LOCUS       NM_020087               7313 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus notch receptor 3 (Notch3), mRNA.
ACCESSION   NM_020087
VERSION     NM_020087.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7313)
  AUTHORS   Zang,X., Wang,Z., Li,Y., Gao,H., Guo,J., Jin,W., Chang,C., Lin,J.,
            Zhu,K. and Xu,C.
  TITLE     Regulation of Hepatocytes in G0 and G1 Phases by NOTCH3 mRNA,
            miR-369-3p, and rno-Rmdn2_0006 during the Initial Stage of Rat
            Liver Regeneration
  JOURNAL   Genet Res (Camb) 2023, 8779758 (2023)
   PUBMED   37153858
  REMARK    GeneRIF: Regulation of Hepatocytes in G0 and G1 Phases by NOTCH3
            mRNA, miR-369-3p, and rno-Rmdn2_0006 during the Initial Stage of
            Rat Liver Regeneration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7313)
  AUTHORS   Zhu,T., Chen,H., He,C. and Liu,X.
  TITLE     Transcription Factor HEY1 Improves Brain Vascular Endothelial Cell
            Function and Alleviates Ischemic Stroke by Upregulating NOTCH3
  JOURNAL   Neurochem Res 47 (5), 1442-1458 (2022)
   PUBMED   35316462
  REMARK    GeneRIF: Transcription Factor HEY1 Improves Brain Vascular
            Endothelial Cell Function and Alleviates Ischemic Stroke by
            Upregulating NOTCH3.
REFERENCE   3  (bases 1 to 7313)
  AUTHORS   Wang,Y., Dai,S., Cheng,X., Prado,E., Yan,L., Hu,J., He,Q., Lv,Y.,
            Lv,Y. and Du,L.
  TITLE     Notch3 signaling activation in smooth muscle cells promotes
            extrauterine growth restriction-induced pulmonary hypertension
  JOURNAL   Nutr Metab Cardiovasc Dis 29 (6), 639-651 (2019)
   PUBMED   30954415
  REMARK    GeneRIF: Up-regulation of Notch3 signaling in pulmonary artery
            smooth muscle cells promotes the development of extrauterine growth
            restriction-induced pulmonary hypertension.
REFERENCE   4  (bases 1 to 7313)
  AUTHORS   Chen,X., Zhou,W., Hu,Q. and Huang,L.
  TITLE     Exploration of the Notch3-HES5 signal pathway in
            monocrotaline-induced pulmonary hypertension using rat model
  JOURNAL   Congenit Heart Dis 14 (3), 396-402 (2019)
   PUBMED   30811836
  REMARK    GeneRIF: Monocrotaline-induced pulmonary hypertension rats had high
            expressions of the Notch3-HES5 signal pathway in the pulmonary
            arterioles.
REFERENCE   5  (bases 1 to 7313)
  AUTHORS   Yang,G.S., Zhou,X.Y., An,X.F., Liu,X.J., Zhang,Y.J. and Yu,D.
  TITLE     Mild hypothermia inhibits the Notch 3 and Notch 4 activation and
            seizure after stroke in the rat model
  JOURNAL   Pathol Res Pract 214 (7), 1008-1016 (2018)
   PUBMED   29754932
  REMARK    GeneRIF: mild hypothermia inhibits Notch 3 and Notch 4 activation
            and seizure after stroke in the rat model
REFERENCE   6  (bases 1 to 7313)
  AUTHORS   Wang,W., Campos,A.H., Prince,C.Z., Mou,Y. and Pollman,M.J.
  TITLE     Coordinate Notch3-hairy-related transcription factor pathway
            regulation in response to arterial injury. Mediator role of
            platelet-derived growth factor and ERK
  JOURNAL   J Biol Chem 277 (26), 23165-23171 (2002)
   PUBMED   11971902
REFERENCE   7  (bases 1 to 7313)
  AUTHORS   Wang,W., Prince,C.Z., Mou,Y. and Pollman,M.J.
  TITLE     Notch3 signaling in vascular smooth muscle cells induces c-FLIP
            expression via ERK/MAPK activation. Resistance to Fas
            ligand-induced apoptosis
  JOURNAL   J Biol Chem 277 (24), 21723-21729 (2002)
   PUBMED   11925448
  REMARK    GeneRIF: Notch3 signaling in vascular smooth muscle cells induces
            c-FLIP expression via ERK/MAPK activation
REFERENCE   8  (bases 1 to 7313)
  AUTHORS   Lindner,V., Booth,C., Prudovsky,I., Small,D., Maciag,T. and Liaw,L.
  TITLE     Members of the Jagged/Notch gene families are expressed in injured
            arteries and regulate cell phenotype via alterations in cell matrix
            and cell-cell interaction
  JOURNAL   Am J Pathol 159 (3), 875-883 (2001)
   PUBMED   11549580
REFERENCE   9  (bases 1 to 7313)
  AUTHORS   Irvin,D.K., Zurcher,S.D., Nguyen,T., Weinmaster,G. and
            Kornblum,H.I.
  TITLE     Expression patterns of Notch1, Notch2, and Notch3 suggest multiple
            functional roles for the Notch-DSL signaling system during brain
            development
  JOURNAL   J Comp Neurol 436 (2), 167-181 (2001)
   PUBMED   11438922
REFERENCE   10 (bases 1 to 7313)
  AUTHORS   Tanigaki,K., Nogaki,F., Takahashi,J., Tashiro,K., Kurooka,H. and
            Honjo,T.
  TITLE     Notch1 and Notch3 instructively restrict bFGF-responsive
            multipotent neural progenitor cells to an astroglial fate
  JOURNAL   Neuron 29 (1), 45-55 (2001)
   PUBMED   11182080
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_020087.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF164486.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               JAXUCZ010000007.1  11834378-11834585   c
            209-290             JAXUCZ010000007.1  11831855-11831936   c
            291-433             JAXUCZ010000007.1  11826834-11826976   c
            434-772             JAXUCZ010000007.1  11826413-11826751   c
            773-895             JAXUCZ010000007.1  11826205-11826327   c
            896-1129            JAXUCZ010000007.1  11825886-11826119   c
            1130-1285           JAXUCZ010000007.1  11824270-11824425   c
            1286-1471           JAXUCZ010000007.1  11823974-11824159   c
            1472-1585           JAXUCZ010000007.1  11822626-11822739   c
            1586-1699           JAXUCZ010000007.1  11822199-11822312   c
            1700-1933           JAXUCZ010000007.1  11821634-11821867   c
            1934-2044           JAXUCZ010000007.1  11821354-11821464   c
            2045-2237           JAXUCZ010000007.1  11819373-11819565   c
            2238-2389           JAXUCZ010000007.1  11819142-11819293   c
            2390-2503           JAXUCZ010000007.1  11818472-11818585   c
            2504-2659           JAXUCZ010000007.1  11817636-11817791   c
            2660-2885           JAXUCZ010000007.1  11815459-11815684   c
            2886-3087           JAXUCZ010000007.1  11814947-11815148   c
            3088-3235           JAXUCZ010000007.1  11814675-11814822   c
            3236-3420           JAXUCZ010000007.1  11814095-11814279   c
            3421-3553           JAXUCZ010000007.1  11811628-11811760   c
            3554-3811           JAXUCZ010000007.1  11811297-11811554   c
            3812-3930           JAXUCZ010000007.1  11811098-11811216   c
            3931-4496           JAXUCZ010000007.1  11810234-11810799   c
            4497-4829           JAXUCZ010000007.1  11807076-11807408   c
            4830-4984           JAXUCZ010000007.1  11804833-11804987   c
            4985-5207           JAXUCZ010000007.1  11804320-11804542   c
            5208-5292           JAXUCZ010000007.1  11803002-11803086   c
            5293-5455           JAXUCZ010000007.1  11800541-11800703   c
            5456-5760           JAXUCZ010000007.1  11798478-11798782   c
            5761-5908           JAXUCZ010000007.1  11797163-11797310   c
            5909-6006           JAXUCZ010000007.1  11787874-11787971   c
            6007-7313           JAXUCZ010000007.1  11784272-11785578   c
FEATURES             Location/Qualifiers
     source          1..7313
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..7313
                     /gene="Notch3"
                     /note="notch receptor 3"
                     /db_xref="GeneID:56761"
                     /db_xref="RGD:620761"
     exon            1..208
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..7047
                     /gene="Notch3"
                     /note="neurogenic locus notch homolog protein 3; Notch
                     gene homolog 3; notch 3"
                     /codon_start=1
                     /product="neurogenic locus notch homolog protein 3
                     precursor"
                     /protein_id="NP_064472.3"
                     /db_xref="GeneID:56761"
                     /db_xref="RGD:620761"
                     /translation="MGPGARGRRRRRRLMALPPPPPPMRALPLLLLLLAGLGAAAPPC
                     LDGSPCANGGRCTHQQPSREAACLCLPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAG
                     VARFSCRCLRGFRGPDCSLPDPCFSSPCAHGAPCSVGSDGRYACACPPGYQGRNCRSD
                     IDECRAGASCRHGGTCINTPGSFHCLCPLGYTGLLCENPIVPCAPSPCRNGGTCRQSS
                     DVTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTED
                     VDECQLQPNACHNGGTCFNLLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDR
                     VASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVSGRAICTCPPGFTGGACDQ
                     DVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLD
                     RIGQFTCICMAGFTGTFCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQL
                     DVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCERNVDDCSPDPCHHGRCVDGIA
                     SFSCACAPGYTGIRCESQVDECRSQPCRYGGKCLDLVDKYLCRCPPGTTGVNCEVNID
                     DCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFH
                     CLCPPGSLPPLCLPVNHPCAHKPCSHGVCHDAPGGFQCVCEPGWSGPRCSQSLAPDAC
                     ESQPCQAGGTCTSDGIGFHCTCAPGFQGHQCEVLSPCTPSLCEHGGHCESDPDQLTVC
                     SCPPGWQGPRCQQDVDECAGASPCGPHGTCTNLPGSFRCICHGGYTGPFCDQDIDDCD
                     PNPCLNGGSCQDGVGSFSCSCLSGFAGPRCARDVDECLSSPCGPGTCTDHVASFTCTC
                     PPGYGGFHCETDLLDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGTHCQYKVDPCFSRP
                     CLHGGICNPTHSGFECTCREGFTGNQCQNPVDWCSQAPCQNGGRCVQTGAYCICPPEW
                     SGPLCDIPSLPCTEAAAHMGVRLEQLCQAGGQCIDKDHSHYCVCPEGRMGSHCEQEVD
                     PCTAQPCQHGGTCRGYMGGYVCECPAGYSGDSCEDDVDECASQPCQNGGSCIDLVAHY
                     LCSCPPGTLGVLCEINEDDCGPGPSLDSGLRCLHNGTCVDLVGGFRCNCPPGYTGLHC
                     EADINECRPGTCHAAHTRDCLQDPGGHFRCICLPGFTGPRCQTALFPCESQPCQHGGQ
                     CRPSLGRGGGLTFTCHCVQPFWGLRCERVARSCRELQCPVGIPCQQTARGPRCACPPG
                     LSGPSCRVSRASPSGATNTSCAATPCLHGGSCLPVQSVPFFRCVCAPGWGGPRCETPS
                     AAPEVPEEPRCPRAACQAKRGDQNCDRECNSPGCGWDGGDCSLNVDDPWRQCEALQCW
                     RLFNNSRCDPACSSPACLYDNFDCYSGGRDRTCNPVYKKYCADHFADGRCDQGCNTEE
                     CGWDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDAR
                     GQAMVFPYHRPSPGSESRVRRELGPEVIGSVVMLEIDNRLCLKSAENDHCFPDAQSAA
                     DYLGALSAVERLDFPYPLRDVRGEPLEPPEQSVPLLPLLVAGAVFLLVIFVLGVMVAR
                     RKREHSTLWFPEGFALHKDIAAGHKGRREPVGQDALGMKNMTKGESLMGEVATDWNDS
                     ECPEAKRLKVEEPGMGAEEPVDCRQWTQHHLVAADIRVAPAMALTPPQGDADADGMDV
                     NVRGPDGFTPLMLASFCGGALEPMPAEEDEADDTSASIISDLICQGAQLGARTDRTGE
                     TALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTD
                     LDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATL
                     ALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQE
                     RLHQDIVRLLDQPSGPRSPSGPHGLGPLLCPPGAFLPGLKAVQSGTKKSRRPPGKTGL
                     GPQGTRGRGKKLTLACPGPLADSSVTLSPVDSLDSPRPFGGPPASPGGFPLEGPYATT
                     ATTVSLAQLGASRAGPLGRQPPGGCVLSLGLLNPVAVPLDWARLPPPAPPGPSFLLPL
                     APGSQLLNPATPVSPHERPPPYLAAPGHGEEYPAAGTHSSPTKARFLRVPSEHPYLTP
                     SPESPEHWASPSPPSLSDWSDSTPSPATATSATAAGALPAQPHPISVPSLPQSQTQLG
                     PQPEVTPKRQVMA"
     exon            209..290
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            291..433
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            434..772
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            773..895
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1129
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1285
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1471
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1585
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1699
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1933
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2044
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2237
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2389
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2503
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2659
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2885
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..3087
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            3088..3235
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3420
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            3421..3553
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            3554..3811
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            3812..3930
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            3931..4496
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            4497..4829
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            4830..4984
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            4985..5207
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            5208..5292
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            5293..5455
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            5456..5760
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            5761..5908
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            5909..6006
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
     exon            6007..7313
                     /gene="Notch3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttggcggc gcggaggctg gcccgggacg tgcccggagc cctgggaaag agggaggagg
       61 gaggagggag ggtcgcggcc ggccgccatg gggccggggg cccggggccg ccgccgccgt
      121 cgtcgcctga tggccctgcc accgccacca ccgcccatgc gggcgctgcc cctgctgctg
      181 ctgctgctag cggggctggg ggctgcagca cccccttgtc tggatggaag cccatgtgca
      241 aatggaggtc gttgcaccca ccagcagccc tcccgggagg ctgcttgcct gtgcctgcca
      301 ggctgggtgg gtgagcggtg ccagctggaa gacccttgcc actctggccc ctgtgccggc
      361 cgaggcgttt gccagagttc agtggtggcg ggcgtcgccc ggttctcctg tcgttgtctc
      421 cgtggcttcc gaggcccaga ctgctccctg ccagacccct gcttcagcag cccctgtgct
      481 cacggtgccc cctgctcagt tgggtcggat ggccgatatg cctgtgcctg cccacctggc
      541 taccagggtc gcaactgccg aagcgacata gatgagtgcc gagctggtgc gtcttgccgt
      601 cacggtggta cctgcatcaa tacacccgga tccttccact gcctgtgtcc acttggctat
      661 acagggctgc tgtgtgaaaa ccccatagtg ccctgcgccc cttccccatg ccgtaatggt
      721 ggcacctgta ggcagagtag tgatgtcaca tatgactgtg cttgtcttcc tggcttcgag
      781 ggccagaact gtgaagtcaa tgtggatgac tgtcctggac atcggtgtct caatggggga
      841 acgtgtgtgg atggtgtcaa tacttataac tgccagtgcc ctcctgagtg gacaggccag
      901 ttctgcacag aagatgtgga tgagtgccag ttgcagccca acgcttgcca caatgggggc
      961 acctgcttca acctactggg cggccacagc tgcgtatgcg tcaacggctg gacgggcgag
     1021 agctgcagtc agaatattga tgactgtgct acagccgttt gcttccatgg ggccacttgc
     1081 catgaccgtg tggcctcttt ctattgtgcc tgccctatgg ggaagacagg cctcttgtgt
     1141 catctggatg atgcatgtgt cagcaacccc tgccatgaag atgctatctg tgacacaaac
     1201 cctgtgagtg gtcgggccat ctgcacctgt ccacccggct tcaccggagg ggcgtgtgac
     1261 caggatgtgg atgagtgctc tattggtgct aacccctgtg aacatttggg tcggtgcgtg
     1321 aacacacagg gctcattctt gtgccagtgt ggccgtggct atactggacc tcgctgtgag
     1381 actgatgtca atgagtgtct gtctgggccc tgccgcaacc aggccacgtg tcttgaccga
     1441 attggccagt tcacttgcat ctgcatggca ggcttcacag gaaccttctg tgaggtggac
     1501 attgatgaat gtcagagcag cccatgtgtc aatggtggtg tctgcaagga tagagtcaat
     1561 ggcttcagct gcacctgccc atcaggattc agtgggtcca cgtgtcagct ggatgtggat
     1621 gaatgtgcaa gcactccttg ccggaacggt gccaagtgtg tggaccagcc tgacggctat
     1681 gagtgtcgct gtgcagaggg ctttgagggc accctgtgtg agcgaaacgt ggacgactgc
     1741 tctccggatc cctgtcacca cgggcggtgt gtcgacggca ttgctagctt ctcatgcgct
     1801 tgtgcgccag gctacacggg catacgctgc gagagccagg tggatgagtg ccgcagccag
     1861 ccctgccgat acgggggcaa atgtctagac ttggtggaca agtacctctg ccgctgtcct
     1921 cccggaacca caggtgtgaa ctgcgaagtc aacatcgatg attgcgccag caacccctgt
     1981 acctttggag tttgccgtga tggcatcaac cgctatgatt gtgtctgtca gcctggattc
     2041 acagggcccc tctgcaacgt ggagatcaat gagtgtgcat ccagcccatg tggagagggt
     2101 ggctcctgtg tggacgggga aaatggcttc cactgcctct gcccacctgg ctccctgcct
     2161 ccactctgcc tacctgtgaa tcacccctgt gcccacaagc cctgtagtca tggagtctgc
     2221 cacgatgcac caggcgggtt tcaatgtgtg tgcgagcccg gttggagtgg ccctcgttgc
     2281 agccagagcc tggctccaga tgcctgtgag tcccagccct gccaggctgg tggcacctgc
     2341 accagtgatg gaataggctt ccactgtacc tgtgcccctg gattccaggg tcatcaatgt
     2401 gaggtgctgt ccccctgcac tccaagtctc tgtgagcacg gaggccactg tgagtctgac
     2461 cctgaccagc tgactgtctg ttcctgtcct ccaggctggc aaggccctcg atgccagcag
     2521 gatgtggatg aatgtgctgg tgcctcacct tgtggccccc atggtacctg caccaacctg
     2581 ccagggagct tcaggtgcat ctgccatgga ggatacactg gccctttctg tgatcaggac
     2641 attgacgact gtgaccccaa cccgtgcctc aatggtggct cctgccagga tggtgtgggc
     2701 tccttttcct gttcttgcct cagtggcttt gctggtcctc gctgtgctcg ggatgtggat
     2761 gaatgtctga gcagtccctg tggccctggc acctgcactg atcatgtagc ctctttcacc
     2821 tgtacctgtc cacctggcta tggaggcttc cactgtgaga ctgacttgct ggactgcagc
     2881 cccagttcct gtttcaatgg agggacctgt gtggatggcg tgaactcctt cagctgtctg
     2941 tgtcgtcctg gctacacagg cacacattgc caatataagg ttgacccctg cttctcccgg
     3001 ccctgtctac atgggggcat ctgcaacccc acccactcag gatttgaatg cacctgccgg
     3061 gagggcttca ctgggaatca gtgtcagaac ccagtggact ggtgcagcca ggcaccctgt
     3121 cagaatgggg gtcgctgtgt ccagactggg gcttactgca tctgtccgcc tgaatggagt
     3181 ggccccctgt gcgacatacc aagcctaccc tgcacggagg ctgcagccca catgggggtg
     3241 cggttggagc agctgtgtca ggcgggtggc cagtgcatag acaaggacca ctcccactac
     3301 tgtgtgtgtc cggagggccg tatgggtagt cactgcgaac aggaggtgga tccctgcaca
     3361 gcccagcctt gccagcatgg gggcacctgc cgtggttaca tgggcggcta tgtgtgtgag
     3421 tgtccagccg gctactctgg tgacagttgt gaggatgatg tggatgagtg cgcttcccag
     3481 ccctgccaga atggaggctc ctgtattgat cttgtggccc actatctctg ctcctgtccc
     3541 cctggcacac tgggagttct ctgtgagatc aatgaggatg actgtggccc aggcccatcc
     3601 ttggactcag gcctccggtg cctacacaac ggcacctgtg tggacctggt gggtggcttc
     3661 cgctgtaact gtcccccagg gtacacaggt ctgcactgtg aggcggacat caatgagtgc
     3721 cgacccggca cctgtcatgc agcacatacc cgggactgcc tacaagatcc aggtgggcac
     3781 ttccgctgca tctgtctccc tggcttcaca gggcctcgat gtcagactgc tctgttcccc
     3841 tgtgagtccc aaccgtgtca gcatggaggc cagtgccgtc ccagcctagg ccgtggaggt
     3901 gggctgacct tcacctgtca ctgtgtccag ccattctggg gtctgcgttg cgagcgggtg
     3961 gcacgctcct gccgggagct gcagtgccca gtgggtatcc catgccagca gacagcccgt
     4021 gggccgcgct gtgcttgtcc tcccgggctg tctgggccct cctgccgggt ttctagggcg
     4081 tcaccctctg gagctactaa caccagctgc gctgctactc cttgtctgca tgggggctcc
     4141 tgcctacctg tacagagtgt ccctttcttc cgctgtgtat gcgctccggg ctggggtggc
     4201 ccgcgttgcg agaccccttc cgcagcccct gaggtccctg aggagccacg gtgcccgcga
     4261 gccgcctgtc aggccaagcg aggggaccag aactgcgacc gtgagtgcaa cagcccaggc
     4321 tgtggctggg acggcggtga ctgctcgctg aatgtggacg acccctggag gcagtgtgag
     4381 gcactgcagt gctggcgtct cttcaacaac agccggtgcg atccagcctg cagctctcct
     4441 gcctgcctct atgacaactt tgactgctac tctggtggcc gcgaccgcac ctgcaacccg
     4501 gtttataaga agtactgcgc cgaccacttt gcagatggcc gttgtgacca gggctgtaac
     4561 accgaggagt gtggctggga tgggctggac tgtgccagtg aggtcccggc ccttttggcc
     4621 cggggggttc tggtcctcac agttcttctg cctcctgaag agttgcttcg ctctagtgcc
     4681 gacttcctgc agcgactcag cgctattctg cgcacctcgc tgcgcttccg cctggatgca
     4741 cgtggccaag ccatggtctt tccctaccac cggccaagtc ctggctccga atcccgggtt
     4801 cgtcgtgagc ttggcccaga ggtgatcggc tctgtagtga tgctggagat tgacaaccgg
     4861 ctctgtctga agtcagcgga gaacgaccac tgcttccctg acgcccagag tgctgccgac
     4921 tacctgggag ccttgtcggc agtggagcgg cttgatttcc catacccact acgggatgtg
     4981 cgaggagagc ccttggagcc tccagagcag agcgtgccac tgctgccgct gctggtggca
     5041 ggggctgtct ttctgctggt catcttcgtc ctgggtgtca tggttgccag gcgcaagcga
     5101 gagcacagca ccctctggtt tcctgagggt tttgcattac acaaggacat agctgctggc
     5161 cacaagggcc ggagggagcc cgtgggacaa gacgcactgg gcatgaagaa catgaccaag
     5221 ggtgagagtc tgatggggga ggtggccaca gactggaatg actcagaatg cccagaggcc
     5281 aagagactga aggtagagga gccaggcatg ggggccgagg agcccgtgga ctgtcgccag
     5341 tggacccaac accacctggt tgctgccgat atccgtgtgg caccagccat ggcactgact
     5401 ccacctcagg gagatgcaga tgccgatggc atggatgtca acgtacgagg gcctgatggc
     5461 ttcaccccac ttatgctggc ctcgttctgt gggggagccc tggagccgat gccagctgag
     5521 gaggatgagg ccgatgacac gtcagccagc attatatcag atctgatctg ccaaggagcc
     5581 cagctcgggg cacgaactga ccgaactggc gagaccgccc tgcatttggc cgcccgatat
     5641 gctcgagccg atgcggccaa gcggctactg gatgctgggg cagacaccaa cgcccaggat
     5701 cattctggcc gcacccctct gcacaccgca gtgacagctg atgcccaggg tgtcttccag
     5761 attctcatca ggaaccgctc cactgacctg gatgcccgaa tggcagatgg ctctactgca
     5821 ttgatcctgg cagcccgcct ggcggtggag ggaatggtgg aagagctcat cgccagccac
     5881 gccgatgtca atgcagtgga tgagctcggg aaatcggcct tacactgggc tgcagccgtg
     5941 aacaatgtgg aggctacctt ggccctgctg aaaaatggag ccaacaagga catgcaggac
     6001 agcaaggagg agactccact gttcttggcc gcccgtgagg gcagctatga ggctgccaag
     6061 ctgctgctgg atcattttgc caaccgggag atcacagatc acttggacag gctgccccgg
     6121 gatgtggccc aggagcggct gcaccaggac attgtgcggt tgctggacca gcccagtggc
     6181 ccccgaagtc cctctggtcc ccatggcttg gggccattgc tctgcccacc aggagccttc
     6241 cttcctggcc tcaaagcggt gcagtctggg accaagaaga gcaggaggcc acctggcaag
     6301 actgggctgg ggccccaggg aactcggggt cggggcaaga agctgacact ggcctgtcca
     6361 ggccctctgg cagacagctc tgtcacactg tcaccagtgg actcgctgga ctcaccacgg
     6421 cctttcggtg ggccccctgc ttcccctgga ggcttcccct tggagggtcc ctatgccacc
     6481 acagccacca cggtgtcctt ggcacagctg ggtgcaagtc gggcgggtcc tctggggcgc
     6541 cagcctcctg ggggctgtgt gctcagcctt ggtttgctca accctgtggc tgttcccctt
     6601 gactgggccc ggctgcctcc acctgcccct ccagggccct cattcctgct gcccctggct
     6661 ccgggatccc agctgctcaa cccggcaacc ccagtttctc cccatgagcg gcccccaccc
     6721 tacctggctg ctccaggaca tggagaggaa taccctgcag cagggaccca cagcagcccc
     6781 acaaaggccc gcttcctgcg ggttcccagc gagcatcctt atttgacccc atctcctgag
     6841 tccccagagc actgggccag cccgtcccct ccctccctct cagactggtc cgactcaacg
     6901 cctagtccag caactgctac cagtgccaca gccgctggag ccctgcctgc tcaaccacac
     6961 cccatatctg ttccctccct ccctcagtcc cagactcagc tggggcccca gccagaagta
     7021 acccccaaga ggcaggtgat ggcctaagtt cttggatttt ggaggggcgt tgaagtggca
     7081 cccctccctg gcttctctct cccccccttt taatctcgct ctcatccctt tatctctgta
     7141 ccagctttcc tgaacctctc tgtcttgaag tgtgacagag ttggtcacca gcccagaccc
     7201 ccagtcttcc tttatttata atgggtaggg gctgacctcc caccacctcg gccctctaag
     7261 gggtctggga cctcctctcg atccctcttc cggcttccac ttcctttttt ccc
//
