LOCUS       NM_001106819            1043 bp    mRNA    linear   ROD 06-OCT-2023
DEFINITION  Rattus norvegicus nicotinamide N-methyltransferase (Nnmt), mRNA.
ACCESSION   NM_001106819 XM_001066533 XM_217138
VERSION     NM_001106819.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1043)
  AUTHORS   Liu M, He A, Chu J, Chen C, Zhang S, He Y, Tao W, Lu M, Hua M, Ju W
            and Fang Z.
  TITLE     Serum N1-methylnicotinamide is Associated with Left Ventricular
            Systolic Dysfunction in Chinese
  JOURNAL   Sci Rep 8 (1), 8581 (2018)
   PUBMED   29872082
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1043)
  AUTHORS   Liu M, Chu J, Gu Y, Shi H, Zhang R, Wang L, Chen J, Shen L, Yu P,
            Chen X, Ju W and Wang Z.
  TITLE     Serum N1-Methylnicotinamide is Associated With Coronary Artery
            Disease in Chinese Patients
  JOURNAL   J Am Heart Assoc 6 (2), e004328 (2017)
   PUBMED   28174167
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1043)
  AUTHORS   Fedorowicz A, Mateuszuk L, Kopec G, Skorka T, Kutryb-Zajac B,
            Zakrzewska A, Walczak M, Jakubowski A, Lomnicka M, Slominska E and
            Chlopicki S.
  TITLE     Activation of the nicotinamide N-methyltransferase
            (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension
  JOURNAL   Respir Res 17 (1), 108 (2016)
   PUBMED   27581040
  REMARK    GeneRIF: Progression of pulmonary hypertension is associated with
            the activation of the NNMT-1-methylnicotinamide pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1043)
  AUTHORS   Sperber H, Mathieu J, Wang Y, Ferreccio A, Hesson J, Xu Z, Fischer
            KA, Devi A, Detraux D, Gu H, Battle SL, Showalter M, Valensisi C,
            Bielas JH, Ericson NG, Margaretha L, Robitaille AM, Margineantu D,
            Fiehn O, Hockenbery D, Blau CA, Raftery D, Margolin AA, Hawkins RD,
            Moon RT, Ware CB and Ruohola-Baker H.
  TITLE     The metabolome regulates the epigenetic landscape during
            naive-to-primed human embryonic stem cell transition
  JOURNAL   Nat Cell Biol 17 (12), 1523-1535 (2015)
   PUBMED   26571212
REFERENCE   5  (bases 1 to 1043)
  AUTHORS   Giuliante R, Sartini D, Bacchetti T, Rocchetti R, Kloting I,
            Polidori C, Ferretti G and Emanuelli M.
  TITLE     Potential involvement of nicotinamide N-methyltransferase in the
            pathogenesis of metabolic syndrome
  JOURNAL   Metab Syndr Relat Disord 13 (4), 165-170 (2015)
   PUBMED   25719492
REFERENCE   6  (bases 1 to 1043)
  AUTHORS   Yao M, Tabuchi H, Nagashima Y, Baba M, Nakaigawa N, Ishiguro H,
            Hamada K, Inayama Y, Kishida T, Hattori K, Yamada-Okabe H and
            Kubota Y.
  TITLE     Gene expression analysis of renal carcinoma: adipose
            differentiation-related protein as a potential diagnostic and
            prognostic biomarker for clear-cell renal carcinoma
  JOURNAL   J Pathol 205 (3), 377-387 (2005)
   PUBMED   15682440
REFERENCE   7  (bases 1 to 1043)
  AUTHORS   Scheller T, Orgacka H, Szumlanski CL and Weinshilboum RM.
  TITLE     Mouse liver nicotinamide N-methyltransferase pharmacogenetics:
            biochemical properties and variation in activity among inbred
            strains
  JOURNAL   Pharmacogenetics 6 (1), 43-53 (1996)
   PUBMED   8845860
REFERENCE   8  (bases 1 to 1043)
  AUTHORS   Seifert,R., Hoshino,J. and Kroger,H.
  TITLE     Nicotinamide methylation. Tissue distribution, developmental and
            neoplastic changes
  JOURNAL   Biochim Biophys Acta 801 (2), 259-264 (1984)
   PUBMED   6236853
REFERENCE   9  (bases 1 to 1043)
  AUTHORS   Ohkubo,M., Sakiyama,S. and Fujimura,S.
  TITLE     Increase of nicotinamide methyltransferase and
            N1-methyl-nicotinamide oxidase activities in the livers of the rats
            administered alkylating agents
  JOURNAL   Cancer Lett 21 (2), 175-181 (1983)
   PUBMED   6652621
REFERENCE   10 (bases 1 to 1043)
  AUTHORS   Hoshino,J., Kuhne,U. and Kroger,H.
  TITLE     Methylation of nicotinamide in rat liver cytosol and its
            correlation with hepatocellular proliferation
  JOURNAL   Biochim Biophys Acta 719 (3), 518-526 (1982)
   PUBMED   6217846
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473975.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001066533.1, XM_217138.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ218924.1, FQ218983.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1043
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..1043
                     /gene="Nnmt"
                     /note="nicotinamide N-methyltransferase"
                     /db_xref="GeneID:300691"
                     /db_xref="RGD:1309606"
     exon            1..349
                     /gene="Nnmt"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..990
                     /gene="Nnmt"
                     /EC_number="2.1.1.1"
                     /codon_start=1
                     /product="nicotinamide N-methyltransferase"
                     /protein_id="NP_001100289.1"
                     /db_xref="GeneID:300691"
                     /db_xref="RGD:1309606"
                     /translation="MESGFTSKDTYLSHFNPRDYLEKYYSFGSRHCAENEILRHLLKN
                     LFKIFCLDGVKGELLIDIGSGPTIYQLLSACESFTEIIVTDYTDQNLWELQKWLKKEP
                     GAFDWSPVVTYVCDLEGNRTKGPEKEEKLRRAIKQVLKCDVSQSQPLGGVSLPPADCL
                     LSTLCLDAACPDLPAYRTALRNLGSLLKPGGFLVMVDALKSSYYMIGEQKFSSLSLDR
                     EAVRDAVEEAGYTIEQFEVISQSYSSTTSNNEGLFSLVGRKPVGSE"
     exon            350..557
                     /gene="Nnmt"
                     /inference="alignment:Splign:2.1.0"
     exon            558..1043
                     /gene="Nnmt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttcctgga atagtctgaa catctgcagt ctattcactg ttaatattta gcaaacatat
       61 gtctctaagg catgggccga gctggaggaa gattgacagc tctaagactc caaaagccaa
      121 cttcacaggg tgactccctg cttctggagg aggagacagg agagcatcgg gctggtgcaa
      181 cagagctgag acacgatgga atctggcttc acctccaagg acacttatct aagtcatttt
      241 aatcctcgag attacttgga aaaatattac agctttgggt ccaggcactg tgcagaaaat
      301 gagatcctca gacatctgct gaaaaatctt tttaagatat tctgcctgga tggtgtaaag
      361 ggagaactcc tgattgacat tggctctggc ccaaccatct atcagcttct ctctgcctgc
      421 gagtccttca cggagatcat tgtcactgac tacacagacc agaacctctg ggagctgcag
      481 aagtggctga agaaggagcc aggagccttt gactggtccc cagtggtcac ctatgtgtgt
      541 gatcttgaag gcaacagaac caagggaccg gagaaggagg agaagttgag gcgagcaatc
      601 aagcaggtgc tgaagtgcga tgtgagccag agccagcctc tgggtggggt ctctctgcct
      661 cctgccgact gcctgctcag cacactgtgc ctggatgctg cctgccctga cctcccggcc
      721 tatcgcactg ccctcaggaa cctgggcagc ctgctcaagc cagggggctt cctggtgatg
      781 gtggacgctc ttaagagtag ctactacatg attggggaac agaagttttc cagcctttcc
      841 ctggaccggg aggctgttcg agatgccgtg gaagaggctg ggtacaccat cgagcagttc
      901 gaggtgattt ctcaaagtta ctcttctacc acatccaata atgaaggact cttctccctt
      961 gtggggcgaa agccggtggg atctgaatga cgtcctgtga tccccattaa aggcttgctg
     1021 gttcacttca ggctgcggct ctg
//
