LOCUS       NP_036931                390 aa            linear   ROD 03-APR-2024
DEFINITION  neuromedin-B receptor [Rattus norvegicus].
ACCESSION   NP_036931 XP_218316
VERSION     NP_036931.1
DBSOURCE    REFSEQ: accession NM_012799.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 390)
  AUTHORS   Li,P., Janczewski,W.A., Yackle,K., Kam,K., Pagliardini,S.,
            Krasnow,M.A. and Feldman,J.L.
  TITLE     The peptidergic control circuit for sighing
  JOURNAL   Nature 530 (7590), 293-297 (2016)
   PUBMED   26855425
  REMARK    GeneRIF: peptidergic pathways comprise the core of a sigh control
            circuit that integrates physiological and perhaps emotional input
            to transform normal breaths into sighs
REFERENCE   2  (residues 1 to 390)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   3  (residues 1 to 390)
  AUTHORS   Giladi,E., Nagalla,S.R. and Spindel,E.R.
  TITLE     Molecular cloning and characterization of receptors for the
            mammalian bombesin-like peptides
  JOURNAL   J Mol Neurosci 4 (1), 41-54 (1993)
   PUBMED   8391296
REFERENCE   4  (residues 1 to 390)
  AUTHORS   Wada,E., Way,J., Shapira,H., Kusano,K., Lebacq-Verheyden,A.M.,
            Coy,D., Jensen,R. and Battery,J.
  TITLE     cDNA cloning, characterization, and brain region-specific
            expression of a neuromedin-B-preferring bombesin receptor
  JOURNAL   Neuron 6 (3), 421-430 (1991)
   PUBMED   1848080
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 17, 2005 this sequence version replaced XP_218316.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U37058.1, SRR26360176.403343.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..390
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p13"
     Protein         1..390
                     /product="neuromedin-B receptor"
                     /note="neuromedin-B-preferring bombesin receptor"
                     /calculated_mol_wt=43404
     Region          1..20
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P24053.1)"
     Site            8
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P24053.1)"
     Site            42..65
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P24053.1)"
     Region          44..335
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          46..70
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410628"
     Region          79..101
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410628"
     Site            80..99
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P24053.1)"
     Region          117..139
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410628"
     Site            118..139
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P24053.1)"
     Site            157..177
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P24053.1)"
     Region          162..178
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Site            192
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P24053.1)"
     Region          210..233
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Site            212..235
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P24053.1)"
     Region          265..287
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Site            267..287
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P24053.1)"
     Site            300..327
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P24053.1)"
     Region          303..328
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     Site            352
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O54799; propagated from
                     UniProtKB/Swiss-Prot (P24053.1)"
     CDS             1..390
                     /gene="Nmbr"
                     /gene_synonym="NMB-R"
                     /coded_by="NM_012799.2:132..1304"
                     /db_xref="GeneID:25264"
                     /db_xref="RGD:3181"
ORIGIN      
        1 mpprslpnls lpteasesel epevwendfl pdsdgttael vircvipsly liiisvgllg
       61 nimlvkiflt nstmrsvpni fisnlaagdl lllltcvpvd asryffdewv fgklgcklip
      121 aiqltsvgvs vftltalsad ryraivnpmd mqtsgvvlwt slkavgiwvv svllavpeav
      181 fsevarigss dnssftacip ypqtdelhpk ihsvliflvy fliplviisi yyyhiaktli
      241 rsahnlpgey nehtkkqmet rkrlakivlv fvgcfvfcwf pnhilylyrs fnykeidpsl
      301 ghmivtlvar vlsfsnscvn pfalyllses frkhfnsqlc cgqksypers tsyllsssav
      361 rmtslksnak nvvtnsvlln ghstkqeial
//
