LOCUS       NM_024358              10723 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus notch receptor 2 (Notch2), mRNA.
ACCESSION   NM_024358
VERSION     NM_024358.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10723)
  AUTHORS   Deng,J., Liang,J., Cao,Y., Tong,X. and Li,H.
  TITLE     CCL2- and Notch2-mediated Central Sensitization in a Rat Chronic
            Pelvic Pain Model
  JOURNAL   In Vivo 38 (1), 205-212 (2024)
   PUBMED   38148075
  REMARK    GeneRIF: CCL2- and Notch2-mediated Central Sensitization in a Rat
            Chronic Pelvic Pain Model.
REFERENCE   2  (bases 1 to 10723)
  AUTHORS   Li,S., Huang,C., Tu,C., Chen,R., Ren,X., Qi,L. and Li,Z.
  TITLE     Bone marrow mesenchymal stem cell-derived exosomes shuttling
            miR-150-5p alleviates mechanical allodynia in rats by targeting
            NOTCH2 in microglia
  JOURNAL   Mol Med 28 (1), 133 (2022)
   PUBMED   36348269
  REMARK    GeneRIF: Bone marrow mesenchymal stem cell-derived exosomes
            shuttling miR-150-5p alleviates mechanical allodynia in rats by
            targeting NOTCH2 in microglia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10723)
  AUTHORS   Wang,X., Xu,Q. and Wang,S.
  TITLE     Overexpression of miR-149-5p Attenuates Cerebral
            Ischemia/Reperfusion (I/R) Injury by Targeting Notch2
  JOURNAL   Neuromolecular Med 24 (3), 279-289 (2022)
   PUBMED   34581980
  REMARK    GeneRIF: Overexpression of miR-149-5p Attenuates Cerebral
            Ischemia/Reperfusion (I/R) Injury by Targeting Notch2.
REFERENCE   4  (bases 1 to 10723)
  AUTHORS   Fang,Y., Che,X., You,M., Xu,Y. and Wang,Y.
  TITLE     Perinatal exposure to nonylphenol promotes proliferation of granule
            cell precursors in offspring cerebellum: Involvement of the
            activation of Notch2 signaling
  JOURNAL   Neurochem Int 140, 104843 (2020)
   PUBMED   32866557
  REMARK    GeneRIF: Perinatal exposure to nonylphenol promotes proliferation
            of granule cell precursors in offspring cerebellum: Involvement of
            the activation of Notch2 signaling.
REFERENCE   5  (bases 1 to 10723)
  AUTHORS   Huang,K.C., Chuang,P.Y., Yang,T.Y., Huang,T.W. and Chang,S.F.
  TITLE     Hyperglycemia inhibits osteoblastogenesis of rat bone marrow
            stromal cells via activation of the Notch2 signaling pathway
  JOURNAL   Int J Med Sci 16 (5), 696-703 (2019)
   PUBMED   31217737
  REMARK    GeneRIF: Hyperglycemia might inhibit osteoblastogenesis of
            mesenchymal progenitors via activation of the Notch2 signaling
            pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10723)
  AUTHORS   Irvin,D.K., Zurcher,S.D., Nguyen,T., Weinmaster,G. and
            Kornblum,H.I.
  TITLE     Expression patterns of Notch1, Notch2, and Notch3 suggest multiple
            functional roles for the Notch-DSL signaling system during brain
            development
  JOURNAL   J Comp Neurol 436 (2), 167-181 (2001)
   PUBMED   11438922
REFERENCE   7  (bases 1 to 10723)
  AUTHORS   Sriuranpong,V., Borges,M.W., Ravi,R.K., Arnold,D.R., Nelkin,B.D.,
            Baylin,S.B. and Ball,D.W.
  TITLE     Notch signaling induces cell cycle arrest in small cell lung cancer
            cells
  JOURNAL   Cancer Res 61 (7), 3200-3205 (2001)
   PUBMED   11306509
REFERENCE   8  (bases 1 to 10723)
  AUTHORS   Blaumueller,C.M., Qi,H., Zagouras,P. and Artavanis-Tsakonas,S.
  TITLE     Intracellular cleavage of Notch leads to a heterodimeric receptor
            on the plasma membrane
  JOURNAL   Cell 90 (2), 281-291 (1997)
   PUBMED   9244302
REFERENCE   9  (bases 1 to 10723)
  AUTHORS   Weinmaster,G., Roberts,V.J. and Lemke,G.
  TITLE     Notch2: a second mammalian Notch gene
  JOURNAL   Development 116 (4), 931-941 (1992)
   PUBMED   1295745
REFERENCE   10 (bases 1 to 10723)
  AUTHORS   Stifani,S., Blaumueller,C.M., Redhead,N.J., Hill,R.E. and
            Artavanis-Tsakonas,S.
  TITLE     Human homologs of a Drosophila Enhancer of split gene product
            define a novel family of nuclear proteins
  JOURNAL   Nat Genet 2 (2), 119-127 (1992)
   PUBMED   1303260
  REMARK    Erratum:[Nat Genet. 1992 Dec;2(4):343. doi: 10.1038/ng1292-343a..
            PMID: 1303292]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Mar 11, 2015 this sequence version replaced NM_024358.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.3326.1,
                                           SRR26643290.9332.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               JAXUCZ010000002.1  188299336-188299570
            236-317             JAXUCZ010000002.1  188333625-188333706
            318-577             JAXUCZ010000002.1  188355497-188355756
            578-913             JAXUCZ010000002.1  188357300-188357635
            914-1036            JAXUCZ010000002.1  188365587-188365709
            1037-1270           JAXUCZ010000002.1  188381216-188381449
            1271-1426           JAXUCZ010000002.1  188382572-188382727
            1427-1615           JAXUCZ010000002.1  188383456-188383644
            1616-1729           JAXUCZ010000002.1  188384772-188384885
            1730-1843           JAXUCZ010000002.1  188385583-188385696
            1844-2077           JAXUCZ010000002.1  188387153-188387386
            2078-2188           JAXUCZ010000002.1  188389789-188389899
            2189-2381           JAXUCZ010000002.1  188393898-188394090
            2382-2527           JAXUCZ010000002.1  188395372-188395517
            2528-2641           JAXUCZ010000002.1  188397639-188397752
            2642-2761           JAXUCZ010000002.1  188399072-188399191
            2762-2914           JAXUCZ010000002.1  188399560-188399712
            2915-3143           JAXUCZ010000002.1  188404487-188404715
            3144-3345           JAXUCZ010000002.1  188405496-188405697
            3346-3499           JAXUCZ010000002.1  188407326-188407479
            3500-3684           JAXUCZ010000002.1  188407753-188407937
            3685-3817           JAXUCZ010000002.1  188409332-188409464
            3818-4054           JAXUCZ010000002.1  188415182-188415418
            4055-4167           JAXUCZ010000002.1  188417259-188417371
            4168-4673           JAXUCZ010000002.1  188418048-188418553
            4674-5021           JAXUCZ010000002.1  188419980-188420327
            5022-5164           JAXUCZ010000002.1  188421080-188421222
            5165-5375           JAXUCZ010000002.1  188421340-188421550
            5376-5472           JAXUCZ010000002.1  188422268-188422364
            5473-5641           JAXUCZ010000002.1  188423674-188423842
            5642-5943           JAXUCZ010000002.1  188425132-188425433
            5944-6091           JAXUCZ010000002.1  188426557-188426704
            6092-6189           JAXUCZ010000002.1  188427456-188427553
            6190-10723          JAXUCZ010000002.1  188428290-188432823
FEATURES             Location/Qualifiers
     source          1..10723
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..10723
                     /gene="Notch2"
                     /note="notch receptor 2"
                     /db_xref="GeneID:29492"
                     /db_xref="RGD:3188"
     exon            1..235
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..7578
                     /gene="Notch2"
                     /note="neurogenic locus notch homolog protein 2; notch
                     gene homolog 2; notch 2"
                     /codon_start=1
                     /product="neurogenic locus notch homolog protein 2
                     precursor"
                     /protein_id="NP_077334.2"
                     /db_xref="GeneID:29492"
                     /db_xref="RGD:3188"
                     /translation="MPALRPAALRALLWLWLCGAGPAHALQCRGGQEPCVNEGTCVTY
                     HNGTGYCRCPEGFLGEYCQHRDPCEKNRCQNGGTCVTQAMLGKATCRCAPGFTGEDCQ
                     YSTSHPCFVSRPCQNGGTCHMLSWDTYECTCQVGFTGKQCQWTDVCLSHPCENGSTCS
                     SVANQFSCRCPAGITGQKCDADINECDIPGRCQHGGTCLNLPGSYRCQCPQGFTGQHC
                     DSPYVPCAPSPCVNGGTCRQTGDFTSECHCLPGFEGSNCERNIDDCPNHKCQNGGVCV
                     DGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCTNRNGGYGCVCVNGWSGDD
                     CSENIDDCAFASCTPGSTCIDRVASFSCLCPEGKAGLLCHLDDACISNPCHKGALCDT
                     NPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAG
                     PRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEVNECQSNPCVNNGQ
                     CVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGTL
                     CDENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCID
                     LVNGYQCNCQPGTSGLNCEINFDDCASNPCLHGACVDGINRYSCVCSPGFTGQRCNID
                     IDECASNPCRKGATCINDVNGFRCMCPEGPHHPSCYSQVNECLSSPCIHGNCTGGLSG
                     YKCLCDAGWVGINCEVDKNECLSNPCQNGGTCNNLVNGYRCTCKKGFKGYNCQVNIDE
                     CASNPCLNQGTCLDDVSGYTCHCMLPYTGKNCQTVLAPCSPNPCENAAVCKEAPNFES
                     FTCLCAPGWQGQRCTVDVDECVSKPCMNNGICHNTQGSYMCECPPGFSGMDCEEDIND
                     CLANPCQNGGSCVDKVNTFSCLCLPGFVGDKCQTDMNECLSEPCKNGGTCSDYVNSYT
                     CTCPAGFHGVHCENNIDECTESSCFNGGTCVDGINSFSCLCPVGFTGPFCLHDINECS
                     SNPCLNSGTCVDGLGTYRCTCPLGYTGKNCQTLVNLCSPSPCKNKGTCAQEKARPRCL
                     CPPGWDGAYCDVLNVSCKAAALQKGVPVEHLCQHSGICINAGNTHHCQCPLGYTGSYC
                     EEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCID
                     LVNHFKCSCPPGTRGLLCEENIDDCAGGPHCLNGGQCVDRIGGYSCRCLPGFAGERCE
                     GDINECLSNPCSSEGSLDCIQLKNNYQCVCRSAFTGRHCETFLDVCPQKPCLNGGTCA
                     VASNVPDGFICRCPPGFSGARCQSSCGQVKCRRGEQCVHTASGPHCFCLNRKDCESGC
                     ASNPCQHGGTCYPQRQPPYYSCRCSPPFWGSHCESYTAPTSTPPATCLSQYCADKARD
                     GICDEACNSHACQWDGGDCSLTMEDPWANCTSSLRCWEYINNQCDELCNTAECLFDNF
                     ECQRNSKTCKYDKYCADHFKDNHCDKGCNNEECGWDGLDCAADQPENLAEGILVIVVL
                     LPPEQLLQDSRSFLRALGTLLHTNLRIKQDSQGALMVYPYYGEKSAAMKKQKVARRSL
                     PDEQEQEIIGSKVFLEIDNRQCVQDSDQCFKNTDAAAALLASHAIQGTLSYPLVSVVS
                     ESEDPRNTPLLYLLAVAVVIILFLILLGVIMAKRKRKHGFLWLPEGFTLRRDSSNHKR
                     REPVGQDAVGLKNLSVQVSEANLIGSTTSEHWGDDEGPQPKKAKAEDDEALLSEDDPV
                     DRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGSS
                     DLSDEDEDAEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAG
                     ADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARMNDGTTPLILAARLAVEG
                     MVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFL
                     AAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGT
                     VLTSALSPVLCGPNRSFLSLKHTPMGKKARRPNTKSTMPTSLPNLAKEAKDVKGSRRK
                     KCLNEKVQLSESSVTLSPVDSLESPHTYVSDATSSPMITSPGILQASPTPLLAAAPAA
                     PVHAQHALSFSNLHEMQPLAPGASTVLPSVSQLLSHHHIVPPGSGSAGSLGRLHSVPV
                     PSDWMNRVEMSETQYSEMFGMVLAPAEGTHPGMAAPQSRAPEGKPIPTQREPLPPIVT
                     FQLIPKGSLAQAAGAPQTQSGCPPAVAGPLPSMYQIPEMARLPSVAFPPTMMPQQEGQ
                     VAQTIVPTYHPFPASVGKYPTPPSQHSYASSNAAERTPNHGGHLQGEHPYLTPSPESP
                     DQWSSSSPHSASDWSDVTTSPTPGGGGGGQRGPGTHMSEPPHSNMQVYA"
     exon            236..317
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            318..577
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            578..913
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1036
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1270
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1426
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1615
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1729
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1843
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..2077
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2188
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2381
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2527
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2641
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2761
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..2914
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..3143
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            3144..3345
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            3346..3499
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            3500..3684
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            3685..3817
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            3818..4054
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            4055..4167
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            4168..4673
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            4674..5021
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            5022..5164
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            5165..5375
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            5376..5472
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            5473..5641
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            5642..5943
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            5944..6091
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            6092..6189
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
     exon            6190..10723
                     /gene="Notch2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccaaactt cgggcggcgg cctggctgcg cggagtgccg gggcggcgta gcggcagctc
       61 ctggactcgg cgagccgcgg gggcagggta gagcacgcga gagcggggct cctggtcggg
      121 acccgctccc catgcggatc tgctttggct gcggcagtga agatgcccgc tctgcgtccc
      181 gccgcgctgc gggcgctgct gtggctctgg ctgtgcggcg cgggccccgc gcacgctttg
      241 cagtgtcgag gtggtcaaga gccctgtgta aatgagggga cctgtgttac ctaccacaac
      301 ggcacaggct actgccgatg tccagagggc ttcttgggag aatattgtca acatcgagac
      361 ccttgtgaga agaaccgctg tcagaatggt ggtacttgtg tgacgcaggc catgttggga
      421 aaagccacct gtcgatgtgc tccagggttc acaggggagg actgccaata ctcgacctct
      481 cacccctgtt ttgtttcccg cccctgtcag aatggaggta cctgccacat gctcagctgg
      541 gacacctatg agtgcacctg tcaagttggc ttcacaggaa agcagtgtca gtggacagat
      601 gtctgtctgt ctcatccctg tgaaaatgga agcacctgta gctctgtggc caaccagttc
      661 tcctgcagat gtcctgcagg catcacaggc cagaagtgtg acgccgacat caatgaatgt
      721 gacattccag gacgctgcca acatggaggc acctgcctca accttcctgg gtcctaccga
      781 tgccaatgcc ctcagggctt cacaggccag cactgtgaca gcccgtacgt gccctgtgca
      841 ccctcaccct gcgtcaatgg aggcacctgc cgtcagactg gagacttcac ttctgaatgc
      901 cattgcctgc caggctttga agggagcaac tgcgagcgga atatcgacga ctgccctaac
      961 cacaagtgtc agaatggagg ggtgtgtgtg gatggcgtca atacttacaa ctgccgctgc
     1021 ccccctcagt ggactgggca gttctgcaca gaagacgtgg atgagtgtct gctgcagccc
     1081 aatgcttgtc agaatggagg cacttgcacc aaccgcaacg gaggctacgg ctgcgtgtgc
     1141 gtgaacggct ggagtgggga tgactgcagc gagaacatcg atgactgtgc cttcgcttcc
     1201 tgcacgccag gctccacctg tattgaccgt gtggcctcct tctcctgcct ttgtccagag
     1261 ggaaaggcag ggctcctgtg tcatctggat gatgcctgta tcagcaaccc ttgtcacaag
     1321 ggggcgctgt gtgataccaa ccccctgaat gggcagtaca tttgcacctg cccacagggc
     1381 tacaagggcg ctgactgcac agaagacgtg gatgagtgtg ctatggccaa cagtaaccct
     1441 tgtgagcatg caggaaagtg tgtgaataca gatggcgcct tccactgcga gtgtctgaag
     1501 ggctacgcag ggcctcgctg tgagatggac atcaacgagt gtcactcaga cccctgtcag
     1561 aacgacgcca cctgcctgga taagattgga ggcttcacct gtctctgcat gccgggtttc
     1621 aaaggtgtgc attgtgaact ggaggtgaat gaatgccaga gcaacccgtg tgtaaacaat
     1681 gggcagtgtg tggacaaagt caatcgcttc cagtgtctgt gtccccctgg tttcacagga
     1741 ccagtgtgcc agatcgacat tgacgactgc tccagtactc cctgcctgaa tggggccaag
     1801 tgcatcgatc acccgaatgg ctatgaatgc cagtgtgcca caggattcac tggcacactg
     1861 tgtgatgaga acatcgacaa ctgtgacccg gatccttgcc accatggcca gtgccaggat
     1921 gggattgact cctacacctg catctgcaac cccgggtaca tgggagccat ctgtagtgac
     1981 cagattgatg aatgctacag cagcccctgc ctgaatgatg gacgctgcat cgacctggtg
     2041 aacggctacc agtgcaactg ccaaccgggt acctcaggcc ttaattgtga aattaatttt
     2101 gatgactgtg ccagcaaccc ttgtctgcac ggagcctgtg tggacggcat caaccgttac
     2161 agttgtgtgt gctctccggg attcacaggg cagaggtgca acatagacat tgatgagtgt
     2221 gcctccaacc cctgtcgcaa gggtgcgacg tgcatcaatg acgtgaatgg tttccggtgt
     2281 atgtgccctg agggaccaca ccatcccagc tgctactcac aggtgaacga gtgtttgagc
     2341 agtccctgca tccatggaaa ctgtactgga ggtctcagtg gctataagtg cctctgcgat
     2401 gcaggctggg ttggtatcaa ctgcgaagtg gacaaaaatg agtgtctttc taacccgtgc
     2461 cagaatggag ggacatgtaa taacctggtg aatggctaca ggtgtacatg caagaagggg
     2521 ttcaaaggct ataactgcca ggtgaacata gatgagtgtg cctcgaaccc gtgtctgaac
     2581 caagggacct gcctcgatga cgtcagtggc tacacctgcc actgcatgct gccttacaca
     2641 ggcaagaatt gtcaaacggt gttggcgccc tgctccccta acccgtgtga gaacgctgca
     2701 gtttgtaaag aggcacccaa ctttgagagc ttcacctgcc tgtgtgcccc tggctggcaa
     2761 ggtcagcgct gtacagttga cgttgatgag tgtgtctcca agccgtgtat gaacaatggc
     2821 atctgccata atactcaggg cagctacatg tgcgagtgcc ctcccggctt cagtggtatg
     2881 gactgtgagg aggacatcaa tgactgcctt gccaacccct gccagaacgg aggctcctgt
     2941 gtggacaaag tgaacacctt ctcctgcctg tgccttcctg gcttcgtagg ggacaagtgc
     3001 caaacagaca tgaatgaatg tctgagcgag ccctgtaaga atggggggac ctgctctgac
     3061 tacgtcaaca gctacacctg cacgtgccct gcgggcttcc atggagtcca ctgtgaaaac
     3121 aacatcgatg agtgcactga gagctcctgt ttcaatggcg gcacgtgtgt tgatgggatc
     3181 aactctttct cttgcttatg ccctgtgggt ttcactggtc ccttctgcct ccatgatatc
     3241 aatgagtgca gctctaaccc gtgcctgaat tcgggaacgt gtgttgatgg cctgggtacc
     3301 taccgatgca cctgtccctt gggctacact gggaaaaact gtcagaccct ggtgaacctc
     3361 tgcagcccct ctccatgtaa aaacaaagga acttgtgctc aggaaaaggc aaggccacgc
     3421 tgcctgtgtc cgcctggatg ggatggcgca tactgtgatg tgctcaatgt gtcctgtaag
     3481 gcggcagcct tgcagaaagg agtacctgtt gaacacttgt gccagcactc gggtatctgt
     3541 atcaatgctg gcaacacgca tcactgccag tgccccctgg gctacacggg gagctactgc
     3601 gaggaacagc ttgacgagtg tgcgtccaat ccatgccagc atggtgccac ctgcagtgac
     3661 ttcatcggag gatacagatg tgagtgtgtt ccagggtatc agggtgtcaa ctgtgagtat
     3721 gaagtggacg agtgccagaa ccagccctgt cagaacggag gcacctgcat cgacctcgtg
     3781 aaccatttca agtgctcgtg cccaccaggc acccggggcc tgctttgtga agagaacatt
     3841 gatgactgtg ctgggggccc ccactgcctt aatggtggcc agtgtgtgga ccggattgga
     3901 ggctacagtt gtcgctgttt gcctggcttt gctggggagc ggtgtgaggg ggacatcaat
     3961 gaatgcctgt ccaatccttg cagctcagag ggcagcctgg actgcattca gctcaaaaat
     4021 aactaccagt gtgtctgccg cagcgccttc acaggccgac actgcgaaac cttcctagat
     4081 gtgtgtcccc agaagccttg cctgaatgga gggacttgtg ctgtggctag caacgtgcct
     4141 gatggcttca tttgtcgttg tcccccaggg ttctccgggg caagatgcca gagcagctgt
     4201 ggacaagtga agtgcagaag aggggagcag tgtgtgcaca ccgcctcggg accccactgc
     4261 ttctgcctga accgcaagga ctgcgagtca ggttgcgcta gtaacccctg ccagcacgga
     4321 ggcacctgct accctcagcg ccagcctcct tactactctt gccgctgctc cccaccgttc
     4381 tggggcagcc actgcgagag ctacacagcc cccaccagca cccctcctgc tacctgtctg
     4441 agtcagtact gtgccgacaa ggctcgggac ggcatctgtg atgaggcctg caacagtcat
     4501 gcctgccagt gggatggagg tgactgttcc ctcactatgg aggacccctg ggccaactgc
     4561 acctcctcac ttcgctgctg ggagtacatc aacaaccagt gtgatgagct gtgcaacact
     4621 gcagagtgcc tgtttgacaa ctttgaatgc cagaggaata gcaaaacctg caagtatgac
     4681 aaatactgtg cagaccactt caaagacaat cactgcgata agggatgcaa caacgaggag
     4741 tgtggctggg acgggctgga ctgcgctgcg gaccagcctg agaacctggc ggagggcatc
     4801 ctggtcatcg tggtgctcct accccctgag cagctgcttc aggattctcg aagcttcttg
     4861 agggccctgg gcaccctgct ccacaccaac ttacgcatta aacaagactc tcagggcgcc
     4921 ctcatggtgt acccctacta tggggagaag tcagctgcca tgaagaagca gaaggtggca
     4981 cgcaggtctc ttcctgatga gcaggaacag gagataatag gctctaaggt atttctggaa
     5041 atcgacaacc gacagtgtgt tcaagactca gaccagtgct tcaagaacac agatgctgca
     5101 gctgctctcc tggcttctca tgccatccaa gggaccttgt cctaccctct ggtgtctgtt
     5161 gtcagtgaat cggaggatcc aaggaacact ccgctcctct atctgcttgc ggttgctgtg
     5221 gtcattatcc tgttcctcat cctgctgggg gtcatcatgg caaagcggaa gcgcaagcac
     5281 ggcttcctct ggctgcctga aggcttcacg cttcgccgag actccagcaa tcacaagcgc
     5341 cgtgaacctg tggggcagga tgccgtgggg ctgaagaatc tctcagtgca agtgtcagag
     5401 gcaaacctga tcggctccac gacaagcgag cattggggtg atgatgaagg accccagcca
     5461 aagaaagcca aggctgagga cgacgaggct ttgctgtcgg aagacgaccc tgtcgaccgg
     5521 cgcccctgga cacagcagca ccttgaagct gcagacatcc gccggactcc atccctggcg
     5581 ctcacccctc ctcaggcaga gcaggaggtg gacgtgctgg acgtgaatgt ccgaggccca
     5641 gatgggtgca ccccactgat gctggcttct ctccgaggag gcagctcaga cctgagtgat
     5701 gaagatgaag atgctgagga ctcttctgcc aacatcatca cagacttggt ctaccaaggt
     5761 gccagcctcc aggcacagac ggaccgcact ggtgagatgg ccctgcacct tgcagcccgc
     5821 tattcgagag ctgatgctgc caaacgcctc ctggatgctg gtgcagatgc caacgcccag
     5881 gacaacatgg gccgctgtcc tcttcatgct gcagttgcag cggatgccca aggtgtcttc
     5941 cagattctga tccgcaaccg agtaacggat ctagacgcca ggatgaatga tggcactacc
     6001 cccctgatcc tggctgcccg cctggctgtg gaaggaatgg tggcagagct gatcaactgc
     6061 caagcagatg tgaacgcagt ggatgaccat ggaaaatctg ccctccactg ggcagccgcc
     6121 gtcaataatg tggaggcaac tcttttgctg ttgaagaatg gggccaaccg ggatatgcag
     6181 gacaacaagg aagagacacc tttgtttctt gctgcccgag agggaagtta tgaagcagcc
     6241 aaaatcctgt tagaccactt tgccaaccgg gacatcacgg accacatgga ccgccttccc
     6301 cgggatgtgg ctcgggaccg catgcaccat gacatagttc gcctcctgga cgagtacaac
     6361 gtgactccca gccctccggg gactgtcttg acttctgctc tctcacctgt cctctgtggg
     6421 cccaacaggt ctttcctcag tctgaagcac accccaatgg gtaagaaggc cagacggccc
     6481 aacaccaaga gcaccatgcc cacaagcctg cctaaccttg ccaaggaggc caaggacgtc
     6541 aaggggagca ggaggaagaa gtgtctcaac gagaaggtcc agctctccga gagctcagtg
     6601 actttatccc ctgtcgactc gctcgagtct cctcacacat atgtttctga tgccacgtct
     6661 tcccccatga tcacgtcccc tgggatctta caggcctcac ccacgcctct tctggctgct
     6721 gccccagctg ccccagtgca tgctcagcat gcactgtctt tctctaacct tcacgaaatg
     6781 cagcctttgg ctcctggagc cagcaccgtg ctcccctcag ttagccagtt gttgtcccac
     6841 caccacatcg tccccccagg gagtggcagt gcaggaagct tgggcaggtt acattcagtc
     6901 cctgtcccct cagactggat gaaccgcgtg gagatgagtg agacccagta cagtgaaatg
     6961 tttggcatgg tcctggctcc tgcagaggga acccaccctg gcatggcagc tcctcagagc
     7021 agagctccgg aagggaagcc catccccaca cagcgtgagc ccttgcctcc cattgtaact
     7081 ttccagctca tcccgaaagg cagccttgct caagcagctg gggctcccca gacacagtcc
     7141 ggctgccccc cagctgtggc aggccccttg ccctctatgt accagatccc agagatggcc
     7201 cgtttgccca gtgtggcttt cccacctacc atgatgcccc agcaggaggg gcaggtagct
     7261 cagaccattg tcccaaccta tcaccctttc ccagcctctg tgggcaagta ccccacaccc
     7321 ccttcccaac acagttatgc ctcctcaaat gctgccgagc gcacccccaa tcatggtggt
     7381 cacctccagg gcgagcaccc gtacctgaca ccatccccag agtctcctga ccaatggtcg
     7441 agctcttcac cgcactctgc gtctgactgg tcagatgtga ccaccagccc aactcctgga
     7501 gggggtggag gcggtcagcg gggacctgga acacacatgt ccgagccacc acacagcaac
     7561 atgcaggttt atgcatgaag agtgcctcag ttagagatgg acgtgcccat cacacgcact
     7621 cctgagggcc gagtgaaggt tatccaagag aaatgaagag acctctaacc agcctctgga
     7681 ggcaggagga aagacgctcc tgacttcaca caagcatgag cagcattatt ttcatcttca
     7741 ctgagtatct gtgcagttta gggaggactc agctcctact gacctttgcc catcctgcaa
     7801 gttcatggag atgcaagatg aatgcaagcc ttggggcccc tcgctctctt cttggagagt
     7861 acgatgaatg cctgttgtcg cccggacatc cttgcagctt gaataccata ctaagccctg
     7921 gaggcttctg cctccatgtg gagactgctc tagaggcgga ctgagaatcg tgccctggga
     7981 ttctgtccaa tcttctcagc cctggaagta gccttgatgt cacttggtgc tttcctctct
     8041 gcgcctgtct gtgattgatc ccgccagtat gtcatgggca gacgtttgtg cccttaatca
     8101 ttcctgacct ggaaaaccgc ttcagcctcc tgtccccaca ttcccagcac ccgaggagcc
     8161 tcacagggtt tgctctggtc atgggtctca accttggcct ctgaagtgcc cgcccatgaa
     8221 aaatgcacac actgcaatcc tcgtgtctcc ttcctagaag ggaagagaac aaaatatttg
     8281 gggaagagaa gcctccttct gaacctgcac cttaatttct ctcccctgcc tctgggaccc
     8341 catatatact catcaggggg aaggatatga gttcttttgt ttgttggcct ggtcagtata
     8401 aaattgtact ctaggaggct taggtactat gatattctct catctttttg taaagtggga
     8461 aaagtgggtg aacgttggga tgtccaggaa ataagctagc ttgcccaaga agcagttacc
     8521 catttacagg cccaacattg atctccactg tgaagcacat tcacccccaa atcttaggac
     8581 ccattgatcc agcagatgaa ggtactcttg gctgctgcac tgctcctcag agatgcccgc
     8641 ctccatttgc ccttgccact taggacagaa cttgcctggg gcacagggga cccagtgact
     8701 gccaacttcc ttaggaccac tttcctctca gatcagaagc cagcttatca gtttccctcc
     8761 acactgtgtg ctctgagtga ttggtgtaca ccgcaggttc tccgtgacga catggaatcc
     8821 gtgtttgggt tccagacgtg gagaatggac agtcccctga gcacacatga ggcggccttt
     8881 gctagttgtt gccgcactgt cttccttccc tagagtcccc ttcagatgat gatggctcct
     8941 cactgtcctt gtgttcagac taagattgta cctcatccaa acctgcttcc tgtattgtgg
     9001 tttcagtgat gtcccggact ctcaagagca gaaacaactt catctgttgt aaatctagga
     9061 tgacagtttt ctccatcttc ccctcagcca gctaataatt ggccctaggg ccatgccatc
     9121 attacttcct ggtgtcatga tgcctgtgac accagaaaat cagttctgcg ggagcatttg
     9181 tgtataatat taggtggatc accttggggg ggtgtttatt tgttgtttta ggggttttgt
     9241 taaattgttg ttttaataat agtctttatt cctgcaatag ttgaaataag tgttcctcca
     9301 ctcattcatc agcctgacct taggaactcc gtgtatctgt taccatggca gtgaggattt
     9361 tagtcccatc caaggtcatt gaatcagcaa aaactatctg ttctgtcctg gtgtatggca
     9421 gattgtttgc tcatttgact ttattatcat gtggcaatat catcctatca gcccctttca
     9481 tggaatatag acgtgttatt gccctaaacg gtgactgtgt ccccatgccc atcagttagt
     9541 cccagataaa gagaaactct gtgtggacct ccctgcctaa agccttagtg ccactgccta
     9601 cgagccacgg ccaaggccaa gaacccagcc actgggtctg tggtcactga tccttcccca
     9661 gacacaaaga acaaacttac cgtttctccg tcagggatcc ctcaaagagg atcctttggg
     9721 tttgggagga gggatgtgaa aactgccatt acagacaaca ggctgcagag atgaagacaa
     9781 cactgccagt cagacacctg atgggtccct tagatgttag aattcttgac ctgtgtggtg
     9841 tctaggaaag gggagaggtc taggaaaggg gagagatctc ctgggatctg agttagaggc
     9901 taaggttgta cgggcacatc cttcattccg tacacaggtc ccagtccctg ttggacttac
     9961 ttttatttgt atgaattctc cctttgactc ctgcctgcct ttgaagatat ttttttaatt
    10021 tgtttttttt tttgtttttg tttttgtttt aagcatcgtt ttcttaggcg atggtggggg
    10081 ggattgaagg aaagaaagac tgtgttaaag attttaatga aagccgacag cacgagttgg
    10141 ttatatcttt ttgttaaact tggccacttg aagtcttgta tagaaaagaa ccaaaggtgt
    10201 aacgttctgt tcgcatgcga tttcaggacc cggactctaa ccagcacgtt gacttcgagg
    10261 actgtttgga aggacacatg tccatgtcct gaggccccac ccttgtctgt catggtacta
    10321 tggcaacgtc cttgtgtaca tttccctgaa aagtgacttt gtatctgttt gtatgagaaa
    10381 ctcagtaacc agaaaatgac tgcatgttcc tgactaaatg tagaaaggag tatgcacact
    10441 gtttttactt tttaaagttt cattctaaaa gtagtttaag atgaaattta tatgaaaaca
    10501 tttttatcac aaaataaaaa gggttccctg tcaaagctca gtggtctcct cctctgccct
    10561 tctcccctgc tgttgccccg gttccacagt gagcaccgca tgatgtcaag gttggtgaga
    10621 gagacctcaa tcttcctcgt cctgaaccct aagcccaccc agtactgacg ctctttcatt
    10681 ttctcgtcta gtttgattat aaataaatgc ttctgagggg aaa
//
