LOCUS       NM_207591               1530 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus NOP53 ribosome biogenesis factor (Nop53), mRNA.
ACCESSION   NM_207591 XM_214816
VERSION     NM_207591.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1530)
  AUTHORS   Lee,S., Cho,Y.E., Kim,S.H., Kim,Y.J. and Park,J.H.
  TITLE     GLTSCR2 promotes the nucleoplasmic translocation and subsequent
            degradation of nucleolar ARF
  JOURNAL   Oncotarget 8 (10), 16293-16302 (2017)
   PUBMED   27323397
REFERENCE   2  (bases 1 to 1530)
  AUTHORS   Chen,H., Han,L., Tsai,H., Wang,Z., Wu,Y., Duo,Y., Cao,W., Chen,L.,
            Tan,Z., Xu,N., Huang,X., Zhuang,J. and Huang,L.
  TITLE     PICT-1 is a key nucleolar sensor in DNA damage response signaling
            that regulates apoptosis through the RPL11-MDM2-p53 pathway
  JOURNAL   Oncotarget 7 (50), 83241-83257 (2016)
   PUBMED   27829214
REFERENCE   3  (bases 1 to 1530)
  AUTHORS   Chen,H., Duo,Y., Hu,B., Wang,Z., Zhang,F., Tsai,H., Zhang,J.,
            Zhou,L., Wang,L., Wang,X. and Huang,L.
  TITLE     PICT-1 triggers a pro-death autophagy through inhibiting rRNA
            transcription and AKT/mTOR/p70S6K signaling pathway
  JOURNAL   Oncotarget 7 (48), 78747-78763 (2016)
   PUBMED   27729611
REFERENCE   4  (bases 1 to 1530)
  AUTHORS   Wang,P., Meng,W., Han,S.C., Li,C.C., Wang,X.J. and Wang,X.J.
  TITLE     The nucleolar protein GLTSCR2 is required for efficient viral
            replication
  JOURNAL   Sci Rep 6, 36226 (2016)
   PUBMED   27824081
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1530)
  AUTHORS   Kim,J.Y., Cho,Y.E. and Park,J.H.
  TITLE     The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of
            the Oncogenic Nucleophosmin-MYC Axis
  JOURNAL   Am J Pathol 185 (7), 2061-2068 (2015)
   PUBMED   25956029
REFERENCE   6  (bases 1 to 1530)
  AUTHORS   Kim,J.Y., Seok,K.O., Kim,Y.J., Bae,W.K., Lee,S. and Park,J.H.
  TITLE     Involvement of GLTSCR2 in the DNA Damage Response
  JOURNAL   Am J Pathol 179 (3), 1257-1264 (2011)
   PUBMED   21741933
REFERENCE   7  (bases 1 to 1530)
  AUTHORS   Chen,H., Mei,L., Zhou,L., Zhang,X., Guo,C., Li,J., Wang,H., Zhu,Y.,
            Zheng,Y. and Huang,L.
  TITLE     Moesin-ezrin-radixin-like protein (merlin) mediates protein
            interacting with the carboxyl terminus-1 (PICT-1)-induced growth
            inhibition of glioblastoma cells in the nucleus
  JOURNAL   Int J Biochem Cell Biol 43 (4), 545-555 (2011)
   PUBMED   21167305
REFERENCE   8  (bases 1 to 1530)
  AUTHORS   Kalt,I., Borodianskiy-Shteinberg,T., Schachor,A. and Sarid,R.
  TITLE     GLTSCR2/PICT-1, a putative tumor suppressor gene product, induces
            the nucleolar targeting of the Kaposi's sarcoma-associated
            herpesvirus KS-Bcl-2 protein
  JOURNAL   J Virol 84 (6), 2935-2945 (2010)
   PUBMED   20042497
REFERENCE   9  (bases 1 to 1530)
  AUTHORS   Okahara,F., Itoh,K., Nakagawara,A., Murakami,M., Kanaho,Y. and
            Maehama,T.
  TITLE     Critical role of PICT-1, a tumor suppressor candidate, in
            phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic
            transformation
  JOURNAL   Mol Biol Cell 17 (11), 4888-4895 (2006)
   PUBMED   16971513
REFERENCE   10 (bases 1 to 1530)
  AUTHORS   Okahara,F., Ikawa,H., Kanaho,Y. and Maehama,T.
  TITLE     Regulation of PTEN phosphorylation and stability by a tumor
            suppressor candidate protein
  JOURNAL   J Biol Chem 279 (44), 45300-45303 (2004)
   PUBMED   15355975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On May 12, 2017 this sequence version replaced NM_207591.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ212888.1, BC086359.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               JAXUCZ010000001.1  85764835-85765089   c
            256-320             JAXUCZ010000001.1  85764275-85764339   c
            321-429             JAXUCZ010000001.1  85762308-85762416   c
            430-629             JAXUCZ010000001.1  85761680-85761879   c
            630-700             JAXUCZ010000001.1  85761259-85761329   c
            701-796             JAXUCZ010000001.1  85759582-85759677   c
            797-901             JAXUCZ010000001.1  85759155-85759259   c
            902-1096            JAXUCZ010000001.1  85758887-85759081   c
            1097-1272           JAXUCZ010000001.1  85758515-85758690   c
            1273-1339           JAXUCZ010000001.1  85758335-85758401   c
            1340-1416           JAXUCZ010000001.1  85757763-85757839   c
            1417-1473           JAXUCZ010000001.1  85757591-85757647   c
            1474-1530           JAXUCZ010000001.1  85757271-85757327   c
FEATURES             Location/Qualifiers
     source          1..1530
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1530
                     /gene="Nop53"
                     /gene_synonym="Gltscr2"
                     /note="NOP53 ribosome biogenesis factor"
                     /db_xref="GeneID:292624"
                     /db_xref="RGD:1303085"
     exon            1..255
                     /gene="Nop53"
                     /gene_synonym="Gltscr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1480
                     /gene="Nop53"
                     /gene_synonym="Gltscr2"
                     /note="preS1 binding protein; glioma tumor suppressor
                     candidate region gene 2 protein"
                     /codon_start=1
                     /product="ribosome biogenesis protein NOP53"
                     /protein_id="NP_997474.1"
                     /db_xref="GeneID:292624"
                     /db_xref="RGD:1303085"
                     /translation="MAAGSNRGGDKRGSKSQADSNFLGLRPTSVDPALRRRRRGPRNK
                     KRGWRRLAEEPLGLEVDQFLEDVRLQERTTGGLLAEAPNEQLFFVDTGLKKKEPRKKR
                     TWVQKKSKHLQKPLRVDLALENHSKIPAPKDILAHQVPNAKKLRRKEELWEKLAKQGE
                     LPRDVRKAQARLLNPPAPKAKPGPQDIIERPFYDLWNPNNPLDKPLIGQDAFFLEQTK
                     KKGVRRPPRLHIKPSQVPAVEVIPAGASYNPTFEDHQALLLEAHEVELQREKEAEKLE
                     RQLALPTAEQAATQESVFREMCEGLLEESEDEDGPGCAEQPEADDGATETSPTGAAGP
                     EKRMEKKTEQQRRREKAARKLRVQQAALRAARLQHQELFRLRGIKAQVARRLAELARR
                     KEQRRIRRLAEADKPRRLGRLKYQAPDIDVQLSSELSDSLRKLKPEGNILRDRFKSFQ
                     KRNMIEPRERAKFKRKYKVKLVEKRAFREIQL"
     exon            256..320
                     /gene="Nop53"
                     /gene_synonym="Gltscr2"
                     /inference="alignment:Splign:2.1.0"
     exon            321..429
                     /gene="Nop53"
                     /gene_synonym="Gltscr2"
                     /inference="alignment:Splign:2.1.0"
     exon            430..629
                     /gene="Nop53"
                     /gene_synonym="Gltscr2"
                     /inference="alignment:Splign:2.1.0"
     exon            630..700
                     /gene="Nop53"
                     /gene_synonym="Gltscr2"
                     /inference="alignment:Splign:2.1.0"
     exon            701..796
                     /gene="Nop53"
                     /gene_synonym="Gltscr2"
                     /inference="alignment:Splign:2.1.0"
     exon            797..901
                     /gene="Nop53"
                     /gene_synonym="Gltscr2"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1096
                     /gene="Nop53"
                     /gene_synonym="Gltscr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1272
                     /gene="Nop53"
                     /gene_synonym="Gltscr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1339
                     /gene="Nop53"
                     /gene_synonym="Gltscr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1416
                     /gene="Nop53"
                     /gene_synonym="Gltscr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1473
                     /gene="Nop53"
                     /gene_synonym="Gltscr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1530
                     /gene="Nop53"
                     /gene_synonym="Gltscr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtttgagcga ctacgctctt cctttaagaa gatggctgcg ggtagtaaca gaggcggtga
       61 taagcgcggc tcgaaaagcc aggcggactc taactttctg gggctgcggc ccacctcggt
      121 ggatcccgct ctgaggcggc ggcggcgggg ccccagaaac aagaagcgcg gctggaggag
      181 gctcgctgag gagccgctgg ggctagaggt agaccagttc ctggaagatg tacggctaca
      241 agagcgcacg accggtggct tgttggcaga ggccccaaat gaacagctct tcttcgtgga
      301 cactggactc aagaaaaaag aaccacgcaa gaagaggacc tgggtccaga agaagtcaaa
      361 gcatctccag aaacccctac gggttgacct tgcccttgag aatcattcta agatccctgc
      421 tcccaaagac atccttgcac accaggtccc caatgccaaa aagctcaggc gaaaggagga
      481 gctatgggag aaactggcaa agcagggaga gctgcccagg gatgtgcgca aggcacaggc
      541 ccggcttctt aaccctcctg caccaaaggc caaacctggg ccccaggata tcattgagcg
      601 gcccttctat gacctctgga acccaaacaa tcctctggat aagcctttga tcggtcagga
      661 tgcatttttt ctggagcaga ccaagaagaa aggtgtgagg cggccaccac gactccacat
      721 caagccttcc caggtgcctg cggtggaagt gattcctgcg ggagcctcct acaacccaac
      781 ctttgaagat caccaggcct tgcttctaga ggcccatgag gtggagctgc agcgtgagaa
      841 agaggcagaa aagctggagc gacagctggc cctgcccact gcagagcaag ctgctaccca
      901 ggagtccgtg tttcgggaga tgtgtgaggg cctgctcgaa gagtctgagg atgaggatgg
      961 gccaggctgt gctgagcagc cagaggctga cgatggggcc actgagacct cacccactgg
     1021 tgctgctggt cctgagaaga ggatggagaa gaagacagag cagcagcggc ggcgggagaa
     1081 ggctgctcgc aagctgcggg tgcagcaggc tgcactgagg gcagcccggc ttcagcacca
     1141 agaactcttc aggctacgtg ggatcaaggc ccaggtggcc cggaggctgg cagagctggc
     1201 acgccggaag gagcagcggc gcatacggcg actggcagag gctgacaaac cccgaaggct
     1261 gggacggctc aagtaccagg cccctgacat tgatgtgcag ctcagctctg agctatctga
     1321 ctcactcagg aaactgaagc cagaaggtaa cattctccga gacaggttca aaagcttcca
     1381 gaagagaaat atgattgagc cccgggaacg agccaagttc aagcgcaaat acaaagtgaa
     1441 gctggtggag aagcgggctt tccgcgagat tcagttgtag ctgtgcagat gttggagcct
     1501 ctgcccctca ataaagtgct gtgaccaacc
//
