LOCUS       NM_001105721            9407 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus notch receptor 1 (Notch1), mRNA.
ACCESSION   NM_001105721 XM_001078434 XM_342392
VERSION     NM_001105721.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9407)
  AUTHORS   Wang,Y.C., Chen,R.F., Liu,K.F., Chen,W.Y., Lee,C.C. and Kuo,Y.R.
  TITLE     Adipose-derived stem cell modulate tolerogenic dendritic
            cell-induced T cell regulation is correlated with activation of
            Notch-NFkappaB signaling
  JOURNAL   Cytotherapy 26 (8), 890-898 (2024)
   PUBMED   38625070
  REMARK    GeneRIF: Adipose-derived stem cell modulate tolerogenic dendritic
            cell-induced T cell regulation is correlated with activation of
            Notch-NFkappaB signaling.
REFERENCE   2  (bases 1 to 9407)
  AUTHORS   Zhang,H., Gu,R., Luo,J., Zhong,C. and Pan,J.
  TITLE     Involvement of NOTCH1-mediated Microglia Activation in
            Neuromodulation of Chronic Prostatitis-related Pain
  JOURNAL   In Vivo 38 (2), 691-698 (2024)
   PUBMED   38418142
  REMARK    GeneRIF: Involvement of NOTCH1-mediated Microglia Activation in
            Neuromodulation of Chronic Prostatitis-related Pain.
REFERENCE   3  (bases 1 to 9407)
  AUTHORS   Li,Y., Ma,L., Deng,Y., Du,Z., Guo,B., Yue,J., Liu,X. and Zhang,Y.
  TITLE     The Notch1/Hes1 signaling pathway affects autophagy by adjusting
            DNA methyltransferases expression in a valproic acid-induced autism
            spectrum disorder model
  JOURNAL   Neuropharmacology 239, 109682 (2023)
   PUBMED   37543138
  REMARK    GeneRIF: The Notch1/Hes1 signaling pathway affects autophagy by
            adjusting DNA methyltransferases expression in a valproic
            acid-induced autism spectrum disorder model.
REFERENCE   4  (bases 1 to 9407)
  AUTHORS   Wang,P., Zhang,S., Hu,C., Ren,L. and Bi,J.
  TITLE     Regulatory role of melatonin in Notch1 signaling pathway in
            cerebral cortex of Abeta1-42-induced Alzheimer's disease rat model
  JOURNAL   Mol Biol Rep 50 (3), 2463-2469 (2023)
   PUBMED   36602704
  REMARK    GeneRIF: Regulatory role of melatonin in Notch1 signaling pathway
            in cerebral cortex of Abeta1-42-induced Alzheimer's disease rat
            model.
REFERENCE   5  (bases 1 to 9407)
  AUTHORS   Yang,C., Pan,J., Luo,X., Li,J. and Jiang,Z.
  TITLE     Hypoxia-induced mesenchymal stem cells inhibit corneal fibroblast
            proliferation by regulating the WWP2/Notch1 axis
  JOURNAL   Regen Med 17 (6), 375-388 (2022)
   PUBMED   35545948
  REMARK    GeneRIF: Hypoxia-induced mesenchymal stem cells inhibit corneal
            fibroblast proliferation by regulating the WWP2/Notch1 axis.
REFERENCE   6  (bases 1 to 9407)
  AUTHORS   de la Pompa,J.L., Wakeham,A., Correia,K.M., Samper,E., Brown,S.,
            Aguilera,R.J., Nakano,T., Honjo,T., Mak,T.W., Rossant,J. and
            Conlon,R.A.
  TITLE     Conservation of the Notch signalling pathway in mammalian
            neurogenesis
  JOURNAL   Development 124 (6), 1139-1148 (1997)
   PUBMED   9102301
REFERENCE   7  (bases 1 to 9407)
  AUTHORS   Conlon,R.A., Reaume,A.G. and Rossant,J.
  TITLE     Notch1 is required for the coordinate segmentation of somites
  JOURNAL   Development 121 (5), 1533-1545 (1995)
   PUBMED   7789282
REFERENCE   8  (bases 1 to 9407)
  AUTHORS   Lindsell,C.E., Shawber,C.J., Boulter,J. and Weinmaster,G.
  TITLE     Jagged: a mammalian ligand that activates Notch1
  JOURNAL   Cell 80 (6), 909-917 (1995)
   PUBMED   7697721
REFERENCE   9  (bases 1 to 9407)
  AUTHORS   Weinmaster,G., Roberts,V.J. and Lemke,G.
  TITLE     Notch2: a second mammalian Notch gene
  JOURNAL   Development 116 (4), 931-941 (1992)
   PUBMED   1295745
REFERENCE   10 (bases 1 to 9407)
  AUTHORS   Weinmaster,G., Roberts,V.J. and Lemke,G.
  TITLE     A homolog of Drosophila Notch expressed during mammalian
            development
  JOURNAL   Development 113 (1), 199-205 (1991)
   PUBMED   1764995
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474001.2.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_342392.3, XM_001078434.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132262, SAMD00132263
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..9407
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..9407
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="notch receptor 1"
                     /db_xref="GeneID:25496"
                     /db_xref="RGD:3187"
     exon            1..287
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..7822
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="neurogenic locus notch homolog protein 1; Notch
                     gene homolog 1; Drosophila Notch homolog 1 (controlling
                     the the ectodermal and neural cell fate in Drosophila);
                     notch 1"
                     /codon_start=1
                     /product="neurogenic locus notch homolog protein 1
                     precursor"
                     /protein_id="NP_001099191.1"
                     /db_xref="GeneID:25496"
                     /db_xref="RGD:3187"
                     /translation="MPRLLAPLLCLTLLPALAARGLRCSQPSGTCLNGGRCEVANGTE
                     ACVCSGAFVGQRCQDPSPCLSTPCKNAGTCYVVDHGGIVDYACSCPLGFSGPLCLTPL
                     ANACLANPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFES
                     SYICGCPPGFHGPTCRQDVNECSQNPGLCRHGGTCHNEIGSYRCACRATHTGPHCELP
                     YVPCSPSPCQNGGTCRPTGDTTHECACLPGFAGQNCEENVDDCPGNNCKNGGACVDGV
                     NTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNSHGGYNCVCVNGWTGEDCSE
                     NIDDCASAACFQGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPV
                     NGKAICTCPSGYTGPACSQDVDECALGANPCEHAGKCLNTLGSFECQCLQGYTGPRCE
                     IDVNECISNPCQNDATCLDQIGEFQCICMPGYEGVYCEINTDECASSPCLHNGRCVDK
                     INEFLCQCPKGFSGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVD
                     IDECDPDPCHYGLCKDGVATFTCLCQPGYTGHHCETNINECHSQPCRHGGTCQDRDNY
                     YLCLCLKGTTGPNCEINLDDCASNPCDSGTCLDKIDGYECACEPGYTGSMCNVNIDEC
                     AGSPCHNGGTCEDGIAGFTCRCPEGYHDPTCLSEVNECNSNPCIHGACRDGLNGYKCD
                     CAPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASN
                     PCLNQGTCIDDVAGYKCNCPLPYTGATCEVVLAPCATSPCKNSGVCKESEDYESFSCV
                     CPTGWQGQTCEIDINECVKSPCRHGASCQNTNGSYRCLCQAGYTGRNCESDIDDCRPN
                     PCHNGGSCTDGVNAAFCDCLPGFQGAFCEEDINECASNPCQNGANCTDCVDSYTCTCP
                     TGFNGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQYDVNECDSRPC
                     LHGGTCQDSYGTYKCTCPQGYTGLNCQNLVRWCDSAPCKNGGKCWQTNTQYHCECRSG
                     WTGFNCDVLSVSCEVAAQKRGIDVTLLCQHGGLCVDEEDKHYCHCQAGYTGSYCEDEV
                     DECSPNPCQNGATCTDYLGGFSCKCVAGYHGSNCSEEINECLSQPCQNGGTCIDLTNT
                     YKCSCPRGTQGVHCEINVDDCHPPLDPASRSPKCFNNGTCVDQVGGYTCTCPPGFVGE
                     RCEGDVNECLSNPCDPRGTQNCVQRVNDFHCECRAGHTGRRCESVINGCRGKPCRNGG
                     VCAVASNTARGFICRCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGSF
                     TGPECQFPASSPCVGSNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFTGGA
                     GRDIPPPQIEEACELPECQEDAGNKVCNLQCNNHACGWDGGDCSLNFNDPWKNCTQSL
                     QCWKYFSDGHCDSQCNSAGCLFDGFDCQLTEGQCNPLYDQYCKDHFSDGHCDQGCNSA
                     ECEWDGLDCAEHVPERLAAGTLVLVVLLPPDQLRNNSFHFLRELSHVLHTNVVFKRDA
                     QGQQMIFPYYGREEELRKHPIKRSAVGWATTSLLPGTNGGRQRRELDPMDIHGSIVYL
                     EIDNRQCVQSSSQCFQSATDVAAFLGALASLGSLNIPYKIEAVKSETVEPPLPSQLHL
                     MYVAAAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGL
                     KPLKNASDGALMDDNQNEWGDEDLETKKFRFEEPVVLPDLDDQTDHRQWTQQHLDAAD
                     LRVSAMAPTPPQGEVDADCMDVNVRGPDGFTPLMIASCSGGGLETGNSEEEEDAPAVI
                     SDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAA
                     VSADAQGVFQILLRNRATDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDD
                     LGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNKEETPLFLAAREGSYETAKVLLDHF
                     ANRDITDHMDRLPRDIAQERMHHDIVRLLDEYNLVRSPQLHGTALGGTPTLSPTLCSP
                     NGYLGNLKSATQGKKARKPSTKGLACSSKEAKDLKARRKKSQDGKGCLLDSSSMLSPV
                     DSLESPHGYLSDVASPPLLPSPFQQSPSMPLSHLPGMPDTHLGISHLNVAAKPEMAAL
                     AGGSRLAFEPPPPRLSHLPVASSASTVLSTNGTGAMNFTVGAPASLNGQCEWLPRLQN
                     GMVPSQYNPLRPGVTPGTLSTQAAGLQHGMMGPIHSSLSTNTLSPIIYQGLPNTRLAT
                     QPHLVQTQQVQPQNLQIQPQNLQPPSQPHLSVSSAANGHLGRSFLSGEPSQADVQPLG
                     PSSLPVHTILPQESQALPTSLPSSMVPPMTTTQFLTPPSQHSYSSSPVDNTPSHQLQV
                     PEHPFLTPSPESPDQWSSSSPHSNISDWSEGISSPPTSMPSQITHIPEAFK"
     exon            288..366
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..629
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..968
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1091
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1325
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1481
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1667
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1781
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1895
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2129
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2240
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2433
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2579
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2693
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..2813
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..2966
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2967..3195
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3397
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3398..3551
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3552..3736
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3737..3869
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3870..4127
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            4128..4240
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            4241..4812
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            4813..5214
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            5215..5363
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            5364..5580
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            5581..5668
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            5669..5834
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            5835..6130
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            6131..6278
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            6279..6376
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            6377..9407
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaggggcgt ggggcgcagg gcgcgggtgc gagcgcagtg aaggaacgag cctgggtgcc
       61 tgtagtgccg gggagaccct gagagcccag cgccgcccac ccgccaggaa agagggcagc
      121 agcgggtgga cgcccgcggg accgcccgtg gtgcgcgtga acgtccgatc cccgccggcc
      181 accgcaagag gccgccgccc cggcagcggg cagctggcga gcaggcatgc cgcggctcct
      241 ggcgcccttg ctctgcctaa cgctgctgcc cgcgctcgcc gcaagaggct tgagatgctc
      301 ccagccaagt gggacctgcc tgaatggagg gaggtgcgaa gtggccaacg gcactgaagc
      361 ctgtgtctgc agcggagcgt tcgtgggcca gcgatgccag gaccccagcc cttgcctcag
      421 cacaccatgt aagaatgctg gaacgtgcta tgttgtggac catggcggca tcgtggacta
      481 tgcctgcagt tgccccctgg gtttctctgg gcccctctgc ctgacacctc tggccaatgc
      541 ctgcctggcc aacccctgcc gcaacggggg gacctgtgac ctgctcactc tcacagaata
      601 caagtgccgg tgcccgccag ggtggtcagg aaagtcatgt cagcaagccg acccctgtgc
      661 ctccaacccc tgtgccaatg gtggccagtg cctgcccttt gagtcttcat acatctgtgg
      721 ctgcccgccc ggcttccatg gccccacctg cagacaagat gttaacgagt gcagccagaa
      781 ccctgggttg tgccgtcatg gcggcacgtg ccacaatgag attggctcct atcgctgtgc
      841 ctgccgtgcc acccacactg gtccccactg cgagctgccc tacgtgccct gcagcccctc
      901 accctgccag aacggaggca cctgccgccc tacgggggac accacccacg agtgtgcctg
      961 cctgccaggc tttgctggac agaactgtga agaaaatgtg gatgactgcc caggaaacaa
     1021 ctgcaagaac gggggtgcct gtgtggacgg tgtgaatacc tacaattgcc gctgcccacc
     1081 ggagtggaca ggtcagtact gcacagagga tgtggacgag tgtcagctca tgcccaacgc
     1141 ctgccagaat ggcggaacct gccacaactc ccacggtggc tacaactgcg tgtgtgtcaa
     1201 tggctggact ggtgaggact gcagtgagaa cattgatgac tgtgccagtg ccgcctgttt
     1261 tcagggtgcc acctgccatg accgtgtggc ttccttctac tgcgagtgtc cacatgggcg
     1321 cacaggcctg ctgtgccacc tgaacgatgc gtgtatcagc aacccctgca acgagggctc
     1381 caactgcgac accaaccctg tcaacggcaa ggccatctgc acttgcccct cggggtacac
     1441 ggggccagcc tgcagccagg acgtggatga gtgcgctcta ggtgccaacc cgtgtgagca
     1501 cgcgggcaag tgcctcaaca cactgggctc tttcgagtgt cagtgtctac agggctacac
     1561 tgggccccgc tgtgagattg atgtcaacga gtgcatctcc aacccatgtc agaatgatgc
     1621 cacgtgcctg gaccagattg gggagtttca gtgtatatgt atgccaggtt atgagggtgt
     1681 atactgtgag atcaacacgg acgagtgtgc cagcagcccc tgtctacaca atggccgctg
     1741 cgtggacaag atcaacgagt tcctgtgtca gtgtcccaaa ggcttcagcg ggcacctgtg
     1801 ccagtatgac gtggatgagt gcgccagcac accatgcaag aacggcgcca agtgcctgga
     1861 tgggcccaac acctacacct gcgtgtgcac agaaggttac acggggaccc actgcgaggt
     1921 ggacattgac gagtgtgacc ctgacccctg tcactatggt ttgtgcaagg atggtgtggc
     1981 cacctttacc tgcctctgcc agccaggcta cacaggccat cactgtgaga ccaacattaa
     2041 tgagtgtcac agccagccgt gccgccatgg cggcacctgc caggaccgtg acaactacta
     2101 cctctgctta tgcctcaagg ggaccacagg acccaactgt gagatcaatc tggatgactg
     2161 tgcgagcaac ccctgtgact ctggcacgtg tctggacaag atcgatggct acgagtgtgc
     2221 gtgcgagcca ggctacacag ggagcatgtg taatgtcaac attgacgaat gtgcgggcag
     2281 cccctgccac aacgggggca cctgtgagga tggcatcgcc ggcttcactt gccgctgccc
     2341 cgagggctac cacgacccta cgtgcctgtc tgaggtcaac gagtgcaaca gtaacccctg
     2401 catccatgga gcttgccggg atggcctcaa tggatacaaa tgtgactgtg cccctgggtg
     2461 gagtgggaca aactgtgaca tcaacaacaa tgagtgtgag tccaaccctt gtgtcaacgg
     2521 tggcacctgc aaagacatga ccagtggcta cgtatgcacc tgccgagaag gcttcagtgg
     2581 ccctaactgc cagaccaaca ttaacgaatg tgcttccaac ccctgcctga accagggcac
     2641 ctgcattgat gatgtcgctg ggtacaaatg caactgccct ctgccctata caggagccac
     2701 atgtgaggtg gtgttggccc catgtgccac cagcccctgc aaaaacagtg gggtatgcaa
     2761 ggagtctgag gactatgaga gcttttcctg tgtctgtccc acaggctggc aaggtcaaac
     2821 ctgcgagatc gacatcaatg agtgtgtgaa aagcccgtgt cgccatggtg cctcttgcca
     2881 gaacaccaat ggcagctacc gctgcctctg ccaggctggc tacacgggtc gcaactgcga
     2941 gagtgacatc gatgactgcc gacccaaccc atgtcacaac gggggttcct gcactgacgg
     3001 ggtcaacgcg gccttctgcg actgcctgcc cggcttccag ggtgccttct gtgaggagga
     3061 catcaacgaa tgcgccagca atccatgcca aaatggcgcc aactgcactg actgcgtgga
     3121 cagctacacg tgcacctgcc ccacgggctt caatggcatc cattgcgaga acaacacacc
     3181 tgactgtacc gagagctcct gtttcaatgg tggcacctgt gtggatggta tcaactcctt
     3241 cacctgtctg tgcccacctg gcttcacggg cagctactgc cagtatgacg tcaatgagtg
     3301 tgactcacgg ccctgtctgc atggtggcac ctgccaagac agctatggta cctataagtg
     3361 tacctgccca cagggctaca ctggtctcaa ctgccagaac cttgtgcgct ggtgtgactc
     3421 agctccctgc aagaatggcg gcaagtgctg gcagaccaac acacagtacc actgcgagtg
     3481 ccgcagcggc tggactggct tcaactgcga cgtgctcagt gtgtcctgcg aggtggctgc
     3541 acagaagcga ggcatcgatg tcactctcct atgccagcac ggagggctct gtgtggatga
     3601 ggaagacaag cattactgcc actgccaggc aggatacacg ggcagctact gtgaggacga
     3661 ggtggacgag tgctcaccta atccctgcca gaacggagcc acctgcactg actatctcgg
     3721 tggcttttcc tgcaagtgtg tggctgggta ccatggctct aactgctctg aggagatcaa
     3781 cgagtgccta tcccaaccct gccagaatgg gggtacctgc attgatctga ccaacaccta
     3841 caagtgctcc tgccccaggg gcacacaggg tgtacactgt gagatcaacg tcgatgactg
     3901 ccatcctccc ctagaccctg cttcccgaag ccccaaatgc ttcaataatg gcacctgcgt
     3961 ggaccaggtg ggtggctata cctgcacctg cccgccaggc ttcgtcgggg agcggtgcga
     4021 gggcgatgtc aatgagtgtc tctccaaccc ctgtgaccca cgtggcaccc agaactgcgt
     4081 gcagcgtgtt aatgacttcc actgcgagtg ccgggctggc cacactggac gccgctgtga
     4141 gtcggtcatt aatggctgca ggggcaaacc atgcaggaat ggaggtgtct gtgctgtggc
     4201 ctccaacacc gcccgtggat tcatctgtag gtgccctgcg ggcttcgagg gtgccacttg
     4261 tgaaaatgac gcccgcactt gtggcagttt gcgctgcctc aacggtggta cgtgcatctc
     4321 aggcccacgc agtcccacct gcctatgcct gggctccttc actggccctg aatgccagtt
     4381 cccagccagc agcccctgtg tgggtagcaa cccctgctac aatcagggca cctgtgagcc
     4441 cacatccgag agccctttct accgctgtct atgccctgcc aaattcaacg ggctgctgtg
     4501 ccacatcctg gactacagct tcacaggtgg cgccgggcgc gacattcccc cgccacagat
     4561 tgaggaggcc tgcgaactgc ctgagtgcca ggaggatgca ggcaataagg tctgcaacct
     4621 tcagtgtaat aatcacgcgt gtggctggga cggcggcgac tgctccctca acttcaatga
     4681 cccttggaag aactgcactc agtccctgca gtgctggaag tattttagtg acggccactg
     4741 tgacagccag tgcaactcag ctggctgcct ttttgatggc ttcgactgcc agctcaccga
     4801 gggacagtgc aaccccctgt atgaccagta ctgcaaggac cacttcagtg atggccactg
     4861 cgaccagggc tgcaacagtg ccgagtgtga gtgggatgga ctggactgtg cagagcatgt
     4921 ccccgagcga ctggcagccg gcacactggt gctggtggtg ctgcttccgc ccgatcagct
     4981 acgcaacaac tccttccact tcctgcggga gctcagccac gtgctgcaca ccaacgtggt
     5041 cttcaagcgt gacgcgcagg gccagcagat gatcttcccc tactatggcc gcgaggaaga
     5101 gctacgcaag cacccgatca agcgttctgc agtgggctgg gccacaacgt cactgcttcc
     5161 tggcaccaat ggtgggcgcc agcgcaggga gctggacccc atggacatcc atggctccat
     5221 cgtctacctg gagatcgaca accggcagtg tgtacagtca tcctcgcaat gcttccagag
     5281 cgccaccgat gtggctgcct tcctaggtgc tcttgcctcc ctcggcagcc tcaatatccc
     5341 ctacaagatc gaagccgtaa agagtgagac ggtggagcct ccgctgccct cacagctgca
     5401 cctcatgtac gtggcggcag ctgccttcgt gctcctgttc tttgtgggct gtggggtgct
     5461 gctgtcccgc aagcgcaggc ggcagcatgg ccagctctgg ttccctgagg gtttcaaagt
     5521 gtcagaggcc agcaagaaga agcggagaga acccctcggc gaggactcag tcggcctcaa
     5581 gcccctgaag aacgcctcag atggtgccct gatggacgac aatcagaacg agtgggggga
     5641 cgaagacctg gagaccaaga agttccggtt tgaggaacca gtggttctcc ctgacctgga
     5701 tgatcagact gaccaccggc agtggaccca gcagcacctg gatgccgctg acctacgtgt
     5761 gtctgccatg gccccaacgc cgcctcaggg ggaggtagat gctgactgca tggacgtcaa
     5821 tgttcgagga ccagatggct tcactcccct aatgattgcc tcctgcagcg gagggggcct
     5881 ggagacaggc aacagtgagg aagaagaaga tgcacctgct gtcatctccg acttcatcta
     5941 tcagggtgcc agcttgcaca accagacgga ccgcacaggg gagactgccc tgcacctggc
     6001 tgcccgatac tctcgttcag atgctgccaa gcgcttgctg gaggccagcg cagatgccaa
     6061 catccaagac aacatggggc gtaccccatt acatgccgct gtttctgcag acgctcaggg
     6121 tgtcttccag atcctgctcc ggaacagagc cacagatctg gatgcccgaa tgcatgatgg
     6181 cacaacccct ctgatcctgg cggcacgcct ggccgtggaa ggcatgctag aggacctcat
     6241 caactctcac gctgatgtca atgctgtgga tgacctaggc aagtcagctc tgcactgggc
     6301 agccgctgtg aacaatgtgg acgctgctgt tgtgctcctg aagaacggag ccaacaaaga
     6361 catgcagaac aacaaggagg agactcccct gttcctggcc gcccgtgagg gcagctatga
     6421 gactgccaaa gtgttgctgg accactttgc caaccgggac atcacggatc acatggaccg
     6481 attgccacgg gacattgcac aggagcgcat gcaccacgat atcgtgcggc ttttggatga
     6541 atacaacctg gtgcgcagcc cacagctgca tggcactgcc ttgggtggca cacccactct
     6601 gtctcccaca ctctgctcgc ccaacggcta cctgggcaac ctcaagtctg ccacacaggg
     6661 caagaaggcc cgaaagccca gcaccaaagg gctggcttgc agtagcaagg aagctaagga
     6721 cctcaaggcc cggaggaaga agtcccagga tggcaagggc tgcctgttgg acagctcaag
     6781 catgctgtca cccgtggact ccctcgagtc accccatggc tacttgtcag atgtggcctc
     6841 accacccctc cttccctccc cgttccagca gtctccatcc atgcctctca gccacctgcc
     6901 aggtatgcct gacacccacc tgggcatcag ccacttgaat gtggcagcca agcccgagat
     6961 ggcagctctg gccggaggca gccggttggc ctttgagcca cccccaccac gcctctccca
     7021 cctgcctgta gcctccagtg ccagcacagt gctgagtacc aatggcacag gggctatgaa
     7081 tttcaccgtg ggtgcaccgg caagcttgaa tggccagtgt gagtggcttc cccggctcca
     7141 gaatggcatg gtgcccagcc agtacaaccc gctaaggcca ggtgtgactc cgggcacact
     7201 aagcacacag gcagctggcc tccagcatgg catgatgggc ccgatacaca gcagcctctc
     7261 caccaatacc ttgtccccga ttatctacca gggcctgccc aacacaaggc tggccacaca
     7321 gccccacctg gtgcagaccc agcaggtgca gccacagaac ttacaaatcc agcctcagaa
     7381 cctgcagcca ccatcgcagc cacacctcag tgtgagctca gcagccaatg ggcacctggg
     7441 tcggagcttc ctgagcgggg agcccagcca ggcagacgta cagccgctgg gccccagcag
     7501 tctgcctgtg cacaccattc tgccccagga aagccaggct ctgccgacat cactgccatc
     7561 ctccatggtc ccacccatga ccactaccca gttcctgacc cctccttctc agcacagcta
     7621 ctcatcctca cctgtggaca acacccccag ccaccagctg caggtgccag agcacccctt
     7681 cctcacccca tcccctgagt cccctgacca gtggtccagc tcctccccgc attccaacat
     7741 ctctgattgg tccgagggca tctctagccc gcccacgagc atgccgtccc agatcaccca
     7801 cattccagag gcatttaagt aaacagagat gtgggatgaa ggaccccagc ttccgttccc
     7861 aagctctgtt gggagtcctt tccagtgctc caggatgctg gggcgaccaa aggagccttt
     7921 taaaaaaaaa tgtttttata caaaataaga ggacaagaat ttccattttt ttttttagta
     7981 tttatttatg tacttttatt ttccacagaa acactgcctt tttatttata tgtattgttt
     8041 tctatggcac taggggaaaa catctgttcc aagaaaataa actagttctg agagcctcga
     8101 ttttcctggt cagggtgaag ttccctgtgt gtttgtaaaa tacgaacaag gattcatgat
     8161 ttgtaaatgc cgtttattta ttgattgctt ctttccaaaa tcgtcgagaa agaaagaaag
     8221 aaaaagaaag aaagaaagaa agaaaggaaa gaaagaaaga aaggcatgct aggagaaagg
     8281 aggaggaggc tggaaacttc ctcgccagat ttccccctcc ccagatgcct gctaccccac
     8341 tcactgcccc tcctcccagt gtcacctggg atttgcagat gtgtttagaa acaggccaag
     8401 accttgaacc tcgggtacat ggattagttt tgtatctaaa acaggaaaca agtaaaatga
     8461 tgtggtttgt acattttctg taaccaccgc atgggcttgg agaagtgtcc tcggtgtgtg
     8521 tggagtgttc tacccagtac caggtatgaa tctgcaggct tcagtgttct gtactagtgt
     8581 ttatggccct tgggagtact actcccctgc cctgccctgc cctgccctgc cctgccctgc
     8641 ccaactgtcc ccttcctgac atcttgagcc agtaagccaa gtggggtgtg gtgcctcctg
     8701 gagaatgaca ctgcctggac tgttccgtgc gtcacccctg aacagcatca tccaaattca
     8761 actgaggatg gactgtccct gcctgggcct gggctcctga catccgactg ccaaagggct
     8821 ccaatgtgca ctgtgaactc accagagcag cctacattga gacctcaaga agatataagc
     8881 tgtgtggcct ctgatccccc aactggcctg ggtggggacg tgccttgagt gtgctggaat
     8941 gtgggcggag cctgcctctg ggccacccct cctggttcag ggcggtgctc acagcagatt
     9001 tttgcagtat caagtatacg cctgtggcag aataagtatc tgtaaataca tgtttaaagg
     9061 tggattttgt ttaagaaatc taaaggaaca agtctgtccc gtgtcaagct gatgaggaat
     9121 gtcagaccat ggctcagctc ggtgtgaccc aggccttgtg acctgacagt agctcctaag
     9181 agcacaaccc aggatggccc atctgctgtc caccaagccc tttcccagcc actgtgtgcg
     9241 gggagggggg ctttcggggg cagctgccta cctcctcagg gcagctcctc ctggcctttt
     9301 gggaagcagt gtctgcgcta tacctaatag atatgaccag acacatccta agatgttgat
     9361 tcttactgtg ttttattaaa aaaaaatgta gtttacagaa aaaagaa
//
