LOCUS       NM_001048042            1239 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus nicotinamide nucleotide adenylyltransferase 2
            (Nmnat2), mRNA.
ACCESSION   NM_001048042 XM_001071224 XM_213900
VERSION     NM_001048042.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1239)
  AUTHORS   Yu,J., Meng,J., Qin,Z., Yu,Y., Liang,Y., Wang,Y. and Min,D.
  TITLE     Dysbiosis of gut microbiota inhibits NMNAT2 to promote
            neurobehavioral deficits and oxidative stress response in the
            6-OHDA-lesioned rat model of Parkinson's disease
  JOURNAL   J Neuroinflammation 20 (1), 117 (2023)
   PUBMED   37208728
  REMARK    GeneRIF: Dysbiosis of gut microbiota inhibits NMNAT2 to promote
            neurobehavioral deficits and oxidative stress response in the
            6-OHDA-lesioned rat model of Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1239)
  AUTHORS   Cai,Y., Yu,S.S., Chen,S.R., Pi,R.B., Gao,S., Li,H., Ye,J.T. and
            Liu,P.Q.
  TITLE     Nmnat2 protects cardiomyocytes from hypertrophy via activation of
            SIRT6
  JOURNAL   FEBS Lett 586 (6), 866-874 (2012)
   PUBMED   22449973
  REMARK    GeneRIF: Data show that overexpression of Nmnat2 but not its
            catalytically inactive mutant blocked angiotensin II (Ang
            II)-induced cardiac hypertrophy, which was dependent on activation
            of SIRT6 through maintaining the intracellular NAD level.
REFERENCE   3  (bases 1 to 1239)
  AUTHORS   Mayer,P.R., Huang,N., Dewey,C.M., Dries,D.R., Zhang,H. and Yu,G.
  TITLE     Expression, localization, and biochemical characterization of
            nicotinamide mononucleotide adenylyltransferase 2
  JOURNAL   J Biol Chem 285 (51), 40387-40396 (2010)
   PUBMED   20943658
REFERENCE   4  (bases 1 to 1239)
  AUTHORS   Houtkooper,R.H., Canto,C., Wanders,R.J. and Auwerx,J.
  TITLE     The secret life of NAD+: an old metabolite controlling new
            metabolic signaling pathways
  JOURNAL   Endocr Rev 31 (2), 194-223 (2010)
   PUBMED   20007326
  REMARK    Review article
REFERENCE   5  (bases 1 to 1239)
  AUTHORS   Sorci,L., Cimadamore,F., Scotti,S., Petrelli,R., Cappellacci,L.,
            Franchetti,P., Orsomando,G. and Magni,G.
  TITLE     Initial-rate kinetics of human NMN-adenylyltransferases: substrate
            and metal ion specificity, inhibition by products and
            multisubstrate analogues, and isozyme contributions to NAD+
            biosynthesis
  JOURNAL   Biochemistry 46 (16), 4912-4922 (2007)
   PUBMED   17402747
REFERENCE   6  (bases 1 to 1239)
  AUTHORS   Berger,F., Lau,C., Dahlmann,M. and Ziegler,M.
  TITLE     Subcellular compartmentation and differential catalytic properties
            of the three human nicotinamide mononucleotide adenylyltransferase
            isoforms
  JOURNAL   J Biol Chem 280 (43), 36334-36341 (2005)
   PUBMED   16118205
REFERENCE   7  (bases 1 to 1239)
  AUTHORS   Raffaelli,N., Sorci,L., Amici,A., Emanuelli,M., Mazzola,F. and
            Magni,G.
  TITLE     Identification of a novel human nicotinamide mononucleotide
            adenylyltransferase
  JOURNAL   Biochem Biophys Res Commun 297 (4), 835-840 (2002)
   PUBMED   12359228
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from DQ022370.1.
            
            On or before Sep 14, 2006 this sequence version replaced
            XM_213900.4, XM_001071224.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ022370.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1239
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..1239
                     /gene="Nmnat2"
                     /note="nicotinamide nucleotide adenylyltransferase 2"
                     /db_xref="GeneID:289095"
                     /db_xref="RGD:1307331"
     exon            1..215
                     /gene="Nmnat2"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1054
                     /gene="Nmnat2"
                     /EC_number="2.7.7.1"
                     /EC_number="2.7.7.18"
                     /note="nicotinamide mononucleotide adenylyltransferase 2;
                     NMN adenylyltransferase 2; naMN adenylyltransferase 1;
                     nicotinate-nucleotide adenylyltransferase 1; naMN
                     adenylyltransferase 2; NMN/NaMN adenylyltransferase 2;
                     nicotinate-nucleotide adenylyltransferase 2"
                     /codon_start=1
                     /product="nicotinamide/nicotinic acid mononucleotide
                     adenylyltransferase 2"
                     /protein_id="NP_001041507.1"
                     /db_xref="GeneID:289095"
                     /db_xref="RGD:1307331"
                     /translation="MTETTKTHVILLACGSFNPITKGHIQMFERARDYLHKTGRFIVI
                     GGIVSPVHDSYGKQGLVSSRHRLIMCQLAVQNSDWIRVDPWECYQDTWQTTCSVLEHH
                     RDLMKRVTGCILSNVNTPSMTPVIGQPQHENTQPIYQNSNVPTKPTAAKILGKVGESL
                     GRICCVRPPVERFTFVDENANLGTVMRYEEIELRILLLCGSDLLESFCIPGLWNEADM
                     EVIVGDFGIVVVPRDAADADRIMNHSSILRKYKNNIMVVKDDINHPMSVVSSTKSRLA
                     LQHGDGHVVDYLSQPVIDYILKSQLYINASG"
     exon            216..304
                     /gene="Nmnat2"
                     /inference="alignment:Splign:2.1.0"
     exon            305..372
                     /gene="Nmnat2"
                     /inference="alignment:Splign:2.1.0"
     exon            373..451
                     /gene="Nmnat2"
                     /inference="alignment:Splign:2.1.0"
     exon            452..578
                     /gene="Nmnat2"
                     /inference="alignment:Splign:2.1.0"
     exon            579..659
                     /gene="Nmnat2"
                     /inference="alignment:Splign:2.1.0"
     exon            660..704
                     /gene="Nmnat2"
                     /inference="alignment:Splign:2.1.0"
     exon            705..781
                     /gene="Nmnat2"
                     /inference="alignment:Splign:2.1.0"
     exon            782..883
                     /gene="Nmnat2"
                     /inference="alignment:Splign:2.1.0"
     exon            884..951
                     /gene="Nmnat2"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1239
                     /gene="Nmnat2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgtctagag cggctccttg gagtccacag catccaccgc cggagcctcg ccttcctttc
       61 tccgtctgca gacatatcga gacacaaaaa gaggaaaccc ctggatccgt gcgagggacc
      121 tattcccaat atgaccgaga ccacaaagac ccacgttatc ctgctggcct gcggcagctt
      181 caatcccatc actaaagggc acattcagat gttcgaaaga gccagggatt atctgcacaa
      241 gactggaaga tttattgtga ttggtggtat tgtctctcca gtccacgact cctatggaaa
      301 acagggtctt gtgtcaagtc ggcaccgtct catcatgtgt cagctggctg tccaaaattc
      361 tgactggatc agggtggacc catgggagtg ctaccaggac acctggcaga caacctgcag
      421 tgtgttagag caccatcgag acctcatgaa gagggtgacc ggctgcatcc tctccaacgt
      481 caacacgcct tccatgacac ctgtgattgg acagccacaa cacgagaaca cccagcccat
      541 ttaccagaac agcaatgtgc ccaccaagcc cactgcagcc aagatcttgg gaaaggtggg
      601 agagagcctc ggccggatct gctgtgtccg tccacccgtg gagcgcttca cttttgtaga
      661 tgagaacgcc aacctgggca cagtgatgcg gtatgaggag atcgagctgc gcatcttgct
      721 gctgtgcggt agtgacctgc tggagtcctt ctgcatccca ggactctgga atgaggcaga
      781 tatggaagtg attgttgggg attttgggat tgtggtggtg ccccgggatg cagcggacgc
      841 agaccgaatc atgaatcact cctcaatact ccgcaaatac aaaaacaaca tcatggtagt
      901 gaaggatgac atcaaccatc ccatgtctgt agtcagctcc accaaaagca ggctggccct
      961 gcagcatggg gatggccacg ttgtggatta cctgtcccag ccggtcatcg actacatcct
     1021 caagagtcag ctgtacatca atgcctcggg ctagcagata cccagctttc tgctctactc
     1081 tccccttgtc ctctgccaac atactggccc cctccagtca ctgtcagacc ccggtttctc
     1141 tcctgcctct ctgtttctct gtgttcatct tgactgttct ccccactggc tgacttaacc
     1201 cccacagtgt ggagggcctg cgaagaaccg tgaaccgtg
//
