LOCUS       NM_001395702            2083 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus nicotinamide nucleotide adenylyltransferase 3
            (Nmnat3), transcript variant 2, mRNA.
ACCESSION   NM_001395702 XM_006243608
VERSION     NM_001395702.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2083)
  AUTHORS   Yue,Z., Ma,Y., You,J., Li,Z., Ding,Y., He,P., Lu,X., Jiang,J.,
            Chen,S. and Liu,P.
  TITLE     NMNAT3 is involved in the protective effect of SIRT3 in Ang
            II-induced cardiac hypertrophy
  JOURNAL   Exp Cell Res 347 (2), 261-273 (2016)
   PUBMED   27423420
  REMARK    GeneRIF: NMNAT3 regulates the activity of SIRT3 via synthesis of
            mitochondria NAD.
REFERENCE   2  (bases 1 to 2083)
  AUTHORS   Kitaoka,Y., Munemasa,Y., Kojima,K., Hirano,A., Ueno,S. and
            Takagi,H.
  TITLE     Axonal protection by Nmnat3 overexpression with involvement of
            autophagy in optic nerve degeneration
  JOURNAL   Cell Death Dis 4 (10), e860 (2013)
   PUBMED   24136224
  REMARK    GeneRIF: These results suggest that the axonal-protective effect of
            Nmnat3 may be involved in autophagy machinery.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2083)
  AUTHORS   Houtkooper,R.H., Canto,C., Wanders,R.J. and Auwerx,J.
  TITLE     The secret life of NAD+: an old metabolite controlling new
            metabolic signaling pathways
  JOURNAL   Endocr Rev 31 (2), 194-223 (2010)
   PUBMED   20007326
  REMARK    Review article
REFERENCE   4  (bases 1 to 2083)
  AUTHORS   Sasaki,Y., Araki,T. and Milbrandt,J.
  TITLE     Stimulation of nicotinamide adenine dinucleotide biosynthetic
            pathways delays axonal degeneration after axotomy
  JOURNAL   J Neurosci 26 (33), 8484-8491 (2006)
   PUBMED   16914673
REFERENCE   5  (bases 1 to 2083)
  AUTHORS   Berger,F., Lau,C., Dahlmann,M. and Ziegler,M.
  TITLE     Subcellular compartmentation and differential catalytic properties
            of the three human nicotinamide mononucleotide adenylyltransferase
            isoforms
  JOURNAL   J Biol Chem 280 (43), 36334-36341 (2005)
   PUBMED   16118205
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jul 30, 2021 this sequence version replaced XM_006243608.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.431445.1,
                                           SRR26360181.2977591.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               JAXUCZ010000008.1  107771613-107771968
            357-499             JAXUCZ010000008.1  107824832-107824974
            500-683             JAXUCZ010000008.1  107870772-107870955
            684-763             JAXUCZ010000008.1  107874778-107874857
            764-2083            JAXUCZ010000008.1  107881964-107883283
FEATURES             Location/Qualifiers
     source          1..2083
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..2083
                     /gene="Nmnat3"
                     /note="nicotinamide nucleotide adenylyltransferase 3"
                     /db_xref="GeneID:363118"
                     /db_xref="RGD:1309140"
     exon            1..356
                     /gene="Nmnat3"
                     /inference="alignment:Splign:2.1.0"
     exon            357..499
                     /gene="Nmnat3"
                     /inference="alignment:Splign:2.1.0"
     CDS             391..1128
                     /gene="Nmnat3"
                     /EC_number="2.7.7.1"
                     /note="nicotinamide mononucleotide adenylyltransferase 3"
                     /codon_start=1
                     /product="nicotinamide/nicotinic acid mononucleotide
                     adenylyltransferase 3"
                     /protein_id="NP_001382631.1"
                     /db_xref="GeneID:363118"
                     /db_xref="RGD:1309140"
                     /translation="MKNRIPVVLLACGSFNPITNMHLRLFEVARDHLHQTGKYQVIEG
                     IISPVNDSYGKKDLVASHHRVAMARLALQTSDWIRVDPWESEQAQWMETVKVLRHHHG
                     ELLRSVAQMDGPDPSKIPSASAALPELKLLCGADVLKTFHTPNLWKDSHIQEIVEKFG
                     LVCVNRSGHDPKRYILDSPILQQFQHNIHLAREPVLNEISATYVRKALSQGQSVKYLL
                     PEAVITYIRDQGLYINDSSGKGKGKTG"
     exon            500..683
                     /gene="Nmnat3"
                     /inference="alignment:Splign:2.1.0"
     exon            684..763
                     /gene="Nmnat3"
                     /inference="alignment:Splign:2.1.0"
     exon            764..2083
                     /gene="Nmnat3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttagtgttgg ggcggtctag cccgtgacct gattctccac tctggtcgag cagcagattc
       61 gcggtcccgg tggacctccg agcttctccc gtgccgccgc ggagccccgc gccgcgcagt
      121 taagcacagc caacagcctt gactgctgcc cgcgtgggtg cccacgaggc cctgagtccg
      181 acgtacctcc caggcccccg tgactcggag gcggcgactc gggtgcgcgc gcactcgggc
      241 gtcagatggc tgcggagcgc agaaccgtgc tagccccacg gtcacgtttc tgacggacag
      301 gatcgggttg acccgggttc ggatccctcc tgcagcacgt atacagtcag ttaaaaggtg
      361 gccactggag gtttggatgt gtgtgacagc atgaagaacc gaatccccgt ggtgctcctg
      421 gcctgtggtt ccttcaaccc catcacgaat atgcacctgc gtttgtttga ggtggccaga
      481 gaccacctgc accagacagg aaagtaccag gtgatcgagg gcatcatctc gcctgtcaat
      541 gacagttatg ggaagaaaga cctggtggct tcccaccacc gcgtggccat ggcccggctg
      601 gccctgcaga catctgactg gattcgggta gacccctggg agagcgagca ggcacagtgg
      661 atggaaacgg tgaaggtcct gaggcatcat cacggggagc tgctcagatc cgtggcccag
      721 atggatggcc cagaccccag caaaatacca tcagcctctg cggcactgcc tgagctgaaa
      781 ctcctctgtg gagctgacgt cctcaagacc ttccacaccc ccaacctctg gaaagactcg
      841 cacatccagg agatagtgga gaagttcggt ttggtgtgtg tgaaccggag cggtcatgac
      901 ccgaagaggt acatcttgga ttcacccatc ctccaacagt tccagcacaa cattcacctg
      961 gccagggaac ccgttctgaa cgagatcagt gccacatatg tcaggaaagc cttgagccaa
     1021 gggcagagcg tgaagtacct cctccccgag gctgtcatca cctacatcag ggaccagggc
     1081 ctctacatca atgacagttc cgggaaagga aaaggaaaga ctggctagag ggccttctgg
     1141 ggcgtcaggg gtgattttgc tctggttctg tgtttgtttc tacagtggtt ctaccatggg
     1201 tgacttcctg ctccgggaag agattgggcc tctggcaggg acagtcatgt aacatcagag
     1261 caaactaagt tgcttaacat cagagcacga caggtcatag gagtaggcaa aacctctcag
     1321 ggtcactaat gagaagacct gcttactgtg taaatggcac gtatagaagt cacactgatg
     1381 ctgttctgag catggccggc ccctgagggg tccaccacag tcacccttgt tcgttttttt
     1441 ttttttaaag tcaggcctgg cgaagcatta ctggtctaga taggccatat ttgatatggt
     1501 gctaattact gaacagaggg ccttttcaac atccttgttt caaacagaat aaaagcaagc
     1561 gaggattcag atatctggaa acagcattat cactgatttc cagtgtattc tcccttgcaa
     1621 accatgccct gcctgcctac ctgttttaaa agttttgacc acgttctttc tatgttgtgg
     1681 tcaagtgata tgtgtttaag atctatttta ttatatgtgt gtgtgcatgt atgtgtacat
     1741 gcatatggga gggacatcgg agtgcctgaa gccagagtta ctggcagttg tgagccccct
     1801 gatgtgggtg ctgggaccca aactccagtc ttacagaaga gcagcaaatg ctcttaacca
     1861 ctgagccgcc tctccagccc cctcgagcaa tattttttga tacagcatgt atttttacac
     1921 ccatatagtc taaacaccag ggttcctgat atcctgattt ctaaaaagga actgaagtaa
     1981 aacagatgcc tgtctgcttt agaagatctt ttgaatgttt tatgactgtc tgcttgtttg
     2041 aatattggca aaaagataaa taataaattg acatcaaaaa ata
//
