LOCUS       NM_022275               3320 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus neuromedin U receptor 2 (Nmur2), mRNA.
ACCESSION   NM_022275
VERSION     NM_022275.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3320)
  AUTHORS   Vallof,D., Kalafateli,A.L. and Jerlhag,E.
  TITLE     Brain region-specific neuromedin U signalling regulates
            alcohol-related behaviours and food intake in rodents
  JOURNAL   Addict Biol 25 (3), e12764 (2020)
   PUBMED   31069918
  REMARK    GeneRIF: Brain region-specific neuromedin U signalling regulates
            alcohol-related behaviours and food intake in rodents.
REFERENCE   2  (bases 1 to 3320)
  AUTHORS   Peng,S., Lu,Y., Li,P., Liu,P., Shi,X., Liu,C., Zhang,Y., Liu,S. and
            Wang,J.
  TITLE     The short interference RNA (siRNA) targeting NMUR2 relieves
            nociception in a bone cancer pain model of rat through PKC-ERK and
            PI3K-AKT pathways
  JOURNAL   Biochem Biophys Res Commun 512 (3), 616-622 (2019)
   PUBMED   30914203
  REMARK    GeneRIF: NMUR2 is upregulated in bone cancer pain rat model. Short
            interference RNA NMUR2 alleviates nociception in bone cancer pain
            rat model.
REFERENCE   3  (bases 1 to 3320)
  AUTHORS   McCue,D.L., Kasper,J.M., A and Hommel,J.D.
  TITLE     Incubation of feeding behavior is regulated by neuromedin U
            receptor 2 in the paraventricular nucleus of the hypothalamus
  JOURNAL   Behav Brain Res 359, 763-770 (2019)
   PUBMED   30227148
  REMARK    GeneRIF: This study shown that modulation of neuromedin U receptor
            2 (NMUR2) in the paraventricular nucleus of the hypothalamus (PVN)
            results in increased food intake and motivation for energy-dense
            foods.
REFERENCE   4  (bases 1 to 3320)
  AUTHORS   Benzon,C.R., Johnson,S.B., McCue,D.L., Li,D., Green,T.A. and
            Hommel,J.D.
  TITLE     Neuromedin U receptor 2 knockdown in the paraventricular nucleus
            modifies behavioral responses to obesogenic high-fat food and leads
            to increased body weight
  JOURNAL   Neuroscience 258, 270-279 (2014)
   PUBMED   24269937
  REMARK    GeneRIF: Results demonstrate that NMUR2 signaling in the
            paraventricular nucleus of the hypothalamus regulates consumption
            and preference for high-fat foods without disrupting feeding
            behavior associated with non-obesogenic standard chow
REFERENCE   5  (bases 1 to 3320)
  AUTHORS   Lin,T.Y., Wu,F.J., Lee,W.Y., Hsiao,C.L. and Luo,C.W.
  TITLE     Ovarian regulation of neuromedin U and its local actions in the
            ovary, mediated through neuromedin U receptor 2
  JOURNAL   Am J Physiol Endocrinol Metab 304 (8), E800-E809 (2013)
   PUBMED   23423171
  REMARK    GeneRIF: NMU and NMU receptor 2 compose a novel autocrine system in
            theca/interstitial cells in which the intensity of signaling is
            tightly controlled by gonadotropins.
REFERENCE   6  (bases 1 to 3320)
  AUTHORS   Qiu,D.L., Chu,C.P., Tsukino,H., Shirasaka,T., Nakao,H., Kato,K.,
            Kunitake,T., Katoh,T. and Kannan,H.
  TITLE     Neuromedin U receptor-2 mRNA and HCN channels mRNA expression in
            NMU-sensitive neurons in rat hypothalamic paraventricular nucleus
  JOURNAL   Neurosci Lett 374 (1), 69-72 (2005)
   PUBMED   15631899
  REMARK    GeneRIF: These results suggest that NMU modulates the function of
            the PVN putative parvocellular neurons and is involved in the
            regulation of OTergic and VPergic neurons by enhanced HCN ion
            channels activity via NMU-receptor 2.
REFERENCE   7  (bases 1 to 3320)
  AUTHORS   Yu,X.H., Cao,C.Q., Mennicken,F., Puma,C., Dray,A., O'Donnell,D.,
            Ahmad,S. and Perkins,M.
  TITLE     Pro-nociceptive effects of neuromedin U in rat
  JOURNAL   Neuroscience 120 (2), 467-474 (2003)
   PUBMED   12890516
REFERENCE   8  (bases 1 to 3320)
  AUTHORS   Raddatz,R., Wilson,A.E., Artymyshyn,R., Bonini,J.A., Borowsky,B.,
            Boteju,L.W., Zhou,S., Kouranova,E.V., Nagorny,R., Guevarra,M.S.,
            Dai,M., Lerman,G.S., Vaysse,P.J., Branchek,T.A., Gerald,C.,
            Forray,C. and Adham,N.
  TITLE     Identification and characterization of two neuromedin U receptors
            differentially expressed in peripheral tissues and the central
            nervous system
  JOURNAL   J Biol Chem 275 (42), 32452-32459 (2000)
   PUBMED   10899166
REFERENCE   9  (bases 1 to 3320)
  AUTHORS   Hosoya,M., Moriya,T., Kawamata,Y., Ohkubo,S., Fujii,R., Matsui,H.,
            Shintani,Y., Fukusumi,S., Habata,Y., Hinuma,S., Onda,H.,
            Nishimura,O. and Fujino,M.
  TITLE     Identification and functional characterization of a novel subtype
            of neuromedin U receptor
  JOURNAL   J Biol Chem 275 (38), 29528-29532 (2000)
   PUBMED   10887190
REFERENCE   10 (bases 1 to 3320)
  AUTHORS   Howard,A.D., Wang,R., Pong,S.S., Mellin,T.N., Strack,A., Guan,X.M.,
            Zeng,Z., Williams,D.L. Jr., Feighner,S.D., Nunes,C.N., Murphy,B.,
            Stair,J.N., Yu,H., Jiang,Q., Clements,M.K., Tan,C.P., McKee,K.K.,
            Hreniuk,D.L., McDonald,T.P., Lynch,K.R., Evans,J.F., Austin,C.P.,
            Caskey,C.T., Van der Ploeg,L.H. and Liu,Q.
  TITLE     Identification of receptors for neuromedin U and its role in
            feeding
  JOURNAL   Nature 406 (6791), 70-74 (2000)
   PUBMED   10894543
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1, AB041229.1, AF242875.1, CB556410.1 and
            BM384513.1.
            
            On Aug 2, 2012 this sequence version replaced NM_022275.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.36724.1, AB041229.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN17050745 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation, longest
                                                protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               JAXUCZ010000010.1  40682515-40682679   c
            166-1162            AB041229.1         166-1162
            1163-1314           AF242875.1         1037-1188
            1315-1537           CB556410.1         486-708
            1538-3033           JAXUCZ010000010.1  40667096-40668591   c
            3034-3320           BM384513.1         1-287               c
FEATURES             Location/Qualifiers
     source          1..3320
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..3320
                     /gene="Nmur2"
                     /gene_synonym="FM-4; Nmu2r"
                     /note="neuromedin U receptor 2"
                     /db_xref="GeneID:64042"
                     /db_xref="RGD:621155"
     exon            1..828
                     /gene="Nmur2"
                     /gene_synonym="FM-4; Nmu2r"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1314
                     /gene="Nmur2"
                     /gene_synonym="FM-4; Nmu2r"
                     /note="NMU-R2; G-protein-coupled receptor FM-4; G-protein
                     coupled receptor TGR-1"
                     /codon_start=1
                     /product="neuromedin-U receptor 2"
                     /protein_id="NP_071611.3"
                     /db_xref="GeneID:64042"
                     /db_xref="RGD:621155"
                     /translation="MGKLENASWIHDPLMKYLNSTEEYLAHLCGPKRSDLSLPVSVAY
                     ALIFLVGVMGNLLVCMVIVRHQTLKTPTNYYLFSLAVSDLLVLLLGMPLEIYEMWHNY
                     PFLFGPVGCYFKTALFETVCFASILSVTTVSVERYVAIVHPFRAKLESTRRRALRILS
                     LVWSFSVVFSLPNTSIHGIKFQHFPNGSSVPGSATCTVTKPMWVYNLIIQATSFLFYI
                     LPMTLISVLYYLMGLRLKRDESLEANKVAVNIHRPSRKSVTKMLFVLVLVFAICWTPF
                     HVDRLFFSFVEEWTESLAAVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFRAAFRNVV
                     SPTCKWCHPRHRPQGPPAQKIIFLTECHLVELTEDAGPQFPGQSSIHNTNLTTAPCAG
                     EVP"
     exon            829..913
                     /gene="Nmur2"
                     /gene_synonym="FM-4; Nmu2r"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1039
                     /gene="Nmur2"
                     /gene_synonym="FM-4; Nmu2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..3305
                     /gene="Nmur2"
                     /gene_synonym="FM-4; Nmu2r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgatgctat cctttcactc tctcagacct tctccaggag cctctgcttt cagactcctt
       61 ctggctcagc ttgggacaga cacccagaac aagggacacc tgtggttgtg gattttaagc
      121 tcagtaatgg gaaaacttga aaatgcttcc tggatccacg atcctctcat gaagtacttg
      181 aacagcacag aggagtactt ggcccacctg tgtggaccca agcgcagtga cctatccctt
      241 ccggtgtctg tggcctatgc gctgatcttc ctggtggggg taatgggcaa tcttctggtg
      301 tgcatggtga ttgtccgaca tcagactttg aagacaccca ccaactacta tctcttcagc
      361 ttggcagtct cagatctgct ggtcctgctc ttggggatgc ctctggaaat ctacgagatg
      421 tggcacaatt accctttcct gttcgggcct gtgggatgct acttcaagac agccctcttc
      481 gagactgtgt gctttgcctc cattctcagt gtcaccacgg ttagcgtaga gcgctatgtg
      541 gccattgtcc accctttccg agccaagctg gagagcacgc ggcgacgggc cctcaggatc
      601 ctcagcctag tctggagctt ctctgtggtc ttttctttgc ccaataccag catccatggc
      661 atcaagttcc agcactttcc caacgggtcc tccgtacctg gctcagccac ctgcacagtc
      721 accaaaccca tgtgggtgta taacttgatc atccaagcta ccagcttcct cttctacatc
      781 ctcccaatga ccctcatcag cgtcctctac tacctcatgg ggctcaggct gaagagagat
      841 gaatcccttg aggcgaacaa agtggctgtg aatattcaca gaccctctag aaagtcagtc
      901 accaagatgc tgtttgtctt ggtcctcgtg tttgccatct gctggacccc cttccatgtg
      961 gaccggctct tcttcagctt tgtggaagag tggacagagt ccctggctgc tgtgttcaac
     1021 ctcatccatg tggtatcagg tgtcttcttt tatctgagct ccgcggtcaa ccccattatc
     1081 tataacctcc tgtctcggcg cttccgggcg gcctttcgaa atgttgtctc ccctacctgc
     1141 aaatggtgcc atccccggca tcggccacag ggacctccag cccagaagat catcttcttg
     1201 acagaatgtc acctcgtgga gctgacagag gatgcaggcc cccagttccc tggtcagtca
     1261 tccatccaca acaccaacct taccacggcc ccctgtgcag gagaggtacc ataaaaggag
     1321 tggtcagaag gcctcttcag aaggcctgga ttctgtgatt gacatccatc tatgtgccaa
     1381 aactgcaagg agggacaccc tgtcacctat gcctccttgc gtgccattaa gagaggtaac
     1441 aaggctctta gattctacgt actcactact ttttttaatg ttaaaactca gacttcgttc
     1501 tgggccccag cacagtcctt atactccata tctctgtatt gtgagttttc ataactgtga
     1561 ttacagtgtg ctacggagtc tcacttaacg atattctcat gatgggtggg tttagcctac
     1621 taaaggcatg gtagagtagc taagcagcac agcacagtta tcccaacctc caaacccagg
     1681 atgcaggaga aactactggg tgttactcgg acggctggct cagaactgct cataaaagcc
     1741 taatcctcca atagttaggg cttttgcaac tctgttgtca aatgagcgat ggcttgaaat
     1801 cagtcatggc agaaatattt gtgctacaga aattaacaag ctctgtaaat cagagctaaa
     1861 taatttttat cgcccagaga gctggcccac gagcaggttg agagctatta atgagctggc
     1921 actgtgccag cttgccgcga cgcgtgtgac tcgttttttt cagaacagat gctggtaacg
     1981 ctgcaattat ggactactta gagtcatggt taactgtgaa aagatgctat ggactagatt
     2041 taaaaataaa aaataactag agtttctaca caaagtaggc aaaatgctgc taattaagcc
     2101 aatggaagca gcatcagcgg tttataatta acctagagaa gaagggttat ttttggatgc
     2161 catccattaa cattaatgca gaaaacaaca atggaccggg tgttgtttcc cctcacacgt
     2221 ctgtatttgc agagcccaca ggatatgttg tcaaaacaga tgacttttct atagtcatct
     2281 ccacttggct gcagatttat ttccttctta acgggtagaa actcagccta ggactggagg
     2341 gacgacgcaa cggacaaagg cacccgccac caagcctgag gatctgaatt ccatacccgg
     2401 aacacacatg gtggaaggag agagaactga cttcctcaag ttgtccttgg acctccaaac
     2461 atgcaccatg gcaatatgcc ctcccccacc ccaacacttg ccacactgga taagttaata
     2521 taaaaaaaaa taaagaagta tattgttaat ccatagtgtg gaagctaaca ggtatactgt
     2581 cttctagaag cctagaaaac cagtggttgc ctgaatgctc catggagtct gcttctgtca
     2641 ctcaacctgt gccactgtag aagctctttc aaggcaatgt cagtaattga aagttttgac
     2701 taatttatgt atgggaccca tattgtagaa tctacctaca ttatatacca ggatatcact
     2761 gctagtgaaa tatgttcatt acacaaaaca gactattaac ttagagactt agaaagatgg
     2821 acaagtcagg caaagaaagt caaagtccag gacaaagaga agcaaagctg gagagacaag
     2881 aaatgtctca tgggcaaagg catttgtgca taagcctgct ggtccaagtt ttttggttaa
     2941 ggaagagatc caatgcctga aattgttctc tgacctccat agtcaccatg gtttgtgtca
     3001 aaaaacctcc tcacacgtaa taatgaaaga attgctttaa agaaaagcaa tttacccttt
     3061 caaactcatt cactgctatg aaaccacatg gacacataga taagaaattc tgtgagttag
     3121 tagtcatttt gaagatagat cttaaaaggc ttcatagaac atgcttattt gtatatttcc
     3181 acagcataaa gactatcttt tacgaacact ttctgctctg ttttataaat gctgaaaatt
     3241 tcaggtcctg attttgacca cccgttcctc agtattgaaa tggaataaag gttgccctgt
     3301 ccacaaaaaa aaaaaaaaaa
//
