LOCUS       NM_138548                736 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus NME/NM23 nucleoside diphosphate kinase 1 (Nme1),
            mRNA.
ACCESSION   NM_138548
VERSION     NM_138548.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 736)
  AUTHORS   Yu,B.Y.K., Tossounian,M.A., Hristov,S.D., Lawrence,R., Arora,P.,
            Tsuchiya,Y., Peak-Chew,S.Y., Filonenko,V., Oxenford,S., Angell,R.,
            Gouge,J., Skehel,M. and Gout,I.
  TITLE     Regulation of metastasis suppressor NME1 by a key metabolic
            cofactor coenzyme A
  JOURNAL   Redox Biol 44, 101978 (2021)
   PUBMED   33903070
  REMARK    GeneRIF: Regulation of metastasis suppressor NME1 by a key
            metabolic cofactor coenzyme A.
REFERENCE   2  (bases 1 to 736)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 736)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   4  (bases 1 to 736)
  AUTHORS   Wei,X., Das,J., Fragoza,R., Liang,J., Bastos de Oliveira,F.M.,
            Lee,H.R., Wang,X., Mort,M., Stenson,P.D., Cooper,D.N., Lipkin,S.M.,
            Smolka,M.B. and Yu,H.
  TITLE     A massively parallel pipeline to clone DNA variants and examine
            molecular phenotypes of human disease mutations
  JOURNAL   PLoS Genet 10 (12), e1004819 (2014)
   PUBMED   25502805
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 736)
  AUTHORS   Teoh,J., Boulos,S., Chieng,J., Knuckey,N.W. and Meloni,B.P.
  TITLE     Erythropoietin increases neuronal NDPKA expression, and NDPKA
            up-regulation as well as exogenous application protects cortical
            neurons from in vitro ischemia-related insults
  JOURNAL   Cell Mol Neurobiol 34 (3), 379-392 (2014)
   PUBMED   24395206
  REMARK    GeneRIF: NDPKA up-regulation increased neuronal survival in
            cortical neurons from cerebral ischemia models.
REFERENCE   6  (bases 1 to 736)
  AUTHORS   Leary,J.A., Kerr,J., Chenevix-Trench,G., Doris,C.P., Hurst,T.,
            Houghton,C.R. and Friedlander,M.L.
  TITLE     Increased expression of the NME1 gene is associated with metastasis
            in epithelial ovarian cancer
  JOURNAL   Int J Cancer 64 (3), 189-195 (1995)
   PUBMED   7622307
REFERENCE   7  (bases 1 to 736)
  AUTHORS   Okabe-Kado,J., Kasukabe,T., Hozumi,M., Honma,Y., Kimura,N.,
            Baba,H., Urano,T. and Shiku,H.
  TITLE     A new function of Nm23/NDP kinase as a differentiation inhibitory
            factor, which does not require it's kinase activity
  JOURNAL   FEBS Lett 363 (3), 311-315 (1995)
   PUBMED   7737424
REFERENCE   8  (bases 1 to 736)
  AUTHORS   Kanayama,H., Takigawa,H. and Kagawa,S.
  TITLE     Analysis of nm23 gene expressions in human bladder and renal
            cancers
  JOURNAL   Int J Urol 1 (4), 324-331 (1994)
   PUBMED   7614395
REFERENCE   9  (bases 1 to 736)
  AUTHORS   Murty,V.V., Bosl,G.J., Houldsworth,J., Meyers,M., Mukherjee,A.B.,
            Reuter,V. and Chaganti,R.S.
  TITLE     Allelic loss and somatic differentiation in human male germ cell
            tumors
  JOURNAL   Oncogene 9 (8), 2245-2251 (1994)
   PUBMED   7518576
REFERENCE   10 (bases 1 to 736)
  AUTHORS   Gilles,A.M., Presecan,E., Vonica,A. and Lascu,I.
  TITLE     Nucleoside diphosphate kinase from human erythrocytes. Structural
            characterization of the two polypeptide chains responsible for
            heterogeneity of the hexameric enzyme
  JOURNAL   J Biol Chem 266 (14), 8784-8789 (1991)
   PUBMED   1851158
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D13374.1.
            
            On Aug 31, 2012 this sequence version replaced NM_138548.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D13374.1, CO570835.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-736               D13374.1           2-737
FEATURES             Location/Qualifiers
     source          1..736
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..736
                     /gene="Nme1"
                     /note="NME/NM23 nucleoside diphosphate kinase 1"
                     /db_xref="GeneID:191575"
                     /db_xref="RGD:70497"
     exon            1..106
                     /gene="Nme1"
                     /inference="alignment:Splign:2.1.0"
     exon            107..236
                     /gene="Nme1"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..569
                     /gene="Nme1"
                     /EC_number="2.7.4.6"
                     /note="NDP kinase beta; expressed in non-metastatic cells
                     1, protein (NM23A) (nucleoside diphosphate kinase);
                     nucloside diphosphate kinase; NDK A; NDP kinase A;
                     metastasis inhibition factor NM23; non-metastatic cells 1,
                     protein (NM23A) expressed in; tumor metastatic
                     process-associated protein"
                     /codon_start=1
                     /product="nucleoside diphosphate kinase A"
                     /protein_id="NP_612557.1"
                     /db_xref="GeneID:191575"
                     /db_xref="RGD:70497"
                     /translation="MANSERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFIQAS
                     EDLLKEHYIDLKDRPFFSGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPG
                     TIRGDFCIQVGRNIIHGSDSVESAEKEISLWFQPEELVDYKSCAQNWIYE"
     exon            237..338
                     /gene="Nme1"
                     /inference="alignment:Splign:2.1.0"
     exon            339..451
                     /gene="Nme1"
                     /inference="alignment:Splign:2.1.0"
     exon            452..736
                     /gene="Nme1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      736
                     /gene="Nme1"
ORIGIN      
        1 ctgtatgaaa gttccgagct tgcagctgta gggaaccacg taaggccagg gcgcgtttcc
       61 ggtgcgggca gtcgccacca gagttaaaga ccgggcgtca gaaggggacc atggccaaca
      121 gcgagcgtac cttcatcgcc atcaagcctg atggggtcca gcgggggctt gtgggagaga
      181 tcatcaagcg attcgagcag aagggattcc gcctggttgg tttgaaattt atacaggctt
      241 cagaggatct tctcaaggag cactacattg acctgaagga ccgccccttc ttttctggcc
      301 tggtgaagta catgcactca ggaccggtgg ttgctatggt ctgggaggga ctgaatgttg
      361 tgaagacagg ccgggtgatg cttggagaga ccaaccccgc agactctaag cctgggacca
      421 tacgaggaga cttttgcatt caagttggca ggaacatcat tcatggcagc gattctgtgg
      481 agagtgcgga gaaggagatc agtttgtggt ttcagcctga ggagctggtg gactacaaga
      541 gctgtgcgca gaactggatc tatgagtgac agcagggccc ctgctttttt tctgtctact
      601 gacccttgat ctcacaggca ggggagcagc agctctagat ctttctggaa cttctctgaa
      661 ctggaagaag cctctgggcg ctgtgactcc ctgtgcagtg ttaagtgcca ctggtagatt
      721 aaagtgtttt gtctgt
//
