LOCUS       NM_001109149             660 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus neuromedin B (Nmb), mRNA.
ACCESSION   NM_001109149 XM_001066816 XM_574481
VERSION     NM_001109149.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 660)
  AUTHORS   Boughton CK, Patel SA, Thompson EL, Patterson M, Curtis AE, Amin A,
            Chen K, Ghatei MA, Bloom SR and Murphy KG.
  TITLE     Neuromedin B stimulates the hypothalamic-pituitary-gonadal axis in
            male rats
  JOURNAL   Regul Pept 187, 6-11 (2013)
   PUBMED   24120470
  REMARK    GeneRIF: NMB stimulates the reproductive axis in male rats.
REFERENCE   2  (bases 1 to 660)
  AUTHORS   Shimizu F, Matsuzaki T, Iwasa T, Minakuchi M, Kuwahara A, Yasui T
            and Irahara M.
  TITLE     Estradiol suppresses NMU mRNA expression during sexual maturation
            in the female rat pituitary
  JOURNAL   Int J Dev Neurosci 26 (3-4), 381-384 (2008)
   PUBMED   18258403
  REMARK    GeneRIF: The expression of NMU mRNA in the female rat pituitary is
            reduced as the rats develop from the pubertal to the mature period.
            Additionally, the reduction of pituitary NMU is related to the
            increases in estradiol and insulin that occur during puberty.
REFERENCE   3  (bases 1 to 660)
  AUTHORS   Bouchard L, Drapeau V, Provencher V, Lemieux S, Chagnon Y, Rice T,
            Rao DC, Vohl MC, Tremblay A, Bouchard C and Perusse L.
  TITLE     Neuromedin beta: a strong candidate gene linking eating behaviors
            and susceptibility to obesity
  JOURNAL   Am J Clin Nutr 80 (6), 1478-1486 (2004)
   PUBMED   15585758
REFERENCE   4  (bases 1 to 660)
  AUTHORS   Oeffner F, Bornholdt D, Ziegler A, Hinney A, Gorg T, Gerber G,
            Goldschmidt HP, Siegfried W, Wright A, Hebebrand J and Grzeschik
            KH.
  TITLE     Significant association between a silent polymorphism in the
            neuromedin B gene and body weight in German children and
            adolescents
  JOURNAL   Acta Diabetol 37 (2), 93-101 (2000)
   PUBMED   11194934
REFERENCE   5  (bases 1 to 660)
  AUTHORS   Kirkham TC, Perez S and Gibbs J.
  TITLE     Prefeeding potentiates anorectic actions of neuromedin B and
            gastrin releasing peptide
  JOURNAL   Physiol Behav 58 (6), 1175-1179 (1995)
   PUBMED   8623017
REFERENCE   6  (bases 1 to 660)
  AUTHORS   Itoh S, Takashima A, Itoh T and Morimoto T.
  TITLE     Open-field behavior of rats following intracerebroventricular
            administration of neuromedin B, neuromedin C, and related amphibian
            peptides
  JOURNAL   Jpn J Physiol 44 (3), 271-281 (1994)
   PUBMED   7823417
REFERENCE   7  (bases 1 to 660)
  AUTHORS   Wang LH, Battey JF, Wada E, Lin JT, Mantey S, Coy DH and Jensen RT.
  TITLE     Activation of neuromedin B-preferring bombesin receptors on rat
            glioblastoma C-6 cells increases cellular Ca2+ and
            phosphoinositides
  JOURNAL   Biochem J 286 (Pt 2) (Pt 2), 641-648 (1992)
   PUBMED   1326946
REFERENCE   8  (bases 1 to 660)
  AUTHORS   Rettori V, Pazos-Moura CC, Moura EG, Polak J and McCann SM.
  TITLE     Role of neuromedin B in control of the release of thyrotropin in
            hypothyroid and hyperthyroid rats
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 3035-3039 (1992)
   PUBMED   1557409
REFERENCE   9  (bases 1 to 660)
  AUTHORS   Williams G, Cardoso HM, Lee YC, Ball JM, Ghatei MA, Stock MJ and
            Bloom SR.
  TITLE     Hypothalamic regulatory peptides in obese and lean Zucker rats
  JOURNAL   Clin Sci (Lond) 80 (5), 419-426 (1991)
   PUBMED   1709601
REFERENCE   10 (bases 1 to 660)
  AUTHORS   Moody,T.W., Korman,L.Y. and O'Donohue,T.L.
  TITLE     Neuromedin B-like peptides in rat brain: biochemical
            characterization, mechanism of release and localization in
            synaptosomes
  JOURNAL   Peptides 7 (5), 815-820 (1986)
   PUBMED   3797343
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473980.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_574481.2, XM_001066816.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB725635.1, CB613057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..660
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..660
                     /gene="Nmb"
                     /gene_synonym="RGD1562710"
                     /note="neuromedin B"
                     /db_xref="GeneID:499194"
                     /db_xref="RGD:1562710"
     exon            1..222
                     /gene="Nmb"
                     /gene_synonym="RGD1562710"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..419
                     /gene="Nmb"
                     /gene_synonym="RGD1562710"
                     /codon_start=1
                     /product="neuromedin-B precursor"
                     /protein_id="NP_001102619.1"
                     /db_xref="GeneID:499194"
                     /db_xref="RGD:1562710"
                     /translation="MTRQAGSTWLLRGLLLFALFVSGITPFSWDLPEPRSRASKIRVH
                     PRGNLWATGHFMGKKSLEPPSLSLVGTAPPITQREQRLQLSHDLLRILLLQKALGMNL
                     SGPAPPIQYRRLLQK"
     exon            223..395
                     /gene="Nmb"
                     /gene_synonym="RGD1562710"
                     /inference="alignment:Splign:2.1.0"
     exon            396..660
                     /gene="Nmb"
                     /gene_synonym="RGD1562710"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaggcgggc ttcaagaact agctagtatc ctgagagtgc cagagaaaac ccgtttggca
       61 cagccatgac ccggcaagca gggagcactt ggctgctccg tggtctcctg ctctttgcct
      121 tgttcgtttc cggcatcacc cccttttcct gggatctccc ggagccccgc agccgagcaa
      181 gcaagattcg agtgcaccct cggggcaacc tctgggcgac tggtcacttc atgggcaaga
      241 agagtctgga acccccgagc ctgtcactgg tgggtacagc accccctatc acccagaggg
      301 agcagagact acagctgagt catgatctgc tcaggatcct cctgctacag aaagcgctag
      361 gcatgaacct cagtggtcca gctcccccaa tccagtacag gaggctgctg cagaagtgac
      421 gccaataatg gaacaaacac ggcactgggc gtagcatgcg tccatccagg gaaactgagg
      481 aatggaaccc tagcagtggc ctcctctgga tgtgaaacct aagctcaaat gtgttactct
      541 gttactgtga tttctggttg ggtcaccagg aatgttaacg atacagacac agtctttcct
      601 gctgtatttc ttgcttccct ggtgaagttg tgaataaaaa tactgctctt tacgaagact
//
