LOCUS       NP_001013175            1086 aa            linear   ROD 22-MAR-2023
DEFINITION  NAD(P) transhydrogenase, mitochondrial [Rattus norvegicus].
ACCESSION   NP_001013175 XP_227084
VERSION     NP_001013175.1
DBSOURCE    REFSEQ: accession NM_001013157.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1086)
  AUTHORS   Picklo MJ and Thyfault JP.
  TITLE     Vitamin E and vitamin C do not reduce insulin sensitivity but
            inhibit mitochondrial protein expression in exercising obese rats
  JOURNAL   Appl Physiol Nutr Metab 40 (4), 343-352 (2015)
   PUBMED   25761734
REFERENCE   2  (residues 1 to 1086)
  AUTHORS   Lopert P and Patel M.
  TITLE     Nicotinamide nucleotide transhydrogenase (Nnt) links the substrate
            requirement in brain mitochondria for hydrogen peroxide removal to
            the thioredoxin/peroxiredoxin (Trx/Prx) system
  JOURNAL   J Biol Chem 289 (22), 15611-15620 (2014)
   PUBMED   24722990
  REMARK    GeneRIF: Nnt is the critical link between the metabolic and H2O2
            antioxidant function in brain mitochondria and is a potential
            therapeutic target to improve the redox balance in conditions of
            oxidative stress associated with neurodegenerative diseases.
REFERENCE   3  (residues 1 to 1086)
  AUTHORS   Meimaridou E, Kowalczyk J, Guasti L, Hughes CR, Wagner F, Frommolt
            P, Nurnberg P, Mann NP, Banerjee R, Saka HN, Chapple JP, King PJ,
            Clark AJ and Metherell LA.
  TITLE     Mutations in NNT encoding nicotinamide nucleotide transhydrogenase
            cause familial glucocorticoid deficiency
  JOURNAL   Nat Genet 44 (7), 740-742 (2012)
   PUBMED   22634753
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1086)
  AUTHORS   Yin F, Sancheti H and Cadenas E.
  TITLE     Silencing of nicotinamide nucleotide transhydrogenase impairs
            cellular redox homeostasis and energy metabolism in PC12 cells
  JOURNAL   Biochim Biophys Acta 1817 (3), 401-409 (2012)
   PUBMED   22198343
  REMARK    GeneRIF: Disruption of electron flux from fuel substrates to redox
            components due to NNT suppression induces not only mitochondrial
            dysfunction but also cellular disorders through redox-sensitive
            signaling.
REFERENCE   5  (residues 1 to 1086)
  AUTHORS   Houtkooper RH, Canto C, Wanders RJ and Auwerx J.
  TITLE     The secret life of NAD+: an old metabolite controlling new
            metabolic signaling pathways
  JOURNAL   Endocr Rev 31 (2), 194-223 (2010)
   PUBMED   20007326
  REMARK    Review article
REFERENCE   6  (residues 1 to 1086)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (residues 1 to 1086)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (residues 1 to 1086)
  AUTHORS   Da Cruz S, Xenarios I, Langridge J, Vilbois F, Parone PA and
            Martinou JC.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   9  (residues 1 to 1086)
  AUTHORS   White SA, Peake SJ, McSweeney S, Leonard G, Cotton NP and Jackson
            JB.
  TITLE     The high-resolution structure of the NADP(H)-binding component
            (dIII) of proton-translocating transhydrogenase from human heart
            mitochondria
  JOURNAL   Structure 8 (1), 1-12 (2000)
   PUBMED   10673423
REFERENCE   10 (residues 1 to 1086)
  AUTHORS   Arkblad EL, Helou K, Levan G and Rydstrom J.
  TITLE     Mapping of the rat and mouse nicotinamide nucleotide
            transhydrogenase gene
  JOURNAL   Mamm Genome 8 (9), 703 (1997)
   PUBMED   9271681
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091271.1.
            
            On Apr 20, 2005 this sequence version replaced XP_227084.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091271.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1086
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q15"
     Protein         1..1086
                     /product="NAD(P) transhydrogenase, mitochondrial"
                     /EC_number="1.6.1.2"
                     /note="Nicotinamide nucleotide transhydrogenase (NAD(P)+
                     transhydrogenase)"
                     /calculated_mol_wt=113739
     Region          57..587
                     /region_name="pntA"
                     /note="Re/Si-specific NAD(P)(+) transhydrogenase subunit
                     alpha; PRK09424"
                     /db_xref="CDD:236507"
     Region          622..1079
                     /region_name="PNTB"
                     /note="NAD(P) transhydrogenase beta subunit; pfam02233"
                     /db_xref="CDD:460502"
     CDS             1..1086
                     /gene="Nnt"
                     /coded_by="NM_001013157.1:144..3404"
                     /db_xref="GeneID:310378"
                     /db_xref="RGD:1587346"
ORIGIN      
        1 mahllktvvt gclcpsvsnl gsckvlpgkk dflrtfrthq alwckspakp gipykqltvg
       61 vpkeifqnek rvalspagvq alvkqgfnvv vesgageask fpddlyraag aqiqgtkevl
      121 asdlvvkvra pmvnptlgah eadflkpsgt lisfiypaqn pdllnklser kttvlamdqv
      181 prvtiaqgyd alssmanisg ykavvlaanh fgrfftgqit aagkvppaki livgggvagl
      241 asagaaksmg avvrgfdtra aaleqfkslg aeplevdlke sgegqggyak emskefieae
      301 mklfaqqcke vdilistali pgkkapvlfs kemiesmkeg svvvdlaaea ggnfettkpg
      361 elyvhkgith igytdlpsrm atqastlysn nitkllkais pdkdnfhfev kddfdfgtms
      421 hvirgtvvmk dgnvifpapt pknipkeapa kqktvaelea ekagtvsmyt ktlrtasvys
      481 agltgmlglg ivapnlafsq mvttfglagi igyhtvwgvt palhsplmsv tnaisgltav
      541 gglalmgghf ypsttsqsla alatfissvn iaggflvtqr mldmfkrptd ppeynylyll
      601 pggtfvggyl aalyggynie eimylgsglc cvgalgglst qgtarlgnal gmigvaggla
      661 atlgglkpdp qllaqmsgam amggtiglai akriqisdlp qlvaafhslv glaavltcma
      721 eyiveyphfa mdatsnftki vayigtyigg vtfsgslvay gklqgilksa plllpgrhal
      781 nagllaasvg giipfmadps fttgimclgs vsalstlmgv tltaaiggad mpvvitvlns
      841 ysgwalcaeg fllnnnllti vgaligssga ilsyimcvam nrslanvilg gygttstagg
      901 kpmeisgtht einldnavem ireansivit pgyglcaaka qypiadlvkm lteqgkkvrf
      961 gihpvagrmp gqlnvllaea gvpydivlem deinsdfpdt dlvlvigand tvnsaaqedp
     1021 nsiiagmpvl evwkskqviv mkrslgvgya avdnpifykp ntamllgdak ktcdalqakv
     1081 resyqk
//
