LOCUS       NM_023100               1713 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus neuromedin U receptor 1 (Nmur1), mRNA.
ACCESSION   NM_023100
VERSION     NM_023100.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1713)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   2  (bases 1 to 1713)
  AUTHORS   Panetta,R., Meury,L., Cao,C.Q., Puma,C., Mennicken,F., Cassar,P.A.,
            Laird,J. and Groblewski,T.
  TITLE     Functional genomics of the rat neuromedin U receptor 1 reveals a
            naturally occurring deleterious allele
  JOURNAL   Physiol Genomics 45 (2), 89-97 (2013)
   PUBMED   23212943
  REMARK    GeneRIF: Genetic analysis of the Nmur1 gene in a population of
            Sprague-Dawley rats revealed that this strain is highly
            heterogeneous for the inactivating polymorphism.
REFERENCE   3  (bases 1 to 1713)
  AUTHORS   Trejter,M., Neri,G., Rucinski,M., Majchrzak,M., Nussdorfer,G.G. and
            Malendowicz,L.K.
  TITLE     Neuromedin-U stimulates enucleation-induced adrenocortical
            regeneration in the rat
  JOURNAL   Int J Mol Med 21 (6), 683-687 (2008)
   PUBMED   18506360
  REMARK    GeneRIF: NMU stimulates regeneration of rat adrenal cortex, via a
            mechanism independent of pituitary ACTH and involving the
            activation of NMUR1 located on adrenocortical cells.
REFERENCE   4  (bases 1 to 1713)
  AUTHORS   Brighton,P.J., Wise,A., Dass,N.B. and Willars,G.B.
  TITLE     Paradoxical behavior of neuromedin U in isolated smooth muscle
            cells and intact tissue
  JOURNAL   J Pharmacol Exp Ther 325 (1), 154-164 (2008)
   PUBMED   18180374
  REMARK    GeneRIF: endogenous rat NmU receptors couple to both Galpha(q/11)
            and Galpha(i) G-proteins. Challenge of either circular or
            longitudinal rat isolated colonic smooth muscle.
REFERENCE   5  (bases 1 to 1713)
  AUTHORS   Kaczmarek,P., Malendowicz,L.K., Pruszynska-Oszmalek,E.,
            Wojciechowicz,T., Szczepankiewicz,D., Szkudelski,T. and Nowak,K.W.
  TITLE     Neuromedin U receptor 1 expression in the rat endocrine pancreas
            and evidence suggesting neuromedin U suppressive effect on insulin
            secretion from isolated rat pancreatic islets
  JOURNAL   Int J Mol Med 18 (5), 951-955 (2006)
   PUBMED   17016626
  REMARK    GeneRIF: NmUR1 but not NmUR2 is specifically expressed in isolated
            rat pancreatic islets.
REFERENCE   6  (bases 1 to 1713)
  AUTHORS   Boulland,J.L., Rafiki,A., Levy,L.M., Storm-Mathisen,J. and
            Chaudhry,F.A.
  TITLE     Highly differential expression of SN1, a bidirectional glutamine
            transporter, in astroglia and endothelium in the developing rat
            brain
  JOURNAL   Glia 41 (3), 260-275 (2003)
   PUBMED   12528181
REFERENCE   7  (bases 1 to 1713)
  AUTHORS   Raddatz,R., Wilson,A.E., Artymyshyn,R., Bonini,J.A., Borowsky,B.,
            Boteju,L.W., Zhou,S., Kouranova,E.V., Nagorny,R., Guevarra,M.S.,
            Dai,M., Lerman,G.S., Vaysse,P.J., Branchek,T.A., Gerald,C.,
            Forray,C. and Adham,N.
  TITLE     Identification and characterization of two neuromedin U receptors
            differentially expressed in peripheral tissues and the central
            nervous system
  JOURNAL   J Biol Chem 275 (42), 32452-32459 (2000)
   PUBMED   10899166
REFERENCE   8  (bases 1 to 1713)
  AUTHORS   Kojima,M., Haruno,R., Nakazato,M., Date,Y., Murakami,N., Hanada,R.,
            Matsuo,H. and Kangawa,K.
  TITLE     Purification and identification of neuromedin U as an endogenous
            ligand for an orphan receptor GPR66 (FM3)
  JOURNAL   Biochem Biophys Res Commun 276 (2), 435-438 (2000)
   PUBMED   11027493
REFERENCE   9  (bases 1 to 1713)
  AUTHORS   Fujii,R., Hosoya,M., Fukusumi,S., Kawamata,Y., Habata,Y.,
            Hinuma,S., Onda,H., Nishimura,O. and Fujino,M.
  TITLE     Identification of neuromedin U as the cognate ligand of the orphan
            G protein-coupled receptor FM-3
  JOURNAL   J Biol Chem 275 (28), 21068-21074 (2000)
   PUBMED   10783389
REFERENCE   10 (bases 1 to 1713)
  AUTHORS   Howard,A.D., Wang,R., Pong,S.S., Mellin,T.N., Strack,A., Guan,X.M.,
            Zeng,Z., Williams,D.L. Jr., Feighner,S.D., Nunes,C.N., Murphy,B.,
            Stair,J.N., Yu,H., Jiang,Q., Clements,M.K., Tan,C.P., McKee,K.K.,
            Hreniuk,D.L., McDonald,T.P., Lynch,K.R., Evans,J.F., Austin,C.P.,
            Caskey,C.T., Van der Ploeg,L.H. and Liu,Q.
  TITLE     Identification of receptors for neuromedin U and its role in
            feeding
  JOURNAL   Nature 406 (6791), 70-74 (2000)
   PUBMED   10894543
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Jan 29, 2016 this sequence version replaced NM_023100.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081796.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680424, SAMN06680426
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                JAXUCZ010000009.1  94484620-94484653   c
            35-890              JAXUCZ010000009.1  94482395-94483250   c
            891-1713            JAXUCZ010000009.1  94481238-94482060   c
FEATURES             Location/Qualifiers
     source          1..1713
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..1713
                     /gene="Nmur1"
                     /gene_synonym="Gpr66; Nmu-r1"
                     /note="neuromedin U receptor 1"
                     /db_xref="GeneID:65276"
                     /db_xref="RGD:619867"
     exon            1..34
                     /gene="Nmur1"
                     /gene_synonym="Gpr66; Nmu-r1"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1270
                     /gene="Nmur1"
                     /gene_synonym="Gpr66; Nmu-r1"
                     /note="G protein-coupled receptor FM-3; G protein-coupled
                     receptor 66"
                     /codon_start=1
                     /product="neuromedin-U receptor 1"
                     /protein_id="NP_075588.2"
                     /db_xref="GeneID:65276"
                     /db_xref="RGD:619867"
                     /translation="MLSPNASTGLLSCNDSEFKEHFDLEDLNLTHEDLRLKYLGPQQV
                     KQFLPICVTYLLIFVVGTLGNGLTCTVILRQKAMHTPTNFYLFSLAVSDLLVLLVGLP
                     LELYEMQHNYPFQLGAGGCYFRILLLETVCLASVLNVTALSVERYVAVVHPLQAKSVM
                     TRTHVRRMLGAIWVFAILFSLPNTSLHGLSPLYVPCRGPVPDSVTCTLVRPQFFYKLV
                     IQTTILLFFCLPMVTISVLYLLIGLRLRRERILLQEEVKGRISAAARQASHRSIQLRD
                     RERRQVTKMLIALVIVFGTCWVPFHADRLMWSMVSHWTDGLRLAFQSVHLASGVFLYL
                     GSAANPVLYNLMSTRFRESFRETLGLGTRCCHRHQPRHDSHSHLRLTTVSTLCDRNSR
                     DVPLAENRDPGCEQETDPPE"
     exon            35..890
                     /gene="Nmur1"
                     /gene_synonym="Gpr66; Nmu-r1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1713
                     /gene="Nmur1"
                     /gene_synonym="Gpr66; Nmu-r1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcgcagtc aggacttccc ctgcagaagg catgctctcc ccaaatgctt caacaggcct
       61 cttgtcctgc aatgacagtg agttcaagga gcactttgac cttgaggacc tgaaccttac
      121 tcatgaggac ctgaggctga agtacttggg gccacagcag gtaaaacaat ttttgcccat
      181 ctgtgtcacg tacctgttga tcttcgtagt gggcactctg ggcaacgggt tgacctgcac
      241 cgtcatcctg cgccagaagg caatgcacac gcccaccaac ttctacctct tcagtctcgc
      301 ggtgtccgat ttgctggtgc tcctggtggg cttgcccctg gaactttatg agatgcagca
      361 caattaccca ttccagctgg gtgcaggtgg ctgttacttc cggatactgc ttttggagac
      421 tgtctgcctg gcttcagtgc tcaatgtcac agccctaagt gtggagcgtt atgtggccgt
      481 ggtgcaccca ctccaagcca agtctgtgat gacacggacc catgtgcgcc gcatgttggg
      541 agccatctgg gtcttcgcta ttctcttctc tctgcccaac accagcttac atggcctcag
      601 tccactctat gtaccctgcc gggggccggt gcccgattca gttacgtgta cgctggtgcg
      661 tccccagttc ttctacaagt tggtaataca gacgaccata ctgctcttct tctgtctgcc
      721 catggtcacc atcagtgtgc tgtacctgct cattgggctg aggctgcgga gggagaggat
      781 attgctccaa gaggaggtca agggcaggat atctgcagca gccaggcagg cctcccacag
      841 aagtattcag cttcgagata gggaacgcag acaggtgacc aagatgctaa ttgctctggt
      901 tatagtattt ggcacctgct gggttccatt ccatgctgac cgtctcatgt ggagtatggt
      961 gtcccattgg actgacggcc tgcgcctggc cttccagtct gtgcaccttg cttctggtgt
     1021 cttcttgtac ctcggctcag cggctaaccc ggtgctctac aacctcatgt ccactcgctt
     1081 ccgagagtcc ttccgggaaa ccctgggcct tgggacacgg tgctgtcatc gccaccaacc
     1141 gcgtcacgac tcccatagcc accttaggtt gaccacagtc agcaccctgt gtgacaggaa
     1201 cagcagggat gtacccctgg ctgagaacag ggatccaggg tgtgagcaag agacagaccc
     1261 tcctgaataa aatcctgtgg cctcacccac agggccagag ggcctcagac actccggggg
     1321 ctactgggat aagcttagaa agggatttct gccctgccac atatttgagt gttgagggaa
     1381 acagcaagaa aaagagaatt gaaccccagt tgccaaagac ttgcgttaaa ggcctgaaaa
     1441 ggtgactctg cagttaagaa agcttgtagc tcatccagag gacccgagtt caggtcccag
     1501 cacccacatg gcagcttaca accacctgta acttcagcgc taggccctct gacactctct
     1561 cttggcttct gaaggcatct accacatgca catggcacat agcacacacc catatattaa
     1621 aaagacccgg gattggggat ttagctcagt ggtagagtgc ttgcctaaca agcgcaaggc
     1681 cctgggttcg gtccccagct ctgaaaaaaa aaa
//
