LOCUS       NM_001109236            4110 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus nucleotide-binding oligomerization domain
            containing 1 (Nod1), mRNA.
ACCESSION   NM_001109236 XM_001058165 XM_575485
VERSION     NM_001109236.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4110)
  AUTHORS   Liu C, Yang Y, Liang G, Zhang A and Xu F.
  TITLE     MiR-702-3p inhibits the inflammatory injury in septic H9c2 cells by
            regulating NOD1
  JOURNAL   Transpl Immunol 70, 101493 (2022)
   PUBMED   34774740
  REMARK    GeneRIF: MiR-702-3p inhibits the inflammatory injury in septic H9c2
            cells by regulating NOD1.
REFERENCE   2  (bases 1 to 4110)
  AUTHORS   Ma X, Zhang W, Xu C, Zhang S, Zhao J, Pan Q and Wang Z.
  TITLE     Nucleotide-binding oligomerization domain protein 1 enhances
            oxygen-glucose deprivation and reperfusion injury in cortical
            neurons via activation of endoplasmic reticulum stress-mediated
            autophagy
  JOURNAL   Exp Mol Pathol 117, 104525 (2020)
   PUBMED   32888957
  REMARK    GeneRIF: Nucleotide-binding oligomerization domain protein 1
            enhances oxygen-glucose deprivation and reperfusion injury in
            cortical neurons via activation of endoplasmic reticulum
            stress-mediated autophagy.
REFERENCE   3  (bases 1 to 4110)
  AUTHORS   Lu Y, Zheng Y, Coyaud E, Zhang C, Selvabaskaran A, Yu Y, Xu Z, Weng
            X, Chen JS, Meng Y, Warner N, Cheng X, Liu Y, Yao B, Hu H, Xia Z,
            Muise AM, Klip A, Brumell JH, Girardin SE, Ying S, Fairn GD, Raught
            B, Sun Q and Neculai D.
  TITLE     Palmitoylation of NOD1 and NOD2 is required for bacterial sensing
  JOURNAL   Science 366 (6464), 460-467 (2019)
   PUBMED   31649195
REFERENCE   4  (bases 1 to 4110)
  AUTHORS   Xu,S., Wei,S., Guo,Y., Cui,D. and Yao,J.
  TITLE     Involvement of Nucleotide-Binding and Oligomerization Domain-Like
            Receptors in the Intestinal Injury of Severe Acute Pancreatitis in
            Rats
  JOURNAL   Pancreas 47 (2), 245-251 (2018)
   PUBMED   29303910
  REMARK    GeneRIF: Data show that mRNA expression and protein levels of
            nucleotide-binding oligomerization domain-containing proteins
            (NOD1, NOD2) and NLR family, pyrin domain containing 3 protein
            (NLRP3) were significantly increased in the severe acute
            pancreatitis (SAP) models.
REFERENCE   5  (bases 1 to 4110)
  AUTHORS   Hosokawa Y, Hirao K, Yumoto H, Washio A, Nakanishi T, Takegawa D,
            Kitamura C and Matsuo T.
  TITLE     Functional Roles of NOD1 in Odontoblasts on Dental Pulp Innate
            Immunity
  JOURNAL   Biomed Res Int 2016, 9325436 (2016)
   PUBMED   27747243
  REMARK    GeneRIF: These findings indicated that NOD1 expressed in
            odontoblasts functions to upregulate the chemokines expression via
            p38-AP-1 signaling pathway and suggested that NOD1 may play
            important roles in the initiation and progression of pulpitis.
REFERENCE   6  (bases 1 to 4110)
  AUTHORS   Eder W, Klimecki W, Yu L, von Mutius E, Riedler J, Braun-Fahrlander
            C, Nowak D, Holst O and Martinez FD.
  CONSRTM   ALEX-Team
  TITLE     Association between exposure to farming, allergies and genetic
            variation in CARD4/NOD1
  JOURNAL   Allergy 61 (9), 1117-1124 (2006)
   PUBMED   16918516
REFERENCE   7  (bases 1 to 4110)
  AUTHORS   Hysi P, Kabesch M, Moffatt MF, Schedel M, Carr D, Zhang Y, Boardman
            B, von Mutius E, Weiland SK, Leupold W, Fritzsch C, Klopp N, Musk
            AW, James A, Nunez G, Inohara N and Cookson WO.
  TITLE     NOD1 variation, immunoglobulin E and asthma
  JOURNAL   Hum Mol Genet 14 (7), 935-941 (2005)
   PUBMED   15718249
REFERENCE   8  (bases 1 to 4110)
  AUTHORS   Opitz B, Forster S, Hocke AC, Maass M, Schmeck B, Hippenstiel S,
            Suttorp N and Krull M.
  TITLE     Nod1-mediated endothelial cell activation by Chlamydophila
            pneumoniae
  JOURNAL   Circ Res 96 (3), 319-326 (2005)
   PUBMED   15653568
REFERENCE   9  (bases 1 to 4110)
  AUTHORS   Opitz B, Puschel A, Schmeck B, Hocke AC, Rosseau S, Hammerschmidt
            S, Schumann RR, Suttorp N and Hippenstiel S.
  TITLE     Nucleotide-binding oligomerization domain proteins are innate
            immune receptors for internalized Streptococcus pneumoniae
  JOURNAL   J Biol Chem 279 (35), 36426-36432 (2004)
   PUBMED   15215247
REFERENCE   10 (bases 1 to 4110)
  AUTHORS   Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R,
            Merino J, Liu D, Ni J and Nunez G.
  TITLE     Nod1, an Apaf-1-like activator of caspase-9 and nuclear
            factor-kappaB
  JOURNAL   J Biol Chem 274 (21), 14560-14567 (1999)
   PUBMED   10329646
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474011.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_575485.2, XM_001058165.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4110
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..4110
                     /gene="Nod1"
                     /gene_synonym="RGD1562269"
                     /note="nucleotide-binding oligomerization domain
                     containing 1"
                     /db_xref="GeneID:500133"
                     /db_xref="RGD:1562269"
     exon            1..109
                     /gene="Nod1"
                     /gene_synonym="RGD1562269"
                     /inference="alignment:Splign:2.1.0"
     exon            110..429
                     /gene="Nod1"
                     /gene_synonym="RGD1562269"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..3090
                     /gene="Nod1"
                     /gene_synonym="RGD1562269"
                     /codon_start=1
                     /product="nucleotide-binding oligomerization
                     domain-containing protein 1"
                     /protein_id="NP_001102706.1"
                     /db_xref="GeneID:500133"
                     /db_xref="RGD:1562269"
                     /translation="MEKRGQHEMEGVPAGCHSHIKLLRINREHLVTNIRNTQCLVDNL
                     LENGYFSAEDAEIVCACPTQPDKVRKILDLVQSKGEEVSEFFLYVLQQLEDAYVDLRL
                     WLSEIGFSPSQLIRTKTIVNTDPVSRYTQQLRHQLGRDSKFMLCYAQKEDLLLEETYM
                     DTLMELVGFNNENLGSLGGLDCLLDHSTGVLNEHGETVFVFGDAGVGKSMLLQRLQSL
                     WASGRLASKAKFFFHFRCRMFSCFKESDTLTLQDLLFKHFCYPEQDPEEVFSFLLRFP
                     HTALFTFDGLDELHSDFDMSRVPDSCCPWEPAHPLVLLANLLSGRLLKGAGKLLTART
                     GVEVPRQLLRKKVLLRGFSPSHLRAYARRMFPERTAQEHLLQQLDANPNLCSLCGVPL
                     FCWIIFRCFQHFHTAFEGSSQLPDCAVTLTDVFLLVTEVHLNRTQPISLMQRNTRSPA
                     ETLRAGWRTLQALGEVAHRGTDRSLFVFGQEEVQASKLQEGDLQLGFLRALPDVGPEQ
                     SQQSYEFFHLTLQAFFTAFFLVADDKVSTQELLRFFREWTSPGEATSRSCYPSFFSFQ
                     CLGSGSRLGPDPFKNKDHFQFTNLFLCGLLAKARQKLLQQLVPKAILRKKRKALWAHL
                     FASLRSYLKSLPRVQSDGFNQVHAMPTFLWMLRCIYETQSQKVGRLAARGISADYLKL
                     AFCNACSADCSALSFVLHHFHRQLALDLDNNNLNDYGVRELQPCFSRLTVIRLSVNQI
                     TDMGVKVLCEELTKYKIVTFLGLYNNQITDIGARYVAQILDECRGLTHLKLGKNRITS
                     EGGRCVAQAVKNSTSIVEVGMWGNQIGDEGAKAFAEALRDHPSLTTLSLAFNGISPEG
                     GKSLAQALKQNTTLTIIWLTKNELNDEAAECFAEMLRVNQTLKHLWLIQNHITAEGTA
                     QLARALQKNTTITEICLNGNLIKPEEAKVFENEKRIICF"
     exon            430..604
                     /gene="Nod1"
                     /gene_synonym="RGD1562269"
                     /inference="alignment:Splign:2.1.0"
     exon            605..2429
                     /gene="Nod1"
                     /gene_synonym="RGD1562269"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..2513
                     /gene="Nod1"
                     /gene_synonym="RGD1562269"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2597
                     /gene="Nod1"
                     /gene_synonym="RGD1562269"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2681
                     /gene="Nod1"
                     /gene_synonym="RGD1562269"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2765
                     /gene="Nod1"
                     /gene_synonym="RGD1562269"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2849
                     /gene="Nod1"
                     /gene_synonym="RGD1562269"
                     /inference="alignment:Splign:2.1.0"
     exon            2850..2933
                     /gene="Nod1"
                     /gene_synonym="RGD1562269"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3017
                     /gene="Nod1"
                     /gene_synonym="RGD1562269"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..4110
                     /gene="Nod1"
                     /gene_synonym="RGD1562269"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgagcggc agtgctgctg tgccgccaga tctgcgaccc tagtccagga tccctgtgct
       61 gagagccgcc gtactccagg gccacctgag ccaaagtcct gccaacttgg gtcagcaatg
      121 aaaggcggga tcctgggtgg tggccctgaa tcctgaccgc ctgtctgcca gcgagaccca
      181 tgtggtcaaa gatgaatttg aggaaagtag cggctggcta ctcgaacaat ggagaagcgc
      241 ggccaacatg agatggaagg cgtcccagcc ggttgtcact cccacattaa actgttgagg
      301 atcaacaggg aacacctggt caccaacatt cggaacactc agtgcctggt ggacaacttg
      361 ctggagaacg gttacttctc agccgaggat gcagagatcg tgtgtgcttg tcctacccag
      421 cctgacaagg tccgaaagat ccttgacctg gtgcagagca aaggtgagga ggtgtctgag
      481 ttcttcctct acgtgctaca gcagctggag gatgcttacg tggacctcag gctgtggcta
      541 tcagagattg gcttctcccc ttcccagctc atccggacca aaactatcgt caatactgac
      601 ccagtaagca ggtataccca gcagctgcga caccaactgg gccgcgattc caagttcatg
      661 ctgtgctacg ctcagaagga ggacctgctg ctggaggaga cctatatgga cacactcatg
      721 gagctggtag gcttcaacaa tgaaaacctg ggcagcctag gaggcctgga ttgcctgctg
      781 gaccacagca caggtgtcct caacgagcat ggcgagactg tcttcgtgtt cggggacgcg
      841 ggagttggca agtccatgtt gctacagagg ttgcagagcc tctgggcgtc tggcaggctg
      901 gcctcaaaag ccaaattctt cttccacttt cgctgccgta tgttcagctg cttcaaggag
      961 agcgacacat tgactctgca agacctgctc ttcaagcatt tctgctaccc ggagcaggac
     1021 cccgaggagg tgttctcctt cttgctgcgc tttccccaca cagcgctctt cacttttgac
     1081 ggcctggatg agctgcactc agacttcgac atgagccgcg tgccggacag ctgctgcccc
     1141 tgggagccgg cgcaccctct ggtcctgcta gctaacctcc taagcgggag gttgctcaag
     1201 ggtgcgggca aactgctcac tgctcgcaca ggcgtggagg tcccccgcca gctcctgcgc
     1261 aaaaaggtgc tgctccgggg tttttccccc agccacctga gagcctatgc ccgccggatg
     1321 ttccccgagc gcaccgcgca ggaacatctg ctgcagcagc tggatgccaa ccccaacctc
     1381 tgcagcctgt gcggggtgcc gctcttctgc tggatcatct tccgatgttt ccagcatttc
     1441 cacacggcct tcgagggctc ctcgcagctg ccggactgcg ctgtgaccct gaccgatgtc
     1501 tttctgctgg tcaccgaggt gcatctgaac aggacgcagc ccatcagcct gatgcagcga
     1561 aacacgcgca gcccggcgga aaccctacgt gcaggctggc gcacgctgca ggcgctggga
     1621 gaggtggctc accgaggcac ggacaggagt ctctttgtgt ttggccagga ggaggtgcag
     1681 gcgtcgaaac tgcaggaagg ggatctgcag ctgggtttcc tgcgggcttt gcccgatgtg
     1741 ggccctgaac aaagtcagca gtcttatgaa tttttccacc ttacgctcca ggctttcttc
     1801 actgccttct tcctggtagc agatgacaaa gtgagcaccc aggaattgct aaggttcttt
     1861 cgagaatgga cgtctcccgg ggaggcaaca agcaggtcct gctatccttc cttcttctcc
     1921 ttccagtgcc tgggtagcgg tagccggttg ggccctgatc ctttcaagaa caaagatcac
     1981 ttccagttca ccaacctctt cttgtgcggg ctgctggcca aagcccgaca gaaactcctt
     2041 cagcagctgg tgcccaaggc tatcctaagg aagaagcgca aggccctgtg ggctcacctg
     2101 tttgccagcc tgcgctccta cttgaagagc ctaccccggg tccagtctga tgggtttaac
     2161 caggtacatg ccatgcccac attcctgtgg atgctgcgct gcatctatga gacacagagt
     2221 cagaaggtgg ggcgcttagc cgccaggggc atcagtgcgg actacctcaa gctagccttc
     2281 tgcaatgctt gttctgccga ctgtagtgcc ttgtccttcg tcctgcatca cttccacaga
     2341 cagctggccc tagacctgga caacaacaac ctcaatgact atggagttcg agagctgcag
     2401 ccttgcttta gccgtctcac ggttatcaga ctcagtgtca accagatcac cgacatgggg
     2461 gtgaaggtgc tgtgtgagga actgaccaag tacaaaatcg tgacattctt gggtttatac
     2521 aacaaccaga tcactgatat cggagccagg tatgtggccc aaatcctgga tgaatgcaga
     2581 ggcctcacgc accttaaact ggggaaaaac agaataacaa gtgagggcgg caggtgtgtg
     2641 gcccaggctg tgaagaacag cacctccatt gttgaggttg ggatgtgggg caatcagatt
     2701 ggagacgagg gagcaaaagc cttcgcagag gcgctgaggg accaccccag cctgaccact
     2761 cttagtcttg cattcaatgg catctccccg gagggaggga agagccttgc acaggccctg
     2821 aagcagaaca ccactctgac aataatctgg ctgaccaaaa atgaacttaa tgatgaggcc
     2881 gcagagtgct tcgccgagat gctgagggtg aaccagacac tgaagcattt atggctaatc
     2941 cagaatcata tcacagctga ggggacagcc cagctggcca gggcactgca gaagaatacc
     3001 accatcacag agatttgcct caatggaaac ttaattaagc ccgaggaggc caaagtcttt
     3061 gaaaatgaga agcggatcat ctgtttctga tgggcattcc tgggctagat ctttgtcctg
     3121 ggttgttcct cagttgcagc cagcactgtg cagccagcag ggaagcggga tgctgtgcag
     3181 ggcctgcagc aaggtgcctg ccaggagctc acacctccac agtgcaagct gacctcacct
     3241 gcagatgctt ggactggtag caccggagca tggctgagac tgcagaaaca gagtgtttca
     3301 tgagccattg tcaccactca aaacagcaag gcattttctg tactaagatc tcccctcata
     3361 ctgattagtc tgaagctgaa ggaacgaaac agcagaggag gccaaactca gttcccacag
     3421 atgcctgggg actccatggg accgatgatg tcaccttcgg gaaagagctg ggaacttgag
     3481 cagagccaat ggcaacttct tgggggaaag aaggcacccg gtgaccacgt gactatcctg
     3541 aaacctcctt cctctgctta gtacctctca ctgtacagat ctgtttcctc cccacagctg
     3601 tggctgctga agtaggtcca ccatggggag gctcatctga ggacccacag gttgtcaaag
     3661 gctcgtcaca gactctggtt tggttggttc tggattctca ctggcggcaa acaagagtca
     3721 gagaacatcc tcgaagtcag tctcggagga tctccatgct gtgagaggac tgaggtccca
     3781 cccagaattt ttaccaatct ctgctgggtg aaatctctca gggagaatca gttcccaccc
     3841 ttcacagcag caggcacggc ttgcctcgat ggacctgaga tcccagcata actctttccc
     3901 ctgcctgtga gcaggaagta ccttcacatc cacagcagcg ggagggtgac tgaccacagc
     3961 taagacctag agaaccagca aagcatgcca gacatccacc tccgtcccat ggtgggcatt
     4021 tggggatgcc ggtggggtgg gacggttggg atgttgccag ataacatgtt cttttgccac
     4081 ttcatttgtt aataaaatat taaaaatgct
//
