LOCUS       NM_138526               2609 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus nocturnin (Noct), mRNA.
ACCESSION   NM_138526 XM_001055998 XM_227134
VERSION     NM_138526.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2609)
  AUTHORS   Estrella,M.A., Du,J., Chen,L., Rath,S., Prangley,E., Chitrakar,A.,
            Aoki,T., Schedl,P., Rabinowitz,J. and Korennykh,A.
  TITLE     The metabolites NADP+ and NADPH are the targets of the circadian
            protein Nocturnin (Curled)
  JOURNAL   Nat Commun 10 (1), 2367 (2019)
   PUBMED   31147539
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2609)
  AUTHORS   Nishikawa,S., Hatanaka,Y., Tokoro,M., Shin,S.W., Shimizu,N.,
            Nishihara,T., Kato,R., Takemoto,A., Amano,T., Anzai,M.,
            Kishigami,S., Hosoi,Y. and Matsumoto,K.
  TITLE     Functional analysis of nocturnin, a circadian deadenylase, at
            maternal-to-zygotic transition in mice
  JOURNAL   J Reprod Dev 59 (3), 258-265 (2013)
   PUBMED   23449310
REFERENCE   3  (bases 1 to 2609)
  AUTHORS   Niu,S., Shingle,D.L., Garbarino-Pico,E., Kojima,S., Gilbert,M. and
            Green,C.B.
  TITLE     The circadian deadenylase Nocturnin is necessary for stabilization
            of the iNOS mRNA in mice
  JOURNAL   PLoS One 6 (11), e26954 (2011)
   PUBMED   22073225
REFERENCE   4  (bases 1 to 2609)
  AUTHORS   Kawai,M., Delany,A.M., Green,C.B., Adamo,M.L. and Rosen,C.J.
  TITLE     Nocturnin suppresses igf1 expression in bone by targeting the 3'
            untranslated region of igf1 mRNA
  JOURNAL   Endocrinology 151 (10), 4861-4870 (2010)
   PUBMED   20685873
REFERENCE   5  (bases 1 to 2609)
  AUTHORS   Kawai,M., Green,C.B., Lecka-Czernik,B., Douris,N., Gilbert,M.R.,
            Kojima,S., Ackert-Bicknell,C., Garg,N., Horowitz,M.C., Adamo,M.L.,
            Clemmons,D.R. and Rosen,C.J.
  TITLE     A circadian-regulated gene, Nocturnin, promotes adipogenesis by
            stimulating PPAR-gamma nuclear translocation
  JOURNAL   Proc Natl Acad Sci U S A 107 (23), 10508-10513 (2010)
   PUBMED   20498072
REFERENCE   6  (bases 1 to 2609)
  AUTHORS   Zheng,D., Ezzeddine,N., Chen,C.Y., Zhu,W., He,X. and Shyu,A.B.
  TITLE     Deadenylation is prerequisite for P-body formation and mRNA decay
            in mammalian cells
  JOURNAL   J Cell Biol 182 (1), 89-101 (2008)
   PUBMED   18625844
REFERENCE   7  (bases 1 to 2609)
  AUTHORS   Garbarino-Pico,E., Niu,S., Rollag,M.D., Strayer,C.A., Besharse,J.C.
            and Green,C.B.
  TITLE     Immediate early response of the circadian polyA ribonuclease
            nocturnin to two extracellular stimuli
  JOURNAL   RNA 13 (5), 745-755 (2007)
   PUBMED   17400819
REFERENCE   8  (bases 1 to 2609)
  AUTHORS   Volkman,B.F., Prehoda,K.E., Scott,J.A., Peterson,F.C. and Lim,W.A.
  TITLE     Structure of the N-WASP EVH1 domain-WIP complex: insight into the
            molecular basis of Wiskott-Aldrich Syndrome
  JOURNAL   Cell 111 (4), 565-576 (2002)
   PUBMED   12437929
REFERENCE   9  (bases 1 to 2609)
  AUTHORS   Wang,Y., Osterbur,D.L., Megaw,P.L., Tosini,G., Fukuhara,C.,
            Green,C.B. and Besharse,J.C.
  TITLE     Rhythmic expression of Nocturnin mRNA in multiple tissues of the
            mouse
  JOURNAL   BMC Dev Biol 1, 9 (2001)
   PUBMED   11394964
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Mar 22, 2008 this sequence version replaced
            XM_227134.4, XM_001055998.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.9345.1,
                                           SRR26643289.6181.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-406               JAXUCZ010000002.1  137422074-137422479
            407-676             JAXUCZ010000002.1  137438131-137438400
            677-2609            JAXUCZ010000002.1  137440350-137442282
FEATURES             Location/Qualifiers
     source          1..2609
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..2609
                     /gene="Noct"
                     /gene_synonym="Ccr4; Ccrn4l; Ccrn4lb"
                     /note="nocturnin"
                     /db_xref="GeneID:310395"
                     /db_xref="RGD:1587344"
     exon            1..406
                     /gene="Noct"
                     /gene_synonym="Ccr4; Ccrn4l; Ccrn4lb"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1512
                     /gene="Noct"
                     /gene_synonym="Ccr4; Ccrn4l; Ccrn4lb"
                     /EC_number="3.1.3.108"
                     /note="nocturin; CCR4 protein homolog; carbon catabolite
                     epression 4 homolog; CCR4 carbon catabolite repression
                     4-like B; circadian deadenylase NOC; carbon catabolite
                     repression 4-like protein"
                     /codon_start=1
                     /product="nocturnin"
                     /protein_id="NP_612535.1"
                     /db_xref="GeneID:310395"
                     /db_xref="RGD:1587344"
                     /translation="MYQSPRRLCSALLLRDAPGLRRTLVPGPRRTLAPPVLGSRPASP
                     QLQAAASGAARSRPRTVSPMGNGTSRLYSALAKTINSSAAAQHPEYLVSADPEHLEPI
                     DPKELLEECRAVLHTRPPRYQRDFVDLRTDCSSSHPPIRVMQWNILAQALGEGKDNFV
                     QCPVEALKWEERKCLILEEILAYQPDILCLQEVDHYFDTFQPLLSRLGYQGTFFPKPW
                     SPCLDVEHNNGPDGCALFFLQSRFKLINSTNIRLTAMTLKTNQVAIAQTLECKESGRQ
                     FCIAVTHLKARTGWERFRSAQGCDLLQNLQNITEGAKIPLIVCGDFNAEPTEEVYKHF
                     ASSSLNLNSAYKLLSPDGQSEPPYTTWKIRTSGECRHTLDYIWYSRHALSVTSALDLL
                     TEEQIGPNRLPSFHYPSDHLSLVCDFSFNEEPDELL"
     exon            407..676
                     /gene="Noct"
                     /gene_synonym="Ccr4; Ccrn4l; Ccrn4lb"
                     /inference="alignment:Splign:2.1.0"
     exon            677..2609
                     /gene="Noct"
                     /gene_synonym="Ccr4; Ccrn4l; Ccrn4lb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcagcgtg gtagcgctcg ccccgccgcc gctcgccggt tgctccccgg cgctagccag
       61 ctcgcctcag tgagccactg ccgccgccgc gtccgcctca ctacactgct tgcccggtcg
      121 gcgccgaggg acgaggagga aggagcacac cgcagcgcag cggtcccaaa cctccaccgc
      181 cgcccgcctc gctcggcccg gctcgtcagc gcggcggcgc ccggcatgta tcagagcccg
      241 cggcggctct gctcggccct gctgctcagg gacgcccccg gcctgcgccg cacactcgtg
      301 cccggcccgc gccgaacgct cgccccgccg gtgctcggat cccggcccgc gtccccacaa
      361 ctgcaggcgg cggcctcggg cgccgcgagg tcgcgtcccc gaacagtgag tcccatggga
      421 aacggcacca gccggctgta cagcgccctc gccaagacca tcaacagcag tgcagccgct
      481 cagcacccgg agtatttggt gtcagctgac cccgaacatc tggagcccat cgatcctaag
      541 gaacttctcg aggaatgcag ggctgtgctg catacccggc caccccgata ccagagggat
      601 tttgtggacc tgaggacaga ttgctccagt agccatcctc ccattagagt tatgcagtgg
      661 aacatcctcg ctcaagctct cggggaaggc aaagacaact ttgtccagtg tcctgtggaa
      721 gccctcaaat gggaggagag gaaatgcctt atcctggagg aaatcctggc ttaccagcca
      781 gatatattat gcctccaaga agtggaccac tattttgaca ccttccaacc actccttagt
      841 agactgggct atcaaggcac atttttcccc aagccctggt caccatgtct agatgtggag
      901 cacaacaatg gtccagatgg ctgtgcctta ttttttctcc aaagccgatt caagctcatc
      961 aacagcacca atattaggct gacagccatg accctaaaaa ccaatcaggt ggccattgca
     1021 cagaccctgg agtgcaagga gtctgggcga cagttctgca ttgctgtcac ccacttaaaa
     1081 gcacgcactg gctgggagcg gttccgatca gctcagggat gtgacctcct ccagaacctg
     1141 cagaacatca cagagggcgc aaagatcccg ctgatagtct gcggggactt caatgcagag
     1201 ccaaccgaag aggtctacaa acactttgct tcctccagcc tcaacctcaa cagcgcctac
     1261 aagctcctga gccccgatgg acagtcagag cctccctaca caacctggaa gatccggacc
     1321 tcaggggagt gtcgccacac gctggactac atctggtact ccagacatgc tctgagtgtc
     1381 acgtctgctc tggacctgct caccgaagaa cagattgggc ctaaccggct cccatccttc
     1441 cattaccctt cagaccacct gtcactagtg tgtgacttca gctttaacga ggagcctgat
     1501 gaacttttat aaaccctttc atcttagcca caagagtctt aaccagggat gttttgggaa
     1561 actgaactag gataggaaat tgcctggaaa aggacaccca gtttctgcca cttaactctc
     1621 catttccagc atgcccatgg gaaaaatatc gttcacaaac ctttccagtt aaaacctgca
     1681 ttgagaaggt gtttgcactc cagtccgagt gtgtgctgtc atccgtgtac cgtcctctcc
     1741 ccgttagggg catgagtagc ataggctttc ttgtgtttta gttgagggta ttctaaagcc
     1801 cagtttgtga gcccttcaga attcaaagta agatgtagga agttttctag agatcatttc
     1861 aagttattta tttgtgggat ttttaaatgt cagtgggaaa tgcatggtaa tatttatttt
     1921 ttatatcttc atgtaaaatt tcgtggatta tatagcattg tggacatttt agaaccatgc
     1981 aggtacagac ttaattcctt aaaacttaaa aaggatttta tttgctgatc tgacagaatg
     2041 tacactaagg aactatttac ccctggggga tttgtggctt catatgaatg ttcttcacaa
     2101 ataatccgtt tgctatgcct ccaacttcct cattgtgttt cagagattct gtagcgttcg
     2161 gttctagttt ccactgtagt cactgtcggg tatttgtgcc ttttctgttg tgatgacatt
     2221 ggtagatgtg aagattactc catcacttct tctgcaatgt gctttttaca agtagcttga
     2281 gaacagttgc taagaatatt agtgagacat cctatcaaga tgccaggtgt gatcccaaca
     2341 ctcagctgag acaaggaagt ctgtcttgga ggccagcttg ggctgtatat caagaccctc
     2401 tctcaaaaaa aatcccgaag acagccagat gattgggttc aaattttcta aaaaaaaatg
     2461 taagagtcaa aaagataacc tggagttctc ttccaattgt tgaagcctct tccaaacaaa
     2521 ataactgacc agtgtggtaa gatggtaaat agcttaatgt ctgagttctg aatattacct
     2581 aatattaata aacgaactta caaacactg
//
