LOCUS       NM_012990               1628 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus noggin (Nog), mRNA.
ACCESSION   NM_012990 XM_001081231 XM_343954
VERSION     NM_012990.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1628)
  AUTHORS   Liu,W., Luo,F., Wu,H., Li,H. and Bai,G.
  TITLE     Noggin Protein can Induce the Differentiation of Rat Bone Marrow
            Mesenchymal Stem Cells to Neurons and Repair Spinal Cord Injury
  JOURNAL   Discov Med 35 (179), 956-964 (2023)
   PUBMED   38058060
  REMARK    GeneRIF: Noggin Protein can Induce the Differentiation of Rat Bone
            Marrow Mesenchymal Stem Cells to Neurons and Repair Spinal Cord
            Injury.
REFERENCE   2  (bases 1 to 1628)
  AUTHORS   Hayashi,Y., Mikawa,S., Masumoto,K., Katou,F. and Sato,K.
  TITLE     Chordin and noggin expression in the adult rat trigeminal nuclei
  JOURNAL   J Chem Neuroanat 78, 36-41 (2016)
   PUBMED   27546891
  REMARK    GeneRIF: Chordin and noggin were intensely expressed throughout the
            trigeminal nuclei. chordin prefers dendritic expression than
            noggin, suggesting that chordin is involved in the regulation of
            dendritic morphology and synaptic homeostasis. Furthermore, chordin
            and noggin were differentially expressed in the neuropil of the
            trigeminal nuclei.
REFERENCE   3  (bases 1 to 1628)
  AUTHORS   Ishino,T., Takeno,S. and Hirakawa,K.
  TITLE     Novel NOG mutation in Japanese patients with stapes ankylosis with
            broad thumbs and toes
  JOURNAL   Eur J Med Genet 58 (9), 427-432 (2015)
   PUBMED   26211601
REFERENCE   4  (bases 1 to 1628)
  AUTHORS   Qureshi,A.T., Crump,E.K., Pavey,G.J., Hope,D.N., Forsberg,J.A. and
            Davis,T.A.
  TITLE     Early Characterization of Blast-related Heterotopic Ossification in
            a Rat Model
  JOURNAL   Clin Orthop Relat Res 473 (9), 2831-2839 (2015)
   PUBMED   25754758
REFERENCE   5  (bases 1 to 1628)
  AUTHORS   Yang,K., Lu,W., Jia,J., Zhang,J., Zhao,M., Wang,S., Jiang,H., Xu,L.
            and Wang,J.
  TITLE     Noggin inhibits hypoxia-induced proliferation by targeting
            store-operated calcium entry and transient receptor potential
            cation channels
  JOURNAL   Am J Physiol Cell Physiol 308 (11), C869-C878 (2015)
   PUBMED   25740156
  REMARK    GeneRIF: Noggin inhibits hypoxia-induced proliferation by targeting
            store-operated calcium entry and expression of Trpc1 and Trpc6.
REFERENCE   6  (bases 1 to 1628)
  AUTHORS   Gong,Y., Krakow,D., Marcelino,J., Wilkin,D., Chitayat,D.,
            Babul-Hirji,R., Hudgins,L., Cremers,C.W., Cremers,F.P.,
            Brunner,H.G., Reinker,K., Rimoin,D.L., Cohn,D.H., Goodman,F.R.,
            Reardon,W., Patton,M., Francomano,C.A. and Warman,M.L.
  TITLE     Heterozygous mutations in the gene encoding noggin affect human
            joint morphogenesis
  JOURNAL   Nat Genet 21 (3), 302-304 (1999)
   PUBMED   10080184
REFERENCE   7  (bases 1 to 1628)
  AUTHORS   McMahon,J.A., Takada,S., Zimmerman,L.B., Fan,C.M., Harland,R.M. and
            McMahon,A.P.
  TITLE     Noggin-mediated antagonism of BMP signaling is required for growth
            and patterning of the neural tube and somite
  JOURNAL   Genes Dev 12 (10), 1438-1452 (1998)
   PUBMED   9585504
REFERENCE   8  (bases 1 to 1628)
  AUTHORS   Zimmerman,L.B., De Jesus-Escobar,J.M. and Harland,R.M.
  TITLE     The Spemann organizer signal noggin binds and inactivates bone
            morphogenetic protein 4
  JOURNAL   Cell 86 (4), 599-606 (1996)
   PUBMED   8752214
REFERENCE   9  (bases 1 to 1628)
  AUTHORS   Lamb,T.M. and Harland,R.M.
  TITLE     Fibroblast growth factor is a direct neural inducer, which combined
            with noggin generates anterior-posterior neural pattern
  JOURNAL   Development 121 (11), 3627-3636 (1995)
   PUBMED   8582276
REFERENCE   10 (bases 1 to 1628)
  AUTHORS   Valenzuela,D.M., Economides,A.N., Rojas,E., Lamb,T.M., Nunez,L.,
            Jones,P., Lp,N.Y., Espinosa,R. 3rd, Brannan,C.I., Gilbert,D.J. et
            al.
  TITLE     Identification of mammalian noggin and its expression in the adult
            nervous system
  JOURNAL   J Neurosci 15 (9), 6077-6084 (1995)
   PUBMED   7666191
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Oct 13, 2007 this sequence version replaced
            XM_343954.3, XM_001081231.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR23984936.1052431.1,
                                        SRR26360172.2683220.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1628              JAXUCZ010000010.1  74625874-74627501   c
FEATURES             Location/Qualifiers
     source          1..1628
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..1628
                     /gene="Nog"
                     /note="noggin"
                     /db_xref="GeneID:25495"
                     /db_xref="RGD:3183"
     exon            1..1628
                     /gene="Nog"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..948
                     /gene="Nog"
                     /codon_start=1
                     /product="noggin precursor"
                     /protein_id="NP_037122.1"
                     /db_xref="GeneID:25495"
                     /db_xref="RGD:3183"
                     /translation="MERCPSLGVTLYALVVVLGLRAAPAGGQHYLHIRPAPSDNLPLV
                     DLIEHPDPIFDPKEKDLNETLLRSLLGGHYDPGFMATSPPEDRPGGGGGPAGGAEDLA
                     ELDQLLRQRPSGAMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYA
                     WNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRCQRRGGQRCGWI
                     PIQYPIISECKCSC"
ORIGIN      
        1 gcggccgcct tcccaagtag agcggcgggg gggagttgtg accaactcgt gcgcgtcttc
       61 tgcgccgcgg cgggagccgg cgctgcgcga acgcttctcc tcgcggctca tgctgcctgc
      121 cctgcgccag cccagcttcg ggtgagccgc ctccggaggg acccgggagc gcggcagcgc
      181 cgcggactcg gcgtgctctc ctccggggac gcgggacgaa gaggcagccc cgggacgcgc
      241 gcgggaggca tggagcgctg ccccagcctg ggggtcaccc tctacgccct ggtggtggtc
      301 ctggggctgc gggcagcacc agccggcggc cagcactatc tacacatccg cccagcaccc
      361 agcgacaacc tgcccctggt ggacctcatc gaacatccag accctatctt tgaccctaag
      421 gagaaggatc tgaacgagac gctgctgcgc tcgctgctcg ggggccacta cgacccgggt
      481 tttatggcca cttcaccccc agaggaccga cccggagggg gcgggggacc ggctggaggt
      541 gccgaggacc tggcggagct ggaccagctg ctgcggcagc ggccgtcggg ggccatgccg
      601 agcgagatca aagggctgga gttctccgag ggcttggccc aaggcaagaa gcagcgcctg
      661 agcaagaagc tgaggaggaa gttacagatg tggctgtggt cacagacctt ctgcccggtg
      721 ctgtacgcgt ggaacgacct aggcagccgt ttttggccgc gctacgtgaa ggtgggcagc
      781 tgcttcagca agcgctcctg ctctgtgcct gagggcatgg tgtgtaagcc atccaagtct
      841 gtgcacctca ccgtgctgcg gtggcgctgt cagcggcgcg ggggtcagcg ctgcggctgg
      901 attcccatcc agtaccccat catttccgag tgtaagtgtt cctgctagaa ctcggggccc
      961 cctgcccgcg cctagacact tgatggatcc ccaccaacgc cccccacccc caccgcctcc
     1021 aaccagttcc accaccctct agcgagggtt ttcaatgaac tttttttttc ttcttggcta
     1081 cagagacctg gctttctggt tcatgtaatg cactgtttaa ctgtgtagga atgtatatgt
     1141 gtgtatatac ggtcccagtt ttaatttact tattaaaagg tcagtattat acgtcaaaag
     1201 ttacccggct tctactgtat ttaaaaaaaa taagcaagca aagtgaaaaa aaaagagcag
     1261 agaaaagaga gacttattct ggttgttggt aataatgtta acctgctatt tatatcccaa
     1321 tgcccttcgc atggcgaagc aggggggaaa agttattttt ttcttaaaag tacaaagaga
     1381 gggggaactt ttgtagaagg acttttaaaa aagctatttt ccattcttcg gaaaatgttt
     1441 tgattttcct tagacctcga agaagttata gagttcaatg ttattttaca gttattgtaa
     1501 atatagagaa caaatggaat gactaatcat tgtaaattaa gagtatctgc tatttattct
     1561 ttataatatc ccgtgtagta aataagaaag aagtgcagaa caggattaaa gaaaaccact
     1621 aaaaccga
//
