LOCUS       NM_148891               2246 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus N-myristoyltransferase 1 (Nmt1), mRNA.
ACCESSION   NM_148891
VERSION     NM_148891.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2246)
  AUTHORS   Thinon,E., Serwa,R.A., Broncel,M., Brannigan,J.A., Brassat,U.,
            Wright,M.H., Heal,W.P., Wilkinson,A.J., Mann,D.J. and Tate,E.W.
  TITLE     Global profiling of co- and post-translationally N-myristoylated
            proteomes in human cells
  JOURNAL   Nat Commun 5, 4919 (2014)
   PUBMED   25255805
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2246)
  AUTHORS   Montgomery,C., Pei,Z., Watkins,P.A. and Miziorko,H.M.
  TITLE     Identification and characterization of an extramitochondrial human
            3-hydroxy-3-methylglutaryl-CoA lyase
  JOURNAL   J Biol Chem 287 (40), 33227-33236 (2012)
   PUBMED   22865860
REFERENCE   3  (bases 1 to 2246)
  AUTHORS   Charavaryamath,C., Lemieux,H., Singh Suri,S., Selvakumar,P.,
            Sharma,R.K. and Singh,B.
  TITLE     Expression and activities of N-myristoyltransferase and calcineurin
            in normal and inflamed lungs
  JOURNAL   Exp Lung Res 35 (9), 729-747 (2009)
   PUBMED   19916857
  REMARK    GeneRIF: cell-specific increase expression of myristoyltransferase
            and calcineurin in lung epithelium and endothelium
REFERENCE   4  (bases 1 to 2246)
  AUTHORS   Shrivastav,A., Varma,S., Saxena,A., DeCoteau,J. and Sharma,R.K.
  TITLE     N-myristoyltransferase: a potential novel diagnostic marker for
            colon cancer
  JOURNAL   J Transl Med 5, 58 (2007)
   PUBMED   18021392
  REMARK    GeneRIF: N-myristoyltransferase may have a role in progression of
            colonic neoplasms
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2246)
  AUTHORS   Rioux,V., Beauchamp,E., Pedrono,F., Daval,S., Molle,D.,
            Catheline,D. and Legrand,P.
  TITLE     Identification and characterization of recombinant and native rat
            myristoyl-CoA: protein N-myristoyltransferases
  JOURNAL   Mol Cell Biochem 286 (1-2), 161-170 (2006)
   PUBMED   16538398
  REMARK    GeneRIF: NMT1 protein exhibited functional myristoyltransferase
            activity.
REFERENCE   6  (bases 1 to 2246)
  AUTHORS   Yang,S.H., Shrivastav,A., Kosinski,C., Sharma,R.K., Chen,M.H.,
            Berthiaume,L.G., Peters,L.L., Chuang,P.T., Young,S.G. and
            Bergo,M.O.
  TITLE     N-myristoyltransferase 1 is essential in early mouse development
  JOURNAL   J Biol Chem 280 (19), 18990-18995 (2005)
   PUBMED   15753093
REFERENCE   7  (bases 1 to 2246)
  AUTHORS   Rajala,R.V., Kakkar,R., Kanthan,R., Radhi,J.M., Wang,X., Wang,R.,
            Datla,R.S. and Sharma,R.K.
  TITLE     Altered expression and localization of N-myristoyltransferase in
            experimentally induced rat model of ischemia-reperfusion
  JOURNAL   J Cell Biochem 86 (3), 509-519 (2002)
   PUBMED   12210757
  REMARK    GeneRIF: Altered expression and localization of
            N-myristoyltransferase in experimentally induced rat model of
            ischemia-reperfusion.
REFERENCE   8  (bases 1 to 2246)
  AUTHORS   Giang,D.K. and Cravatt,B.F.
  TITLE     A second mammalian N-myristoyltransferase
  JOURNAL   J Biol Chem 273 (12), 6595-6598 (1998)
   PUBMED   9506952
REFERENCE   9  (bases 1 to 2246)
  AUTHORS   Glover,C.J., Hartman,K.D. and Felsted,R.L.
  TITLE     Human N-myristoyltransferase amino-terminal domain involved in
            targeting the enzyme to the ribosomal subcellular fraction
  JOURNAL   J Biol Chem 272 (45), 28680-28689 (1997)
   PUBMED   9353336
  REMARK    Erratum:[J Biol Chem 1998 Mar 6;273(10):5988]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097277.1.
            
            On Jun 12, 2005 this sequence version replaced NM_148891.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097277.1, AJ492222.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2246
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..2246
                     /gene="Nmt1"
                     /note="N-myristoyltransferase 1"
                     /db_xref="GeneID:259274"
                     /db_xref="RGD:628642"
     exon            1..510
                     /gene="Nmt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             380..1870
                     /gene="Nmt1"
                     /EC_number="2.3.1.97"
                     /note="NMT 1; type I N-myristoyltransferase; peptide
                     N-myristoyltransferase 1; myristoyl-CoA:protein
                     N-myristoyltransferase 1"
                     /codon_start=1
                     /product="glycylpeptide N-tetradecanoyltransferase 1"
                     /protein_id="NP_683689.1"
                     /db_xref="GeneID:259274"
                     /db_xref="RGD:628642"
                     /translation="MADESETAVKLPAPSLPLMMEGNGNGHEHCSDCENEEDISHNRG
                     GLSPANDTGAKKKKKKQKKKKEKGNDMDSTQDQPVKMNSLPAERIQEIQKAIELFSVG
                     QGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDA
                     LDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVS
                     SRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGI
                     FQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPK
                     TAGLRPMEKKDIPVVHQLLSRYLKQFNLTPVMNQEEVEHWFYPQENIIDTFVVENANG
                     EVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVF
                     NALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ"
     exon            511..619
                     /gene="Nmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..764
                     /gene="Nmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            765..883
                     /gene="Nmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..975
                     /gene="Nmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1092
                     /gene="Nmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1263
                     /gene="Nmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1372
                     /gene="Nmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1543
                     /gene="Nmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1711
                     /gene="Nmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1849
                     /gene="Nmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2205
                     /gene="Nmt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgtggccc ggtgattacc aagggtgcgc tgcaaacctt ggactttgca agcccttcac
       61 tcgccaaact ctaattcaac atggaactgc aactcccagc atgccccgcg accaccctgt
      121 aaggcgtgta gctctcttcg tcttgagctt ggctgaacct aggggcttcc ggaattgctg
      181 ccagctcctc ccaaggcagc gtccctacgt gatttctggg ttttgtagtt cacattggta
      241 cagtttcttg agaacaagcc tcccttagtg tcaggtttcg tcacataaac tacaaaaccc
      301 agaatacagc gcgaatttcc cctatccaat aggagccctc catgtagcgg ggcgcggagt
      361 ccggctctcg caacccaaga tggcggatga gagtgagaca gcagtgaagc tgccggcacc
      421 ttcgctgcca ctgatgatgg aagggaatgg aaacggccat gagcactgca gcgattgcga
      481 gaacgaggag gacatcagcc acaacagggg tggcttgagt ccagccaatg acactggagc
      541 caaaaagaag aaaaagaaac aaaagaagaa gaaagagaaa ggcaacgaca tggattccac
      601 ccaggatcag cctgtgaaga tgaactcttt gccagcagag aggatccagg aaatacagaa
      661 agccattgag ctgttctcag tgggtcaggg gcccgccaaa accatggagg aagccagtaa
      721 acgaagctac cagttctggg atacacagcc agtgcccaaa ttaggtgaag tggtaaacac
      781 ccatggccct gtggaacctg acaaagacaa cattcgccag gagccctaca ccctacccca
      841 gggcttcact tgggatgcct tggacctggg agaccgtggt gtgctaaaag aactgtacac
      901 cctcctgaac gagaactatg tggaagatga cgataacatg ttccgattcg attattcccc
      961 agagtttctc ttgtgggctc tccggccacc aggctggctc ccacagtggc actgcggggt
     1021 ccgagtggtc tcaagtcgga aactggttgg attcatcagt gccatcccag caaacatcca
     1081 catctatgac acagagaaga agatggtgga gatcaacttc ctgtgtgtcc acaagaagct
     1141 acgctccaag cgggtggctc cagtcttgat ccgagagata acccggcggg tccacctgga
     1201 gggcattttc caagctgttt acactgccgg cgtagtgttg ccaaagcctg ttggcacctg
     1261 caggtactgg catcggtccc tgaaccctcg gaagctgatt gaagtcaagt tctcccacct
     1321 gagcagaaac atgaccatgc agcgcaccat gaagctgtac cggctgccag agactcccaa
     1381 gacagctggg ctacgcccga tggaaaagaa ggacattccg gtagtgcacc agctgctcag
     1441 caggtacctg aagcagttta acctcacccc cgtcatgaac caggaggagg tagagcactg
     1501 gttctacccc caggagaaca tcattgacac ttttgtggta gagaatgcca atggtgaggt
     1561 gactgatttc ctgagctttt atacacttcc ttccaccatc atgaaccatc caacccacaa
     1621 gagtctgaaa gctgcatact ccttctacaa cgtccacacc cagacccctc ttctagacct
     1681 catgagcgac gccctcgttc tagccaaaat gaaagggttc gacgtattca atgcactgga
     1741 tctcatggag aacaaaacat tcctggagaa gctcaagttc ggcatagggg acggcaacct
     1801 gcagtattac ctgtacaatt ggaagtgccc gagcatgggg gccgagaagg ttgggttggt
     1861 gttacagtaa ccagctgcca gtgagattct ggataaagcc actgagaatc caaaccagga
     1921 aacggaaccc tccacttgtg gtccagctct cacagatgtg agatcgctgg caaacagaac
     1981 agaactgaac cggctttacc aaaccgccag cgaacttgac aattatattg ccatggcgtg
     2041 ggctgcgtga cgtcaccttt agccatgttt ctggtctccc tgttttcagt gaattaccat
     2101 gctcatgcag ccatgatcaa gggaatggaa ctgctgaaac ctcgctcgtg attggcatat
     2161 tatggagtta acgggtgaat aataaaagta tatatattat atataaaaaa aaaaaaaaaa
     2221 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
