LOCUS       NM_134375               3510 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus NLR family, pyrin domain containing 6 (Nlrp6),
            mRNA.
ACCESSION   NM_134375 XM_001061777 XM_577848
VERSION     NM_134375.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3510)
  AUTHORS   Meng,C., Zhang,J., Zhang,L., Wang,Y., Li,Z. and Zhao,J.
  TITLE     Effects of NLRP6 in Cerebral Ischemia/Reperfusion (I/R) Injury in
            Rats
  JOURNAL   J Mol Neurosci 69 (3), 411-418 (2019)
   PUBMED   31267316
  REMARK    GeneRIF: Peak expression of NLRP6 is in 48-h post-cerebral I/R
            injury. NRP6 has a pro-inflammatory effect in cerebral I/R injury
REFERENCE   2  (bases 1 to 3510)
  AUTHORS   Wlodarska,M., Thaiss,C.A., Nowarski,R., Henao-Mejia,J., Zhang,J.P.,
            Brown,E.M., Frankel,G., Levy,M., Katz,M.N., Philbrick,W.M.,
            Elinav,E., Finlay,B.B. and Flavell,R.A.
  TITLE     NLRP6 inflammasome orchestrates the colonic host-microbial
            interface by regulating goblet cell mucus secretion
  JOURNAL   Cell 156 (5), 1045-1059 (2014)
   PUBMED   24581500
REFERENCE   3  (bases 1 to 3510)
  AUTHORS   Hu,B., Elinav,E., Huber,S., Strowig,T., Hao,L., Hafemann,A.,
            Jin,C., Wunderlich,C., Wunderlich,T., Eisenbarth,S.C. and
            Flavell,R.A.
  TITLE     Microbiota-induced activation of epithelial IL-6 signaling links
            inflammasome-driven inflammation with transmissible cancer
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9862-9867 (2013)
   PUBMED   23696660
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12852.
            Wunderlich, Claudia [added]; Wunderlich, Thomas [added]]
REFERENCE   4  (bases 1 to 3510)
  AUTHORS   Huber,S., Gagliani,N., Zenewicz,L.A., Huber,F.J., Bosurgi,L.,
            Hu,B., Hedl,M., Zhang,W., O'Connor,W. Jr., Murphy,A.J.,
            Valenzuela,D.M., Yancopoulos,G.D., Booth,C.J., Cho,J.H., Ouyang,W.,
            Abraham,C. and Flavell,R.A.
  TITLE     IL-22BP is regulated by the inflammasome and modulates
            tumorigenesis in the intestine
  JOURNAL   Nature 491 (7423), 259-263 (2012)
   PUBMED   23075849
REFERENCE   5  (bases 1 to 3510)
  AUTHORS   Anand,P.K., Malireddi,R.K., Lukens,J.R., Vogel,P., Bertin,J.,
            Lamkanfi,M. and Kanneganti,T.D.
  TITLE     NLRP6 negatively regulates innate immunity and host defence against
            bacterial pathogens
  JOURNAL   Nature 488 (7411), 389-393 (2012)
   PUBMED   22763455
REFERENCE   6  (bases 1 to 3510)
  AUTHORS   Herrera,V.L., Bagamasbad,P., Didishvili,T., Decano,J.L. and
            Ruiz-Opazo,N.
  TITLE     Overlapping genes in Nalp6/PYPAF5 locus encode two V2-type
            vasopressin isoreceptors: angiotensin-vasopressin receptor (AVR)
            and non-AVR
  JOURNAL   Physiol Genomics 34 (1), 65-77 (2008)
   PUBMED   18413781
  REMARK    GeneRIF: AVR is distinct from Nalp6/PYPAF5 based on different mRNA
            and protein sizes, subcellular localization, and tissue-specific
            expression patterns.
REFERENCE   7  (bases 1 to 3510)
  AUTHORS   Albrecht,M., Domingues,F.S., Schreiber,S. and Lengauer,T.
  TITLE     Identification of mammalian orthologs associates PYPAF5 with
            distinct functional roles
  JOURNAL   FEBS Lett 538 (1-3), 173-177 (2003)
   PUBMED   12633874
REFERENCE   8  (bases 1 to 3510)
  AUTHORS   Ruiz-Opazo,N., Lopez,L.V. and Herrera,V.L.
  TITLE     The dual AngII/AVP receptor gene N119S/C163R variant exhibits
            sodium-induced dysfunction and cosegregates with salt-sensitive
            hypertension in the Dahl salt-sensitive hypertensive rat model
  JOURNAL   Mol Med 8 (1), 24-32 (2002)
   PUBMED   11984003
  REMARK    GeneRIF: The dual AngII/AVP receptor gene N119S/C163R variant
            exhibits sodium-induced dysfunction and cosegregates with
            salt-sensitive hypertension in the Dahl salt-sensitive hypertensive
            rat model.
REFERENCE   9  (bases 1 to 3510)
  AUTHORS   Gonzalez,C.B., Herrera,V.L. and Ruiz-Opazo,N.
  TITLE     Renal immunocytochemical distribution and pharmacological
            properties of the dual angiotensin II/AVP receptor
  JOURNAL   Hypertension 29 (4), 957-961 (1997)
   PUBMED   9095083
REFERENCE   10 (bases 1 to 3510)
  AUTHORS   Ruiz-Opazo,N., Akimoto,K. and Herrera,V.L.
  TITLE     Identification of a novel dual angiotensin II/vasopressin receptor
            on the basis of molecular recognition theory
  JOURNAL   Nat Med 1 (10), 1074-1081 (1995)
   PUBMED   7489366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 11, 2021 this sequence version replaced NM_134375.4.
            
            Summary: The protein encoded by this gene binds
            arginine-vasopressin and may be involved in the
            arginine-vasopressin-mediated regulation of renal salt-water
            balance. The encoded protein also mediates inflammatory responses
            in the colon to allow recovery from intestinal epithelial damage
            and protects against tumorigenesis and the development of colitis.
            Finally, this protein can increase activation of NF-kappa-B,
            activation of CASP1 through interaction with ASC, and cAMP
            accumulation. [provided by RefSeq, Feb 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ631800.1, SRR26643288.4910.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345331 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               JAXUCZ010000001.1  205434484-205434640
            158-429             JAXUCZ010000001.1  205435176-205435447
            430-465             JAXUCZ010000001.1  205435685-205435720
            466-2218            JAXUCZ010000001.1  205435931-205437683
            2219-2311           JAXUCZ010000001.1  205438430-205438522
            2312-2482           JAXUCZ010000001.1  205439550-205439720
            2483-2650           JAXUCZ010000001.1  205439796-205439963
            2651-3510           JAXUCZ010000001.1  205440386-205441245
FEATURES             Location/Qualifiers
     source          1..3510
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..3510
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR"
                     /note="NLR family, pyrin domain containing 6"
                     /db_xref="GeneID:171390"
                     /db_xref="RGD:708549"
     exon            1..157
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..2774
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR"
                     /note="dual angiotensin II/vasopressin receptor; NACHT,
                     leucine rich repeat and PYD containing 6;
                     non-angiotensin-vasopressin receptor; NACHT, LRR and PYD
                     domains-containing protein 6-like"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein 6"
                     /protein_id="NP_599202.4"
                     /db_xref="GeneID:171390"
                     /db_xref="RGD:708549"
                     /translation="MDAAGASCSSSEAVARELLLAALQDLSQEQLKRFRHKLRDAPLD
                     GRSIPWGRLEHSDAVDLTDKLIEFYAPEPAVDVTRKILKKADIRDVSLRLKEQQLQRL
                     GSSSALLTVSEYKKKYREHVLRQHAKVKERNARSVKINKRFTKLLIAPGSGAGEDELL
                     GTSGEPEPERARRSDTHTFNRLFRGNDDEGPRPLTVVLQGPAGIGKTMAAKKILYDWA
                     GGKLYHSQVDFAFFMPCGELLERPGTRSLADLILEQCPDRTAPVRRILAQPHRLLFIL
                     DGADELPTLAAPEATPCRDPFEATSGLRVLSGLLSQELLPSARLLVTSRNATLGRLQG
                     RLCSPQCAEVRGFSDKDKKKYFFKFFRDERKAERAYRFVKENETLYALCFVPFVCWIV
                     CTVLLQQMELGRDLSRTSKTTTSVYLLFITSMLKSAGTNGPRVQGELRMLCRLAREGI
                     LKHQAQFSEKDLERLKLQGSQVQTMFLSKKELPGVLETVVTYQFIDQSFQEFLAALSY
                     LLDAEGAPGNSAGSVQMLLNSDAGLRGHLALTTRFLFGLLSTERIRDIGNHFGCVVPG
                     RVKQDTLRWVQGQSQPKVATVGAEKKDELKDEEAEEEEEEEEEEEEELNFGLELLYCL
                     YETQEDDFVRQALSSLPEMVLERVRLTRMDLEVLSYCVQCCPDGQALRLVSCGLVAAK
                     EKKKKKKSFMNRLKGSQSTGKQPPASLLRPLCEAMITQQCGLSILTLSHCKLPDAVCR
                     DLSEALKVAPSLRELGLLQNRLTEAGLRLLSQGLAWPKCKVQTLRIQMPGLQEVIHYL
                     VIVLQQSPVLTTLDLSGCQLPGTVVEPLCSALKHPKCGLKTLSLTSVELTENPLRELQ
                     AVKTLKPDLAIIHSKLGTHPQPLKG"
     exon            158..429
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR"
                     /inference="alignment:Splign:2.1.0"
     exon            430..465
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR"
                     /inference="alignment:Splign:2.1.0"
     exon            466..2218
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2311
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2482
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR"
                     /inference="alignment:Splign:2.1.0"
     exon            2483..2650
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..3510
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagacgccgc tgagctagaa tgaacaagac cgagaaacac cgccactccc aggatgagac
       61 cagtttagcc caggaaggct cacctctgtt cccagcctct gcatctgaga gctagatcct
      121 gagactccat ggatgccgct ggagcctcct gctccagctc ggaggcggtg gcaagggaac
      181 tgcttctggc cgcactgcag gatctgagcc aggagcagct gaagcgtttt cgccacaagc
      241 tccgggatgc gcccctggat ggccgcagca tcccgtgggg gcgactggag cactcagacg
      301 ctgtggacct cacagacaag ctgattgagt tctatgcgcc agagccagcc gtagatgtga
      361 cccgaaagat cctgaagaag gcggatattc gagatgtgtc gttgcgactc aaggagcagc
      421 agctgcagag gctcggctcc agctcggcgc ttctcaccgt gtcggagtac aagaagaagt
      481 accgcgagca cgtgctacga cagcatgcta aggtgaagga gaggaatgcc cgctccgtga
      541 agatcaacaa gcgcttcacc aagctgctca ttgcgccggg gagcggcgcc ggggaggacg
      601 agctgctggg aacgtcgggg gagcccgagc ccgagcgcgc aaggcgctcg gacacacaca
      661 ctttcaatcg gctcttccga ggaaatgatg acgagggccc gcggccgctg accgtggtgc
      721 tgcagggccc ggcaggcatc ggcaaaacca tggccgccaa gaaaatcctc tacgactggg
      781 caggaggcaa gctataccac agccaagtgg actttgcctt cttcatgccg tgcggcgagc
      841 tgctggagcg gccaggtacg cgcagcttgg cggacctgat actggaacag tgcccggacc
      901 gcaccgcgcc ggtgcggcgg atactagcgc aaccgcatcg tctactgttc atcctggacg
      961 gtgcagacga attgcctact ttagcagccc cagaagccac tccctgcaga gaccctttcg
     1021 aggctacgag tggcttgaga gtgctgagcg ggctgctgag ccaggagctg ttaccatcgg
     1081 ctcgcttgct ggtgacttca cgcaacgcca ccctcgggag gctgcagggc agactttgct
     1141 caccacagtg cgcagaagtg cgcggcttct cagacaaaga caagaaaaag tatttcttca
     1201 agtttttccg ggacgagagg aaggcagagc gcgcttaccg cttcgtgaaa gagaatgaga
     1261 cgctgtacgc actgtgcttt gtgccgtttg tgtgctggat cgtgtgcacc gtgctgctgc
     1321 agcaaatgga gctgggccgg gatctgtctc gtacctccaa gaccactaca tctgtgtacc
     1381 tgctcttcat caccagcatg ctgaagtctg caggtaccaa tggaccccgg gttcagggag
     1441 agctgcgaat gctgtgccgc ctggcccggg agggcatcct gaagcatcaa gcacagttct
     1501 cagaaaagga cctggagaga ttgaagcttc agggttccca agttcagaca atgtttctca
     1561 gcaagaagga gctgccagga gtgctagaaa ctgtggtcac ctaccagttc attgaccaga
     1621 gcttccagga gttcttggct gcattgtcat acctactaga cgctgaggga gccccaggga
     1681 actccgcagg aagtgtgcag atgctcctga actctgacgc ggggctgcgt ggtcatctgg
     1741 cactcaccac tagattcctc tttggactgc taagtacaga gaggattcgt gacattggaa
     1801 accattttgg ctgtgtggtg ccagggcgtg tgaaacagga caccttgcgg tgggtacaag
     1861 gacaaagcca acccaaggtg gcgacagtag gagcagaaaa gaaggatgag ctgaaggacg
     1921 aggaagcaga ggaggaggag gaggaggagg aagaagagga ggaggaactc aactttggac
     1981 tggagctgtt gtactgcctg tatgagacac aagaggatga ttttgttcgc caggctctca
     2041 gcagccttcc agagatggta ctggagcgag ttaggctgac ccgcatggac cttgaggttc
     2101 tgagctactg cgtgcagtgc tgcccggacg gccaggctct gagactggtg agctgtggac
     2161 tggtggcggc aaaggagaag aagaagaaga agaagagctt catgaaccgg ctgaagggtt
     2221 ctcaaagcac cgggaaacaa cccccagcct ccttgctgcg tccactctgt gaggcaatga
     2281 ttacccagca atgtggtctg agtattctga ccttgtcaca ctgcaaactc cctgatgcag
     2341 tttgtcgaga cctttctgag gctctgaagg tagctccttc cctaagggag ctgggcctcc
     2401 tccagaaccg actcactgag gcaggcctgc gtttactaag ccaaggcctg gcttggccca
     2461 aatgcaaggt gcagacactc aggatacaga tgcctggcct ccaagaggtg atccactacc
     2521 tggtcattgt gctccagcag agcccagtcc taaccactct ggacctcagt ggctgtcagc
     2581 tgcctggcac tgtggtggaa cctctgtgtt cagccctgaa gcaccctaaa tgtggcctaa
     2641 agaccctcag tctgacttct gtggagctga ctgagaatcc actgagagag cttcaagctg
     2701 tgaagacatt aaagccagat ctggccatca tacattcaaa attgggcaca catcctcagc
     2761 ctctgaaggg atgaagcagt gtcttctgag ccccggagtc cagaacagga tattgctgaa
     2821 gtcaacgttc ttctgaatat gtctccccat tcaaaagcaa gtagatgcca gcttctccct
     2881 ccaggcaagt ctttcaagcc aagaagccac agaagggcaa gcaaaagacc caggtagata
     2941 taggcactta agagcccctg gatatagacc tggcacatgt cctgccccgg acactcggag
     3001 gttagtcttc cctcagcccc ataaccgcca atacctccct ttctgggccc accaatctgt
     3061 cccttgaaga taatcccaac agtaacagaa gtatttgttg tggcttgccc tggagttctc
     3121 tgtgttttga tgctacttcc actgccccaa ggacggctgc ctagtctgta ctcaggactc
     3181 gggtgacttc accagaacct tctccctatt taatttgtaa aataccaatg agggcaggta
     3241 caagatagaa ggaggcctgt cattggatga gaagaaagga tgggtgggag aaacgtttga
     3301 aggaagagga ggagactgga ctggaaagga gaaagagaca ggagggacag agaaagtagc
     3361 catggcggga caatgtggaa gctgatgtta agattccaat aagatcccac gctgtacctt
     3421 tacaggttgt tatgaatgtt cttaagggat ggatgtgtat ggggctttgt atgtttaggt
     3481 gggcaaatat atcttatcaa ttggatcaga
//
