LOCUS       NM_022239                708 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus neuromedin U (Nmu), mRNA.
ACCESSION   NM_022239
VERSION     NM_022239.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 708)
  AUTHORS   Kasper,J.M., Smith,A.E., Miller,S.N., Ara, Russell,W.K.,
            Cunningham,K.A. and Hommel,J.D.
  TITLE     Role of neuropeptide neuromedin U in the nucleus accumbens shell in
            cocaine self-administration in male rats
  JOURNAL   Neuropsychopharmacology 47 (11), 1875-1882 (2022)
   PUBMED   34916591
  REMARK    GeneRIF: Role of neuropeptide neuromedin U in the nucleus accumbens
            shell in cocaine self-administration in male rats.
REFERENCE   2  (bases 1 to 708)
  AUTHORS   Vallof,D., Kalafateli,A.L. and Jerlhag,E.
  TITLE     Brain region-specific neuromedin U signalling regulates
            alcohol-related behaviours and food intake in rodents
  JOURNAL   Addict Biol 25 (3), e12764 (2020)
   PUBMED   31069918
  REMARK    GeneRIF: Brain region-specific neuromedin U signalling regulates
            alcohol-related behaviours and food intake in rodents.
REFERENCE   3  (bases 1 to 708)
  AUTHORS   Aizawa,S., Gu,T., Kaminoda,A., Fujioka,R., Ojima,F., Sakata,I.,
            Sakai,T., Ogoshi,M., Takahashi,S. and Takeuchi,S.
  TITLE     Adenosine stimulates neuromedin U mRNA expression in the rat pars
            tuberalis
  JOURNAL   Mol Cell Endocrinol 496, 110518 (2019)
   PUBMED   31344393
  REMARK    GeneRIF: This is the first report to demonstrate that Nmu
            expression in the pars tuberalis is regulated by adenosine, which
            acts as an intravital central metabolic signal, in addition to
            melatonin, which acts as an external photoperiodic environmental
            signal.
REFERENCE   4  (bases 1 to 708)
  AUTHORS   Mori,K., Ida,T., Fudetani,M., Mori,M., Kaiya,H., Hino,J.,
            Nakahara,K., Murakami,N., Miyazato,M. and Kangawa,K.
  TITLE     Identification of neuromedin U precursor-related peptide and its
            possible role in the regulation of prolactin release
  JOURNAL   Sci Rep 7 (1), 10468 (2017)
   PUBMED   28874765
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 708)
  AUTHORS   Masuda,Y., Kumano,S., Noguchi,J., Sakamoto,K., Inooka,H. and
            Ohtaki,T.
  TITLE     PEGylated neuromedin U-8 shows long-lasting anorectic activity and
            anti-obesity effect in mice by peripheral administration
  JOURNAL   Peptides 94, 99-105 (2017)
   PUBMED   28400225
  REMARK    GeneRIF: PEGylated rat NMU-8 showed potent and robust anorectic
            activity and anti-obesity effect in diet-induced obesity mice.
REFERENCE   6  (bases 1 to 708)
  AUTHORS   Austin,C., Oka,M., Nandha,K.A., Legon,S., Khandan-Nia,N., Lo,G. and
            Bloom,S.R.
  TITLE     Distribution and developmental pattern of neuromedin U expression
            in the rat gastrointestinal tract
  JOURNAL   J Mol Endocrinol 12 (3), 257-263 (1994)
   PUBMED   7916966
REFERENCE   7  (bases 1 to 708)
  AUTHORS   Lo,G., Legon,S., Austin,C., Wallis,S., Wang,Z. and Bloom,S.R.
  TITLE     Characterization of complementary DNA encoding the rat neuromedin U
            precursor
  JOURNAL   Mol Endocrinol 6 (10), 1538-1544 (1992)
   PUBMED   1448109
REFERENCE   8  (bases 1 to 708)
  AUTHORS   Benito-Orfila,M.A., Domin,J., Nandha,K.A. and Bloom,S.R.
  TITLE     The motor effect of neuromedin U on rat stomach in vitro
  JOURNAL   Eur J Pharmacol 193 (3), 329-333 (1991)
   PUBMED   2055247
REFERENCE   9  (bases 1 to 708)
  AUTHORS   Minamino,N., Kangawa,K., Honzawa,M. and Matsuo,H.
  TITLE     Isolation and structural determination of rat neuromedin U
  JOURNAL   Biochem Biophys Res Commun 156 (1), 355-360 (1988)
   PUBMED   3178840
REFERENCE   10 (bases 1 to 708)
  AUTHORS   Conlon,J.M., Domin,J., Thim,L., DiMarzo,V., Morris,H.R. and
            Bloom,S.R.
  TITLE     Primary structure of neuromedin U from the rat
  JOURNAL   J Neurochem 51 (3), 988-991 (1988)
   PUBMED   3411332
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 27, 2020 this sequence version replaced NM_022239.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M94555.1, SRR26643288.51429.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               JAXUCZ010000014.1  32198943-32199172
            231-289             JAXUCZ010000014.1  32204250-32204308
            290-337             JAXUCZ010000014.1  32211464-32211511
            338-397             JAXUCZ010000014.1  32215893-32215952
            398-427             JAXUCZ010000014.1  32217361-32217390
            428-478             JAXUCZ010000014.1  32217482-32217532
            479-553             JAXUCZ010000014.1  32219953-32220027
            554-601             JAXUCZ010000014.1  32222716-32222763
            602-641             JAXUCZ010000014.1  32224296-32224335
            642-708             JAXUCZ010000014.1  32226203-32226269
FEATURES             Location/Qualifiers
     source          1..708
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..708
                     /gene="Nmu"
                     /note="neuromedin U"
                     /db_xref="GeneID:63887"
                     /db_xref="RGD:68388"
     exon            1..230
                     /gene="Nmu"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..637
                     /gene="Nmu"
                     /note="neuromedin U precursor-related peptide/neuromedin U
                     preproprotein"
                     /codon_start=1
                     /product="neuromedin-U precursor"
                     /protein_id="NP_071575.1"
                     /db_xref="GeneID:63887"
                     /db_xref="RGD:68388"
                     /translation="MSRAANRRPGLSAGQLAAATASPLLSLLLLLACCADACRGTPIS
                     PQRLPPEQELQLWNEIPEACASFLSVDSQPQASVALRKLCRVLMEIFQKPQEQTEKDN
                     AKRFLFHYSKTQKLGNSNVVSSVVHPLLQLVPQLHERRMKRYKVNEYQGPVAPSGGFF
                     LFRPRNGKRSTSFI"
     exon            231..289
                     /gene="Nmu"
                     /inference="alignment:Splign:2.1.0"
     exon            290..337
                     /gene="Nmu"
                     /inference="alignment:Splign:2.1.0"
     exon            338..397
                     /gene="Nmu"
                     /inference="alignment:Splign:2.1.0"
     exon            398..427
                     /gene="Nmu"
                     /inference="alignment:Splign:2.1.0"
     exon            428..478
                     /gene="Nmu"
                     /inference="alignment:Splign:2.1.0"
     exon            479..553
                     /gene="Nmu"
                     /inference="alignment:Splign:2.1.0"
     exon            554..601
                     /gene="Nmu"
                     /inference="alignment:Splign:2.1.0"
     exon            602..641
                     /gene="Nmu"
                     /inference="alignment:Splign:2.1.0"
     exon            642..708
                     /gene="Nmu"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttggtgtc tgagctcagc aagaggcgct cgggggacgc tgagggacag ctttaacacc
       61 cgcacaacac agggtacctg gttcccagtc cagagctgct tggagggcag agatgtcgcg
      121 agcagctaat cgccgcccag ggctctccgc aggacaattg gccgctgcaa ctgcatctcc
      181 tctcctgtca ctgctgctgc tgctcgcctg ctgtgcggac gcttgcagag gtacgccaat
      241 atcgcctcaa agattaccac cagaacaaga actacaattg tggaatgaga ttcctgaagc
      301 ttgtgcgtcc tttctgtctg ttgattccca gcctcaggca tctgttgcat tgaggaagct
      361 ttgccgtgtc ctgatggaga ttttccagaa gcctcaggag caaactgaga aagataatgc
      421 taagaggttc ttatttcatt attcaaagac acagaagttg ggaaattcaa atgttgtgtc
      481 gtctgtcgtg catccgttgc tgcagctcgt tcctcaactg catgagagaa gaatgaagag
      541 atacaaagtg aatgaatacc agggtcctgt agctccaagt gggggattct ttttatttag
      601 gccacgcaat gggaagaggt caacaagttt catttaaaat ggatgccaaa tgatcttttc
      661 attgaaaact ctgctatggg atataaaatg tactcacatt ttgttctc
//
