LOCUS       NM_001012356            2438 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus non-POU domain containing, octamer-binding
            (Nono), mRNA.
ACCESSION   NM_001012356 XM_228554
VERSION     NM_001012356.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2438)
  AUTHORS   Lei,Y.Q., Ye,Z.J., Wei,Y.L., Zhu,L.P., Zhuang,X.D., Wang,X.R. and
            Cao,H.
  TITLE     Nono deficiency impedes the proliferation and adhesion of H9c2
            cardiomyocytes through Pi3k/Akt signaling pathway
  JOURNAL   Sci Rep 13 (1), 7134 (2023)
   PUBMED   37130848
  REMARK    GeneRIF: Nono deficiency impedes the proliferation and adhesion of
            H9c2 cardiomyocytes through Pi3k/Akt signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2438)
  AUTHORS   Itai,T., Sugie,A., Nitta,Y., Maki,R., Suzuki,T., Shinkai,Y.,
            Watanabe,Y., Nakano,Y., Ichikawa,K., Okamoto,N., Utsuno,Y.,
            Koshimizu,E., Fujita,A., Hamanaka,K., Uchiyama,Y., Tsuchida,N.,
            Miyake,N., Misawa,K., Mizuguchi,T., Miyatake,S. and Matsumoto,N.
  TITLE     A novel NONO variant that causes developmental delay and cardiac
            phenotypes
  JOURNAL   Sci Rep 13 (1), 975 (2023)
   PUBMED   36653413
  REMARK    Erratum:[Sci Rep. 2023 Mar 9;13(1):3954. doi:
            10.1038/s41598-023-30968-3.. PMID: 36894578]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2438)
  AUTHORS   Fu,W., Ren,H., Shou,J., Liao,Q., Li,L., Shi,Y., Jose,P.A., Zeng,C.
            and Wang,W.E.
  TITLE     Loss of NPPA-AS1 promotes heart regeneration by stabilizing
            SFPQ-NONO heteromer-induced DNA repair
  JOURNAL   Basic Res Cardiol 117 (1), 10 (2022)
   PUBMED   35247074
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2438)
  AUTHORS   Zhang,J., Rui,Y., Gao,M., Wang,L. and Yan,B.C.
  TITLE     Expression of Long Non-coding RNA RGD1566344 in the Brain Cortex of
            Male Mice After Focal Cerebral Ischemia-Reperfusion and the
            Neuroprotective Effect of a Non-coding RNA RGD1566344 Inhibitor
  JOURNAL   Cell Mol Neurobiol 41 (4), 705-716 (2021)
   PUBMED   32424772
REFERENCE   5  (bases 1 to 2438)
  AUTHORS   Xu,(.). X, Xu,(.). X, Mao,(.). Y, Lu,(.). L, Ma,(.). J, Zheng,(.).
            T, Zhang,(.). J, Zhang,(.). M, Meng,(.). L, Ma,(.). L, Cheng,(.).
            J, Chen,(.). W, Jiang,(.). H, Zhang,(.). Y and Zhang,(.). C.
  TITLE     Knockout of the NONO Gene Inhibits Neointima Formation in a Mouse
            Model of Vascular Injury
  JOURNAL   Arterioscler Thromb Vasc Biol 41 (4), 1428-1445 (2021)
   PUBMED   33626912
REFERENCE   6  (bases 1 to 2438)
  AUTHORS   Bianconcini,A., Lupo,A., Capone,S., Quadro,L., Monti,M., Zurlo,D.,
            Fucci,A., Sabatino,L., Brunetti,A., Chiefari,E., Gottesman,M.E.,
            Blaner,W.S. and Colantuoni,V.
  TITLE     Transcriptional activity of the murine retinol-binding protein gene
            is regulated by a multiprotein complex containing HMGA1, p54
            nrb/NonO, protein-associated splicing factor (PSF) and
            steroidogenic factor 1 (SF1)/liver receptor homologue 1 (LRH-1)
  JOURNAL   Int J Biochem Cell Biol 41 (11), 2189-2203 (2009)
   PUBMED   19389484
REFERENCE   7  (bases 1 to 2438)
  AUTHORS   Clemson,C.M., Hutchinson,J.N., Sara,S.A., Ensminger,A.W., Fox,A.H.,
            Chess,A. and Lawrence,J.B.
  TITLE     An architectural role for a nuclear noncoding RNA: NEAT1 RNA is
            essential for the structure of paraspeckles
  JOURNAL   Mol Cell 33 (6), 717-726 (2009)
   PUBMED   19217333
REFERENCE   8  (bases 1 to 2438)
  AUTHORS   Fox,A.H., Bond,C.S. and Lamond,A.I.
  TITLE     P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles
            in an RNA-dependent manner
  JOURNAL   Mol Biol Cell 16 (11), 5304-5315 (2005)
   PUBMED   16148043
REFERENCE   9  (bases 1 to 2438)
  AUTHORS   Xu,J., Zhong,N., Wang,H., Elias,J.E., Kim,C.Y., Woldman,I.,
            Pifl,C., Gygi,S.P., Geula,C. and Yankner,B.A.
  TITLE     The Parkinson's disease-associated DJ-1 protein is a
            transcriptional co-activator that protects against neuronal
            apoptosis
  JOURNAL   Hum Mol Genet 14 (9), 1231-1241 (2005)
   PUBMED   15790595
REFERENCE   10 (bases 1 to 2438)
  AUTHORS   Brown,S.A., Ripperger,J., Kadener,S., Fleury-Olela,F., Vilbois,F.,
            Rosbash,M. and Schibler,U.
  TITLE     PERIOD1-associated proteins modulate the negative limb of the
            mammalian circadian oscillator
  JOURNAL   Science 308 (5722), 693-696 (2005)
   PUBMED   15860628
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089880.1.
            
            On Feb 18, 2005 this sequence version replaced XM_228554.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089880.1, SRR8487227.186763.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2438
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..2438
                     /gene="Nono"
                     /note="non-POU domain containing, octamer-binding"
                     /db_xref="GeneID:317259"
                     /db_xref="RGD:1549738"
     exon            1..59
                     /gene="Nono"
                     /inference="alignment:Splign:2.1.0"
     exon            60..115
                     /gene="Nono"
                     /inference="alignment:Splign:2.1.0"
     exon            116..293
                     /gene="Nono"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1555
                     /gene="Nono"
                     /codon_start=1
                     /product="non-POU domain-containing octamer-binding
                     protein"
                     /protein_id="NP_001012356.1"
                     /db_xref="GeneID:317259"
                     /db_xref="RGD:1549738"
                     /translation="MQSNKTFNLEKQNHTPRKHHQHHHQQHHQQQQQQQQQQQQQPPP
                     PIPANGQQASSQNEGLTIDLKNFRKPGEKTFTQRSRLFVGNLPPDITEEEMRKLFEKY
                     GKAGEVFIHKDKGFGFIRLETRTLAEIAKVELDNMPLRGKQLRVRFACHSASLTVRNL
                     PQYVSNELLEEAFSVFGQVERAVVIVDDRGRPSGKGIVEFSGKPAARKALDRCSEGSF
                     LLTTFPRPVTVEPMDQLDDEEGLPEKLVIKNQQFHKEREQPPRFAQPGSFEYEYAMRW
                     KALIEMEKQQQDQVDRNIKEAREKLEMEMEAARHEHQVMLMRQDLMRRQEELRRMEEL
                     HNQEVQKRKQLELRQEEERRRREEEMRRQQEEMMRRQQEGFKGTFPDAREQEIRMGQM
                     AMGGAMGINNRGAMPPAPVPPGTPAPPGPAAMMPDGTLGLTPPTTERFGQAATMEGIG
                     AIGGTPPAFNRPAPGAEFAPNKRRRY"
     exon            294..487
                     /gene="Nono"
                     /inference="alignment:Splign:2.1.0"
     exon            488..789
                     /gene="Nono"
                     /inference="alignment:Splign:2.1.0"
     exon            790..885
                     /gene="Nono"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1082
                     /gene="Nono"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1167
                     /gene="Nono"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1270
                     /gene="Nono"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1310
                     /gene="Nono"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1420
                     /gene="Nono"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..2411
                     /gene="Nono"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggacggtgg agaccgtgca gcgtcgccct tagtctgagc gaagaactgt gggcagaggc
       61 agtcggggtt aggactggga ggcagacact tggctgtgtt caaatcgaag tcaagggtgc
      121 aaaaatgcag agcaataaaa cctttaactt ggagaagcag aatcatactc caaggaagca
      181 ccatcagcat caccaccagc agcaccatca gcaacagcag cagcagcagc agcagcagca
      241 gcagcagcca cccccaccaa tacctgcaaa tggacagcag gccagcagcc agaatgaagg
      301 cttgactatt gacctgaaga attttaggaa accaggagag aagaccttta cccaacgtag
      361 ccgtctcttt gtgggcaatc ttccccctga catcactgag gaggaaatga ggaaactttt
      421 tgagaaatat gggaaagcag gcgaagtttt cattcataag gataaaggct ttggctttat
      481 tcgcttggaa acacgaaccc tagcggaaat tgccaaagtg gagctggaca acatgccact
      541 ccgtggaaag cagctgcgag tgcgctttgc ttgtcatagt gcatccctta cggttcgcaa
      601 ccttcctcag tacgtgtcca acgaactgct ggaagaagcc ttttctgtgt ttggccaggt
      661 ggagagggct gtagtcattg tggatgaccg aggaaggccc tcggggaaag gcattgttga
      721 gttctcaggg aagccagctg ctcggaaagc tctggacaga tgcagtgaag gctccttctt
      781 gctaaccaca tttcctcggc ctgtgactgt ggagcctatg gaccagttag atgatgaaga
      841 gggacttccg gagaagttgg ttataaaaaa ccagcaattt cacaaggaga gagaacagcc
      901 acccagattt gcacagcctg ggtcctttga gtatgagtat gccatgcgct ggaaggctct
      961 cattgagatg gagaagcaac agcaggatca agtggaccga aacatcaagg aggctcgtga
     1021 gaagctggag atggagatgg aggcagcacg ccatgagcac caggttatgc taatgaggca
     1081 ggatttgatg agacgtcaag aagagcttcg aagaatggag gagctgcata accaagaggt
     1141 tcagaaacga aagcagttag aactcaggca ggaagaggaa cgcaggcgcc gtgaggaaga
     1201 gatgcggcga cagcaagaag aaatgatgcg acggcagcag gaaggattca agggaacctt
     1261 ccctgatgcg agagaacaag agatacggat gggccaaatg gctatgggag gtgccatggg
     1321 cataaacaat agaggcgcca tgccccctgc tcctgtgcca cctggtactc cagctcctcc
     1381 aggacctgct gctatgatgc cagatggaac ccttggattg actccaccaa caactgaacg
     1441 ttttggccaa gctgctacaa tggaaggaat tggagcaatt ggtggaactc ctcctgcatt
     1501 caaccgtcca gctcctggag ctgaatttgc tccaaataaa cgccgccgat attagataca
     1561 gttgcattgt ctagtttcct gcagccctta aaagaagggc cctttttgga ctagccagaa
     1621 ttctaccctg gaaaagtgtt aggggttctt cccaatagat aggtcttccc tgcttgttct
     1681 attctaggga gtatgcttga aggcacaggg gcaagggagg ggtggtattt aacaaatcag
     1741 tctgtggtat agtgcgttaa agtctgtctg gtgcattcct gaagtatatt gattgttggg
     1801 ggcctggaga accataagga aaatggactc ggttccatta accttgatca ttcctctcct
     1861 cttcctctcc ccccctcatc ctctcatcct ttaatttttc atctttattc ccctcaaccc
     1921 cagagacact gccatgtata ccacaaaacc taaacatgct ccaatgaccc agcccaattc
     1981 ctccattcac tcccaggtga gaattcagac aatgtccaca gaggtcacag catacatacg
     2041 gttctgttat atctcatata tgaccccttc atgtcgtaag gaagacattt tctcttagag
     2101 gttttcattt tagtatatct taaatcttgt gttaacttgc ctccatcttc ttcttgggta
     2161 aggactacac tttcgtgcgt ctgctgttgc tgtccacagc ttttcttgat aggcctagta
     2221 caatcttggg aacagggttg ctgtgtgttg aaggtctgac agtagctctt agtcttgcct
     2281 atcttaggta gttgcgctgt gcatttttat tggtgtacta agatttgttc ctgatacctt
     2341 caatttgaaa atttttctga gaaatggagc agtaatgcag catcacctta ttaaaataca
     2401 tttgaagcct taaaaaaaaa aaaaaaaaaa aaaaaaaa
//
