LOCUS       NM_001191785            2544 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus NOP2 nucleolar protein (Nop2), mRNA.
ACCESSION   NM_001191785 XM_235295
VERSION     NM_001191785.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2544)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2544)
  AUTHORS   Sloan,K.E., Bohnsack,M.T. and Watkins,N.J.
  TITLE     The 5S RNP couples p53 homeostasis to ribosome biogenesis and
            nucleolar stress
  JOURNAL   Cell Rep 5 (1), 237-247 (2013)
   PUBMED   24120868
REFERENCE   3  (bases 1 to 2544)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 2544)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 2544)
  AUTHORS   Sigal,A., Milo,R., Cohen,A., Geva-Zatorsky,N., Klein,Y., Alaluf,I.,
            Swerdlin,N., Perzov,N., Danon,T., Liron,Y., Raveh,T.,
            Carpenter,A.E., Lahav,G. and Alon,U.
  TITLE     Dynamic proteomics in individual human cells uncovers widespread
            cell-cycle dependence of nuclear proteins
  JOURNAL   Nat Methods 3 (7), 525-531 (2006)
   PUBMED   16791210
REFERENCE   6  (bases 1 to 2544)
  AUTHORS   Valdez,B.C., Perlaky,L., Saijo,Y., Henning,D., Zhu,C., Busch,R.K.,
            Zhang,W.W. and Busch,H.
  TITLE     A region of antisense RNA from human p120 cDNA with high homology
            to mouse p120 cDNA inhibits NIH 3T3 proliferation
  JOURNAL   Cancer Res 52 (20), 5681-5686 (1992)
   PUBMED   1394192
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 17, 2010 this sequence version replaced XM_235295.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               JAXUCZ010000004.1  159618966-159619073
            109-219             JAXUCZ010000004.1  159619284-159619394
            220-265             JAXUCZ010000004.1  159620199-159620244
            266-354             JAXUCZ010000004.1  159620393-159620481
            355-533             JAXUCZ010000004.1  159621082-159621260
            534-589             JAXUCZ010000004.1  159623717-159623772
            590-741             JAXUCZ010000004.1  159623855-159624006
            742-941             JAXUCZ010000004.1  159624223-159624422
            942-1031            JAXUCZ010000004.1  159624557-159624646
            1032-1119           JAXUCZ010000004.1  159626005-159626092
            1120-1260           JAXUCZ010000004.1  159626166-159626306
            1261-1400           JAXUCZ010000004.1  159626752-159626891
            1401-1490           JAXUCZ010000004.1  159627021-159627110
            1491-1613           JAXUCZ010000004.1  159627254-159627376
            1614-1842           JAXUCZ010000004.1  159627483-159627711
            1843-2544           JAXUCZ010000004.1  159629996-159630697
FEATURES             Location/Qualifiers
     source          1..2544
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2544
                     /gene="Nop2"
                     /gene_synonym="Nol1"
                     /note="NOP2 nucleolar protein"
                     /db_xref="GeneID:314969"
                     /db_xref="RGD:1304616"
     exon            1..108
                     /gene="Nop2"
                     /gene_synonym="Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            109..219
                     /gene="Nop2"
                     /gene_synonym="Nol1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..2432
                     /gene="Nop2"
                     /gene_synonym="Nol1"
                     /note="putative ribosomal RNA methyltransferase NOP2;
                     nucleolar protein 1; NOP2 nucleolar protein homolog"
                     /codon_start=1
                     /product="probable 28S rRNA
                     (cytosine(4447)-C(5))-methyltransferase"
                     /protein_id="NP_001178714.1"
                     /db_xref="GeneID:314969"
                     /db_xref="RGD:1304616"
                     /translation="MGRKLDPTKKEKRGPGRKARKQKGAETELIRFLPAAGDENFKRL
                     SSRARKRAAKRRSGSVEVPKPNKSPGIKTLPGELPKGAVQVRGKKRPAPIQNSDGDEE
                     EDSEEEDVVTQGELWGSEDSSEDMVDDYGADSEDEEEKLLPIERAALKQKARDPADGT
                     QWSEEDTDEDEGVTPESHPRKDDKAEGDLQINVEEEEAFVLPPAGQTDQDAQTPDLQR
                     VHKRIQDIVGVLRDFGAQREEGRSRTEYLSQLQKDLATYYSYGDFLLSKLMELFPLSE
                     LIEFLEANEVPRPITLRTNTLKTRRRDLAQALINRGVNLDPLGKWSKSGLVVYDSSVP
                     IGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGKTSYIAQLMKNTGVI
                     LANDANAERLKSVVGNLHRLGVTNTIVSHYDGRQFPKVVGGFDRVLLDAPCSGTGVIS
                     KDPAVKTNKDEKDIQRCAHLQKELLLSAIDSVNAASKTGGYLVYCTCSITVEENEWVV
                     DYALKKRNVRLVPTGLDFGQEGFTRFRERRFHPTLRATRRFYPHTHNMDGFFIAKFKK
                     FSNSIPQPHSGNSAAGTPTEPDLKGQVTPKSENSSQPTKKAHGAAKAKQQLVGQQHSK
                     KPFQKMNGISKGPGLPTEPSVPNVQVSARPQESSLSDVKRKRAGKLKQRGPKQSAPPP
                     KVGDLGTPAMQTPSEISATPRPKSPGKAKKREEVKQELPEQPAKGTASLKEDAAPKRL
                     SSPTTAHHSSTRPPPAKRRKSMTKGSSQPLLS"
     exon            220..265
                     /gene="Nop2"
                     /gene_synonym="Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            266..354
                     /gene="Nop2"
                     /gene_synonym="Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            355..533
                     /gene="Nop2"
                     /gene_synonym="Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            534..589
                     /gene="Nop2"
                     /gene_synonym="Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            590..741
                     /gene="Nop2"
                     /gene_synonym="Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..941
                     /gene="Nop2"
                     /gene_synonym="Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1031
                     /gene="Nop2"
                     /gene_synonym="Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1119
                     /gene="Nop2"
                     /gene_synonym="Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1260
                     /gene="Nop2"
                     /gene_synonym="Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1400
                     /gene="Nop2"
                     /gene_synonym="Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1490
                     /gene="Nop2"
                     /gene_synonym="Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1613
                     /gene="Nop2"
                     /gene_synonym="Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1842
                     /gene="Nop2"
                     /gene_synonym="Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..2544
                     /gene="Nop2"
                     /gene_synonym="Nol1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttcgcggt gtgctgcctc tgaactcttc cccaagtgca cgtggagcgg gccttggctg
       61 gaggcactgg gtctgccgga accagtccta ggcaagccga gccttcagtt atcatggggc
      121 gcaagttgga tcctacgaag aaggagaagc gtgggcccgg ccgaaaggct cgaaagcaga
      181 agggtgcaga gaccgaactg atcagatttt tgcctgcagc tggtgatgag aatttcaaga
      241 ggctgtccag tcgtgctcgg aagagggcgg ccaagaggag gtcagggtct gttgaagtcc
      301 ctaagccaaa taagtctcct gggatcaaaa cattgcctgg agagttaccc aaaggagcag
      361 tccaggttcg aggtaagaag cgtccagcac caattcaaaa cagtgatggg gatgaggagg
      421 aagactctga ggaagaagat gtggtgaccc agggggaact ttggggctct gaagacagta
      481 gtgaagatat ggtggacgac tatggagcgg actcggagga tgaggaggaa aagttgttgc
      541 ctattgaaag agctgctctg aagcagaagg cccgggaccc cgcagatggg acccagtgga
      601 gtgaggagga cactgatgaa gatgaaggtg ttacccctga gtcccacccc agaaaggatg
      661 acaaagcaga gggggatttg cagatcaatg tggaagagga ggaagccttc gtgctgcctc
      721 ctgctggaca gacggaccag gatgcccaga ctccagacct gcagcgagtt cacaagcgca
      781 tccaggatat agtaggagtg cttcgggatt ttggggctca gcgagaggaa ggccggtctc
      841 gaactgagta tctgagtcag cttcagaagg atctggccac ctactattct tatggagact
      901 tcctgttgag caagctcatg gagctgttcc cgctgtctga gttgatagag ttcttagaag
      961 ctaatgaggt gccccggcca atcacccttc ggaccaacac cttgaaaacc cgtcgccgag
     1021 accttgctca ggctctgatc aatcgtgggg ttaatctgga tccattggga aagtggtcga
     1081 agtctggact tgtggtatat gattcttcag tgcctattgg tgctactccc gagtacctag
     1141 ctggacacta tatgctgcag ggagcttcga gcatgctgcc tgtcatggcc ctggcacctc
     1201 aggagcatga gcggatcttg gacatgtgtt gtgctcccgg aggaaagacc agctacatag
     1261 ctcagctgat gaagaacacg ggtgtgatcc ttgccaatga cgccaatgca gagcggctca
     1321 agagtgtcgt gggcaacctg caccgcttgg gagtcaccaa caccatcgtc agccactatg
     1381 atgggcgcca gttccccaag gtggtgggcg gctttgatcg ggtgcttctg gacgctcctt
     1441 gcagtggcac aggagtcatc tccaaagacc ctgctgtgaa gacgaacaag gatgagaagg
     1501 acatccagcg ctgtgcccac cttcagaagg aattgctgct cagtgctata gactcagtca
     1561 acgctgcctc caagaccgga ggctacctgg tctactgcac ttgctccatt acggtggaag
     1621 agaacgagtg ggtggtggac tatgccttga agaagaggaa tgtgcggctg gtgcccaccg
     1681 gcctggactt cgggcaggaa ggtttcaccc gcttccgaga aaggcgcttt caccccactc
     1741 tgcgggccac ccgacgcttc taccctcaca ctcacaatat ggatggtttc tttatagcca
     1801 agttcaagaa attttccaat tctatccccc agccccactc aggaaactcg gcagcaggta
     1861 ctcctacaga acctgacctg aagggtcagg tcaccccaaa gtctgagaac agtagtcagc
     1921 ccaccaagaa agcccacggg gctgcaaagg caaagcagca gttagtaggg cagcaacatt
     1981 ccaagaagcc cttccagaag atgaatggca tctccaaagg gccaggcttg cccactgaac
     2041 cttctgtccc aaatgtccaa gtgtctgcta ggccccagga aagcagtctg tctgatgtga
     2101 aacggaagag ggctggaaag ctgaagcagc ggggaccgaa gcagagtgcc cctcccccca
     2161 aggtcgggga cctggggaca cctgctatgc agactccctc tgaaatcagt gccaccccaa
     2221 ggcctaagtc ccctgggaaa gccaaaaaga gagaggaagt aaagcaggag ttaccagagc
     2281 agcctgccaa gggaactgct tccctgaaag aagacgctgc ccccaagaga ctctcttccc
     2341 ccaccacggc tcaccacagt tccaccaggc ccccaccggc aaagaggagg aaatctatga
     2401 ccaagggcag cagccagcca ctgttgtctt aaatggactt ggaaactcac tgacaccgtc
     2461 tctggattga actgttagat cctgttgcaa gaaggcctcc cctgtgcata catatgaaac
     2521 ttaatataca tattaccacc ccta
//
