LOCUS       NM_001106394            2034 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus nodal growth differentiation factor (Nodal),
            mRNA.
ACCESSION   NM_001106394 XM_001055479 XM_228285
VERSION     NM_001106394.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2034)
  AUTHORS   Gao Q, Guan L, Hou R, Meng R, Li Q, Liu J, Jin Y, Shi C, Su D and
            Ma X.
  TITLE     Role of EBAF/Nodal/p27 signaling pathway in development of placenta
            in normal and diabetic rats
  JOURNAL   Dev Biol 481, 172-178 (2022)
   PUBMED   34737126
  REMARK    GeneRIF: Role of EBAF/Nodal/p27 signaling pathway in development of
            placenta in normal and diabetic rats.
REFERENCE   2  (bases 1 to 2034)
  AUTHORS   Arganaraz ME, Zampini R, Apichela SA, Barraza DE, Angiono G and
            Lombardo D.
  TITLE     Embryo presence regulates NODAL/LEFTY2 system in the rat oviduct in
            vivo
  JOURNAL   Mol Reprod Dev 86 (11), 1652-1662 (2019)
   PUBMED   31418961
  REMARK    GeneRIF: These observations have shed new light on the relevance of
            the NODAL/LEFTY2 pathway in the oviduct during early embryo
            development and the role of the embryo in modulating this pathway.
REFERENCE   3  (bases 1 to 2034)
  AUTHORS   Cui Y, Wang JQ, Shi XH, Wang YY, Liu HY, Li Z, Dong Y, Mang J and
            Xu ZX.
  TITLE     Nodal mitigates cerebral ischemia-reperfusion injury via inhibiting
            oxidative stress and inflammation
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (13), 5923-5933 (2019)
   PUBMED   31298343
  REMARK    GeneRIF: Nodal mitigates cerebral ischemia-reperfusion injury via
            inhibiting oxidative stress and inflammation.
REFERENCE   4  (bases 1 to 2034)
  AUTHORS   Wu J, Cheng P, Huang Z, Tan Q and Qu Y.
  TITLE     Nodal increases the malignancy of childhood neuroblastoma cells via
            regulation of Zeb1
  JOURNAL   Biofactors 45 (3), 355-363 (2019)
   PUBMED   30985990
REFERENCE   5  (bases 1 to 2034)
  AUTHORS   Sugrue KF and Zohn IE.
  TITLE     Mechanism for generation of left isomerism in Ccdc40 mutant embryos
  JOURNAL   PLoS One 12 (2), e0171180 (2017)
   PUBMED   28182636
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2034)
  AUTHORS   Ma GT, Soloveva V, Tzeng SJ, Lowe LA, Pfendler KC, Iannaccone PM,
            Kuehn MR and Linzer DI.
  TITLE     Nodal regulates trophoblast differentiation and placental
            development
  JOURNAL   Dev Biol 236 (1), 124-135 (2001)
   PUBMED   11456449
REFERENCE   7  (bases 1 to 2034)
  AUTHORS   Brennan J, Lu CC, Norris DP, Rodriguez TA, Beddington RS and
            Robertson EJ.
  TITLE     Nodal signalling in the epiblast patterns the early mouse embryo
  JOURNAL   Nature 411 (6840), 965-969 (2001)
   PUBMED   11418863
REFERENCE   8  (bases 1 to 2034)
  AUTHORS   Lowe LA, Yamada S and Kuehn MR.
  TITLE     Genetic dissection of nodal function in patterning the mouse embryo
  JOURNAL   Development 128 (10), 1831-1843 (2001)
   PUBMED   11311163
REFERENCE   9  (bases 1 to 2034)
  AUTHORS   Sirard C, de la Pompa JL, Elia A, Itie A, Mirtsos C, Cheung A, Hahn
            S, Wakeham A, Schwartz L, Kern SE, Rossant J and Mak TW.
  TITLE     The tumor suppressor gene Smad4/Dpc4 is required for gastrulation
            and later for anterior development of the mouse embryo
  JOURNAL   Genes Dev 12 (1), 107-119 (1998)
   PUBMED   9420335
REFERENCE   10 (bases 1 to 2034)
  AUTHORS   Conlon FL, Lyons KM, Takaesu N, Barth KS, Kispert A, Herrmann B and
            Robertson EJ.
  TITLE     A primary requirement for nodal in the formation and maintenance of
            the primitive streak in the mouse
  JOURNAL   Development 120 (7), 1919-1928 (1994)
   PUBMED   7924997
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474016.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_228285.4, XM_001055479.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN11044071
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2034
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..2034
                     /gene="Nodal"
                     /note="nodal growth differentiation factor"
                     /db_xref="GeneID:294503"
                     /db_xref="RGD:1305994"
     exon            1..482
                     /gene="Nodal"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1351
                     /gene="Nodal"
                     /codon_start=1
                     /product="nodal homolog precursor"
                     /protein_id="NP_001099864.1"
                     /db_xref="GeneID:294503"
                     /db_xref="RGD:1305994"
                     /translation="MSVHCLPVLLLQTCWTLLHPRVATAAALPLWTRGQPSSPSPLAY
                     MLSLYRDPLPRADIIRSLQAQDVDVTGQNWTFTFDFSFLSQEEDLVWAELRLQLLSPM
                     DSPTKGPLTIDIFHQAKPDPEQDPADCLERVWMERITVTPSQVTFASDSTVLEVTKPL
                     SKWLKDPRALEKQVSSQAGKCWHQSHTQPVPVTSTSVLMLYSNRPQEQRQLGGATLLW
                     EAESSWRAQEGQLSVERSGWGRRQRRHHLPDRSQLCRRVKFQVDFNLIGWGSWIIYPK
                     QYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLYVD
                     NGRVLLEHHKDMIVEECGCL"
     exon            483..1198
                     /gene="Nodal"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..2034
                     /gene="Nodal"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtctcagc aggaagactt ggggtagagg ggcaaggtgc ggaacagcct agactcagcc
       61 tctgtatcca cgccccccac accccccccc gccccggtcc caatttatca gaagtctttc
      121 tcagcacatc acacctcctc ccagcaggga ctcccctgcc ctgcccctcc agggggtgtt
      181 ataggttctt aaggtttctt cggagggagg aagggagggg gggcggggcg gcggcggctc
      241 agatataagg gacccgggcg ttgttggaga gtccaattag cccaccatga gtgtccactg
      301 ccttcccgtt cttcttctcc aaacctgctg gaccctactc cacccgcgcg tcgcgaccgc
      361 ggccgctttg cctctgtgga cacgggggca gccctcgtca ccgtcccctc tggcgtacat
      421 gttgagcctc taccgagacc ctctgcctcg ggcggacatc atccgcagcc tccaggcgca
      481 agatgtggat gtgactgggc agaactggac cttcacgttt gacttctcct ttttgagcca
      541 agaagaggat ctggtatggg cggagctccg gttgcagctg ctcagcccta tggacagccc
      601 caccaagggt ccactcacca ttgacatttt ccaccaggcc aagccggatc cagagcagga
      661 cccggctgac tgcctggagc gtgtttggat ggagaggatc accgtcactc cttctcaggt
      721 cacgtttgcc tcagacagca cagtcctaga ggtgaccaag ccactctcca agtggctaaa
      781 ggaccccagg gcactggaga agcaggtgtc cagtcaagca ggaaagtgtt ggcatcagtc
      841 ccacacccag cctgtccctg tcaccagtac cagtgtgctc atgctttact ccaaccggcc
      901 tcaggagcag aggcagctgg ggggcgccac tttgctctgg gaagcggaga gctcctggcg
      961 ggcccaggag ggacagctgt ccgtagagag gagtggatgg ggcagaaggc aacgccgcca
     1021 tcatttgcca gacagaagcc aactatgtag gagggtcaag ttccaggtgg acttcaacct
     1081 gattggctgg ggctcctgga tcatctaccc gaagcagtac aatgcctatc gctgtgaggg
     1141 cgagtgtcct aaccctgtgg gggaggagtt tcaccctacc aaccacgcct atatccagag
     1201 cctgctgaaa cgttaccagc cccaccgggt tccttctaca tgctgtgctc ccgtgaagac
     1261 caagccactg agcatgcttt atgtggacaa tggcagggtc ctcctggaac accacaagga
     1321 catgattgtg gaggagtgtg ggtgcctctg acagagccag gaggaatgct gaatcatcgg
     1381 cttgccctcc acaatgctgg tgaactctaa ggagactcca ttgtgtctat ccggggagca
     1441 gaagtggaag agctctgcct gctggagcta taggagaagg ccccgccccc tgtgcataca
     1501 gggctcttag acccaacaag ccagaggcta ctgtgggaag gcaggattgg gaagccttgc
     1561 aagggctggc tgggctccct ggaaacagag tttatgaact gcttaaaagt gtgcaaaggc
     1621 tggagtgtat attatatata tatgtattta tttttgaggc catctgtagc ttttttgtat
     1681 tctcaaaagt ggtctgtgac ctgctgtccc tccctcaaga ttagtataat tttattagat
     1741 taaaactagc catttcgctc tccctgcttc aagctgggct aggggagccc cacaactttt
     1801 tggctggctg actggcagtg acaagctggc cttggtcagg gtctctctga tctccaatga
     1861 gttgcctaaa caataaagtc actgtccagt tctccagggc cagctggtgc ctttggccag
     1921 aaaggtgggc acttgtccaa gaggggactg gccatggtgg actttagaag ccagagccct
     1981 cggatgtctg cttggcagac acaacccaag tctattaaaa gtcagtgaca attc
//
