LOCUS       NM_001192013            1575 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus NOBOX oogenesis homeobox (Nobox), mRNA.
ACCESSION   NM_001192013 XM_578257
VERSION     NM_001192013.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1575)
  AUTHORS   Ferrari,I., Bouilly,J., Beau,I., Guizzardi,F., Ferlin,A.,
            Pollazzon,M., Salerno,M., Binart,N., Persani,L. and Rossetti,R.
  TITLE     Impaired protein stability and nuclear localization of NOBOX
            variants associated with premature ovarian insufficiency
  JOURNAL   Hum Mol Genet 25 (23), 5223-5233 (2016)
   PUBMED   27798098
REFERENCE   2  (bases 1 to 1575)
  AUTHORS   Choi,M., Lee,O.H., Jeon,S., Park,M., Lee,D.R., Ko,J.J., Yoon,T.K.,
            Rajkovic,A. and Choi,Y.
  TITLE     The oocyte-specific transcription factor, Nobox, regulates the
            expression of Pad6, a peptidylarginine deiminase in the oocyte
  JOURNAL   FEBS Lett 584 (16), 3629-3634 (2010)
   PUBMED   20659469
  REMARK    Erratum:[FEBS Lett. 2010 Nov 5;584(21):4490]
REFERENCE   3  (bases 1 to 1575)
  AUTHORS   Monti,M. and Redi,C.
  TITLE     Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and
            Oogenesin2) are differentially expressed during natural and
            gonadotropin-induced mouse follicular development
  JOURNAL   Mol Reprod Dev 76 (10), 994-1003 (2009)
   PUBMED   19480014
REFERENCE   4  (bases 1 to 1575)
  AUTHORS   Choi,Y., Qin,Y., Berger,M.F., Ballow,D.J., Bulyk,M.L. and
            Rajkovic,A.
  TITLE     Microarray analyses of newborn mouse ovaries lacking Nobox
  JOURNAL   Biol Reprod 77 (2), 312-319 (2007)
   PUBMED   17494914
  REMARK    Erratum:[Biol Reprod. 2008 Feb;78(2):378]
REFERENCE   5  (bases 1 to 1575)
  AUTHORS   Gazdag,E., Rajkovic,A., Torres-Padilla,M.E. and Tora,L.
  TITLE     Analysis of TATA-binding protein 2 (TBP2) and TBP expression
            suggests different roles for the two proteins in regulation of gene
            expression during oogenesis and early mouse development
  JOURNAL   Reproduction 134 (1), 51-62 (2007)
   PUBMED   17641088
REFERENCE   6  (bases 1 to 1575)
  AUTHORS   Choi,Y. and Rajkovic,A.
  TITLE     Characterization of NOBOX DNA binding specificity and its
            regulation of Gdf9 and Pou5f1 promoters
  JOURNAL   J Biol Chem 281 (47), 35747-35756 (2006)
   PUBMED   16997917
REFERENCE   7  (bases 1 to 1575)
  AUTHORS   Rajkovic,A., Pangas,S.A., Ballow,D., Suzumori,N. and Matzuk,M.M.
  TITLE     NOBOX deficiency disrupts early folliculogenesis and
            oocyte-specific gene expression
  JOURNAL   Science 305 (5687), 1157-1159 (2004)
   PUBMED   15326356
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 17, 2010 this sequence version replaced XM_578257.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                JAXUCZ010000004.1  73134395-73134431   c
            38-328              JAXUCZ010000004.1  73132350-73132640   c
            329-433             JAXUCZ010000004.1  73132144-73132248   c
            434-540             JAXUCZ010000004.1  73131698-73131804   c
            541-647             JAXUCZ010000004.1  73131281-73131387   c
            648-733             JAXUCZ010000004.1  73130936-73131021   c
            734-965             JAXUCZ010000004.1  73130477-73130708   c
            966-1270            JAXUCZ010000004.1  73129857-73130161   c
            1271-1575           JAXUCZ010000004.1  73128926-73129230   c
FEATURES             Location/Qualifiers
     source          1..1575
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..1575
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /note="NOBOX oogenesis homeobox"
                     /db_xref="GeneID:502759"
                     /db_xref="RGD:1563929"
     CDS             1..1575
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /codon_start=1
                     /product="homeobox protein NOBOX"
                     /protein_id="NP_001178942.1"
                     /db_xref="GeneID:502759"
                     /db_xref="RGD:1563929"
                     /translation="MEPPEKLCRKMRGQEAGDKPRTAAQDTEGPPQDPAPLVQGDPDK
                     LSSLPRAGLGKRPLSKTSGDCIDADTCRVHTAPSPAVCSPKPQKKGSSLQEKKAETVK
                     PSMSAGPGQVPNPLNFRERDLKKEPLEATCQFRKKTRTLYRSDQLEELERIFQEDHYP
                     DSDKRHEIAQMVGVTPQRIMVWFQNRRAKWRKVEKLNEKEDNNGPAPPRANSSQCRSA
                     PELLGPMPTDLEPGPVPPENILDGFTEPPVLLTSDQTLTSSQHNESAERVAVTPPLLS
                     PPPIRRTNLPLPLGPFQAPQVLPPLRDVPGSDSIYKDKPCGSWGTSITSPPIYSNLED
                     MGPQDYQASNQLGSFQLTQAPQTPLFPPLQSQVPYLPPFPLPIPSPLPFLPPEDSLFS
                     FPFGLNGDSSQDYYPGPQSGQILLQPTAGNTGPGPWSGHCLPEPPFPRPHHPQGHPLG
                     AEGYFPDLFPTPCAPTLSKQPSLGLSGLLGGTRAVTGTSISKMPDEQTSSSLEQPAPE
                     EVRDKNKDSQVGGAKE"
     exon            1..37
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /inference="alignment:Splign:2.1.0"
     exon            38..328
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /inference="alignment:Splign:2.1.0"
     exon            329..433
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /inference="alignment:Splign:2.1.0"
     exon            434..540
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /inference="alignment:Splign:2.1.0"
     exon            541..647
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /inference="alignment:Splign:2.1.0"
     exon            648..733
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /inference="alignment:Splign:2.1.0"
     exon            734..965
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1270
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1575
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggaacctc cggagaagct ctgtaggaaa atgcggggcc aggaagctgg tgacaagccc
       61 aggactgctg cacaggacac agagggacca ccacaggatc ctgccccact tgtccaaggt
      121 gacccagaca agctgtcctc actccccagg gctggcttgg gaaagaggcc actgtcaaag
      181 acctctgggg attgcattga tgctgacacc tgtagagtgc acacagcccc ctcaccagct
      241 gtgtgtagtc ccaaacccca gaaaaaaggt tcttctctcc aagagaaaaa ggcagagaca
      301 gtgaagccat ccatgtctgc aggcccaggc caagtcccaa atcccctcaa ctttcgagag
      361 agggacctga agaaggaacc cctagaagca acctgtcagt ttcggaaaaa gactcgaacc
      421 ctgtaccgct cagaccagct ggaagagctg gaacggatat tccaggaaga ccactatcct
      481 gacagtgaca aacgccatga gattgcccag atggtggggg tgactcccca acgcatcatg
      541 gtgtggtttc agaaccgtag ggcaaagtgg cgaaaagtag agaaactaaa cgagaaggaa
      601 gataataatg gtcctgcacc cccgagggct aacagcagcc agtgcagatc tgcacctgag
      661 ctcctaggtc ctatgcctac agacctagaa cctggccctg ttcctccaga gaacattctg
      721 gatggcttta ctgagccccc cgtgctgctg acttcggacc agactctaac gtcctctcag
      781 cacaatgaga gtgctgagag ggtggcagtg actccaccac tcctcagtcc cccacctatt
      841 cgaaggacca accttcctct tcctctgggt ccctttcaag ctcctcaagt gctacctccg
      901 ctgagggatg ttcctggcag tgacagcata tacaaggaca agccctgtgg gtcctggggt
      961 actagtatca cctcacctcc catctactca aatttggaag acatgggacc tcaggattac
     1021 caagcaagca accagctggg ttcgttccag ctcacccagg ctccacagac cccccttttc
     1081 ccaccccttc agtcccaggt tccgtatctg cctcccttcc ctctccctat cccaagccca
     1141 ctgccatttc taccaccaga agactctctg ttttcatttc ctttcggcct caatggggac
     1201 tcatcacagg attattaccc agggccccaa tcaggtcaga tcttgctgca gccaacagct
     1261 ggaaacacgg gtccaggacc ctggagcggc cattgtttgc cagaacctcc cttccctcgc
     1321 ccacaccacc cacagggaca ccccctaggg gcagagggct attttcctga cttgtttccc
     1381 actccatgtg ctccaactct gagcaagcag ccttcattag gcctaagtgg gcttctcgga
     1441 ggcactagag cagtgacagg gacctcgata agcaaaatgc cagatgagca gacttcctct
     1501 tcccttgagc agcctgcacc agaggaggtc agagacaaaa ataaggatag ccaagttggt
     1561 ggagctaagg agtaa
//
