LOCUS       NM_001025010            3554 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus NLR family member X1 (Nlrx1), mRNA.
ACCESSION   NM_001025010
VERSION     NM_001025010.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3554)
  AUTHORS   Zhang,Y., Chen,D., Wang,Y., Wang,X., Zhang,Z. and Xin,Y.
  TITLE     Neuroprotective effects of melatonin-mediated mitophagy through
            nucleotide-binding oligomerization domain and leucine-rich
            repeat-containing protein X1 in neonatal hypoxic-ischemic brain
            damage
  JOURNAL   FASEB J 37 (2), e22784 (2023)
   PUBMED   36692416
  REMARK    GeneRIF: Neuroprotective effects of melatonin-mediated mitophagy
            through nucleotide-binding oligomerization domain and leucine-rich
            repeat-containing protein X1 in neonatal hypoxic-ischemic brain
            damage.
REFERENCE   2  (bases 1 to 3554)
  AUTHORS   Guan,X., Zhou,W., Li,L. and Peng,Q.
  TITLE     Dexmedetomidine Alleviates Hypoxic-Ischemic Brain Damage in
            Neonatal Rats Through Reducing MicroRNA-134-5p-Mediated NLRX1
            Downregulation
  JOURNAL   J Stroke Cerebrovasc Dis 31 (5), 106411 (2022)
   PUBMED   35259612
  REMARK    GeneRIF: Dexmedetomidine Alleviates Hypoxic-Ischemic Brain Damage
            in Neonatal Rats Through Reducing MicroRNA-134-5p-Mediated NLRX1
            Downregulation.
REFERENCE   3  (bases 1 to 3554)
  AUTHORS   Tong,R., Jia,T., Shi,R. and Yan,F.
  TITLE     Inhibition of microRNA-15 protects H9c2 cells against CVB3-induced
            myocardial injury by targeting NLRX1 to regulate the NLRP3
            inflammasome
  JOURNAL   Cell Mol Biol Lett 25, 6 (2020)
   PUBMED   32099552
  REMARK    GeneRIF: Inhibition of microRNA-15 protects H9c2 cells against
            CVB3-induced myocardial injury by targeting NLRX1 to regulate the
            NLRP3 inflammasome.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3554)
  AUTHORS   Allen,I.C., Moore,C.B., Schneider,M., Lei,Y., Davis,B.K.,
            Scull,M.A., Gris,D., Roney,K.E., Zimmermann,A.G., Bowzard,J.B.,
            Ranjan,P., Monroe,K.M., Pickles,R.J., Sambhara,S. and Ting,J.P.
  TITLE     NLRX1 protein attenuates inflammatory responses to infection by
            interfering with the RIG-I-MAVS and TRAF6-NF-kappaB signaling
            pathways
  JOURNAL   Immunity 34 (6), 854-865 (2011)
   PUBMED   21703540
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089834.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089834.1, SRR8487230.137780.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3554
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..3554
                     /gene="Nlrx1"
                     /gene_synonym="RGD1311293"
                     /note="NLR family member X1"
                     /db_xref="GeneID:315599"
                     /db_xref="RGD:1311293"
     exon            1..36
                     /gene="Nlrx1"
                     /gene_synonym="RGD1311293"
                     /inference="alignment:Splign:2.1.0"
     exon            37..158
                     /gene="Nlrx1"
                     /gene_synonym="RGD1311293"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..3010
                     /gene="Nlrx1"
                     /gene_synonym="RGD1311293"
                     /codon_start=1
                     /product="NLR family member X1 precursor"
                     /protein_id="NP_001020181.1"
                     /db_xref="GeneID:315599"
                     /db_xref="RGD:1311293"
                     /translation="MRWGCHLPRTSWGSGLGRTVPLPDELRIQSSWPFKGVHHPLRPP
                     RAFIRHHGNSADSAPPPGRHGQLFRSISATEAIQRHRRNLTEWFSRLPREERQFGPTF
                     ALDTVHVDPVIRESTPDDLLRPSTELATGHQRTQAELPPLALSQLFDPDACGRRVQTV
                     VLYGTVGTGKSTLVRKMVLDWCYGRLPAFELLIPFSCEDLSSLGSTPASLCQLVTQRY
                     TPLKEVLPLMNAAGSRLLFVLHGLERLNLDFRLAGTGLCSDPEEPGAPAAIMVNLLRK
                     YMLPEASILVTTRPSAIGRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPDCGYGAG
                     GTGVSVTPAQRDNLIQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFLHAPTSAGQTL
                     TSIYTSFLRLNFNGETLDSTDPSNLSLMSYAARTMGKLAYEGVSSRKTYFSEEDVRGC
                     LEAGIKTEEEFQLLQIFRRDALRFFLAPCVEPGHLGTFVFTVPAMQEYLAALYIVLGL
                     RKTALQRVGKEVFEFVGRVGEDVSLVLGIVAKLLPLRILPLLFNLLKVVPRVFGRMVS
                     KSREAVAQAMVLEMFREEDYYNDDVLDQMGASILGVEGPRRHPDEPPEDEVFELFPMF
                     MSGLLSAHNRAVLAQLGCPIKNLDALENAQAIKKKLGKMGRQVLPPSELLDHLFFHYE
                     FQNQRFSAEVLGSLRQLNLAGVRMTPLKCTVVASVLGSGRHPLDEVNLASCQLDPAGL
                     HTLMPVLLRARKLGLQLNNLGPEACRDLRDLLLHDQCQITTLRLSNNPLTAAGVGVLM
                     DGLAGNTSVTHLSLLHTDLGDEGLELLAAQLDRNKQLQELNVAYNGAGDTVALALAKA
                     ARKHPSLELLHLYFNELSSEGRQVLRDLGGSGEGGARVVASLTEGTAVSEYWSVILSE
                     VQRNLNSWDPVRVQRHLKLLLRDLEDSRGATLNPWRKAQLLRVESEVKTLLEQLGGSG
                     H"
     exon            159..222
                     /gene="Nlrx1"
                     /gene_synonym="RGD1311293"
                     /inference="alignment:Splign:2.1.0"
     exon            223..311
                     /gene="Nlrx1"
                     /gene_synonym="RGD1311293"
                     /inference="alignment:Splign:2.1.0"
     exon            312..931
                     /gene="Nlrx1"
                     /gene_synonym="RGD1311293"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1753
                     /gene="Nlrx1"
                     /gene_synonym="RGD1311293"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..2349
                     /gene="Nlrx1"
                     /gene_synonym="RGD1311293"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2436
                     /gene="Nlrx1"
                     /gene_synonym="RGD1311293"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2688
                     /gene="Nlrx1"
                     /gene_synonym="RGD1311293"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..3522
                     /gene="Nlrx1"
                     /gene_synonym="RGD1311293"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgcggcga caggcaccag ggcctaggca gcctggggca acaggagaga acgtggttct
       61 gagtgtttca ggctccagtt ttccgaggat gaggtggggc tgccatttgc ccaggacctc
      121 ttggggctct ggcctgggaa gaacagtccc gctcccagac gagctccgga ttcagtcgag
      181 ctggcccttt aaaggggtgc atcatcccct taggccccct agggccttta tccgtcacca
      241 tggaaactcg gcagacagtg ctcccccacc agggaggcat gggcagctgt tcaggagcat
      301 ctctgccact gaagctatcc aaaggcatcg tcggaacctc actgagtggt ttagccggct
      361 gcccagagag gagcgccagt ttggaccaac ctttgctcta gacacagttc acgttgaccc
      421 cgtgatccga gagagcaccc cagatgacct gcttcgtcca tccacggagc tggccacagg
      481 gcatcagcga acccaggcag agctcccccc actggccctg tctcagctct ttgacccaga
      541 tgcctgtggg cgccgcgtgc agacagtggt attgtatggg accgtgggta ctggcaagag
      601 cacattggtg cgcaagatgg tcttagactg gtgttatggg agactgcctg cctttgagct
      661 gctcatcccc ttctcctgtg aggacctgtc atccctgggc tccaccccag cttccttatg
      721 ccaacttgtg acccagcgtt acacacccct gaaagaggtg ttgcccctga tgaatgctgc
      781 tggatcccgc ctgctctttg tgctccatgg cttggaacgc ctcaaccttg acttccggct
      841 ggcaggcaca gggctttgca gtgacccgga ggaacccggg gcaccagctg ccatcatggt
      901 caacctgctg cgcaaataca tgcttcctga ggccagcatt ctggtaacca cccggccctc
      961 cgccattggc cgtatcccta gcaagtacgt gggccgctat ggtgaaatct gtggcttctc
     1021 ggataccaac ctgcagaagc tctacttcca gctccgcctt aaccagcctg actgtgggta
     1081 tggtgctggg ggtacaggtg tctcagttac accagctcag cgggacaatc tcattcaaat
     1141 gctgtcccga aacctggagg ggcaccacca gatcgcagcc gcctgctttc tgccctccta
     1201 ctgctggctt gtctgtgcta ccttgcactt cctgcatgct cccacatctg ctggtcagac
     1261 tctcacaagc atctatacca gctttctacg tctgaacttc aatggggaaa cactggacag
     1321 caccgacccc tccaacttat ccctgatgtc ctatgcagcc cggactatgg gtaagttggc
     1381 ctatgagggg gtgtcatccc gaaagaccta cttctctgaa gaggatgtcc gtggctgcct
     1441 ggaagctggc atcaagacag aggaggagtt tcagctgctc cagatcttcc gccgggatgc
     1501 cctgaggttt ttcctggccc cgtgtgtgga accagggcac ctgggtacct tcgtattcac
     1561 cgtacctgcc atgcaggagt atctggctgc cctctacatc gtgcttggtt tgcgcaagac
     1621 agccctgcag cgggtgggca aagaagtgtt tgaatttgtg ggccgtgttg gggaagatgt
     1681 cagcctggta ttgggcattg tggccaaact gttgcccctg cggattctgc ctctgctatt
     1741 caacttgctt aaggtggttc cacgagtgtt tgggcgcatg gtgagtaaga gtcgcgaggc
     1801 ggtggctcag gccatggtgc tggagatgtt ccgggaggaa gactattaca atgacgatgt
     1861 tctggatcag atgggtgcca gcatcctggg tgtggagggc ccccggcgcc acccagatga
     1921 accccctgag gatgaagtct ttgagctctt ccccatgttc atgagtggac ttctctctgc
     1981 ccacaatcgg gcggtgttgg ctcagcttgg ctgtcccatt aagaacctgg atgccctgga
     2041 gaatgcccag gcaatcaaga agaaactggg gaagatgggt cggcaggtgc tgcccccctc
     2101 ggagcttctt gaccatctct tctttcacta tgagttccag aaccagcgct tctcagctga
     2161 ggtgctgggc tccctacgac agctcaattt agcaggtgtg cgaatgacac ccctcaagtg
     2221 cacggtggta gcgtctgtac tgggaagtgg acggcacccc ctggatgaag tgaacttggc
     2281 ctcctgccag ctggaccccg ctgggctaca cactctcatg cctgttctcc tgcgggcccg
     2341 gaaactgggg ttgcaactca acaatctggg ccctgaggcc tgcagagacc tccgagacct
     2401 gctgttacat gaccaatgcc agatcaccac tctccggctg tccaacaacc cactgacagc
     2461 agcaggggtg ggtgtgctga tggacgggct ggcaggaaac acttcggtga cacacctgtc
     2521 cctgctgcac actgaccttg gagatgaggg actggagttg ctggctgccc agctggaccg
     2581 taacaaacaa ctacaggaac tgaatgtggc ctacaatggt gctggggaca cggtggctct
     2641 ggccttggct aaggctgctc ggaagcaccc gtccctggag ctgctgcacc tctacttcaa
     2701 tgagctgagt tcagagggtc gccaggtcct gcgggatttg ggcggctctg gcgaaggtgg
     2761 tgcccgggtt gtagcctcgc tgacagaggg gacagcggtg tctgagtact ggtcagtgat
     2821 cctcagtgaa gtccaacgca acctcaacag ctgggaccct gtccgggtcc agcgccatct
     2881 caagctgctg ctccgagact tggaagacag cagaggtgcc acccttaatc cttggcgcaa
     2941 ggctcagctt ctgcgggtgg agagcgaggt caagactctt ctggagcagc tgggaggctc
     3001 tggacactga gacaatgact gctgggatag agctgtggga ccactggctc tctctgtggc
     3061 ttcctggctt gtacaacttc cagaaagatc ccttcagttc tgcagtcaaa gcagtgggta
     3121 aaactgtgct attccacccc caacaagtcc agcctagaat tcccaaggtc aaatgcggtt
     3181 agctgctgtg gacttcgata tggaacatgt tacctctccc tttgcctaga aggactaagg
     3241 atgtggcaca tcagtgggca aattgcctcg tgacgccacc accagtcctc ctccttcctc
     3301 ctctgacctc tgactgtgtt tgccatgctg ggggttctac catccagcag aggtactaga
     3361 cggctcccca tcctgcctta cgctcacctc tggacacgaa atgccctcac actggtgcct
     3421 ttcccagcct cacgtctctc aaatgcacag gtatcaatgg ctccaaggtt actagggaca
     3481 agtgtgcccg tcttgctatt aaaaagctgc gtgtcttccg ctaaaaaaaa aaaaaaaaaa
     3541 aaaaaaaaaa aaaa
//
