LOCUS       NM_001414911            4584 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus nucleotide-binding oligomerization domain
            containing 2 (Nod2), mRNA.
ACCESSION   NM_001414911 XM_039097570
VERSION     NM_001414911.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4584)
  AUTHORS   Hu J, Dusenge MA, Ye Q, Zhao YQ, Tan L, Feng Y, Zhao J, Gao ZR,
            Zhang SH, Chen Y, Zhou YH, Guo Y and Feng YZ.
  TITLE     Role of NOD2 and hepcidin in inflammatory periapical periodontitis
  JOURNAL   BMC Oral Health 22 (1), 263 (2022)
   PUBMED   35764993
  REMARK    GeneRIF: Role of NOD2 and hepcidin in inflammatory periapical
            periodontitis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4584)
  AUTHORS   Men H, Hankins MA, Bock AS, Beaton BP, Davis DJ, Chesney KL and
            Bryda EC.
  TITLE     Mutational analyses of novel rat models with targeted modifications
            in inflammatory bowel disease susceptibility genes
  JOURNAL   Mamm Genome 32 (3), 173-182 (2021)
   PUBMED   33843019
  REMARK    GeneRIF: Mutational analyses of novel rat models with targeted
            modifications in inflammatory bowel disease susceptibility genes.
REFERENCE   3  (bases 1 to 4584)
  AUTHORS   Lu Y, Zheng Y, Coyaud E, Zhang C, Selvabaskaran A, Yu Y, Xu Z, Weng
            X, Chen JS, Meng Y, Warner N, Cheng X, Liu Y, Yao B, Hu H, Xia Z,
            Muise AM, Klip A, Brumell JH, Girardin SE, Ying S, Fairn GD, Raught
            B, Sun Q and Neculai D.
  TITLE     Palmitoylation of NOD1 and NOD2 is required for bacterial sensing
  JOURNAL   Science 366 (6464), 460-467 (2019)
   PUBMED   31649195
REFERENCE   4  (bases 1 to 4584)
  AUTHORS   Xu,S., Wei,S., Guo,Y., Cui,D. and Yao,J.
  TITLE     Involvement of Nucleotide-Binding and Oligomerization Domain-Like
            Receptors in the Intestinal Injury of Severe Acute Pancreatitis in
            Rats
  JOURNAL   Pancreas 47 (2), 245-251 (2018)
   PUBMED   29303910
  REMARK    GeneRIF: Data show that mRNA expression and protein levels of
            nucleotide-binding oligomerization domain-containing proteins
            (NOD1, NOD2) and NLR family, pyrin domain containing 3 protein
            (NLRP3) were significantly increased in the severe acute
            pancreatitis (SAP) models.
REFERENCE   5  (bases 1 to 4584)
  AUTHORS   Layunta E, Latorre E, Forcen R, Grasa L, Castro M, Arias MA,
            Alcalde AI and Mesonero JE.
  TITLE     NOD2 Modulates Serotonin Transporter and Interacts with TLR2 and
            TLR4 in Intestinal Epithelial Cells
  JOURNAL   Cell Physiol Biochem 47 (3), 1217-1229 (2018)
   PUBMED   29913461
  REMARK    GeneRIF: NOD2 could play a role in intestinal pathophysiology not
            only through its inherent innate immune role but also due to its
            interaction with other receptors as TLR2 and the modulation of the
            intestinal serotonergic system decreasing SERT activity and
            expression.
REFERENCE   6  (bases 1 to 4584)
  AUTHORS   Girardin SE, Boneca IG, Viala J, Chamaillard M, Labigne A, Thomas
            G, Philpott DJ and Sansonetti PJ.
  TITLE     Nod2 is a general sensor of peptidoglycan through muramyl dipeptide
            (MDP) detection
  JOURNAL   J Biol Chem 278 (11), 8869-8872 (2003)
   PUBMED   12527755
REFERENCE   7  (bases 1 to 4584)
  AUTHORS   Miceli-Richard C, Lesage S, Rybojad M, Prieur AM, Manouvrier-Hanu
            S, Hafner R, Chamaillard M, Zouali H, Thomas G and Hugot JP.
  TITLE     CARD15 mutations in Blau syndrome
  JOURNAL   Nat Genet 29 (1), 19-20 (2001)
   PUBMED   11528384
REFERENCE   8  (bases 1 to 4584)
  AUTHORS   Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton
            H, Moran T, Karaliuskas R, Duerr RH, Achkar JP, Brant SR, Bayless
            TM, Kirschner BS, Hanauer SB, Nunez G and Cho JH.
  TITLE     A frameshift mutation in NOD2 associated with susceptibility to
            Crohn's disease
  JOURNAL   Nature 411 (6837), 603-606 (2001)
   PUBMED   11385577
REFERENCE   9  (bases 1 to 4584)
  AUTHORS   Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J,
            Almer S, Tysk C, O'Morain CA, Gassull M, Binder V, Finkel Y, Cortot
            A, Modigliani R, Laurent-Puig P, Gower-Rousseau C, Macry J,
            Colombel JF, Sahbatou M and Thomas G.
  TITLE     Association of NOD2 leucine-rich repeat variants with
            susceptibility to Crohn's disease
  JOURNAL   Nature 411 (6837), 599-603 (2001)
   PUBMED   11385576
REFERENCE   10 (bases 1 to 4584)
  AUTHORS   Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S and Nunez G.
  TITLE     Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes
            and activates NF-kappaB
  JOURNAL   J Biol Chem 276 (7), 4812-4818 (2001)
   PUBMED   11087742
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000306.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001414911.2.
            
            On Dec 14, 2022 this sequence version replaced XM_039097570.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5756307, SAMEA5760383
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JACYVU010000306.1  623270-623315       c
            47-513              JACYVU010000306.1  617248-617714       c
            514-619             JACYVU010000306.1  609932-610037       c
            620-2432            JACYVU010000306.1  605110-606922       c
            2433-2516           JACYVU010000306.1  600425-600508       c
            2517-2600           JACYVU010000306.1  600171-600254       c
            2601-2684           JACYVU010000306.1  598217-598300       c
            2685-2768           JACYVU010000306.1  595886-595969       c
            2769-2852           JACYVU010000306.1  595351-595434       c
            2853-2936           JACYVU010000306.1  588968-589051       c
            2937-3020           JACYVU010000306.1  586505-586588       c
            3021-3694           JACYVU010000306.1  584101-584774       c
            3695-4584           JACYVU010000306.1  582906-583795       c
FEATURES             Location/Qualifiers
     source          1..4584
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..4584
                     /gene="Nod2"
                     /gene_synonym="Card15"
                     /note="nucleotide-binding oligomerization domain
                     containing 2"
                     /db_xref="GeneID:291912"
                     /db_xref="RGD:1306368"
     exon            1..46
                     /gene="Nod2"
                     /gene_synonym="Card15"
                     /inference="alignment:Splign:2.1.0"
     exon            47..513
                     /gene="Nod2"
                     /gene_synonym="Card15"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..3093
                     /gene="Nod2"
                     /gene_synonym="Card15"
                     /note="caspase recruitment domain family, member 15"
                     /codon_start=1
                     /product="nucleotide-binding oligomerization
                     domain-containing protein 2"
                     /protein_id="NP_001401840.1"
                     /db_xref="GeneID:291912"
                     /db_xref="RGD:1306368"
                     /translation="MCSQEDFQAQRSQLVALLVSGSLEGFESILDWLLSWDVLSREDY
                     EGLSLPGQPLSHSARRLLDTVCNKGVWGCQKLFEAVQEAQANSHTFELQGCWDVHSLH
                     PTRDLQSHRPAIVRRLCSHVEAILELARDEGFLSQYECEEIRLPIFTSSQRARRLLDL
                     AAVKANGLAAFLLQHVRKLPASLSLPYEAAECQKFTAKLRTMVSAQSRFLSTYDGSEN
                     LCLEDIYTENTLELRTEVGTAGALQKSPATLGLEELFGTHGHLNKDADTILVVGEAGS
                     GKSTLLQRLHLLWASGQNFREFLFIFPFSCRQLQCMTKPLSLRTLLFEHCCWPDVGQD
                     DVFQFLLDHPDRVLLTFDGLDEFKFRFTDRERHCSPLDPTSVQTLLFNLLQGNLLKNA
                     CKVLTSRPDAVSALLRKFVRTECHLKGFSEEGIKLYLRKHHREPGVADRLIHLIQATS
                     ALHGLCHLPVFSWMVSRCHRELLLQNRGFPTTSTDMYLLILQHFLLHASPPDSFPLGL
                     GPGLLQSRLSTLLHLGHLALQGLAMSCYVFSAQQLQAAQVDSEDISLGFLVRAQSVVP
                     GSKAPLEFLHITFQCFFAAFYLAVSADTSAASLKHLFSCGRPGNSLLLRLLPNLCIQG
                     SRVKGGQAALLQKAEPHNLQITAAFLAGLLSQQHRDLLAACQVPERVLLQRQARARSC
                     LAHSLREHFHSIPPAVPGETKSMHAMPGFIWLIRSLYEMQEVQLAREAVRRLDIGHLK
                     LTFCRVGPAECAALAFVLQHLQRPVALQLDHNSVGDVGVEQLLPCLGVCTALYLRDNN
                     ISDRGARTLVECALRCEQLQKLALFNNKLTDGCASSVAKLLAHKQNFLSLRVGNNHIT
                     AAGAEVLAQGLKSNTSLQFLGFWGNSVGDKGSQALAEVVADHQRLKWLSLVGNNIGSV
                     GAHALALMLEKNKSLEELCLEENHICDEGVYSLAEGLKRNSTLKFLKLSNNGITYRGA
                     EALLQALNRNSTVLEVWLRGNTFSPEEAQTLSSSDARLLL"
     exon            514..619
                     /gene="Nod2"
                     /gene_synonym="Card15"
                     /inference="alignment:Splign:2.1.0"
     exon            620..2432
                     /gene="Nod2"
                     /gene_synonym="Card15"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2516
                     /gene="Nod2"
                     /gene_synonym="Card15"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2600
                     /gene="Nod2"
                     /gene_synonym="Card15"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2684
                     /gene="Nod2"
                     /gene_synonym="Card15"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2768
                     /gene="Nod2"
                     /gene_synonym="Card15"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2852
                     /gene="Nod2"
                     /gene_synonym="Card15"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..2936
                     /gene="Nod2"
                     /gene_synonym="Card15"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..3020
                     /gene="Nod2"
                     /gene_synonym="Card15"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3694
                     /gene="Nod2"
                     /gene_synonym="Card15"
                     /inference="alignment:Splign:2.1.0"
     exon            3695..4584
                     /gene="Nod2"
                     /gene_synonym="Card15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtcactac cgggctgtct gaggaacctc tgcgcagcag ctggcggttg tgacatgtgc
       61 tcacaggaag acttccaggc ccagaggagc cagctggtgg cactgttggt ctcagggtcc
      121 ttggagggct ttgagagcat cttagactgg ctgctgtctt gggatgtgct ctccagggag
      181 gactatgagg gcctcagcct ccctgggcaa cctctctccc attctgccag gcgtctgctg
      241 gacacagtct gcaacaaggg tgtttggggc tgtcagaagc tcttcgaagc tgtgcaggag
      301 gcccaggcca acagtcacac ctttgaactg caagggtgct gggacgttca ctcccttcat
      361 cccaccagag acctgcagag tcaccggcca gcaattgtac ggaggctctg cagccatgta
      421 gaagccatat tggagctggc aagggatgag gggtttctga gccagtacga atgtgaggag
      481 atcaggttgc caatcttcac atcatcccag agggcaagaa gactgcttga tctcgccgca
      541 gtgaaggcaa atggactggc cgccttcctt ctacagcacg tcaggaaatt accagcctca
      601 ctgtctctgc cttacgaggc tgctgagtgt cagaagttca ctgctaagct gaggaccatg
      661 gtgtcagctc agtctcgctt cctcagtact tacgatgggt cggagaatct ttgcctggag
      721 gatatctaca cggagaacac cttagagctg cggacagagg tgggcacagc gggggccttg
      781 cagaagagcc ctgccaccct gggcctggag gaactctttg gaacccacgg ccacctgaac
      841 aaagacgccg acactatact ggtggtgggc gaagcgggca gcggcaagag cacccttctg
      901 caacgtttgc acttgttgtg ggcatcaggg cagaacttcc gagagttcct cttcattttc
      961 ccattcagct gccggcagct gcaatgcatg accaaacctc tgtccctgag gacactgctc
     1021 tttgagcatt gctgttggcc tgatgtcggt caggatgacg tcttccagtt cctccttgac
     1081 catcctgacc gtgtcctgtt aacctttgat ggcttggatg agttcaagtt ccggttcaca
     1141 gaccgggagc gccactgctc tccgctcgac cccacgtcag tccagactct gcttttcaac
     1201 cttcttcagg ggaacctgct gaagaatgcc tgcaaggtac tgaccagccg tccagacgcc
     1261 gtgtcagcgc tcctcagaaa gttcgtccgg acagagtgcc accttaaggg cttctccgaa
     1321 gagggcatca aactgtacct gagaaagcac caccgggaac ccggggtggc agaccgcctc
     1381 atccacctga tccaagctac ctcagccctg cacggtttgt gccacctccc tgtcttctca
     1441 tggatggtgt ccagatgtca ccgagagctg ttgctacaga acaggggctt cccaacaacc
     1501 agcacggaca tgtacctctt gatcctacag catttcctgc tgcacgcctc ccctccggac
     1561 tccttccccc ttggtctggg acctggactc ctccaaagcc ggctctccac cctcctgcac
     1621 cttggccacc tggctctcca gggcctggcc atgagctgct atgtgttctc agcccagcag
     1681 ctgcaggcag cacaggtgga ctctgaggat atttctcttg gtttcctggt acgcgcccaa
     1741 agtgtggtgc ccgggagcaa ggcacccctg gaattcttgc acattacctt ccagtgcttt
     1801 tttgccgcgt tctacttggc tgtcagtgct gacacatcgg cggcctctct caagcacctc
     1861 ttcagctgcg gccggccggg caactcactg ctgctaaggc tgctgcccaa cctgtgtatc
     1921 cagggctcca gagtcaaggg cggccaagca gctctgctgc agaaggctga gccgcacaac
     1981 ctgcagatca cagcagcctt cctagcgggt ctgttgtccc agcagcatcg ggacctgttg
     2041 gctgcatgcc aggtccctga gagggtgctg ctccagcgtc aggcccgtgc ccgctcctgc
     2101 ctggcacaca gcctccggga gcacttccat tccatcccgc cggccgtgcc cggtgagacc
     2161 aagagcatgc atgctatgcc cggcttcatt tggctcatcc ggagcctgta cgagatgcag
     2221 gaggtgcagt tggcccggga ggctgtccgt cgcttggaca ttgggcacct gaagttgacg
     2281 ttttgcaggg tgggccctgc agagtgcgct gccctggcct ttgtgctgca gcatctgcag
     2341 cggcctgtgg ccctgcagtt ggaccacaac tccgttggcg atgtcggagt ggaacagctg
     2401 ctgccatgcc tcggcgtctg cacagctctg tacttgcgag ataacaacat ctccgatcga
     2461 ggtgcccgca cgctggttga gtgtgctctt cgctgtgaac agctgcagaa gctagctctc
     2521 ttcaacaaca aactcactga tggctgtgcc tcctccgtgg ccaagctcct tgcacacaag
     2581 cagaacttcc tatctctgag ggtggggaac aatcacatca ctgctgctgg ggctgaggtg
     2641 ctggcccagg gactcaagag caacacctcc ctgcagttcc tggggttctg gggcaacagt
     2701 gtaggtgata agggctccca agccctggct gaagttgtgg ctgatcacca gaggctaaag
     2761 tggctcagcc tggtaggaaa caacattggc agcgtgggtg cccacgccct agccctgatg
     2821 ctggagaaga acaagtcact agaggagctc tgcctagagg aaaaccatat ctgtgacgaa
     2881 ggggtgtatt ctcttgcaga aggactgaag agaaattcaa ctttgaaatt cttgaaactg
     2941 tccaacaatg gcattaccta ccggggcgca gaagccctcc tgcaggccct taacaggaac
     3001 agcactgttc tggaggtttg gctccgaggg aacacattct ctccggagga agcccaaaca
     3061 ctcagttcca gtgatgccag actcctgctg tgacctctca gcctgtgagt gggcgatgga
     3121 ggcctggact ctggaggatg cataacatca ggatgtatcc ctgtgttact cagggctgga
     3181 ttttgttttt ctgggctcag tatagtcacc ttcggctagc agagaaaggc accccagtgc
     3241 cttctggaat tgacttttcc caaggaggca tgatggttgg tcttggttgt taactgaact
     3301 gacttaagag actcgtgaga ggagaggacc cccgtttctg cctctagaga ggatcatcat
     3361 gtaggactag caactggaag gggaaagatc ctcactgcat gtgggttatg caaccctccg
     3421 cgtgccccac gggggaagtt gaaggaggag gaagaaagcg ggttcgtgag ctcctcttct
     3481 gagtgaggac atttatggct gctgctgtca tgtttgaaca ccagactcca gtgtcgttgg
     3541 cgtttcaaca tagaccagtg atggtttagg gagtttcagg cctgaagctt gatggaactc
     3601 tggctggggg atctgtcgtg cttcttcggc tgggcagtta gcaggttctc tgcccttcca
     3661 gatggccact gttggactac ccagtccggg tggtactcca agcatgggag atgagttcaa
     3721 gaagatccct cggttactat gttgctggct tctggctggg tggccagggt tctgatgggg
     3781 gtcagtggga cgcttggaca ttaactgagt gcctgttgtt gtggagacct ggatccatgt
     3841 agaagacccc tccctcctct ttttttaagg aggagtattc aggaagcagc tctgttcatg
     3901 tctgaattca gcttaccctc taaggccgtc ccactccgta accccccact ccccctgcat
     3961 gaggcctaaa gggcctccac tcagacaacc aacctgatac cctgctctct tttctcaaca
     4021 caaacaacag ccatttgccc tcaggatgtt ctagatttac aaggaaaact gggaccacac
     4081 tgcagccagg atcacacatg acctttggtt tccagtaaca tcaattactc catggctaag
     4141 cctttggaat cagttcctcc cccaactgca gctctttaga attaatctgg gccagaattt
     4201 caaacaaccc caccaggccc tgagccactg cctgtgaact gaactgtgaa tatggacttc
     4261 tgaaacatat tcatgaaaga cagcccttct tatttatgac agaatgcttt aggacataga
     4321 gttggtgggg ggggggcggg tttggaggtt tggaggggac aaagccaagc cttttcttct
     4381 gagcaaagtc tttttgtgtt tttttttttt caaaatctca cctttgtaat tatttaatta
     4441 tacacatttt tctacctttc attttatttt gtgcaaaagt gggttaatat ttataaatga
     4501 cattgcttta ctttgagttg gtgcttttta cggaggatgc gatcatgaac ttcctgctat
     4561 aaataatcac agaggtgaaa gcta
//
