski,J.
  TITLE     Vascular patterning defects associated with expression of activated
            Notch4 in embryonic endothelium
  JOURNAL   Proc Natl Acad Sci U S A 98 (10), 5643-5648 (2001)
   PUBMED   11344305
REFERENCE   7  (bases 1 to 6483)
  AUTHORS   Suzuki,T., Aoki,D., Susumu,N., Udagawa,Y. and Nozawa,S.
  TITLE     Imbalanced expression of TAN-1 and human Notch4 in endometrial
            cancers
  JOURNAL   Int J Oncol 17 (6), 1131-1139 (2000)
   PUBMED   11078798
REFERENCE   8  (bases 1 to 6483)
  AUTHORS   Uyttendaele,H., Closson,V., Wu,G., Roux,F., Weinmaster,G. and
            Kitajewski,J.
  TITLE     Notch4 and Jagged-1 induce microvessel differentiation of rat brain
            endothelial cells
  JOURNAL   Microvasc Res 60 (2), 91-103 (2000)
   PUBMED   10964583
REFERENCE   9  (bases 1 to 6483)
  AUTHORS   Uyttendaele,H., Soriano,J.V., Montesano,R. and Kitajewski,J.
  TITLE     Notch4 and Wnt-1 proteins function to regulate branching
            morphogenesis of mammary epithelial cells in an opposing fashion
  JOURNAL   Dev Biol 196 (2), 204-217 (1998)
   PUBMED   9576833
REFERENCE   10 (bases 1 to 6483)
  AUTHORS   Sarkar,N.H., Haga,S., Lehner,A.F., Zhao,W., Imai,S. and Moriwaki,K.
  TITLE     Insertional mutation of int protooncogenes in the mammary tumors of
            a new strain of mice derived from the wild in China: normal- and
            tumor-tissue-specific expression of int-3 transcripts
  JOURNAL   Virology 203 (1), 52-62 (1994)
   PUBMED   8030284
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BX883044.1.
            
            On Apr 19, 2005 this sequence version replaced XM_579090.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132262, SAMD00132264
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..6483
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..6483
                     /gene="Notch4"
                     /note="notch receptor 4"
                     /db_xref="GeneID:406162"
                     /db_xref="RGD:1303282"
     exon            1..227
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..6049
                     /gene="Notch4"
                     /note="neurogenic locus notch homolog protein 4; notch 4"
                     /codon_start=1
                     /product="neurogenic locus notch homolog protein 4
                     precursor"
                     /protein_id="NP_001002827.1"
                     /db_xref="GeneID:406162"
                     /db_xref="RGD:1303282"
                     /translation="MQRQWLLLLLLPLSFPVILTRELLCGGSPEPCANGGTCLRLSQG
                     QGTCQCAPGFLGETCQFPDPCWDTQLCENGGSCQALLPTAPSSHSPTSPLTPHFSCTC
                     PSGFTGDRCQSPLEELCPPSFCSNGGHCSVQVSGRPQCSCEPGWTGEQCQLRDFCSAN
                     PCANGGVCLATYPQIQCRCPTGFEGHICERDVNECFLEPGPCPRGTSCHNTLGSFQCL
                     CPVGQEGPQCKLRKGACLPGTCLNGGTCQLVPEGDTTFHLCLCPPGFTGLNCEMNPDD
                     CVRNQCQNGATCQDGLGTYTCLCPKTWKGWDCSEDIDECEAQGPPRCRNGGTCQNSAG
                     GFHCVCVSGWGGEGCDENLDDCAAATCALGSTCIDRVGSFSCLCPPGRTGLLCHLEDM
                     CLRQPCHVNAQCSTNPLTGSTLCICQPGYSGPTCHQDLDECQMAQQGPSPCEHGGSCI
                     NTPGSFNCLCLPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFQCLCPPGLEGRLCE
                     VEINECASNPCLNQAACHDQLNGFLCLCLPGFTGARCEKDMDECSSAPCANGGHCQDQ
                     PGAFHCECLPGFEGPRCETEADECRSDPCPVGASCLDLPGAFLCLCRPGFTGQLCEVP
                     LCSPILCQPGQQCQDQEHRAPCLCPDGSPGCVPAEDDCPCHHGHCQRSLCVCNEGWTG
                     PECETELGGCLSTPCAHGGTCHPQPSGYNCSCLAGYTGLTCSEEITACHSGPCLNGGS
                     CSIHPEGYSCTCPPSHTGPHCQTAVDHCASASCLNGGTCMSKPGTFFCHCATGFQGLH
                     CEKKIHPSCADNPCRNKATCQDTPRGARCLCSPGYTGSSCQTLIDLCARKPCPHTARC
                     LQSGPSFHCLCHQGWTGSLCDLPLSCQAAAMSQGVEISNLCQNGGLCIDTGSSYFCRC
                     PPGFEGKLCQDTVNPCTSKPCLHGATCVPQPNGYVCQCAPGYEGQNCSKVHDACQSGP
                     CHNHGTCTPRPGGFHCACPPGFVGLRCEGDVDECLDRPCHPSGTASCHSLANAFYCQC
                     LPGHTGQRCEVEMDLCQSQPCSNGGSCEVTTGPPPGFTCRCPEGFEGPTCSRKAPACG
                     NHHCHNGGLCLPSPKPGSPPLCACLSGFGGPDCLTPPAPPGCGPPSPCMHNGSCTETP
                     GLGNPGFQCTCPPDSPGPRCQRPGANGCEGRGGDGACDAGCSGPGGDWDGGDCSLGVP
                     DPWKGCPPHSQCWLLFRDGRCHPQCDSEECLFDGYDCEIPPTCTPAYDQYCRDHFHNG
                     HCEKGCNNAQCGWDGGDCRPEGDDSEGGPSLALLVVLSPPALDQQLLALARVLSLTLR
                     VGLWVRKDSEGRNMVFPYPGTRAKEELSGTRDSSSWERQAPHTQTPGKETESLGAGFV
                     VVMGVDLSRCGPEHPASRCPRDSGLLLRFLAAMAAVGALEPLLPGPLLAAHPQAGTGS
                     PATRLPWPILCSPVVGVLLLALGALLVLQLIRRRRREHGALWLPPGFIRRPQTQQAPH
                     RRRPPLGEDNIGLKALKPEAEVDEDGVVMCSGPEEGEAEKTASASRCQLWPLRSGCEG
                     LPQAVMLTPPQECESELPDSDTCGPDGVTPLMSAVFCGGVQSTTVQRLGLGNPEPWEP
                     LLDRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVA
                     ADAREVCQLLLASRQTAVDARTDDGTTPLMLAARLAVEDLVEELIAARADVGARDKRG
                     KTALHWAAAVNNARAARCLLQTGADKDAQDSREQTPLFLAAREGAVEVAQLLLEIGAA
                     RGLRDQAGLAPADVARQRSHWDLLTLLEGAGPITQEARSHARNTPGGGAAPRCRTLSA
                     GARPRGGGACLQARTWSVDLGARRGAVYARCRSRSGGSGGPSMRGRRLSADSRGRRGA
                     RVSQDDWPRDWVALEACGSACSAPIPPPSLTPSPERGSPQVSWGLPVHQEVPLNSGGR
                     NQN"
     exon            228..309
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            310..605
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            606..953
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1076
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1313
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1469
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1664
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1778
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1892
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2015
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2175
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2321
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2474
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2592
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2680
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..2831
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..3016
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..3269
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            3270..3382
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            3383..3906
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            3907..4290
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            4291..4466
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            4467..4686
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            4687..4756
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            4757..4895
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            4896..5191
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            5192..5339
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            5340..5437
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            5438..6483
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacattgtgt gactcaggaa acagctcaga ctgaggcgtg cagcaggccc aggaggaaga
       61 agggcggtag aggcagagga ggtggccttg cctggccaca aacgctctga gggtccttgc
      121 ctggagaggg agaggagacc gagccaggga caggcgctct gggatgcagc gccagtggct
      181 gctgcttctg ctcttgccgc tcagcttccc agtcatcctg accagagagc ttctgtgtgg
      241 aggatcccca gagccctgtg ccaacggagg cacctgcctg aggctatctc agggacaagg
      301 gacctgccag tgtgcccctg gatttctggg tgagacttgc cagttccctg acccctgctg
      361 ggacacccaa ctctgcgaga acggtggcag ctgtcaagcc ttgctcccca cagccccaag
      421 ctcccacagc cccacttctc cactgacccc ccacttctcc tgcacctgcc cctctggctt
      481 cactggtgat cgatgccaaa gccctctgga agagctctgt ccgccttctt tctgttccaa
      541 cgggggtcac tgctctgtcc aggtctcggg ccgcccacag tgttcctgcg agcccgggtg
      601 gacaggtgag cagtgccagc tccgagactt ctgctcagcc aacccctgtg ccaacggagg
      661 tgtgtgcttg gccacatacc cccagatcca gtgtcgttgt ccaaccggct tcgagggtca
      721 catctgtgaa cgcgacgtca atgaatgctt cctggagccc ggaccctgcc ctcggggcac
      781 ctcctgtcac aacaccttgg gctccttcca gtgcctctgc cctgtggggc aggaaggtcc
      841 ccagtgcaag ctcaggaagg gagcctgcct tcctggaacc tgtctcaatg gaggcacctg
      901 ccagctggtg ccagagggag acactacctt tcatctctgc ctctgtcccc caggtttcac
      961 agggctgaac tgtgagatga atccagatga ctgtgtcagg aaccagtgtc agaacggggc
     1021 cacctgccag gatgggctgg gcacctacac ctgcctctgc cccaagacgt ggaagggctg
     1081 ggactgctcc gaagacatag atgaatgtga agcccagggt ccgcctcgat gcagaaacgg
     1141 tggcacctgc cagaactcgg ctggtggctt tcactgtgtg tgtgtgagtg gctggggagg
     1201 cgagggctgt gacgagaacc tggatgactg tgcggccgcc acctgtgccc tgggatccac
     1261 ctgcatcgac cgtgtgggct ccttctcctg cctctgccca cctggacgca caggcctcct
     1321 gtgccacctg gaagacatgt gtttgaggca gccgtgccat gtgaatgccc agtgcagcac
     1381 caaccccctg acggggtcta ccctctgcat atgccagccg ggctactcgg gacccacctg
     1441 ccaccaagat ctggatgagt gtcaaatggc ccagcaagga cccagtccct gtgaacacgg
     1501 cggctcctgc atcaacaccc ctggctcctt caactgcctc tgcctgcctg gctacacggg
     1561 ctcccgctgc gaggctgacc acaatgagtg cctgtcgcag ccctgtcacc cgggcagcac
     1621 ctgcctggac ctgcttgcca ccttccagtg cctctgccca ccaggcctgg aagggaggct
     1681 ctgtgaagtg gagatcaatg agtgtgcctc taacccctgc ctcaaccaag ctgcctgtca
     1741 cgaccagctc aacggcttcc tgtgcctctg ccttcctgga ttcactggtg ccagatgcga
     1801 gaaagacatg gacgagtgca gcagcgcccc ctgtgccaat ggggggcact gccaagacca
     1861 gcctggagcc ttccactgcg agtgtctccc aggctttgaa gggccacgct gtgagactga
     1921 agcggatgaa tgtcggagtg acccctgccc cgtgggagcc agctgccttg atcttcccgg
     1981 ggcgttcctc tgcctctgcc ggcctggttt cacaggtcaa ctttgtgagg ttcccttgtg
     2041 tagccccatc ctgtgccaac ctggacagca atgccaagac caggaacaca gagccccctg
     2101 cctctgccct gacggaagtc ctggctgtgt tcctgctgag gacgactgcc cctgccacca
     2161 tggccattgc cagagatcct tgtgtgtgtg taacgagggc tggactggac cagagtgtga
     2221 gacagagctg ggcggctgcc tctccacacc ctgtgcccat ggggggacct gccacccaca
     2281 gccctctggc tacaactgta gctgccttgc aggctacacg gggctgacct gtagtgagga
     2341 gataacagct tgtcactcag ggccctgtct caatggtggc tcctgcagca tccatcctga
     2401 gggctactct tgcacctgcc ctccaagtca cacaggtccc cactgccaga ctgccgtgga
     2461 ccactgtgcg tctgcctcgt gtctcaacgg gggtacctgc atgagcaaac ctggcacttt
     2521 cttctgccac tgtgccactg gcttccaggg gctgcactgt gagaagaaga ttcaccccag
     2581 ctgtgcagac aacccctgca ggaacaaggc aacctgccaa gacacacctc gaggggcccg
     2641 ctgcctctgc agccctggct acacaggaag cagctgccag actctgatag acttgtgtgc
     2701 ccggaagccc tgtccacaca ctgcccgatg cctccagagt gggccctcct tccactgcct
     2761 gtgccaccag ggatggacag ggtctctctg tgacctccca ctgtcctgcc aggcggccgc
     2821 gatgagccaa ggtgtagaga tctccaacct gtgccagaat gggggcctct gtattgacac
     2881 gggctcctcc tatttctgtc gctgccctcc tggattcgag ggcaagttat gccaggatac
     2941 tgtgaacccc tgcacgtcca agccttgcct tcacggggct acctgtgtgc cccagcccaa
     3001 cggctatgtc tgccagtgtg ccccaggcta tgaaggacag aactgctcaa aagtacacga
     3061 cgcttgccag tccgggccgt gccacaacca tggaacctgt acccccaggc ctggaggctt
     3121 ccactgtgcc tgccctccag gttttgtggg gctgcgctgt gagggggatg tggacgagtg
     3181 tctcgaccgg ccctgccacc cctcgggcac tgcgtcctgc cattctttag ccaacgcctt
     3241 ctattgccag tgtctgcctg ggcacacagg ccagcggtgt gaagtggaga tggacctctg
     3301 ccagagccag ccctgctcca atggagggtc ctgtgaggtc acaacaggac cgccccctgg
     3361 cttcacctgc cgctgccccg agggttttga aggccccacc tgcagccgca aagcccctgc
     3421 ctgcggcaac catcattgcc acaacggagg cctatgtctg ccctccccta agccaggctc
     3481 cccacccctc tgtgcctgcc tcagtggctt cgggggccct gactgtctga cacctccagc
     3541 tccaccaggg tgcggtcctc cctccccctg catgcacaat ggtagctgca ctgagacccc
     3601 cgggttgggc aatcctggct ttcaatgcac ctgccctcct gactctccgg ggccccggtg
     3661 tcaaaggcca ggggcgaatg gatgtgaggg ccgaggtggc gatggagcct gtgatgctgg
     3721 ctgcagtggc ccaggagggg actgggatgg aggggactgt tccctggggg tcccagaccc
     3781 ctggaagggc tgtcccccgc attcccagtg ctggcttctc ttccgggatg ggcggtgcca
     3841 cccacagtgc gactctgagg agtgtctgtt tgatggctat gactgtgaga tccctccaac
     3901 ttgcacccca gcctacgacc agtactgccg agatcacttc cacaacgggc actgtgagaa
     3961 aggctgcaac aacgctcagt gtggctggga tgggggtgac tgcaggccag aaggggatga
     4021 ctcagagggg ggcccctccc tggccctgct ggtggtgctg agtcccccag ccttggatca
     4081 gcagctgctt gccctggctc gagtactgtc cctgactctg agggtcggtc tctgggtgag
     4141 gaaggacagt gaaggcagga acatggtgtt cccctatcct gggacccggg ccaaagagga
     4201 gctgagtgga actagagatt cctcttcgtg ggaaagacaa gcccctcaca ctcagacccc
     4261 gggcaaagag acagagtccc ttggtgcagg gtttgtggta gtgatgggag tggatttgtc
     4321 ccgctgtggt ccagagcatc ctgcgtcccg ctgtccccgg gactctgggc tcctgctgcg
     4381 tttccttgca gcaatggccg cagtgggagc tctggagccc ctgctgcctg gacccttgct
     4441 ggctgctcac cctcaagcag ggaccgggtc ccccgccacc cggcttccct ggcccattct
     4501 gtgttcgcca gtggtcgggg tgctcctcct ggcccttggg gctcttctcg tcctccagct
     4561 catccggcgc cggcggcggg aacacggggc cctgtggctg ccccctggtt tcattcgaag
     4621 gccacagaca cagcaggcac cccaccggcg gaggccccca ctgggcgagg acaacattgg
     4681 tctcaaggcg ctgaagccag aggcagaagt ggatgaggac ggagtggtca tgtgctcggg
     4741 ccctgaagag ggcgaggcag aaaaaacagc ctcagcctcc aggtgccagc tctggccact
     4801 gcgcagcggc tgtgaagggc tcccacaggc agtcatgctg acccctcctc aggagtgtga
     4861 atcagaactt ccagattcgg acacctgtgg acctgatggg gtgacacccc tgatgtctgc
     4921 cgtcttctgt gggggagtgc agtccaccac tgtacagaga ctgggactag gaaatcccga
     4981 accctgggaa ccactgctgg atagaggggc ctgcccccag gctcacactg tgggcactgg
     5041 agagacgccc ctgcacctag ctgcccgatt ctctcggcca actgctgccc gacgcctcct
     5101 ggaggctgga gccaacccca accagccaga ccgggctggg cgtaccccac ttcacactgc
     5161 agtagctgct gatgctcggg aggtttgcca gctcctattg gccagcagac agaccgctgt
     5221 agacgcgcgc acagacgacg ggactacacc tttgatgctg gctgccaggt tggccgtgga
     5281 ggacctggtt gaagaattga tcgcagcccg agcagatgta ggagccagag ataaaagggg
     5341 aaaaactgca ctgcactggg ccgctgcagt gaacaacgcc cgagctgccc gctgtctcct
     5401 ccagactgga gcggataaag atgcccagga cagtagggag cagacgccgc tgttcctggc
     5461 tgcgcgcgaa ggcgccgtgg aggtggcaca gctgctgctg gagatcgggg cagcgcgggg
     5521 gctgcgggac caggccgggc tggccccagc agatgtggcc cgccagcgta gtcattggga
     5581 cctgctgacg ctgctggagg gggcaggacc gatcacgcag gaggcccgtt cgcacgcacg
     5641 caacacgccg gggggcgggg ccgcgccgcg ctgccggacg ctgtctgccg gagcgcgccc
     5701 gcgcgggggc ggagcttgtc tgcaagctcg cacttggtcg gtggacttgg gagcgcgccg
     5761 aggggcggta tacgcgcgct gccggagccg atcaggaggc tctggaggcc cctccatgcg
     5821 cggccgcagg ctttccgcgg actcccgtgg acgacgcggg gctagagtat cacaggatga
     5881 ctggcctcgg gactgggtgg ccctggaagc ctgcggctct gcctgcagtg cgccgatccc
     5941 gcctcccagc cttaccccgt ccccagaacg cggatcccct caagtttcct ggggtcttcc
     6001 agtccaccaa gaggtcccct taaactcggg tggaaggaat cagaactagg caacttcgtg
     6061 gaaggaagga agtgacacga acgagtctgg aaggccccgg acttttaagg ccaagctaaa
     6121 cgttatgccc acttgtcttc cccatagagt atgaacagca atggcaagag ggtttaggat
     6181 gcccggatta gatatgccgt gctttttcct ggaaaatagg gcagctccaa gaggacagag
     6241 tggattttga gaatccctaa actgaaacca aaaactgtgg gcaaattggg tgtaaaatgt
     6301 ttcttatgta tggttttcca gaaggagcct ctgctatcta ctccccaaaa gtagctggca
     6361 aatatttatt gagcacctac tatgtgccag gtgttgtgta gatgatgaaa gctaaccagt
     6421 ggccagtcca gctgatgact ccttgccctc tctccgcctt ccccacaagg aaactggtac
     6481 agg
//
