LOCUS       NM_199086               1547 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus NIN1 (RPN12) binding protein 1 homolog (Nob1),
            mRNA.
ACCESSION   NM_199086 XM_214674
VERSION     NM_199086.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1547)
  AUTHORS   Henras,A.K., Plisson-Chastang,C., O'Donohue,M.F., Chakraborty,A.
            and Gleizes,P.E.
  TITLE     An overview of pre-ribosomal RNA processing in eukaryotes
  JOURNAL   Wiley Interdiscip Rev RNA 6 (2), 225-242 (2015)
   PUBMED   25346433
  REMARK    Review article
REFERENCE   2  (bases 1 to 1547)
  AUTHORS   Zemp,I., Wandrey,F., Rao,S., Ashiono,C., Wyler,E., Montellese,C.
            and Kutay,U.
  TITLE     CK1delta and CK1epsilon are components of human 40S subunit
            precursors required for cytoplasmic 40S maturation
  JOURNAL   J Cell Sci 127 (Pt 6), 1242-1253 (2014)
   PUBMED   24424021
REFERENCE   3  (bases 1 to 1547)
  AUTHORS   Preti,M., O'Donohue,M.F., Montel-Lehry,N., Bortolin-Cavaille,M.L.,
            Choesmel,V. and Gleizes,P.E.
  TITLE     Gradual processing of the ITS1 from the nucleolus to the cytoplasm
            during synthesis of the human 18S rRNA
  JOURNAL   Nucleic Acids Res 41 (8), 4709-4723 (2013)
   PUBMED   23482395
REFERENCE   4  (bases 1 to 1547)
  AUTHORS   Sloan,K.E., Mattijssen,S., Lebaron,S., Tollervey,D., Pruijn,G.J.
            and Watkins,N.J.
  TITLE     Both endonucleolytic and exonucleolytic cleavage mediate ITS1
            removal during human ribosomal RNA processing
  JOURNAL   J Cell Biol 200 (5), 577-588 (2013)
   PUBMED   23439679
REFERENCE   5  (bases 1 to 1547)
  AUTHORS   Lei,B.
  TITLE     Rod-driven OFF pathway responses in the distal retina: dark-adapted
            flicker electroretinogram in mouse
  JOURNAL   PLoS One 7 (8), e43856 (2012)
   PUBMED   22937111
REFERENCE   6  (bases 1 to 1547)
  AUTHORS   Han,Y., Hong,L., Chen,Y., Zhong,C., Wang,Y., Zhao,D., Xue,T.,
            Qiao,L. and Qiu,J.
  TITLE     Up-regulation of Nob1 in the rat auditory system with noise-induced
            hearing loss
  JOURNAL   Neurosci Lett 491 (1), 79-82 (2011)
   PUBMED   21219967
  REMARK    GeneRIF: Nob1 may play an important role in auditory function
            following acoustic trauma.
REFERENCE   7  (bases 1 to 1547)
  AUTHORS   Fatica,A., Oeffinger,M., Dlakic,M. and Tollervey,D.
  TITLE     Nob1p is required for cleavage of the 3' end of 18S rRNA
  JOURNAL   Mol Cell Biol 23 (5), 1798-1807 (2003)
   PUBMED   12588997
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY341886.1.
            
            On Jan 1, 2004 this sequence version replaced XM_214674.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY341886.1, BC126076.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1547
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1547
                     /gene="Nob1"
                     /gene_synonym="Nob1p"
                     /note="NIN1 (RPN12) binding protein 1 homolog"
                     /db_xref="GeneID:291996"
                     /db_xref="RGD:735222"
     exon            1..71
                     /gene="Nob1"
                     /gene_synonym="Nob1p"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..1241
                     /gene="Nob1"
                     /gene_synonym="Nob1p"
                     /note="nin one binding protein; NIN1/PSMD8 binding protein
                     1 homolog"
                     /codon_start=1
                     /product="RNA-binding protein NOB1"
                     /protein_id="NP_954517.1"
                     /db_xref="GeneID:291996"
                     /db_xref="RGD:735222"
                     /translation="MAPVEHVVADAGAFLRDAPLQDIGKNIYTIREVVREIRDKATRR
                     RLAVLPYELRFKEPFPEYVRLVTEFSKKTGDYPSLSATDIQVLALTYQLEAEFVGVSH
                     LKKEPEKVKVSSSIQHPETPLHISGFHLPSKSKALQETVDHGPPADGSENLEFSSFMF
                     WRNPLPNIDHELQQLLIDGREEEEEEEEEEEEEDELEDSDDDGGGWITPSNIKQIQHE
                     SEQCDIPKDVQVGCVTTDFAMQNVLLQMGLHVLAVNGMLVREARSYILRCHGCFKTTS
                     DMNRVFCGHCGNKTLKKVSVTINDDGTLHMHFSRNPKVLNPRGLRYSLPTPKGGKYAV
                     NPHLTEDQRFPQLRLSHKARQKTNVFAPDYIAGVSPFAENDISSRSAILQVRDSMLGA
                     GRRRLNPNASRKKFVKKR"
     exon            72..204
                     /gene="Nob1"
                     /gene_synonym="Nob1p"
                     /inference="alignment:Splign:2.1.0"
     exon            205..335
                     /gene="Nob1"
                     /gene_synonym="Nob1p"
                     /inference="alignment:Splign:2.1.0"
     exon            336..407
                     /gene="Nob1"
                     /gene_synonym="Nob1p"
                     /inference="alignment:Splign:2.1.0"
     exon            408..536
                     /gene="Nob1"
                     /gene_synonym="Nob1p"
                     /inference="alignment:Splign:2.1.0"
     exon            537..728
                     /gene="Nob1"
                     /gene_synonym="Nob1p"
                     /inference="alignment:Splign:2.1.0"
     exon            729..826
                     /gene="Nob1"
                     /gene_synonym="Nob1p"
                     /inference="alignment:Splign:2.1.0"
     exon            827..971
                     /gene="Nob1"
                     /gene_synonym="Nob1p"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1529
                     /gene="Nob1"
                     /gene_synonym="Nob1p"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagccaacat ggcgcctgtg gagcacgttg tggctgacgc cggagctttc ttgagggatg
       61 cgcctctaca ggacatcgga aaaaacatct acaccatccg ggaggtggtg agagagattc
      121 gcgacaaggc cacacgcagg cggctggcag tgctgcccta cgagctgcgg ttcaaggaac
      181 ccttcccgga gtacgtgagg ctagtaactg agttttccaa gaaaactggg gactacccca
      241 gcctctctgc cacagatatc caggtgctgg ctctgaccta ccagctggaa gcagaatttg
      301 ttggggtgtc tcatctaaag aaagaaccag agaaggttaa agtgagctct tcaattcagc
      361 accctgaaac tcctctgcac atttctggtt tccatctgcc ctccaagtct aaagccttac
      421 aagaaacggt ggatcatggt cccccagctg atgggtctga gaacctggaa ttcagctcct
      481 tcatgttctg gaggaaccct ctgcctaaca ttgaccatga gctgcagcag ctgctgattg
      541 atggaaggga ggaggaagag gaagaggagg aggaggagga ggaagaagat gaacttgaag
      601 acagtgatga cgatgggggt gggtggataa cccccagcaa catcaagcag atccagcatg
      661 agtcagagca gtgcgacatc ccaaaggacg tgcaggttgg ctgtgtgacc acagacttcg
      721 ccatgcagaa tgttctactt cagatggggc tgcacgtgct ggcagtgaac ggcatgctgg
      781 tccgagaggc ccggagctac atcttgcgct gtcatggctg tttcaagaca acatcggaca
      841 tgaaccgagt gttctgtggg cattgtggga acaagaccct gaagaaagtg tctgtgacta
      901 tcaatgatga cggtaccttg cacatgcatt tctcccgaaa cccgaaagtt ctgaatcctc
      961 gaggcctccg gtactcacta cccactccaa aagggggcaa atatgccgtc aacccccacc
     1021 tgaccgagga tcagcgcttc ccccagctgc gactctccca caaggccagg cagaagacca
     1081 acgtgtttgc ccccgactac atagctgggg tttctccctt cgcagagaat gacatctcca
     1141 gccgctcagc catcctgcaa gtccgggaca gcatgttggg tgctgggagg agacgcttaa
     1201 atcccaatgc ttccagaaag aagtttgtaa agaaaaggtg acatcgtaag ccctgcaggc
     1261 aaagcagact ggctagctgc tgaggaggct gtagtgtcat ccccagtgtc tgctctgcaa
     1321 accatctaga cagaagcagt gggcctggct ctcccaactg cctgagactc tgttgtgtgg
     1381 ctttgcagtc tgatatggct gccccgtctg tgaatatgca gagccagggc tccaccatgg
     1441 gagggagctt ggagcaaagg ctgagcccag aagttcaaag gacaaataac cacacgataa
     1501 cctttttcta ataaacctga tggccagcga aaaaaaaaaa aaaaaaa
//
