LOCUS       NM_207590               4432 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Rattus norvegicus N-myristoyltransferase 2 (Nmt2), transcript
            variant 1, mRNA.
ACCESSION   NM_207590 XM_214515
VERSION     NM_207590.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4432)
  AUTHORS   Sun,Y., Zhao,D., Song,Q., Cong,T., Li,L., Wu,H. and Xiao,Z.
  TITLE     NMT2 alleviates depression-like behavior in a rat model of chronic
            unpredictable stress: An integrated proteomic and phosphoproteomic
            analysis
  JOURNAL   J Psychiatr Res 176, 119-128 (2024)
   PUBMED   38852542
  REMARK    GeneRIF: NMT2 alleviates depression-like behavior in a rat model of
            chronic unpredictable stress: An integrated proteomic and
            phosphoproteomic analysis.
REFERENCE   2  (bases 1 to 4432)
  AUTHORS   Thinon,E., Serwa,R.A., Broncel,M., Brannigan,J.A., Brassat,U.,
            Wright,M.H., Heal,W.P., Wilkinson,A.J., Mann,D.J. and Tate,E.W.
  TITLE     Global profiling of co- and post-translationally N-myristoylated
            proteomes in human cells
  JOURNAL   Nat Commun 5, 4919 (2014)
   PUBMED   25255805
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4432)
  AUTHORS   Rioux,V., Beauchamp,E., Pedrono,F., Daval,S., Molle,D.,
            Catheline,D. and Legrand,P.
  TITLE     Identification and characterization of recombinant and native rat
            myristoyl-CoA: protein N-myristoyltransferases
  JOURNAL   Mol Cell Biochem 286 (1-2), 161-170 (2006)
   PUBMED   16538398
  REMARK    GeneRIF: NMT2 protein exhibited functional myristoyltransferase
            activity, but appeared to be 4-time less active than NMT1.
REFERENCE   4  (bases 1 to 4432)
  AUTHORS   Kolluri,S.K., Balduf,C., Hofmann,M. and Gottlicher,M.
  TITLE     Novel target genes of the Ah (dioxin) receptor: transcriptional
            induction of N-myristoyltransferase 2
  JOURNAL   Cancer Res 61 (23), 8534-8539 (2001)
   PUBMED   11731439
REFERENCE   5  (bases 1 to 4432)
  AUTHORS   Giang,D.K. and Cravatt,B.F.
  TITLE     A second mammalian N-myristoyltransferase
  JOURNAL   J Biol Chem 273 (12), 6595-6598 (1998)
   PUBMED   9506952
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Sep 29, 2022 this sequence version replaced NM_207590.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2115946.1,
                                           SRR22582416.567982.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               JAXUCZ010000017.1  79870065-79870259   c
            196-331             JAXUCZ010000017.1  79849940-79850075   c
            332-374             JAXUCZ010000017.1  79849475-79849517   c
            375-424             JAXUCZ010000017.1  79847880-79847929   c
            425-569             JAXUCZ010000017.1  79845173-79845317   c
            570-688             JAXUCZ010000017.1  79841491-79841609   c
            689-780             JAXUCZ010000017.1  79841314-79841405   c
            781-897             JAXUCZ010000017.1  79841092-79841208   c
            898-1068            JAXUCZ010000017.1  79839405-79839575   c
            1069-1177           JAXUCZ010000017.1  79838490-79838598   c
            1178-1348           JAXUCZ010000017.1  79832904-79833074   c
            1349-1516           JAXUCZ010000017.1  79830952-79831119   c
            1517-1654           JAXUCZ010000017.1  79830536-79830673   c
            1655-4432           JAXUCZ010000017.1  79826999-79829776   c
FEATURES             Location/Qualifiers
     source          1..4432
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..4432
                     /gene="Nmt2"
                     /note="N-myristoyltransferase 2"
                     /db_xref="GeneID:291318"
                     /db_xref="RGD:1303175"
     exon            1..195
                     /gene="Nmt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1675
                     /gene="Nmt2"
                     /EC_number="2.3.1.97"
                     /function="protein N-myristoylation"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glycylpeptide N-tetradecanoyltransferase 2"
                     /codon_start=1
                     /product="glycylpeptide N-tetradecanoyltransferase 2
                     isoform 1"
                     /protein_id="NP_997473.2"
                     /db_xref="GeneID:291318"
                     /db_xref="RGD:1303175"
                     /translation="MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGDLG
                     AKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQQSSKHNAIWQQISAGAAMGGDTME
                     GEWIDLRMYHKNPTIPIQKLQDIQRAMELLSACQGPARNIDEATKRRYQFWDTQPVPK
                     LNEVITSHGAIEPDKDNIRQEPYSLPQGFMWDTLDLSNAEVLKELYTLLNENYVEDDD
                     NMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKRMV
                     EINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPVATCRYWHRSL
                     NPRKLVEVKFSHLSRNMTLQRTMKLYRLPDVTKTSGLRPMEPKDIRAVRELINVYLKQ
                     FHLAPVMGDEEVAHWFLPREHIIDTFVVESPSGKLTDFLSFYTLPSTVMHHPAHKSLK
                     AAYSFYNIHTETPLLDLMNDALIIAKLKGFDVFNALDLMENKTFLEKLKFGIGDGNLQ
                     YYLYNWRCPGTDSEKVGLVLQ"
     exon            196..331
                     /gene="Nmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            332..374
                     /gene="Nmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            375..424
                     /gene="Nmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            425..569
                     /gene="Nmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            570..688
                     /gene="Nmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            689..780
                     /gene="Nmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            781..897
                     /gene="Nmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1068
                     /gene="Nmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1177
                     /gene="Nmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1348
                     /gene="Nmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1516
                     /gene="Nmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1654
                     /gene="Nmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..4432
                     /gene="Nmt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tagagggagc tgcggccgcg cccgccctgt cgcgccttgc ttgctgctcg gagcgccgcc
       61 tccccagccg ctcggagccg ccgcgatggc ggaggacagc gagtctgcgg ccagccagca
      121 gagcctagag ctggacgacc aggacacgtg cggaatagac ggagacaatg aggaggagac
      181 ggaacacgcc aaaggaagcc ctggagggga tttgggagca aaaaagaaaa agaagaaaca
      241 gaagagaaaa aaggagaagc caaactctgg gggtaccaag tccgactccg catctgactc
      301 ccaggagatt aagattcagc agtcttctaa acacaacgcc atctggcagc agatttcagc
      361 aggagcagcc atgggtggtg atactatgga aggtgaatgg atagatttaa gaatgtatca
      421 taagaatccc accatcccta ttcagaagct acaggacatc cagagagcaa tggagctgct
      481 ctctgcatgc caaggcccag ccaggaacat tgatgaggcc acaaaacgca gataccagtt
      541 ctgggacaca cagccagtgc ccaaattgaa tgaagtcata acatctcatg gtgcaattga
      601 accagacaaa gacaatatcc gccaggaacc gtattctttg ccacaaggtt tcatgtggga
      661 cacattagac ttgagtaatg ctgaagtgct caaggagttg tacacgttgc tgaacgagaa
      721 ttatgtggaa gacgatgaca atatgttccg ctttgactac tcacctgagt ttctcttgtg
      781 ggctctgcgt cccccaggat ggcttctgca gtggcactgt ggggtccgag tgtcttccaa
      841 taaaaagtta gtaggcttca taagtgccat cccagcaaac atccgaattt atgacagtgt
      901 gaagaggatg gtggaaatca actttctttg tgtgcataag aaactgagat ccaaacgggt
      961 agcccctgtg ttaatccggg aaataactag aagagtgaac ctggaaggca tctttcaggc
     1021 cgtgtatact gcaggagtgg ttctccctaa gcctgtggcc acatgcaggt attggcaccg
     1081 atccctaaac cccaggaaac tggtggaagt gaaattttct catctgagta gaaacatgac
     1141 cttacagaga acgatgaagc tttacagact tccagatgtt acaaagactt caggtctgag
     1201 accgatggaa ccaaaagata tcagagcagt ccgagagcta atcaacgtct acttgaagca
     1261 gtttcatcta gctccagtga tgggagacga agaagtggcc cactggttcc tccccaggga
     1321 gcacatcatt gacacctttg tggtggagag ccccagtggg aagctgaccg acttcctgag
     1381 cttctacaca ctcccctcca cggttatgca ccaccccgct cacaagagcc tcaaggctgc
     1441 ctattccttc tacaacattc acacagagac gcccctgctg gacctcatga acgacgcgct
     1501 cattatagcc aaattgaaag gatttgatgt gttcaatgca ctagatttga tggaaaataa
     1561 gaccttcttg gaaaagctca agtttggtat aggagacggc aacttacagt attatttgta
     1621 caactggagg tgtccaggga cagactctga aaaggttgga cttgttctac agtagatgga
     1681 tgttattcct agaaggctga cattctcgtt tgttagtgtt ctatctagtg atgcctggaa
     1741 ctgtcattcc aaagaagaat aaaagcacaa gttgagtgaa actggagtag ttgctaacaa
     1801 tcagaacaga tggccagttg tacacatttc tagttagggt attgggagcc agtctccact
     1861 gttggctaac gtgggaggga ttaaaggtgt ctgagagctc tcacggtaga gagaggatgt
     1921 tgtctgtcta ctctagaaat ggttctgtct ctgtgaacca aacaagtggc agcatcatgt
     1981 tatggcctct gctgttggga gagccactgc tgctttctgt gtgttaaatg gtgatatact
     2041 tgtaaaacag acaaggatcc atgtgtatca cccgacatga tgctactggg aatgtttata
     2101 gagttgacat gtggtagata cttacttaag gagcaatatg aaaatgtacc agtgacttag
     2161 cacacttact atcccataag catagtagcc aaaccagtca tacacagctt tgtcttttgc
     2221 tcttcagcca gtggattgtt tcaaaagcag agtttggggc atttgttcag tgtgctcact
     2281 aaagggtaca cagctgacgg atcagacctt ggggctgctg tgcaatctca tttctcagca
     2341 atgtcaagga tgtgtgaggg aaaggaagtc aaagctctaa ggtcagatca aagacccagc
     2401 ggtggagtag tgctgtcagc acacagatgg tctgaatgtt tttattatgc aaaattgcac
     2461 atgttccttt atgctgactt taatttatca tgaaaattgt catgctaatg gaaaatgtct
     2521 tacttgtaaa taagtattca taattttgtt actgaagttg tttttaccta gaacttaaaa
     2581 accaagtttc acagtgtata tatgtgtgta tatgctgcca ctaatccaag ggaaaataaa
     2641 ctactcgaca cggccattgt atagactggg cctttgagtc agatgccaca aagtagatct
     2701 tcttcctgcc tttactgcag tgcctccgct ccagtccaga catggcattc ccttccctac
     2761 tagaaaggag tcaccaaatg tgacctgtag gctgtccccc ctgttggctg ctctttacag
     2821 ctcacaaact gagagctttt ggcttttttt tttttttttt tttaatggtt gggggaaata
     2881 gtccaaagaa tgacgttttg tagcatgcaa atcttaggaa atccaaacat tgtatcagat
     2941 tacagccaca ccttcattat gtcctaccta tggttgcctc atgctacaaa gggaaatcaa
     3001 gtagttgtca cagactgggc tgtacattgc ctacaaagtt cgaatgtttg ctctctggcc
     3061 tcctgtggac aggtcctaaa taggccacaa attgtgccat ccctgataac accactagag
     3121 ggggcacctg ggccccacaa gtggtgcaga agtgggacca gtactgtttc tagacacatg
     3181 acagatttct cactttatac catgcccaac tgtgtcgaat ttttaaccga acaccttcag
     3241 gaaatgaaac tacctattca ttgcagcact atttagaaag tcagtgagtt tgtcgatcta
     3301 gatttacaac tctttgggaa ttagtacact catttttatg tctaatacaa attgaatttt
     3361 caggtcagaa tttccaatca ggaattttgt cgtgggctta tttattattt acctcatgaa
     3421 gaaactgtta accattcctt tagagattgt tattgtagaa ctgttacttt aaatacacta
     3481 atagttaacg gtggtgtctt cataatttaa gcacatgagc agttggtatt ttagagaatc
     3541 cgtaaccagg gcaactgctt gagtataaat agctattaaa accaaatgta aaaggaagtc
     3601 tcaagtgaag ttacactgcc ctgtactcca tatccaaatt gtgctgtaag gtttcttccc
     3661 ttcaaaacag gaaatttgtc accaagagga acaaagtggg acagcctgtg agttcaccca
     3721 aaacttggga tgaaaaagtt ttaacaatac cctcttacct cctaaactac agaatgattt
     3781 tcagagtgga tttgtaaagc accgacagcc ccactccccg cctgaaagac ccatcaatgt
     3841 ctgtcctctc cccatctggg tgccatctag gttactactg tagctaagtc tggcttaggt
     3901 tttgttgctg tttgtagttt gttggctttg ctttttgttt ggttttggtg ctagggatca
     3961 agccagggat tatatgtgct ggtaagcaca tattctgcca tagagctgtg ccctgatgta
     4021 ctttcgatag atgttacctg ttacaaggaa gttaatggtg tgcagggagg gaattctcat
     4081 ccagacaacc tatcaggctt cttttctctg tcagtcaagc ctttctgcca agcctgtgtg
     4141 catcagtgct tacctacaga gaaagccaaa ttaccagagt aaaaatgaca tggcgctcct
     4201 gaggacagtg taccgcttag catttagtgt ctctcccttg tagctgagag ccttcctcag
     4261 ctgttcaccc accttgctag accatgtctg tggctcattt tccaagtttg gtagagatct
     4321 gttaagtgct gtaggaaact gatgttcttg caagcaagca ttgtagcagc ctttaaagca
     4381 gcaaatttat atgtgcatgg acattaggct taataaactt tggttttgtt aa
//
