LOCUS       NM_031833                660 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus NME/NM23 nucleoside diphosphate kinase 2 (Nme2),
            mRNA.
ACCESSION   NM_031833
VERSION     NM_031833.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 660)
  AUTHORS   Kopylov,M., Bass,H.W. and Stroupe,M.E.
  TITLE     The maize (Zea mays L.) nucleoside diphosphate kinase1 (ZmNDPK1)
            gene encodes a human NM23-H2 homologue that binds and stabilizes
            G-quadruplex DNA
  JOURNAL   Biochemistry 54 (9), 1743-1757 (2015)
   PUBMED   25679041
REFERENCE   2  (bases 1 to 660)
  AUTHORS   Lahiri,D.K., Maloney,B., Rogers,J.T. and Ge,Y.W.
  TITLE     PuF, an antimetastatic and developmental signaling protein,
            interacts with the Alzheimer's amyloid-beta precursor protein via a
            tissue-specific proximal regulatory element (PRE)
  JOURNAL   BMC Genomics 14, 68 (2013)
   PUBMED   23368879
  REMARK    GeneRIF: PuF may regulate the APP gene promoter
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 660)
  AUTHORS   Lipskaya,T.Y. and Voinova,V.V.
  TITLE     Activity of nucleoside diphosphate kinase alpha (NDPK alpha)
            capable of binding to outer mitochondrial membrane accounts for
            less than 10% of total NDPK activity present in cytoplasm of liver
            cells
  JOURNAL   Biochemistry (Mosc) 77 (6), 593-602 (2012)
   PUBMED   22817458
  REMARK    GeneRIF: the sites of NDPK binding to the outer mitochondrial
            membrane are not identical to those of hexokinase and glycerol
            kinase.
REFERENCE   4  (bases 1 to 660)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 660)
  AUTHORS   Tan,W.L., Bhattacharya,B., Loh,M., Balasubramanian,I., Akram,M.,
            Dong,D., Wong,L., Thakkar,B., Salto-Tellez,M., Soo,R.A.,
            Fichtner,I., Iacopetta,B. and Soong,R.
  TITLE     Low cytosine triphosphate synthase 2 expression renders resistance
            to 5-fluorouracil in colorectal cancer
  JOURNAL   Cancer Biol Ther 11 (6), 599-608 (2011)
   PUBMED   21378502
REFERENCE   6  (bases 1 to 660)
  AUTHORS   Ishikawa,N., Shimada,N., Munakata,Y., Watanabe,K. and Kimura,N.
  TITLE     Isolation and characterization of a gene encoding rat nucleoside
            diphosphate kinase
  JOURNAL   J Biol Chem 267 (20), 14366-14372 (1992)
   PUBMED   1321145
REFERENCE   7  (bases 1 to 660)
  AUTHORS   Hemmerich,S. and Pecht,I.
  TITLE     Oligomeric structure and autophosphorylation of nucleoside
            diphosphate kinase from rat mucosal mast cells
  JOURNAL   Biochemistry 31 (19), 4580-4587 (1992)
   PUBMED   1316152
REFERENCE   8  (bases 1 to 660)
  AUTHORS   Hemmerich,S., Yarden,Y. and Pecht,I.
  TITLE     A cromoglycate binding protein from rat mast cells of a leukemia
            line is a nucleoside diphosphate kinase
  JOURNAL   Biochemistry 31 (19), 4574-4579 (1992)
   PUBMED   1316151
REFERENCE   9  (bases 1 to 660)
  AUTHORS   Gilles,A.M., Presecan,E., Vonica,A. and Lascu,I.
  TITLE     Nucleoside diphosphate kinase from human erythrocytes. Structural
            characterization of the two polypeptide chains responsible for
            heterogeneity of the hexameric enzyme
  JOURNAL   J Biol Chem 266 (14), 8784-8789 (1991)
   PUBMED   1851158
REFERENCE   10 (bases 1 to 660)
  AUTHORS   Kimura,N., Shimada,N., Nomura,K. and Watanabe,K.
  TITLE     Isolation and characterization of a cDNA clone encoding rat
            nucleoside diphosphate kinase
  JOURNAL   J Biol Chem 265 (26), 15744-15749 (1990)
   PUBMED   2168422
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Apr 17, 2023 this sequence version replaced NM_031833.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086599.1, FQ217563.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840110, SAMN12840112
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                JAXUCZ010000010.1  79400338-79400418   c
            82-211              JAXUCZ010000010.1  79400007-79400136   c
            212-313             JAXUCZ010000010.1  79397733-79397834   c
            314-426             JAXUCZ010000010.1  79396779-79396891   c
            427-660             JAXUCZ010000010.1  79394999-79395232   c
FEATURES             Location/Qualifiers
     source          1..660
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..660
                     /gene="Nme2"
                     /gene_synonym="NDKB; nm23-2; p18-12d"
                     /note="NME/NM23 nucleoside diphosphate kinase 2"
                     /db_xref="GeneID:83782"
                     /db_xref="RGD:619877"
     exon            1..81
                     /gene="Nme2"
                     /gene_synonym="NDKB; nm23-2; p18-12d"
                     /inference="alignment:Splign:2.1.0"
     exon            82..211
                     /gene="Nme2"
                     /gene_synonym="NDKB; nm23-2; p18-12d"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..544
                     /gene="Nme2"
                     /gene_synonym="NDKB; nm23-2; p18-12d"
                     /EC_number="2.7.4.6"
                     /EC_number="2.7.13.3"
                     /note="P18; NDK B; NDP kinase B; histidine protein kinase
                     NDKB; NDP kinase alpha; expressed in non-metastatic cells
                     2; non-metastatic cells 2, protein (NM23B) expressed in"
                     /codon_start=1
                     /product="nucleoside diphosphate kinase B"
                     /protein_id="NP_114021.2"
                     /db_xref="GeneID:83782"
                     /db_xref="RGD:619877"
                     /translation="MANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRAS
                     EEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPG
                     TIRGDFCIQVGRNIIHGSDSVESAEKEIGLWFKPEELIDYKSCAHDWVYE"
     exon            212..313
                     /gene="Nme2"
                     /gene_synonym="NDKB; nm23-2; p18-12d"
                     /inference="alignment:Splign:2.1.0"
     exon            314..426
                     /gene="Nme2"
                     /gene_synonym="NDKB; nm23-2; p18-12d"
                     /inference="alignment:Splign:2.1.0"
     exon            427..660
                     /gene="Nme2"
                     /gene_synonym="NDKB; nm23-2; p18-12d"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctccgcgc gccggctggt ggtcgttcta gtctctgctc tcttcgctct ccgctggcac
       61 cagccgaccc accagctttc ggaccatggc caacctcgag cgtaccttca ttgccatcaa
      121 gccagatggc gtgcagcgcg gcctggtggg cgagatcatc aagcgattcg agcagaaggg
      181 gttccgcctg gtggccatga agttccttcg ggcttctgag gaacacctga agcagcacta
      241 tattgacctg aaagaccgtc ctttcttccc ggggctggtg aagtacatga actcagggcc
      301 tgtggtggcc atggtctggg aggggctcaa tgtggtgaaa acaggccgag tgatgctggg
      361 ggagaccaat ccagctgatt cgaagccagg caccattcgt ggggatttct gcattcaagt
      421 tggcaggaac atcattcacg gcagtgattc agtggagagt gccgagaaag agatcggtct
      481 atggtttaag cccgaagaac tgattgacta taagtcttgt gcccatgact gggtgtatga
      541 gtagacgcgg agaaaccaga gtccttttca gcactactga tggggttcct ggacacagct
      601 cttcatccca ctgactggat ggaccatctt ttctaaaaca ataaagactt tggaactggg
//
