LOCUS       NM_012611               3793 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Rattus norvegicus nitric oxide synthase 2 (Nos2), mRNA.
ACCESSION   NM_012611 XM_220732
VERSION     NM_012611.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3793)
  AUTHORS   Li,L., Jia,L., Hou,S., Zhang,T., Zhou,M., Chen,T. and Song,J.
  TITLE     Temporal and spatial effects on C-reactive protein's regulation of
            inducible nitric oxide synthase production in periodontal disease
  JOURNAL   J Periodontol 95 (3), 268-280 (2024)
   PUBMED   37515488
  REMARK    GeneRIF: Temporal and spatial effects on C-reactive protein's
            regulation of inducible nitric oxide synthase production in
            periodontal disease.
REFERENCE   2  (bases 1 to 3793)
  AUTHORS   Ghasemi-Dehnoo,M., Amini-Khoei,H., Lorigooini,Z., AnjomShoa,M.,
            Bijad,E. and Rafieian-Kopaei,M.
  TITLE     Inhibition of TLR4, NF-kappaB, and INOS pathways mediates
            ameliorative effect of syringic acid in experimental ulcerative
            colitis in rats
  JOURNAL   Inflammopharmacology 32 (1), 795-808 (2024)
   PUBMED   38095803
  REMARK    GeneRIF: Inhibition of TLR4, NF-kappaB, and INOS pathways mediates
            ameliorative effect of syringic acid in experimental ulcerative
            colitis in rats.
REFERENCE   3  (bases 1 to 3793)
  AUTHORS   Obaid,A.A., Almasmoum,H., Almaimani,R.A., El-Boshy,M., Aslam,A.,
            Idris,S., Ghaith,M.M., El-Readi,M.Z., Ahmad,J., Farrash,W.F.,
            Mujalli,A., Eid,S.Y., Elzubier,M.E. and Refaat,B.
  TITLE     Vitamin D and calcium co-therapy mitigates pre-established cadmium
            nephropathy by regulating renal calcium homeostatic molecules and
            improving anti-oxidative and anti-inflammatory activities in rat
  JOURNAL   J Trace Elem Med Biol 79, 127221 (2023)
   PUBMED   37244046
REFERENCE   4  (bases 1 to 3793)
  AUTHORS   de Jager,L., Vidigal,C.B., de Campos,B.H., Reginato,G.S.,
            Fernandes,L.M., Ariza,D., Higashi-Mckeown,C.M., Bertozzi,M.M.,
            Rasquel de Oliveira,F.S., Verri,W.A. Jr., Ceravolo,G.S.,
            Crestani,C.C., Pinge-Filho,P. and Martins-Pinge,M.C.
  TITLE     Role of the iNOS isoform in the cardiovascular dysfunctions of male
            rats with 6-OHDA-induced Parkinsonism
  JOURNAL   Nitric Oxide 134-135, 49-60 (2023)
   PUBMED   37054808
  REMARK    GeneRIF: Role of the iNOS isoform in the cardiovascular
            dysfunctions of male rats with 6-OHDA-induced Parkinsonism.
REFERENCE   5  (bases 1 to 3793)
  AUTHORS   He,A., Guo,Y., Xu,Z., Yan,J., Xie,L., Li,Y., Lv,D. and Luo,M.
  TITLE     Hypoglycaemia aggravates impaired endothelial-dependent
            vasodilation in diabetes by suppressing endothelial nitric oxide
            synthase activity and stimulating inducible nitric oxide synthase
            expression
  JOURNAL   Microvasc Res 146, 104468 (2023)
   PUBMED   36513147
  REMARK    GeneRIF: Hypoglycaemia aggravates impaired endothelial-dependent
            vasodilation in diabetes by suppressing endothelial nitric oxide
            synthase activity and stimulating inducible nitric oxide synthase
            expression.
REFERENCE   6  (bases 1 to 3793)
  AUTHORS   Morrissey,J.J., McCracken,R., Kaneto,H., Vehaskari,M., Montani,D.
            and Klahr,S.
  TITLE     Location of an inducible nitric oxide synthase mRNA in the normal
            kidney
  JOURNAL   Kidney Int 45 (4), 998-1005 (1994)
   PUBMED   7516453
REFERENCE   7  (bases 1 to 3793)
  AUTHORS   Galea,E., Reis,D.J. and Feinstein,D.L.
  TITLE     Cloning and expression of inducible nitric oxide synthase from rat
            astrocytes
  JOURNAL   J Neurosci Res 37 (3), 406-414 (1994)
   PUBMED   7513765
REFERENCE   8  (bases 1 to 3793)
  AUTHORS   Charles,I.G., Palmer,R.M., Hickery,M.S., Bayliss,M.T., Chubb,A.P.,
            Hall,V.S., Moss,D.W. and Moncada,S.
  TITLE     Cloning, characterization, and expression of a cDNA encoding an
            inducible nitric oxide synthase from the human chondrocyte
  JOURNAL   Proc Natl Acad Sci U S A 90 (23), 11419-11423 (1993)
   PUBMED   7504305
REFERENCE   9  (bases 1 to 3793)
  AUTHORS   Stuehr,D.J. and Ikeda-Saito,M.
  TITLE     Spectral characterization of brain and macrophage nitric oxide
            synthases. Cytochrome P-450-like hemeproteins that contain a flavin
            semiquinone radical
  JOURNAL   J Biol Chem 267 (29), 20547-20550 (1992)
   PUBMED   1383204
REFERENCE   10 (bases 1 to 3793)
  AUTHORS   Deng,Y. and Rapp,J.P.
  TITLE     Cosegregation of blood pressure with angiotensin converting enzyme
            and atrial natriuretic peptide receptor genes using Dahl
            salt-sensitive rats
  JOURNAL   Nat Genet 1 (4), 267-272 (1992)
   PUBMED   1363813
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D12520.1.
            
            [WARNING] On May 2, 2024 this sequence was replaced by NM_012611.4.
            
            On May 25, 2007 this sequence version replaced NM_012611.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D12520.1, L12562.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3793
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q25"
     gene            1..3793
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /note="nitric oxide synthase 2"
                     /db_xref="GeneID:24599"
                     /db_xref="RGD:3185"
     exon            1..143
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            144..300
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..3634
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /EC_number="1.14.13.39"
                     /note="NOS type II; inducible NOS; inducible NO synthase;
                     peptidyl-cysteine S-nitrosylase NOS2; nitric oxide
                     synthase 2, inducible, macrophage; inducible nitric oxide
                     synthase; nitric oxide synthase, inducible-like"
                     /codon_start=1
                     /product="nitric oxide synthase, inducible"
                     /protein_id="NP_036743.3"
                     /db_xref="GeneID:24599"
                     /db_xref="RGD:3185"
                     /translation="MACPWKFLFRVKSYQGDLKEEKDINNNVEKTPGAIPSPTTQDDP
                     KSHKHQNGFPQFLTGTAQNVPESLDKLHVTPSTRPQHVRIKNWGNGEIFHDTLHHKAT
                     SDISCKSKLCMGSIMNSKSLTRGPRDKPTPVEELLPQAIEFINQYYGSFKEAKIEEHL
                     ARLEAVTKEIETTGTYQLTLDELIFATKMAWRNAPRCIGRIQWSNLQVFDARSCSTAS
                     EMFQHICRHILYATNSGNIRSAITVFPQRSDGKHDFRIWNSQLIRYAGYQMPDGTIRG
                     DPATLEFTQLCIDLGWKPRYGRFDVLPLVLQAHGQDPEVFEIPPDLVLEVTMEHPKYE
                     WFQELGLKWYALPAVANMLLEVGGLEFPACPFNGWYMGTEIGVRDFCDTQRYNILEEV
                     GRSMGLETHTLASLWKDRAVTEINAAVLHSFQKQNVTIMDHHTASESFMKHMQNEYRA
                     RGGCPADWIWLVPPVSGSITPVFHQEMLNYVLSPFYYYQIEPWKTHIWQDEKLRPRRR
                     EIRFTVLVKAVFFASVLMRKVMASRVRATVLFATETGKSEALARDLAALFSYAFNTKV
                     VCMEQYKANTLEEEQLLLVVTSTFGNGDCPSNGQTLKKSLFMMKELGHTFRYAVFGLG
                     SSMYPQFCAFAHDIDQKLSHLGASQLAPTGEGDELSGQEDAFRSWAVQTFRAACETFD
                     VRSKHCIQIPKRYTSNATWEPEQYKLTQSPESLDLNKALSSIHAKNVFTMRLKSLQNL
                     QSEKSSRTTLLVQLTFEGSRGPSYLPGEHLGIFPGNQTALVQGILERVVDCSSPDQTV
                     CLEVLDESGSYWVKDKRLPPCSLRQALTYFLDITTPPTQLQLHKLARFATEETHRQRL
                     EALCQPSEYNDWKFSNNPTFLEVLEEFPSLRVPAAFLLLQLPILKPRYYSISSSQDHT
                     PSEVHLTVAVVTYRTRDGQGPLHHGVCSTWINNLKPEDPVPCFVRSVSGFQLPEDPSQ
                     PCILIGPGTGIAPFRSFWQQRLHDSQHRGLKGGRMTLVFGCRHPEEDHLYQEEMQEMV
                     RKGVLFQVHTGYSRLPGKPKVYVQDILQKELADEVFSVLHGEQGHLYVCGDVRMARDV
                     ATTLKKLVAAKLNLSEEQVEDYFFQLKSQKRYHEDIFGAVFSYGAKKGNTLEEPKGTR
                     L"
     exon            301..376
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            377..499
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            500..648
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            649..811
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            812..903
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1045
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1185
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1360
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1462
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1657
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1740
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1885
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1990
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2040
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2215
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2348
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2427
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2609
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2773
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2981
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3069
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3070..3191
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3192..3340
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3341..3535
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3536..3793
                     /gene="Nos2"
                     /gene_synonym="iNos; Nos2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttgaagac tgagactctg gccccacggg acacagtgtc gctggtttga aacttctcag
       61 ccaccttggt gaggggactg gacttttaga gacgcttctg aggttcctca ggcttgggtc
      121 ttgttagcct agtcaactac aagccccacg gagaacagca gagttggtgc agaagcacaa
      181 agtcacagac atggcttgcc cctggaagtt tctcttcaga gtcaaatcct accaaggtga
      241 cctgaaagag gaaaaggaca ttaacaacaa cgtggagaaa accccaggtg ctattcccag
      301 cccaacaaca caggatgacc ctaagagtca caagcatcaa aatggtttcc cccagttcct
      361 cactgggact gcacagaatg ttccagaatc cctggacaag ctgcatgtga ctccatcgac
      421 ccgcccacag cacgtgagga tcaaaaactg gggcaatgga gagatttttc acgacaccct
      481 tcaccacaag gccacctcgg atatctcttg caagtccaaa ttatgcatgg ggtccatcat
      541 gaactccaag agtttgacca gaggacccag agacaagccc accccagtgg aggagcttct
      601 gcctcaagcc attgaattca ttaaccagta ttatggctcc ttcaaagagg caaaaataga
      661 ggaacatctg gccaggctgg aagccgtaac aaaggaaata gaaacaacag gaacctacca
      721 gctcactctg gatgagctca tctttgccac caagatggcc tggaggaacg cccctcgctg
      781 catcggcagg attcagtggt ccaacctgca ggtcttcgat gcccggagct gtagcactgc
      841 atcagaaatg ttccagcata tctgcagaca catactttac gccactaaca gtggcaacat
      901 caggtcggcc attactgtgt tcccccagcg gagcgatggg aagcatgact tccggatctg
      961 gaattcccag ctcatccggt acgctggcta ccagatgccc gatggcacca tcagagggga
     1021 tcctgccacc ttggagttca cccagttgtg catcgacctg ggctggaagc cccgctatgg
     1081 ccgcttcgat gtgctgcctc tggtcctgca ggctcacggt caagatccag aggtctttga
     1141 aatccctcct gatcttgtgc tggaggtgac catggagcat cccaagtacg agtggttcca
     1201 ggagctcggg ctgaagtggt atgcgctgcc tgccgtggcc aacatgctcc tggaggtggg
     1261 tggcctcgag ttcccagcct gccccttcaa tggttggtac atgggcaccg agattggagt
     1321 ccgagacttc tgtgacacac agcgctacaa catcctggag gaagtgggca ggagcatggg
     1381 cctggagacc cacacactgg cctccctctg gaaagaccgg gctgtcaccg agatcaatgc
     1441 agctgtgctc catagttttc agaagcagaa tgtgaccatc atggaccacc acacagcctc
     1501 agagtccttc atgaagcaca tgcagaatga gtaccgggcc cgaggaggct gccctgcaga
     1561 ctggatttgg ctggtccctc cggtgtccgg gagcatcacc cctgtgttcc accaggagat
     1621 gttgaactac gtcctatctc cattctacta ctaccagatc gagccctgga agacccacat
     1681 ctggcaggat gagaagctga ggcccaggag gagagagatc cggttcacag tcttggtgaa
     1741 agcggtgttc tttgcttctg tgctaatgcg gaaggtcatg gcttcccgcg tcagagccac
     1801 agtcctcttt gctactgaga caggaaagtc ggaagcgcta gccagggacc tggctgcctt
     1861 gttcagctac gccttcaaca ccaaggttgt ctgcatggaa cagtataagg caaacacctt
     1921 ggaagaggaa caactactgc tggtggttac aagcacattt ggcaatggag actgccccag
     1981 caatgggcag actctgaaga aatctctgtt catgatgaaa gaactcgggc ataccttcag
     2041 gtatgcggta tttggcctgg gctccagcat gtaccctcag ttctgtgcct ttgctcatga
     2101 catcgaccag aaactgtctc acctgggagc ctcccagctt gccccaaccg gagaagggga
     2161 cgaactcagc gggcaggagg acgccttccg cagctgggct gtgcaaacct tccgggcagc
     2221 ctgtgagacg ttcgatgttc gaagcaaaca ttgcattcag atcccgaaac gctacacttc
     2281 caacgcaaca tgggagccag agcagtacaa gctcacccag agcccagagt ctctagacct
     2341 caacaaagct ctcagcagca tccacgccaa gaacgtgttc accatgaggc tgaaatccct
     2401 ccagaatctg cagagtgaga agtccagccg caccaccctc cttgttcaac tcaccttcga
     2461 gggcagccga ggccccagct acctacctgg ggaacacctg gggattttcc caggcaacca
     2521 gacggccctg gtgcaaggga tcttggagcg agttgtggat tgttcttcgc cagaccaaac
     2581 tgtgtgcctg gaggttctag atgagagtgg cagctactgg gtcaaagaca agaggcttcc
     2641 cccctgctca ctcaggcaag ccctcaccta cttcctggac atcactaccc ctcccaccca
     2701 gctgcagctc cacaagctgg cccgctttgc cacggaagag acgcacaggc agaggttgga
     2761 ggccttgtgt cagccctcag agtacaacga ttggaagttc agcaacaacc ccacgttcct
     2821 ggaggtgctg gaagagttcc catcattgcg tgtgcctgct gccttcctgc tgttgcagct
     2881 ccccattctg aagccccgct actactccat cagctcctcc caggaccaca ccccctcgga
     2941 ggtccacctc actgtggctg tggtcaccta tcgcacccga gatggtcagg gtcccctgca
     3001 ccatggcgtc tgcagcactt ggatcaataa cctgaagccc gaagacccag tgccctgctt
     3061 tgtgcggagt gtcagtggct tccagctccc tgaggacccc tcccagccct gcatcctcat
     3121 tgggcccggt acaggcattg cccccttccg aagtttctgg cagcagcggc tccatgactc
     3181 tcagcacaga gggctcaaag gaggccgcat gaccttggtg tttgggtgca ggcacccaga
     3241 ggaggaccac ctctatcagg aagaaatgca ggagatggtc cgcaagggag tgttgttcca
     3301 ggtgcacaca ggctactccc ggctgcccgg aaaacccaag gtctacgttc aagacatcct
     3361 gcagaaagag ctggccgacg aggtgttcag cgtgctccac ggggagcagg gccaccttta
     3421 tgtttgtggc gatgtgcgca tggctcggga tgtggctacc actttgaaga agctggtggc
     3481 cgccaagctg aacttgagtg aggagcaggt tgaggattac ttcttccagc tcaagagcca
     3541 gaaacgttat catgaggata tcttcggtgc ggtcttttcc tatggagcaa aaaagggcaa
     3601 caccttggag gagcccaaag gcacaagact ctgacaccca gaagagttac agcatctggc
     3661 cctaaataaa atgacagtga ggggtttgga gagacagaag tgcgatcccc cccaaacccc
     3721 tcacatcatc tcccctcctc taccctacca agtagtattg tactattgtg gactactgaa
     3781 tctctctcct ctc
//
