LOCUS       NM_053601               1285 bp    mRNA    linear   ROD 06-FEB-2024
DEFINITION  Rattus norvegicus neuronatin (Nnat), transcript variant 1, mRNA.
ACCESSION   NM_053601
VERSION     NM_053601.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1285)
  AUTHORS   Kanno,N., Yoshida,S., Kato,T. and Kato,Y.
  TITLE     Characteristic Localization of Neuronatin in Rat Testis, Hair
            Follicle, Tongue, and Pancreas
  JOURNAL   J Histochem Cytochem 67 (7), 495-509 (2019)
   PUBMED   30869556
  REMARK    GeneRIF: Localization of Neuronatin in Rat Testis, Hair Follicle,
            Tongue, and Pancreas
REFERENCE   2  (bases 1 to 1285)
  AUTHORS   Kanno,N., Fujiwara,K., Yoshida,S., Kato,T. and Kato,Y.
  TITLE     Dynamic Changes in the Localization of Neuronatin-Positive Cells
            during Neurogenesis in the Embryonic Rat Brain
  JOURNAL   Cells Tissues Organs 207 (3-4), 127-137 (2019)
   PUBMED   31805566
  REMARK    GeneRIF: NNAT signals were broadly observed across the developing
            brain on embryonic day E13.5 and gradually more localized in later
            stages, eventually concentrated in the alar and basal parts of the
            terminal hypothalamus, the alar plate of prosomere 2 of the
            thalamus, and the choroid plexus in the lateral and fourth
            ventricles on embryonic day E20.5.
REFERENCE   3  (bases 1 to 1285)
  AUTHORS   Iida,S., Hara,T., Araki,D., Ishimine-Kuroda,C., Kurozumi,A.,
            Sakamoto,S., Miyazaki,T. and Minagi,S.
  TITLE     Memory-related gene expression profile of the male rat hippocampus
            induced by teeth extraction and occlusal support recovery
  JOURNAL   Arch Oral Biol 59 (2), 133-141 (2014)
   PUBMED   24370184
  REMARK    GeneRIF: Trh, Tnxa and Nnat genes were affected according to the
            degree of memory in male rats.
REFERENCE   4  (bases 1 to 1285)
  AUTHORS   Oyang,E.L., Davidson,B.C., Lee,W. and Poon,M.M.
  TITLE     Functional characterization of the dendritically localized mRNA
            neuronatin in hippocampal neurons
  JOURNAL   PLoS One 6 (9), e24879 (2011)
   PUBMED   21935485
  REMARK    GeneRIF: Data propose that neuronatin may impact synaptic
            plasticity by modulating dendritic calcium levels during
            homeostatic plasticity, thereby potentially regulating neuronal
            excitability, receptor trafficking, and calcium dependent
            signaling.
REFERENCE   5  (bases 1 to 1285)
  AUTHORS   Chen,K.H., Yang,C.H., Cheng,J.T., Wu,C.H., Sy,W.D. and Lin,C.R.
  TITLE     Altered neuronatin expression in the rat dorsal root ganglion after
            sciatic nerve transection
  JOURNAL   J Biomed Sci 17 (1), 41 (2010)
   PUBMED   20509861
  REMARK    GeneRIF: significant correlation between mechanical hyperalgesia in
            axotomy of sciatic nerve and the increased expression of Nnat in
            C-fiber and A-delta fiber of adult dorsal root ganglion neurons
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1285)
  AUTHORS   Chu,K. and Tsai,M.J.
  TITLE     Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas,
            is involved in glucose-mediated insulin secretion
  JOURNAL   Diabetes 54 (4), 1064-1073 (2005)
   PUBMED   15793245
REFERENCE   7  (bases 1 to 1285)
  AUTHORS   Yamashita,M., Glasgow,E., Zhang,B.J., Kusano,K. and Gainer,H.
  TITLE     Identification of cell-specific messenger ribonucleic acids in
            oxytocinergic and vasopressinergic magnocellular neurons in rat
            supraoptic nucleus by single-cell differential hybridization
  JOURNAL   Endocrinology 143 (11), 4464-4476 (2002)
   PUBMED   12399444
REFERENCE   8  (bases 1 to 1285)
  AUTHORS   Joseph,R., Tsang,W., Dou,D., Nelson,K. and Edvardsen,K.
  TITLE     Neuronatin mRNA in PC12 cells: downregulation by nerve growth
            factor
  JOURNAL   Brain Res 738 (1), 32-38 (1996)
   PUBMED   8949924
REFERENCE   9  (bases 1 to 1285)
  AUTHORS   Joseph,R., Dou,D. and Tsang,W.
  TITLE     Neuronatin mRNA: alternatively spliced forms of a novel
            brain-specific mammalian developmental gene
  JOURNAL   Brain Res 690 (1), 92-98 (1995)
   PUBMED   7496812
REFERENCE   10 (bases 1 to 1285)
  AUTHORS   Joseph,R., Dou,D. and Tsang,W.
  TITLE     Molecular cloning of a novel mRNA (neuronatin) that is highly
            expressed in neonatal mammalian brain
  JOURNAL   Biochem Biophys Res Commun 201 (3), 1227-1234 (1994)
   PUBMED   8024565
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM037467.1, BC127473.1 and CB711943.1.
            
            [WARNING] On Apr 29, 2024 this sequence was replaced by
            NM_053601.3.
            
            On Aug 4, 2012 this sequence version replaced NM_053601.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ212548.1, U08290.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                FM037467.1         1-66
            67-193              BC127473.1         1-127
            194-274             CB711943.1         130-210
            275-1285            BC127473.1         128-1138
FEATURES             Location/Qualifiers
     source          1..1285
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1285
                     /gene="Nnat"
                     /gene_synonym="Peg5"
                     /note="neuronatin"
                     /db_xref="GeneID:94270"
                     /db_xref="RGD:620155"
     exon            1..193
                     /gene="Nnat"
                     /gene_synonym="Peg5"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..367
                     /gene="Nnat"
                     /gene_synonym="Peg5"
                     /note="isoform alpha is encoded by transcript variant 1;
                     neuronatin alpha"
                     /codon_start=1
                     /product="neuronatin isoform alpha"
                     /protein_id="NP_446053.1"
                     /db_xref="GeneID:94270"
                     /db_xref="RGD:620155"
                     /translation="MAAVAAASAELLIIGWYIFRVLLQVFLECCIYWVGFAFRNPPGT
                     QPIARSEVFRYSLQKLAHTVSRTGRQVLGERRHRAPN"
     exon            194..274
                     /gene="Nnat"
                     /gene_synonym="Peg5"
                     /inference="alignment:Splign:2.1.0"
     exon            275..1264
                     /gene="Nnat"
                     /gene_synonym="Peg5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1195..1200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nnat"
                     /gene_synonym="Peg5"
     polyA_site      1264
                     /gene="Nnat"
                     /gene_synonym="Peg5"
ORIGIN      
        1 gtggcaggag ggtacttaag gcgcggccac cggggctgcg gcattgcgcc cagcagcgga
       61 ctccgagatc catagacctc ggcgaaccct tgctctcgac cacccaccca ctttcggaac
      121 catggccgca gtggcagcag cctcggcaga actgctcatc atcggctggt acatcttccg
      181 cgtgctgctg caggtgttcc tggaatgctg catttactgg gtaggattcg cttttcgaaa
      241 tcctccaggg acacagccca ttgcgagaag tgaggtgttc aggtactccc tgcagaagct
      301 ggcgcacacg gtgtcccgga ccgggcggca ggtgctgggg gagcgcaggc accgagcccc
      361 caactgaggc cccatctccc agccctgggc ggccgtgtca tcaggtgctc ctgtgcttct
      421 cgaccagcat gggagccaat gccgcgcagg aatggggggt cccctgtgct ccctcgtcag
      481 aggagcactt gccaaggtca gtgaggggcc ggtaggtccc cagaaaagca gcaccgacaa
      541 tgatgaagac atcagttcct ttcccagccc cctcccccct ttgcccctgt cccatggccg
      601 gcgggtggga gaggatgggg gaagagggga gcaaccctcg agatatgggc gtaggcacca
      661 cattctgatc tggaccaagt tggaacagca ccatctcagc cgcacaagat cctaccatgg
      721 agagctaaca ccccaccaac cagcagaatg gacattctga catcaccagc tgaaaccctg
      781 aatctcggtg cagaagagaa agtgtcaact gcgtgcagca ctgggggagt ggagggtgtg
      841 ggtggtggag gaagagggtt aagaaaacta gtggggccct cttgctgtcc cttgcctatg
      901 gcacgcatat tcctgccttg ctccctcact ccccctctcc cctgccttcc aaagccccac
      961 cccccaaaaa tgtgtcactt gattcggacc tattcaacca gtaattggat cccaccttta
     1021 ccaaaacacc gtctctgacc cccggccctt cactgatctt gcttatccct ggtctcacgc
     1081 agcagttgtg gttgctattg tggtagtcgc taattgtact agtttacgtg tgcattagtt
     1141 gtgtctcccc ggctagattg taagctcctg gagacaggga ccacctccac aaaaaataaa
     1201 aaaacggacc tctcctgtct tgtagtgtcc taggaccctg cagggcagtg ggggtgcacc
     1261 aaaaaaaaaa aaaaaaaaaa aaaaa
//
