LOCUS       NM_052799               4594 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Rattus norvegicus nitric oxide synthase 1 (Nos1), mRNA.
ACCESSION   NM_052799 XM_346438
VERSION     NM_052799.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4594)
  AUTHORS   Jiang,T., Wan,G., Zhang,H., Gyawali,Y.P., Underbakke,E.S. and
            Feng,C.
  TITLE     Mapping the Intersubunit Interdomain FMN-Heme Interactions in
            Neuronal Nitric Oxide Synthase by Targeted Quantitative
            Cross-Linking Mass Spectrometry
  JOURNAL   Biochemistry 63 (11), 1395-1411 (2024)
   PUBMED   38747545
  REMARK    GeneRIF: Mapping the Intersubunit Interdomain FMN-Heme Interactions
            in Neuronal Nitric Oxide Synthase by Targeted Quantitative
            Cross-Linking Mass Spectrometry.
REFERENCE   2  (bases 1 to 4594)
  AUTHORS   Gyawali,Y.P., Jiang,T., Yang,J., Zheng,H., Liu,R., Zhang,H. and
            Feng,C.
  TITLE     Differential superoxide production in phosphorylated neuronal
            nitric oxide synthase mu and alpha variants
  JOURNAL   J Inorg Biochem 251, 112454 (2024)
   PUBMED   38100901
  REMARK    GeneRIF: Differential superoxide production in phosphorylated
            neuronal nitric oxide synthase mu and alpha variants.
REFERENCE   3  (bases 1 to 4594)
  AUTHORS   Chen,R., Qian,L., Fu,J., Qin,J., Chen,X. and Xu,X.
  TITLE     Downregulation of Preso protects against
            ischemic/reperfusion-mediated neuronal injury through regulating
            PSD95-nNOS/YAP pathways
  JOURNAL   Neurochem Int 169, 105586 (2023)
   PUBMED   37442439
  REMARK    GeneRIF: Downregulation of Preso protects against
            ischemic/reperfusion-mediated neuronal injury through regulating
            PSD95-nNOS/YAP pathways.
REFERENCE   4  (bases 1 to 4594)
  AUTHORS   Yang,Z., Li,P., Yuan,Q., Wang,X., Ma,H.H. and Zhuan,B.
  TITLE     Inhibition of miR-4640-5p alleviates pulmonary hypertension in
            chronic obstructive pulmonary disease patients by regulating nitric
            oxide synthase 1
  JOURNAL   Respir Res 24 (1), 92 (2023)
   PUBMED   36964568
  REMARK    GeneRIF: Inhibition of miR-4640-5p alleviates pulmonary
            hypertension in chronic obstructive pulmonary disease patients by
            regulating nitric oxide synthase 1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4594)
  AUTHORS   Vasu,D., Li,H., Hardy,C.D., Poulos,T.L. and Silverman,R.B.
  TITLE     2-Aminopyridines with a shortened amino sidechain as potent,
            selective, and highly permeable human neuronal nitric oxide
            synthase inhibitors
  JOURNAL   Bioorg Med Chem 69, 116878 (2022)
   PUBMED   35772285
REFERENCE   6  (bases 1 to 4594)
  AUTHORS   Kobzik,L., Reid,M.B., Bredt,D.S. and Stamler,J.S.
  TITLE     Nitric oxide in skeletal muscle
  JOURNAL   Nature 372 (6506), 546-548 (1994)
   PUBMED   7527495
REFERENCE   7  (bases 1 to 4594)
  AUTHORS   Seo,H.G., Tatsumi,H., Fujii,J., Nishikawa,A., Suzuki,K., Kangawa,K.
            and Taniguchi,N.
  TITLE     Nitric oxide synthase from rat colorectum: purification, peptide
            sequencing, partial PCR cloning, and immunohistochemistry
  JOURNAL   J Biochem 115 (3), 602-607 (1994)
   PUBMED   7520037
REFERENCE   8  (bases 1 to 4594)
  AUTHORS   Stuehr,D.J. and Ikeda-Saito,M.
  TITLE     Spectral characterization of brain and macrophage nitric oxide
            synthases. Cytochrome P-450-like hemeproteins that contain a flavin
            semiquinone radical
  JOURNAL   J Biol Chem 267 (29), 20547-20550 (1992)
   PUBMED   1383204
REFERENCE   9  (bases 1 to 4594)
  AUTHORS   Bredt,D.S., Hwang,P.M., Glatt,C.E., Lowenstein,C., Reed,R.R. and
            Snyder,S.H.
  TITLE     Cloned and expressed nitric oxide synthase structurally resembles
            cytochrome P-450 reductase
  JOURNAL   Nature 351 (6329), 714-718 (1991)
   PUBMED   1712077
REFERENCE   10 (bases 1 to 4594)
  AUTHORS   Bredt,D.S. and Snyder,S.H.
  TITLE     Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme
  JOURNAL   Proc Natl Acad Sci U S A 87 (2), 682-685 (1990)
   PUBMED   1689048
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            [WARNING] On Mar 11, 2025 this sequence was replaced by
            NM_052799.3.
            
            On Nov 26, 2020 this sequence version replaced NM_052799.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U67309.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-811               JAXUCZ010000012.1  44371027-44371837   c
            812-938             JAXUCZ010000012.1  44361500-44361626   c
            939-1067            JAXUCZ010000012.1  44346837-44346965   c
            1068-1213           JAXUCZ010000012.1  44344899-44345044   c
            1214-1376           JAXUCZ010000012.1  44343943-44344105   c
            1377-1468           JAXUCZ010000012.1  44342991-44343082   c
            1469-1610           JAXUCZ010000012.1  44340688-44340829   c
            1611-1750           JAXUCZ010000012.1  44337541-44337680   c
            1751-1925           JAXUCZ010000012.1  44335088-44335262   c
            1926-2027           JAXUCZ010000012.1  44332341-44332442   c
            2028-2222           JAXUCZ010000012.1  44330155-44330349   c
            2223-2308           JAXUCZ010000012.1  44329533-44329618   c
            2309-2453           JAXUCZ010000012.1  44327523-44327667   c
            2454-2558           JAXUCZ010000012.1  44326477-44326581   c
            2559-2617           JAXUCZ010000012.1  44325945-44326003   c
            2618-2719           JAXUCZ010000012.1  44324838-44324939   c
            2720-2836           JAXUCZ010000012.1  44320884-44321000   c
            2837-3011           JAXUCZ010000012.1  44317855-44318029   c
            3012-3150           JAXUCZ010000012.1  44315332-44315470   c
            3151-3229           JAXUCZ010000012.1  44314553-44314631   c
            3230-3423           JAXUCZ010000012.1  44304537-44304730   c
            3424-3593           JAXUCZ010000012.1  44302662-44302831   c
            3594-3804           JAXUCZ010000012.1  44298305-44298515   c
            3805-3892           JAXUCZ010000012.1  44297546-44297633   c
            3893-4014           JAXUCZ010000012.1  44295692-44295813   c
            4015-4163           JAXUCZ010000012.1  44294100-44294248   c
            4164-4358           JAXUCZ010000012.1  44291819-44292013   c
            4359-4477           JAXUCZ010000012.1  44288836-44288954   c
            4478-4594           JAXUCZ010000012.1  44287614-44287730   c
FEATURES             Location/Qualifiers
     source          1..4594
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..4594
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="nitric oxide synthase 1"
                     /db_xref="GeneID:24598"
                     /db_xref="RGD:3184"
     exon            1..811
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..4493
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /EC_number="1.14.13.39"
                     /note="nitric oxide synthase, brain; nitric oxidase
                     synthase; nNOS; N-NOS; NC-NOS; NOS type I; neuronal NOS;
                     constitutive NOS; peptidyl-cysteine S-nitrosylase NOS1;
                     nitric oxide synthase 1, neuronal"
                     /codon_start=1
                     /product="nitric oxide synthase 1"
                     /protein_id="NP_434686.2"
                     /db_xref="GeneID:24598"
                     /db_xref="RGD:3184"
                     /translation="MEENTFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIIS
                     DLIRGGAAEQSGLIQAGDIILAVNDRPLVDLSYDSALEVLRGIASETHVVLILRGPEG
                     FTTHLETTFTGDGTPKTIRVTQPLGPPTKAVDLSHQPSASKDQSLAVDRVTGLGNGPQ
                     HAQGHGQGAGSVSQANGVAIDPTMKSTKANLQDIGEHDELLKEIEPVLSILNSGSKAT
                     NRGGPAKAEMKDTGIQVDRDLDGKSHKAPPLGGDNDRVFNDLWGKDNVPVVLNNPYSE
                     KEQSPTSGKQSPTKNGSPSRCPRFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGS
                     IMLPSQHTRKPEDVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTS
                     TYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYAT
                     NKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQ
                     GWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFDWFKDLGLKWYGLPA
                     VSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSL
                     WKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPP
                     MSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKF
                     SAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKAMSMEEYDIVHLEH
                     EALVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKYPEPLRFFPRKGPSLSH
                     VDSEAHSLVAARDSQHRSYKVRFNSVSSYSDSRKSSGDGPDLRDNFESTGPLANVRFS
                     VFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAA
                     CDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTYVAEAPDLTQGLSNVHKKRVSAAR
                     LLSRQNLQSPKSSRSTIFVRLHTNGNQELQYQPGDHLGVFPGNHEDLVNALIERLEDA
                     PPANHVVKVEMLEERNTALGVISNWKDESRLPPCTIFQAFKYYLDITTPPTPLQLQQF
                     ASLATNEKEKQRLLVLSKGLQEYEEWKWGKNPTMVEVLEEFPSIQMPATLLLTQLSLL
                     QPRYYSISSSPDMYPDEVHLTVAIVSYHTRDGEGPVHHGVCSSWLNRIQADDVVPCFV
                     RGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGCRQS
                     KIDHIYREETLQAKNKGVFRELYTAYSREPDRPKKYVQDVLQEQLAESVYRALKEQGG
                     HIYVCGDVTMAADVLKAIQRIMTQQGKLSEEDAGVFISRLRDDNRYHEDIFGVTLRTY
                     EVTNRLRSESIAFIEESKKDADEVFSS"
     exon            812..938
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1067
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1213
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1376
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1468
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1610
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1750
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1925
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2027
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2222
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2308
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2453
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2558
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2617
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2719
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2836
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2837..3011
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3150
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3151..3229
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3230..3423
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3424..3593
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3594..3804
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3805..3892
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3893..4014
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4015..4163
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4164..4358
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4359..4477
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4478..4594
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacagaggc gacagaaact ctgcagccag ctcttgcccc cgaggagctc aggttcctgc
       61 aggagtcatt ttagcttagt cttctgaagg acacagatac catggaagag aacacgtttg
      121 gggttcagca gatccaaccc aatgtaattt ctgttcgtct cttcaaacgc aaagtgggag
      181 gtctgggctt cctggtgaag gaacgggtca gcaagcctcc cgtgatcatc tcagacctga
      241 ttcgaggagg tgctgcggag cagagcggcc ttatccaagc tggagacatc attctcgcag
      301 tcaacgatcg gcccttggta gacctcagct atgacagtgc cctggaggtt ctcaggggca
      361 ttgcctctga gacccacgtg gtcctcattc tgaggggccc tgagggcttc actacacatc
      421 tggagaccac cttcacaggg gatggaaccc ccaagaccat ccgggtgacc cagcccctcg
      481 gtcctcccac caaagccgtc gatctgtctc accagccttc agccagcaaa gaccagtcat
      541 tagcagtaga cagagtcaca ggtctgggta atggccctca gcatgcccaa ggccatgggc
      601 agggagctgg ctcagtctcc caagctaatg gtgtggccat tgaccccacg atgaaaagca
      661 ccaaggccaa cctccaggac atcggggaac atgatgaact gctcaaagag atagaacctg
      721 tgctgagcat cctcaacagt gggagcaaag ccaccaacag agggggacca gccaaagcag
      781 agatgaaaga cacaggaatc caggtggaca gagacctcga tggcaaatcg cacaaagctc
      841 cgcccctggg cggggacaat gaccgcgtct tcaatgacct gtgggggaag gacaacgttc
      901 ctgtggtcct taacaacccg tattcagaga aggaacagtc ccctacctcg gggaaacagt
      961 ctcccaccaa gaacggcagc ccttccaggt gcccccgttt cctcaaggtc aagaactggg
     1021 agacggacgt ggtcctcacc gacaccctgc acctgaagag cacactggaa acggggtgca
     1081 cagagcacat ctgcatgggc tcgatcatgc tgccttccca gcacacgcgg aagccagaag
     1141 atgtccgcac aaaggaccag ctcttccctc tagccaaaga atttctcgac caatactact
     1201 catccattaa gagatttggc tccaaggccc acatggacag gctggaggag gtgaacaagg
     1261 agattgaaag caccagcacc taccagctca aggacaccga gctcatctat ggcgccaagc
     1321 atgcctggcg gaacgcctct cgatgtgtgg gcaggatcca gtggtccaag ctgcaggtgt
     1381 tcgatgcccg agactgcacc acagcccacg gcatgttcaa ctacatctgt aaccatgtca
     1441 agtatgccac caacaaaggg aatctcaggt cggccatcac gatattccct cagaggactg
     1501 acggcaaaca tgacttccga gtgtggaact cgcagctcat ccgctacgcg ggctacaagc
     1561 agccagatgg ctctaccttg ggggatccag ccaatgtgca gttcacggag atctgtatac
     1621 agcagggctg gaaagcccca agaggccgct tcgacgtgct gcctctcctg cttcaggcca
     1681 atggcaatga ccctgagctc ttccagatcc ccccagagct ggtgctggaa gtgcccatca
     1741 ggcaccccaa gttcgactgg tttaaggacc tggggctcaa atggtatggc ctccccgctg
     1801 tgtccaacat gctgctggag atcgggggcc tggagttcag cgcctgtccc ttcagcggct
     1861 ggtacatggg cacagagatc ggcgtccgtg actactgtga caactctcga tacaacatcc
     1921 tggaggaagt agccaagaag atggatttgg acatgaggaa gacctcgtcc ctctggaagg
     1981 accaagcact ggtggagatc aacattgctg ttctatatag cttccagagt gacaaggtga
     2041 ccatcgttga ccaccactct gccacggagt ccttcatcaa acacatggag aatgaatacc
     2101 gctgcagagg gggctgcccc gccgactggg tgtggattgt gcctcccatg tcgggcagca
     2161 tcacccctgt cttccaccag gagatgctca actatagact caccccgtcc tttgaatacc
     2221 agcctgatcc atggaacacc cacgtgtgga agggcaccaa cgggaccccc acgaagcggc
     2281 gagctatcgg ctttaagaaa ttggcagagg ccgtcaagtt ctcagccaag ctaatggggc
     2341 aggccatggc caagagggtc aaggcgacca ttctctacgc cacagagaca ggcaaatcac
     2401 aagcctatgc caagaccctg tgtgagatct tcaagcacgc cttcgatgcc aaggcaatgt
     2461 ccatggagga gtatgacatc gtgcacctgg agcacgaagc cctggtcttg gtggtcacca
     2521 gcacctttgg caatggagac ccccctgaga acggggagaa attcggctgt gctttaatgg
     2581 agatgaggca ccccaactct gtgcaggagg agagaaagta cccggaaccc ttgcgtttct
     2641 ttccccgtaa agggccttcc ctctcccatg ttgactctga agcccacagt ctggttgctg
     2701 cccgtgacag ccaacacagg agctacaagg tccgattcaa cagcgtctcc tcctattctg
     2761 actcccgaaa gtcatcgggc gacggacccg acctcagaga caactttgaa agtactggac
     2821 ccctggccaa tgtgaggttc tcagtgttcg gcctcggctc tcgggcgtac ccccacttct
     2881 gtgcctttgg gcatgcggtg gacaccctcc tggaggaact gggaggggag aggattctga
     2941 agatgaggga gggggatgag ctttgcggac aggaagaagc tttcaggacc tgggccaaga
     3001 aagtcttcaa ggcagcctgt gatgtgttct gcgtggggga tgacgtcaac atcgagaagg
     3061 cgaacaactc cctcattagc aatgaccgaa gctggaagag gaacaagttc cgcctcacgt
     3121 atgtggcgga agctccagat ctgacccaag gtctttccaa tgttcacaaa aaacgagtct
     3181 cggctgctcg actcctcagc cgccaaaacc tgcaaagccc taagtccagc cgatcgacca
     3241 tcttcgtgcg tctccacacc aacgggaatc aggagctgca gtaccagcca ggggaccacc
     3301 tgggtgtctt ccccggcaac cacgaggacc tcgtgaatgc actcattgaa cggctggagg
     3361 atgcaccgcc tgccaaccac gtggtgaagg tggagatgct ggaggagagg aacactgctc
     3421 tgggtgtcat cagtaattgg aaggatgaat ctcgcctccc accctgcacc atcttccagg
     3481 ccttcaagta ctacctggac atcaccacgc cgcccacgcc cctgcagctg cagcagttcg
     3541 cctctctggc cactaatgag aaagagaagc agcggttgct ggtcctcagc aaggggctcc
     3601 aggaatatga ggagtggaag tggggcaaga accccacaat ggtggaggtg ctggaggagt
     3661 tcccgtccat ccagatgccg gctacacttc tcctcactca gctgtcgctg ctgcagcctc
     3721 gctactactc catcagctcc tctccagaca tgtaccccga cgaggtgcac ctcaccgtgg
     3781 ccatcgtctc ctaccacacc cgagacggag aaggaccggt ccaccacggg gtgtgctcct
     3841 cctggctcaa cagaatacag gctgacgatg tagtcccctg cttcgtgaga ggtgccccta
     3901 gcttccacct gcctcgaaac ccccaggtgc cttgcatcct ggttggccca ggcactggca
     3961 tcgcaccctt ccgaagcttc tggcaacagc gacaatttga catccaacac aaaggaatga
     4021 atccgtgccc catggttctg gtctttgggt gtcgacaatc caagatagat catatctaca
     4081 gagaggagac cctgcaggcc aagaacaagg gcgtcttcag agagctgtac actgcctatt
     4141 cccgggaacc ggacaggcca aagaaatatg tacaggacgt gctgcaggaa cagctggctg
     4201 agtctgtgta ccgcgccctg aaggagcaag gaggccacat ttatgtctgt ggggacgtta
     4261 ccatggccgc cgatgtcctc aaagccatcc agcgcataat gacccagcag gggaaactct
     4321 cagaggagga cgctggtgta ttcatcagca ggctgaggga tgacaaccgg taccacgagg
     4381 acatctttgg agtcaccctc agaacgtatg aagtgaccaa ccgccttaga tctgagtcca
     4441 tcgccttcat cgaagagagc aaaaaagacg cagatgaggt tttcagctcc taactggatc
     4501 ctcctgcccc cgtgcgtgcg atgtggggcg gctgccccaa gtgcccaagt gagggcggcc
     4561 gcaggttgac taaattcgga cacacacggc tgaa
//
