LOCUS       NM_138922               4941 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus nitric oxide synthase 1 adaptor protein (Nos1ap),
            mRNA.
ACCESSION   NM_138922
VERSION     NM_138922.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4941)
  AUTHORS   Matiiv,A.B., Moskalenko,S.E., Sergeeva,O.S., Zhouravleva,G.A. and
            Bondarev,S.A.
  TITLE     NOS1AP Interacts with alpha-Synuclein and Aggregates in Yeast and
            Mammalian Cells
  JOURNAL   Int J Mol Sci 23 (16), 9102 (2022)
   PUBMED   36012368
  REMARK    GeneRIF: NOS1AP Interacts with alpha-Synuclein and Aggregates in
            Yeast and Mammalian Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4941)
  AUTHORS   Hernandez,K., Swiatkowski,P., Patel,M.V., Liang,C., Dudzinski,N.R.,
            Brzustowicz,L.M. and Firestein,B.L.
  TITLE     Overexpression of Isoforms of Nitric Oxide Synthase 1 Adaptor
            Protein, Encoded by a Risk Gene for Schizophrenia, Alters Actin
            Dynamics and Synaptic Function
  JOURNAL   Front Cell Neurosci 10, 6 (2016)
   PUBMED   26869880
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4941)
  AUTHORS   Clattenburg,L., Wigerius,M., Qi,J., Rainey,J.K., Rourke,J.L.,
            Muruganandan,S., Sinal,C.J. and Fawcett,J.P.
  TITLE     NOS1AP Functionally Associates with YAP To Regulate Hippo Signaling
  JOURNAL   Mol Cell Biol 35 (13), 2265-2277 (2015)
   PUBMED   25918243
REFERENCE   4  (bases 1 to 4941)
  AUTHORS   Carrel,D., Hernandez,K., Kwon,M., Mau,C., Trivedi,M.P.,
            Brzustowicz,L.M. and Firestein,B.L.
  TITLE     Nitric oxide synthase 1 adaptor protein, a protein implicated in
            schizophrenia, controls radial migration of cortical neurons
  JOURNAL   Biol Psychiatry 77 (11), 969-978 (2015)
   PUBMED   25542305
  REMARK    GeneRIF: This study showed that critical role for the
            schizophrenia-associated gene NOS1AP in cortical patterning and
            neuron migration.
REFERENCE   5  (bases 1 to 4941)
  AUTHORS   Lu,C.J., Hao,G., Nikiforova,N., Larsen,H.E., Liu,K., Crabtree,M.J.,
            Li,D., Herring,N. and Paterson,D.J.
  TITLE     CAPON modulates neuronal calcium handling and cardiac sympathetic
            neurotransmission during dysautonomia in hypertension
  JOURNAL   Hypertension 65 (6), 1288-1297 (2015)
   PUBMED   25916729
  REMARK    GeneRIF: CAPON modulates neuronal calcium during dysautonomia in
            hypertension.
REFERENCE   6  (bases 1 to 4941)
  AUTHORS   Fang,M., Jaffrey,S.R., Sawa,A., Ye,K., Luo,X. and Snyder,S.H.
  TITLE     Dexras1: a G protein specifically coupled to neuronal nitric oxide
            synthase via CAPON
  JOURNAL   Neuron 28 (1), 183-193 (2000)
   PUBMED   11086993
REFERENCE   7  (bases 1 to 4941)
  AUTHORS   Ort,T., Maksimova,E., Dirkx,R., Kachinsky,A.M., Berghs,S.,
            Froehner,S.C. and Solimena,M.
  TITLE     The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ
            domains of beta2-syntrophin and nNOS in pancreatic beta-cells
  JOURNAL   Eur J Cell Biol 79 (9), 621-630 (2000)
   PUBMED   11043403
REFERENCE   8  (bases 1 to 4941)
  AUTHORS   Che,Y.H., Tamatani,M. and Tohyama,M.
  TITLE     Changes in mRNA for post-synaptic density-95 (PSD-95) and
            carboxy-terminal PDZ ligand of neuronal nitric oxide synthase
            following facial nerve transection
  JOURNAL   Brain Res Mol Brain Res 76 (2), 325-335 (2000)
   PUBMED   10762708
REFERENCE   9  (bases 1 to 4941)
  AUTHORS   Tochio,H., Hung,F., Li,M., Bredt,D.S. and Zhang,M.
  TITLE     Solution structure and backbone dynamics of the second PDZ domain
            of postsynaptic density-95
  JOURNAL   J Mol Biol 295 (2), 225-237 (2000)
   PUBMED   10623522
REFERENCE   10 (bases 1 to 4941)
  AUTHORS   Jaffrey,S.R., Snowman,A.M., Eliasson,M.J., Cohen,N.A. and
            Snyder,S.H.
  TITLE     CAPON: a protein associated with neuronal nitric oxide synthase
            that regulates its interactions with PSD95
  JOURNAL   Neuron 20 (1), 115-124 (1998)
   PUBMED   9459447
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Oct 20, 2022 this sequence version replaced NM_138922.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF037071.1, SRR26360194.2481799.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-539               JAXUCZ010000013.1  85353203-85353741   c
            540-611             JAXUCZ010000013.1  85278065-85278136   c
            612-704             JAXUCZ010000013.1  85154898-85154990   c
            705-763             JAXUCZ010000013.1  85141269-85141327   c
            764-872             JAXUCZ010000013.1  85115151-85115259   c
            873-1014            JAXUCZ010000013.1  85103813-85103954   c
            1015-1181           JAXUCZ010000013.1  85094767-85094933   c
            1182-1364           JAXUCZ010000013.1  85093130-85093312   c
            1365-1530           JAXUCZ010000013.1  85085921-85086086   c
            1531-4941           JAXUCZ010000013.1  85080558-85083968   c
FEATURES             Location/Qualifiers
     source          1..4941
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..4941
                     /gene="Nos1ap"
                     /gene_synonym="Capon"
                     /note="nitric oxide synthase 1 adaptor protein"
                     /db_xref="GeneID:192363"
                     /db_xref="RGD:620106"
     exon            1..539
                     /gene="Nos1ap"
                     /gene_synonym="Capon"
                     /inference="alignment:Splign:2.1.0"
     CDS             435..1946
                     /gene="Nos1ap"
                     /gene_synonym="Capon"
                     /note="nitric oxide synthase 1 (neuronal) adaptor protein;
                     C-terminal PDZ ligand of neuronal nitric oxide synthase
                     protein; C-terminal PDZ domain ligand of neuronal nitric
                     oxide synthase"
                     /codon_start=1
                     /product="carboxyl-terminal PDZ ligand of neuronal nitric
                     oxide synthase protein"
                     /protein_id="NP_620277.2"
                     /db_xref="GeneID:192363"
                     /db_xref="RGD:620106"
                     /translation="MPSKTKYNLVDDGHDLRIPLHNEDAFQHGISFEAKYVGSLDVPR
                     PNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKKKEWTWDESKML
                     VMQDPIYRIFYVSHDSQDLKIFSYIARDGASNIFRCNVFKSKKKSQAMRIVRTVGQAF
                     EVCHKLSLQHTQQNADGQEDGESERNSDGSGDPGRQLTGAERVSTATAEETDIDAVEV
                     PLPGNDILEFSRGVTDLDAIGKDGGSHIDATVSPHPQEPMLAASPRMLLPSSSSSKPP
                     GLGTGTPLSTHHQMQLLQQLLQQQQQQTQVAVAQVHLLKDQLAAEAAARLEAQARVHQ
                     LLLQNKDMLQHISLLVKQVQELELKLSGQSTMGSQDSLLEITFRSGALPVLCESTTPK
                     PEDLHSPLLGAGLADFAHPVGSPLGRRDCLVKLECFRFLPAEDNQPMAQGEPLLGGLE
                     LIKFRESGIASEYESNTDESEERDSWSQEELPRLLNVLQRQELGDSLDDEIAV"
     exon            540..611
                     /gene="Nos1ap"
                     /gene_synonym="Capon"
                     /inference="alignment:Splign:2.1.0"
     exon            612..704
                     /gene="Nos1ap"
                     /gene_synonym="Capon"
                     /inference="alignment:Splign:2.1.0"
     exon            705..763
                     /gene="Nos1ap"
                     /gene_synonym="Capon"
                     /inference="alignment:Splign:2.1.0"
     exon            764..872
                     /gene="Nos1ap"
                     /gene_synonym="Capon"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1014
                     /gene="Nos1ap"
                     /gene_synonym="Capon"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1181
                     /gene="Nos1ap"
                     /gene_synonym="Capon"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1364
                     /gene="Nos1ap"
                     /gene_synonym="Capon"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1530
                     /gene="Nos1ap"
                     /gene_synonym="Capon"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..4941
                     /gene="Nos1ap"
                     /gene_synonym="Capon"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accctgctcc gccgccaccg ctgccgccgc tgctgccttt cttccttgtc ccgggtcgtg
       61 cgcgccgagc tcgggatccg gctcccagtc tagccccgct tcgggccgtg cgccctttgc
      121 tcggcgtccg gctccggggc tccgcgccac ccgctcccgc ctgcccggcc gcctggccgc
      181 ctccccgtag tcagagcgcg gccaccgagc tgctcgcgcc agccgcatcc gcgccgcccc
      241 tgccgatcgg ccctccggag gcaccgctcc gggtcccccc cgccactgcc tggcacccag
      301 gctgcccacc tcgcgacccg ggtcctcgct gccgcctcgc ccggccccac tgttctctcc
      361 acggggtctc gccagctctt tctcgtcgcc gccaccgccg cccccttgga gcagcgggtc
      421 cgccgcgggt caccatgccc agcaaaacca agtacaacct tgtggacgat gggcacgact
      481 tacggatccc tttgcacaac gaggacgcct tccagcacgg catctctttt gaggccaagt
      541 acgtgggaag cctggatgtg cccagaccca acagcagggt tgagatcgtg gctgccatgc
      601 gcagaatccg gtatgagttt aaagccaaga atatcaagaa gaagaaagta agcatcatgg
      661 tctccgtgga cggtgtcaaa gtgattctga agaagaagaa aaagaaaaag gagtggacgt
      721 gggatgagag caagatgctg gtgatgcagg accctatcta caggatcttc tatgtctctc
      781 atgactccca agacttgaaa atcttcagct atatcgctcg agatggtgcc agcaatatct
      841 tcagatgcaa tgtctttaaa tccaagaaga agagccaagc tatgagaatc gtacggacag
      901 tgggacaggc ctttgaggtc tgccacaagt tgagcctgca gcacacacag cagaatgcag
      961 atggccagga agatggagag agcgagagga acagcgatgg ctcaggagac ccaggccgcc
     1021 agctcactgg agctgagagg gtctccacag ccaccgcaga ggagaccgac attgacgctg
     1081 tggaggtccc actccccggg aatgacattc tagaattcag ccgaggtgtg actgacctgg
     1141 atgctattgg gaaggacgga ggctcccaca tagacgcgac ggtctcaccc catccacagg
     1201 agcccatgct ggcagcctcc cctcgcatgc tgctcccttc ttcttcttcc tcgaagccac
     1261 cgggcttggg cactgggacg cccctgtcca ctcaccacca gatgcagctc ctccagcagc
     1321 tcctccagca gcagcagcag cagacacaag tggctgtggc tcaggttcac ttgctgaagg
     1381 atcagttggc tgctgaggct gcggcacggc tggaggccca ggcacgagtg caccagctcc
     1441 tgctacagaa caaagacatg cttcagcaca tctctctgct ggttaagcag gtgcaggagc
     1501 tggaactgaa gctgtcagga cagagcacca tgggctccca ggacagcttg ctggagatca
     1561 ccttccgttc aggtgccctg cctgtgctct gtgaatccac cactcctaag ccagaggacc
     1621 tacactcacc actgctgggc gctggcttgg ctgactttgc ccacccagtg ggcagcccct
     1681 taggtaggcg tgactgcttg gtgaagctgg agtgctttcg tttcctccca gccgaggata
     1741 accagccgat ggcacagggt gagccgctcc taggtggcct ggagctcatc aagttccgag
     1801 agtcaggcat cgcctcagag tatgagtcca acacagacga aagcgaggag cgtgactcgt
     1861 ggtcgcagga agagctgcca cgcctgctca atgtcctaca gcggcaggag ttgggtgaca
     1921 gtttggatga tgagatcgcc gtgtaggtgc agggcaagga gctagtgaag gtggcagcat
     1981 gatgccaagg gggtcaagtc tgcctgtccc cggctgggga agcccagggg aaagcaccgc
     2041 tgagaaaaac acccagggct gagagtgtag ggtttcagaa gagggttggg attttgcttt
     2101 ggaaggtaaa gcagggaaga aaatggattc ctagacacag gaatcagcac ctgtattctg
     2161 ctaatgactg aatgggacgg aagcagggct ttccagaacc caggaccttg ggatgggtcc
     2221 gccttcagaa tcacagttct ggaaggcctg ttgctcccac cgttatagtc aggttctact
     2281 caatctgtcc gtgatgtctc agtggcctac actctcctgt ctctgtggtg cagatcataa
     2341 atggaagcca ttgataccgt ctcacgtact ttgttttgga tatcaggatg ctacaagttg
     2401 cctaaccctc ccttaagctg taggagaatt ccttccccag gccctggctg agatcagaga
     2461 ggttggagga tttccctcac tgctgggaaa ttgagactct gccattcagt gagcatggag
     2521 gtgacagcag tcacaagtca cagtgaataa actaggaatt tactctaagt ggggtgttgg
     2581 atgttgcttc tgaggaagct aggagtatga ataggattga ggaccctgca gggagagcct
     2641 ggggagggtt agcctagggg agggttagcc tagagaaggg ttagcctagg agtgctgatg
     2701 acagttgtgg cagctcatgt aggtgtgatt cttcagtttg gaaaccatgc cccttaccca
     2761 tctcctgcct gcaacccagc tcatataaac gaggctaaga actatcataa tatccccttt
     2821 tcttgcctca ggggctgtgc ctgcctaagc tttgacagta ctatgccttt gtgtaagtct
     2881 cagagaccca gaaccccctg ccttacctct ctctacctgt cccctccact gggcagtagt
     2941 ggtcagtttt tactgagaaa aagaaaaaga aagaaagaaa gaaatggaca taagctgata
     3001 gctgagaccg tctatcctta agaatcactg ccacttagat gagatcaggg accacagctg
     3061 tgccacccca gcctgtttct ctgcaggtgc gtgccttgag cacaagagtt aaaagtgcaa
     3121 ctttaatctc ttgccatcta ggccttgcct agggggtctc cactcaataa taggctggct
     3181 aggccaatga gaaaagttcc ttttccccca taagacctta actggtgaat agattttcaa
     3241 cccctgaaga gaaagctgac acatgttcaa agtcatatga tgtggggagg aggtcatgtt
     3301 catcctggac aaactgtagg ccaaaccgca gtgttatcag agggaaagga tggagttccc
     3361 ccaatggagt tcttcaaccc cagctttgct ttgaaatgta tctaaatgca agcatggccc
     3421 tttttatagc cacagtgtag tcattgttaa aggaaattaa caaagctttg ttatctttac
     3481 tccctagtgc atgggggtgt caatagtaat agaatggggt ggcgtgtgtg tatgtgtgtg
     3541 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtggtgtgt gtggtgtgtg tgtgtggtgt
     3601 gcgcgtggtg tgtgtgtgtg tgtgtgtgtg tgtatgtgtt tgtgcgtgtt gtggacatgc
     3661 ttttagactt ctgagaagtg actagaaaga ttctccaggg tgttcagata aacagtagaa
     3721 ttgtatcctt ttcccaacct gattttgttg acaaggtaga attctgtttg ttgattttct
     3781 aattaaccat cagaaggata tccagataca cagggaaggg agaattccag gtgtgaggtc
     3841 cacaacactg aaggggcaga tatgtggcgg gattcaagat aggctgagca gaatttactc
     3901 aattccaatc caggatcgaa ggtcctggag tctaggcttt tgtgtatctg agggagtggg
     3961 tggtctgttt cttcaaggtc tacttcctgt gagcgggagc tgagagtaaa atcagaaaca
     4021 agtagaagtg tgtggattgt gggtggaaag ggtttgtagg atagagtgaa gcagtgtgtg
     4081 ggtaggatac tggttcttaa agccctggaa aggaaagagg agggaatgga agatatggaa
     4141 gggttggaaa catgtctaat ggatgggtag acgatgactt gagactcatg gaagactttg
     4201 cccttggttt ctgtcttctt tgaccctccc ctttccctga ttaagacttc cctggagaat
     4261 ccatttgtgt gccatatcct ccccagtaag acccgaatct ggacacactt ggtctgtgga
     4321 gatgggaaac aaagagcaga tctaggggcc ttatgaggtc accagccacc gaccatccat
     4381 ttaggccaac agacaggaca gggaatgccg cagacccagg tccccaacaa cagctgcacc
     4441 cttctttgct tcttgcgctg ctaactcaac gctgccttcc tccttttcac ccttctactc
     4501 tgccctgtgt ggaggacaca tgaacatcag gggttcctta gtgatgccca ccccaggtgc
     4561 aggaaaactc ttgggcatac aaggctttgc agtcgcagag gcaggacaga tcttctctgc
     4621 acaggatgga cggcacgtgg gaaccggaaa ctgcattcct tacattcctg cttttactga
     4681 tgctatctgt gaaaaccttc ctgactctca gctgaccttg tttccggatt gtgttccttt
     4741 atttgctctt tgctcgactg ttctcctccc ttctccctcc tccctcccac ctatcctagc
     4801 ctcctgcttc ctaaaactgt tttgtcctta actgttgggt cagctctctg ggaaacggtt
     4861 ctgttgatgt aagtgcactt accctgggat gttgtcacta gttagtggct tttgctaaat
     4921 aaacctttct tatttctcaa a
//
