LOCUS       NM_001024292            1591 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus nicotinamide riboside kinase 1 (Nmrk1), mRNA.
ACCESSION   NM_001024292 XM_574636
VERSION     NM_001024292.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1591)
  AUTHORS   Houtkooper,R.H., Canto,C., Wanders,R.J. and Auwerx,J.
  TITLE     The secret life of NAD+: an old metabolite controlling new
            metabolic signaling pathways
  JOURNAL   Endocr Rev 31 (2), 194-223 (2010)
   PUBMED   20007326
  REMARK    Review article
REFERENCE   2  (bases 1 to 1591)
  AUTHORS   Tempel,W., Rabeh,W.M., Bogan,K.L., Belenky,P., Wojcik,M.,
            Seidle,H.F., Nedyalkova,L., Yang,T., Sauve,A.A., Park,H.W. and
            Brenner,C.
  TITLE     Nicotinamide riboside kinase structures reveal new pathways to NAD+
  JOURNAL   PLoS Biol 5 (10), e263 (2007)
   PUBMED   17914902
REFERENCE   3  (bases 1 to 1591)
  AUTHORS   Bieganowski,P. and Brenner,C.
  TITLE     Discoveries of nicotinamide riboside as a nutrient and conserved
            NRK genes establish a Preiss-Handler independent route to NAD+ in
            fungi and humans
  JOURNAL   Cell 117 (4), 495-502 (2004)
   PUBMED   15137942
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079144.1.
            
            On May 27, 2005 this sequence version replaced XM_574636.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079144.1, FQ100202.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132277, SAMD00132290
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1591
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q51"
     gene            1..1591
                     /gene="Nmrk1"
                     /gene_synonym="Nrk1"
                     /note="nicotinamide riboside kinase 1"
                     /db_xref="GeneID:499330"
                     /db_xref="RGD:1564687"
     exon            1..52
                     /gene="Nmrk1"
                     /gene_synonym="Nrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            53..116
                     /gene="Nmrk1"
                     /gene_synonym="Nrk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..675
                     /gene="Nmrk1"
                     /gene_synonym="Nrk1"
                     /EC_number="2.7.1.22"
                     /EC_number="2.7.1.173"
                     /note="RNK 1; nmR-K 1; ribosylnicotinamide kinase 1;
                     ribosylnicotinic acid kinase 1; nicotinic acid riboside
                     kinase 1"
                     /codon_start=1
                     /product="nicotinamide riboside kinase 1"
                     /protein_id="NP_001019463.1"
                     /db_xref="GeneID:499330"
                     /db_xref="RGD:1564687"
                     /translation="MKTFVIGIGGVTNGGKTTLAKNLQKRLPNCSVISQDDFFKPESE
                     IDIDENGFLQYDVLEALNMEKMMSAVSCWMENPGSSAGPAALESAQGVPILIIEGFLL
                     FNYKPLDTIWNRSYFLTVPYEECKRRRSTRVYEPPDPPGYFDGHVWPMYLKHRQEMNS
                     ITWDIVYLDGTRSEEDLFSQVYEDVKQELEKQNGL"
     exon            117..207
                     /gene="Nmrk1"
                     /gene_synonym="Nrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            208..256
                     /gene="Nmrk1"
                     /gene_synonym="Nrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            257..404
                     /gene="Nmrk1"
                     /gene_synonym="Nrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            405..476
                     /gene="Nmrk1"
                     /gene_synonym="Nrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            477..583
                     /gene="Nmrk1"
                     /gene_synonym="Nrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            584..667
                     /gene="Nmrk1"
                     /gene_synonym="Nrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..1567
                     /gene="Nmrk1"
                     /gene_synonym="Nrk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtcttgcag cctgctctgc ggccctgctg gggaggattc gaacccgctt tggacatatt
       61 aggaagctgt gatttccaaa gccaattatg aagacatttg tcattggaat tggtggtgtg
      121 acaaatggag ggaagacaac actggctaag aacctgcaga aacgccttcc caactgcagc
      181 gtaatatctc aggacgactt cttcaagcca gagtctgaga tagacataga tgagaatggt
      241 tttctgcagt atgatgtgct tgaagcactt aacatggaaa aaatgatgtc agccgtttcc
      301 tgttggatgg agaacccagg aagctctgcg gggccagcag ccttggaaag tgctcaaggg
      361 gttcccattt taattattga agggttcctg ctctttaatt ataagcctct ggacaccata
      421 tggaacagaa gctatttcct gaccgttcca tatgaagaat gtaagagaag gaggagtacc
      481 agagtctatg agcctccaga ccctccaggg tacttcgatg gccacgtgtg gcccatgtac
      541 ctgaagcaca ggcaggagat gaactccatc acctgggaca ttgtttacct ggacggaaca
      601 aggtctgaag aggacctctt ctcccaagtg tatgaagatg tcaagcaaga attggagaag
      661 caaaatggtt tgtgataaca ccacccagat gcagtgcagc aagtcttccc gggatggatt
      721 cggacccttg aagggatatt ctgaagaaca ttaaccgagt ttcagtatgt ctttctggca
      781 gtgacagctc gtctgtatgt tcatttttct cacactttcc ccaacatacg gagccatgtg
      841 tgcgcacgcc accagacagg aaccttctca ggaaagcaag aatggcttga tctcactctg
      901 cgggaggcac agcacagttt gtgcacaaag ggtcagtccc tctacaggaa caaaagccaa
      961 aatttcctga ctgttaccta gcagggaaac cattgccatg tacaccagca atgtgtgctg
     1021 tgctgtgtat gattctgcat ttgtatgtat atgtatgtat ttatacatat gctcacatac
     1081 tacaaaatga accttgtata ctacacagca tgtttttttt ccagttttca ttttgttcct
     1141 attgattata atatataatt tgaaaaatgg tctcatagca gtgccccccc ccacctacaa
     1201 ctgacggcat tacccaaagt aaaggtccca tattgactga gtcagcagtt taaggcagag
     1261 cctggagact ttgtgcttgt agccataggc tttcttgtat ctgtcgaata ctgtgtctct
     1321 gtgagatttt tttttttata tccatagacg tttttggtat gttttacttg gttttctgaa
     1381 actgacactc cgaaatacag aatcatatag tttcttcaat catatataaa accaaggcct
     1441 ttctttgaaa agcacaggca ggagaagtga attggggaat ctcttagtgc ctctttcaat
     1501 gtgggaatta aaatcatgaa ttcatgtatg gagattgttt attaataata aaaataactg
     1561 cccatgaaaa aaaaaaaaaa aaaaaaaaaa a
//
