LOCUS       NM_001037556            2130 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus nicotinamide nucleotide adenylyltransferase 1
            (Nmnat1), mRNA.
ACCESSION   NM_001037556 XM_001075600
VERSION     NM_001037556.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2130)
  AUTHORS   Fragoza R, Das J, Wierbowski SD, Liang J, Tran TN, Liang S, Beltran
            JF, Rivera-Erick CA, Ye K, Wang TY, Yao L, Mort M, Stenson PD,
            Cooper DN, Wei X, Keinan A, Schimenti JC, Clark AG and Yu H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2130)
  AUTHORS   Sasaki Y, Nakagawa T, Mao X, DiAntonio A and Milbrandt J.
  TITLE     NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated
            NAD+ depletion
  JOURNAL   Elife 5, e19749 (2016)
   PUBMED   27735788
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2130)
  AUTHORS   Wright RH, Lioutas A, Le Dily F, Soronellas D, Pohl A, Bonet J,
            Nacht AS, Samino S, Font-Mateu J, Vicent GP, Wierer M, Trabado MA,
            Schelhorn C, Carolis C, Macias MJ, Yanes O, Oliva B and Beato M.
  TITLE     ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for
            chromatin remodeling
  JOURNAL   Science 352 (6290), 1221-1225 (2016)
   PUBMED   27257257
REFERENCE   4  (bases 1 to 2130)
  AUTHORS   Zhou,R.M., Shen,Y., Yao,J., Yang,H., Shan,K., Li,X.M., Jiang,Q. and
            Yan,B.
  TITLE     Nmnat 1: a Security Guard of Retinal Ganglion Cells (RGCs) in
            Response to High Glucose Stress
  JOURNAL   Cell Physiol Biochem 38 (6), 2207-2218 (2016)
   PUBMED   27184051
  REMARK    GeneRIF: Nmnat1 protects Retinal Ganglion Cells against high
            glucose-induced injury via p38-MAPK signaling pathway.
REFERENCE   5  (bases 1 to 2130)
  AUTHORS   Wei X, Das J, Fragoza R, Liang J, Bastos de Oliveira FM, Lee HR,
            Wang X, Mort M, Stenson PD, Cooper DN, Lipkin SM, Smolka MB and Yu
            H.
  TITLE     A massively parallel pipeline to clone DNA variants and examine
            molecular phenotypes of human disease mutations
  JOURNAL   PLoS Genet 10 (12), e1004819 (2014)
   PUBMED   25502805
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2130)
  AUTHORS   Sasaki Y, Araki T and Milbrandt J.
  TITLE     Stimulation of nicotinamide adenine dinucleotide biosynthetic
            pathways delays axonal degeneration after axotomy
  JOURNAL   J Neurosci 26 (33), 8484-8491 (2006)
   PUBMED   16914673
REFERENCE   7  (bases 1 to 2130)
  AUTHORS   Berger F, Lau C, Dahlmann M and Ziegler M.
  TITLE     Subcellular compartmentation and differential catalytic properties
            of the three human nicotinamide mononucleotide adenylyltransferase
            isoforms
  JOURNAL   J Biol Chem 280 (43), 36334-36341 (2005)
   PUBMED   16118205
REFERENCE   8  (bases 1 to 2130)
  AUTHORS   Revollo JR, Grimm AA and Imai S.
  TITLE     The NAD biosynthesis pathway mediated by nicotinamide
            phosphoribosyltransferase regulates Sir2 activity in mammalian
            cells
  JOURNAL   J Biol Chem 279 (49), 50754-50763 (2004)
   PUBMED   15381699
REFERENCE   9  (bases 1 to 2130)
  AUTHORS   Schweiger M, Hennig K, Lerner F, Niere M, Hirsch-Kauffmann M,
            Specht T, Weise C, Oei SL and Ziegler M.
  TITLE     Characterization of recombinant human nicotinamide mononucleotide
            adenylyl transferase (NMNAT), a nuclear enzyme essential for NAD
            synthesis
  JOURNAL   FEBS Lett 492 (1-2), 95-100 (2001)
   PUBMED   11248244
  REMARK    Erratum:[FEBS Lett 2001 May 4;496(1):68]
REFERENCE   10 (bases 1 to 2130)
  AUTHORS   Emanuelli M, Carnevali F, Saccucci F, Pierella F, Amici A,
            Raffaelli N and Magni G.
  TITLE     Molecular cloning, chromosomal localization, tissue mRNA levels,
            bacterial expression, and enzymatic properties of human NMN
            adenylyltransferase
  JOURNAL   J Biol Chem 276 (1), 406-412 (2001)
   PUBMED   11027696
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC127446.1.
            
            On or before Nov 14, 2006 this sequence version replaced
            XM_001075600.1, NM_001037556.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127446.1, AY788917.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2130
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2130
                     /gene="Nmnat1"
                     /note="nicotinamide nucleotide adenylyltransferase 1"
                     /db_xref="GeneID:298653"
                     /db_xref="RGD:1310996"
     exon            1..40
                     /gene="Nmnat1"
                     /inference="alignment:Splign:2.1.0"
     exon            41..211
                     /gene="Nmnat1"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..954
                     /gene="Nmnat1"
                     /EC_number="2.7.7.1"
                     /note="nicotinamide mononucleotide adenylyl transferase 1"
                     /codon_start=1
                     /product="nicotinamide/nicotinic acid mononucleotide
                     adenylyltransferase 1"
                     /protein_id="NP_001032645.2"
                     /db_xref="GeneID:298653"
                     /db_xref="RGD:1310996"
                     /translation="MDSSKKTEVVLLACGSFNPITNMHLRLFELAKDYLNATGEYKVI
                     KGIISPVGDAYKKKGLIPAHHRIIMAELATKNSHWVEVDTWESLQKEWVETVKVLRHH
                     QEKLATGSRSHPQSSPVLERPGRKRKWADQKQDSSPQKPQEPKPTGVPRVKLLCGADL
                     LESFSVPNLWKMEDITQIVANFGLICVTRAGSDAQKFIYESDVLWRHQSNIHLVTEWI
                     TNDISSTKIRRALRRGQSIRYLVPDLVQEYIEEHDLYNSESEDRNAGVTLAPLQRNTS
                     EAKHNHSTR"
     exon            212..395
                     /gene="Nmnat1"
                     /inference="alignment:Splign:2.1.0"
     exon            396..538
                     /gene="Nmnat1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..2104
                     /gene="Nmnat1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcctgga ggactagggc cgtttggcct tcacggcctg acaacaacat cggcatcaga
       61 ggactccatt tagatcagca actgcaactt ctccccatgg actcatccaa gaagacagag
      121 gtggttctcc tggcctgtgg ttcttttaac ccaatcacca acatgcacct caggctgttt
      181 gagctggcca aggactatct gaacgctaca ggagaataca aagttatcaa aggcatcatc
      241 tcaccagtcg gtgatgcata caagaagaaa ggactcatcc cagcccacca ccgaatcatc
      301 atggcggaac ttgccaccaa gaattcacac tgggtggaag tagacacatg ggaaagcctt
      361 cagaaggaat gggtggagac cgtgaaggtg ctcagacacc atcaggagaa gctggcaact
      421 ggcagccgca gtcacccgca aagctcacct gtgctggaaa ggcctgggcg gaagaggaag
      481 tgggctgatc aaaagcaaga ttctagccca cagaagcccc aagaacccaa accaacaggt
      541 gtgcccaggg tgaaattgct gtgtggcgca gacttgctgg agtccttcag cgtccccaac
      601 ttgtggaaga tggaggacat cacgcaaatc gtggccaact ttgggctcat ctgtgtcact
      661 cgggctggca gtgacgctca gaaattcatc tacgagtccg acgtgctgtg gcgacaccag
      721 agcaacatcc acctggtgac cgagtggatc accaatgaca tctcatccac caagatccgc
      781 cgagcgctca ggaggggcca gagcatccgc tacttggtgc cggacctcgt ccaagagtac
      841 attgaggagc atgatctgta caactctgag agcgaagacc ggaatgccgg ggtcaccctg
      901 gcacctctac agaggaacac ctcggaggcc aaacacaacc attccacccg atgacacccc
      961 gcaacgtccg atgatcctct ccaggcccaa aacaattggt gttagtaact cagggaagga
     1021 cttgccatcc tgttttataa actgaaattt aaaggtttga ttaaaaaaac caacagggaa
     1081 ttaagatcag ttactgagat gaatgttcta aataagacca tataagaaag aatgtaatac
     1141 acctttaaaa taacagctca ttcactaaaa tgagatgtca atgatgccct ctctaaatac
     1201 attttttcaa gaaaggaccc tgtgctgtgc tctaccacac aagaggccgg agacatagtt
     1261 ccgaggttaa gagcacagac tgcccttcca gagcattcag attcagctcc cagcacctgc
     1321 aaggcagctc acaactgtct gtaactccag tcccagggga tccgatgccc tctctgtccc
     1381 ctatgggctg taggccacaa atggtgcata gacagacata caggcaaaag atacatacat
     1441 acacacactc acagatacac gcacagatac acacagacac aaaaacacac acgcacagat
     1501 acgcatacat acacatacat acacacacac atacacacat acatacatac acacatacac
     1561 gtattcacac acacacacac acacacacac acacacacac acacacacac acacacaaag
     1621 aagaacctca ctttaaccag actcagtgat ggccacctac agccccagct gcaccaggag
     1681 ttgacgtagg agaatcactt tgaacccagg agtctgagat gactctagac aacatggacc
     1741 ctttctgaaa acaaaaacaa aacagaatcc tagctctagt tatgaagaga gctgtccatg
     1801 gctggcgccg gccatcttta tccagagtag aaggaaggaa ttctttacga cgtgaccttg
     1861 gctgggcatg cagctcggtc ggtagagcat tggcccgcag gcccgaggcc ctgggttaga
     1921 tccccagagc cacatcgact gggcacggca gtgcacacct gtgatcctgg cactcgggag
     1981 attgaagcag aaggatcaaa agctcgaggt catccttgac aaccagcaag tttgaggccg
     2041 tcaagagatg ccaaagaccc cttctctaaa ttaaacaaat aaataaatga ctctgtaaaa
     2101 tgcaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
