LOCUS       NM_001109478             873 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus NME/NM23 nucleoside diphosphate kinase 4 (Nme4),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001109478 XM_001064805
VERSION     NM_001109478.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 873)
  AUTHORS   Ren M, Phoon CK and Schlame M.
  TITLE     Metabolism and function of mitochondrial cardiolipin
  JOURNAL   Prog Lipid Res 55, 1-16 (2014)
   PUBMED   24769127
  REMARK    Review article
REFERENCE   2  (bases 1 to 873)
  AUTHORS   Schlattner U, Tokarska-Schlattner M, Ramirez S, Tyurina YY,
            Amoscato AA, Mohammadyani D, Huang Z, Jiang J, Yanamala N, Seffouh
            A, Boissan M, Epand RF, Epand RM, Klein-Seetharaman J, Lacombe ML
            and Kagan VE.
  TITLE     Dual function of mitochondrial Nm23-H4 protein in phosphotransfer
            and intermembrane lipid transfer: a cardiolipin-dependent switch
  JOURNAL   J Biol Chem 288 (1), 111-121 (2013)
   PUBMED   23150663
  REMARK    GeneRIF: Nm23-H4 acts as a lipid-dependent mitochondrial switch
            with dual function in phosphotransfer serving local GTP supply and
            cardiolipin transfer for apoptotic signaling and putative other
            functions
REFERENCE   3  (bases 1 to 873)
  AUTHORS   Tokarska-Schlattner M, Boissan M, Munier A, Borot C, Mailleau C,
            Speer O, Schlattner U and Lacombe ML.
  TITLE     The nucleoside diphosphate kinase D (NM23-H4) binds the inner
            mitochondrial membrane with high affinity to cardiolipin and
            couples nucleotide transfer with respiration
  JOURNAL   J Biol Chem 283 (38), 26198-26207 (2008)
   PUBMED   18635542
  REMARK    GeneRIF: NM23-H4 binds the inner mitochondrial membrane with high
            affinity to cardiolipin and couples nucleotide transfer with
            respiration
REFERENCE   4  (bases 1 to 873)
  AUTHORS   Hong SJ, Li H, Becker KG, Dawson VL and Dawson TM.
  TITLE     Identification and analysis of plasticity-induced late-response
            genes
  JOURNAL   Proc Natl Acad Sci U S A 101 (7), 2145-2150 (2004)
   PUBMED   14766980
REFERENCE   5  (bases 1 to 873)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (bases 1 to 873)
  AUTHORS   Kowluru A, Tannous M and Chen HQ.
  TITLE     Localization and characterization of the mitochondrial isoform of
            the nucleoside diphosphate kinase in the pancreatic beta cell:
            evidence for its complexation with mitochondrial succinyl-CoA
            synthetase
  JOURNAL   Arch Biochem Biophys 398 (2), 160-169 (2002)
   PUBMED   11831846
REFERENCE   7  (bases 1 to 873)
  AUTHORS   Lacombe ML, Milon L, Munier A, Mehus JG and Lambeth DO.
  TITLE     The human Nm23/nucleoside diphosphate kinases
  JOURNAL   J Bioenerg Biomembr 32 (3), 247-258 (2000)
   PUBMED   11768308
  REMARK    Review article
REFERENCE   8  (bases 1 to 873)
  AUTHORS   Milon L, Meyer P, Chiadmi M, Munier A, Johansson M, Karlsson A,
            Lascu I, Capeau J, Janin J and Lacombe ML.
  TITLE     The human nm23-H4 gene product is a mitochondrial nucleoside
            diphosphate kinase
  JOURNAL   J Biol Chem 275 (19), 14264-14272 (2000)
   PUBMED   10799505
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On Oct 4, 2007 this sequence version replaced XM_001064805.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132270,
                              SAMD00132286 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..873
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..873
                     /gene="Nme4"
                     /note="NME/NM23 nucleoside diphosphate kinase 4"
                     /db_xref="GeneID:685679"
                     /db_xref="RGD:1591334"
     exon            1..103
                     /gene="Nme4"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..576
                     /gene="Nme4"
                     /EC_number="2.7.4.6"
                     /note="expressed in non-metastatic cells 4, protein;
                     nucleoside diphosphate kinase 4; non-metastatic cells 4,
                     protein expressed in"
                     /codon_start=1
                     /product="nucleoside diphosphate kinase, mitochondrial"
                     /protein_id="NP_001102948.1"
                     /db_xref="GeneID:685679"
                     /db_xref="RGD:1591334"
                     /translation="MGCLFDRAALRALLCGPRFQCLLVRPSSGGPPWPQERTLVAVKP
                     DGVQRRLVGTVIHRFERRGFKLVGMKMLQAPESILAEHYRDLQRKPFYPALISYMSSG
                     PVVAMVWEGHNVVHISRAMIGHTDSTEAAPGTIRGDFSVHISRNVIHASDSVDGAQRE
                     IELWFQSSELLNWADGGHHSSCYPA"
     exon            104..237
                     /gene="Nme4"
                     /inference="alignment:Splign:2.1.0"
     exon            238..339
                     /gene="Nme4"
                     /inference="alignment:Splign:2.1.0"
     exon            340..452
                     /gene="Nme4"
                     /inference="alignment:Splign:2.1.0"
     exon            453..873
                     /gene="Nme4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccgggctag cccgcaccat gggttgcttg ttcgatcgcg ccgcgctgcg ggcgctgttg
       61 tgcgggccac gctttcagtg cctgctggtg cgccccagtt ccggagggcc cccctggccc
      121 caagagcgga ccctggttgc tgtgaagcca gatggggtac agaggaggct agtggggact
      181 gtgatacacc gctttgagag gcggggcttc aagctggtgg ggatgaagat gttgcaggca
      241 ccagagagca tccttgctga gcactaccgg gacctacaga ggaagccatt ctacccagcc
      301 ctcatcagct acatgagctc tgggccagtg gtggccatgg tctgggaagg ccacaatgtg
      361 gtccacatct caagggccat gataggacac acggactcaa cagaggcagc ccctgggaca
      421 atcaggggcg acttcagtgt tcacatcagc aggaatgtca ttcatgctag cgattccgtg
      481 gacggggccc agagggagat cgagctatgg tttcagagca gcgaactatt gaactgggca
      541 gacggtggtc accacagcag ctgctaccct gcctgagagt ttgcactgcc ttctgcactt
      601 gagggtctgc ccatcaacca ccaactacct ctggcaacaa gaactcaagc ccacatgttt
      661 cccatgtccc caaaccattc cctgctcccc ttctgtccaa cgccagccca ggggagtcta
      721 agcctcaact ttatgtgcct ttttgtatcc taagccagca caaatattgg accttatcct
      781 gtgcacaaaa gtgcccggca acctttgggg cattgccaaa ggtgacctca cctgcctcaa
      841 aggagagaca ttaaaatttt atgcttaaaa tgg
//
