LOCUS       NP_599202                881 aa            linear   ROD 01-APR-2024
DEFINITION  NACHT, LRR and PYD domains-containing protein 6 [Rattus
            norvegicus].
ACCESSION   NP_599202 XP_001061777 XP_577848
VERSION     NP_599202.4
DBSOURCE    REFSEQ: accession NM_134375.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 881)
  AUTHORS   Meng,C., Zhang,J., Zhang,L., Wang,Y., Li,Z. and Zhao,J.
  TITLE     Effects of NLRP6 in Cerebral Ischemia/Reperfusion (I/R) Injury in
            Rats
  JOURNAL   J Mol Neurosci 69 (3), 411-418 (2019)
   PUBMED   31267316
  REMARK    GeneRIF: Peak expression of NLRP6 is in 48-h post-cerebral I/R
            injury. NRP6 has a pro-inflammatory effect in cerebral I/R injury
REFERENCE   2  (residues 1 to 881)
  AUTHORS   Wlodarska,M., Thaiss,C.A., Nowarski,R., Henao-Mejia,J., Zhang,J.P.,
            Brown,E.M., Frankel,G., Levy,M., Katz,M.N., Philbrick,W.M.,
            Elinav,E., Finlay,B.B. and Flavell,R.A.
  TITLE     NLRP6 inflammasome orchestrates the colonic host-microbial
            interface by regulating goblet cell mucus secretion
  JOURNAL   Cell 156 (5), 1045-1059 (2014)
   PUBMED   24581500
REFERENCE   3  (residues 1 to 881)
  AUTHORS   Hu,B., Elinav,E., Huber,S., Strowig,T., Hao,L., Hafemann,A.,
            Jin,C., Wunderlich,C., Wunderlich,T., Eisenbarth,S.C. and
            Flavell,R.A.
  TITLE     Microbiota-induced activation of epithelial IL-6 signaling links
            inflammasome-driven inflammation with transmissible cancer
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9862-9867 (2013)
   PUBMED   23696660
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12852.
            Wunderlich, Claudia [added]; Wunderlich, Thomas [added]]
REFERENCE   4  (residues 1 to 881)
  AUTHORS   Huber,S., Gagliani,N., Zenewicz,L.A., Huber,F.J., Bosurgi,L.,
            Hu,B., Hedl,M., Zhang,W., O'Connor,W. Jr., Murphy,A.J.,
            Valenzuela,D.M., Yancopoulos,G.D., Booth,C.J., Cho,J.H., Ouyang,W.,
            Abraham,C. and Flavell,R.A.
  TITLE     IL-22BP is regulated by the inflammasome and modulates
            tumorigenesis in the intestine
  JOURNAL   Nature 491 (7423), 259-263 (2012)
   PUBMED   23075849
REFERENCE   5  (residues 1 to 881)
  AUTHORS   Anand,P.K., Malireddi,R.K., Lukens,J.R., Vogel,P., Bertin,J.,
            Lamkanfi,M. and Kanneganti,T.D.
  TITLE     NLRP6 negatively regulates innate immunity and host defence against
            bacterial pathogens
  JOURNAL   Nature 488 (7411), 389-393 (2012)
   PUBMED   22763455
REFERENCE   6  (residues 1 to 881)
  AUTHORS   Herrera,V.L., Bagamasbad,P., Didishvili,T., Decano,J.L. and
            Ruiz-Opazo,N.
  TITLE     Overlapping genes in Nalp6/PYPAF5 locus encode two V2-type
            vasopressin isoreceptors: angiotensin-vasopressin receptor (AVR)
            and non-AVR
  JOURNAL   Physiol Genomics 34 (1), 65-77 (2008)
   PUBMED   18413781
  REMARK    GeneRIF: AVR is distinct from Nalp6/PYPAF5 based on different mRNA
            and protein sizes, subcellular localization, and tissue-specific
            expression patterns.
REFERENCE   7  (residues 1 to 881)
  AUTHORS   Albrecht,M., Domingues,F.S., Schreiber,S. and Lengauer,T.
  TITLE     Identification of mammalian orthologs associates PYPAF5 with
            distinct functional roles
  JOURNAL   FEBS Lett 538 (1-3), 173-177 (2003)
   PUBMED   12633874
REFERENCE   8  (residues 1 to 881)
  AUTHORS   Ruiz-Opazo,N., Lopez,L.V. and Herrera,V.L.
  TITLE     The dual AngII/AVP receptor gene N119S/C163R variant exhibits
            sodium-induced dysfunction and cosegregates with salt-sensitive
            hypertension in the Dahl salt-sensitive hypertensive rat model
  JOURNAL   Mol Med 8 (1), 24-32 (2002)
   PUBMED   11984003
  REMARK    GeneRIF: The dual AngII/AVP receptor gene N119S/C163R variant
            exhibits sodium-induced dysfunction and cosegregates with
            salt-sensitive hypertension in the Dahl salt-sensitive hypertensive
            rat model.
REFERENCE   9  (residues 1 to 881)
  AUTHORS   Gonzalez,C.B., Herrera,V.L. and Ruiz-Opazo,N.
  TITLE     Renal immunocytochemical distribution and pharmacological
            properties of the dual angiotensin II/AVP receptor
  JOURNAL   Hypertension 29 (4), 957-961 (1997)
   PUBMED   9095083
REFERENCE   10 (residues 1 to 881)
  AUTHORS   Ruiz-Opazo,N., Akimoto,K. and Herrera,V.L.
  TITLE     Identification of a novel dual angiotensin II/vasopressin receptor
            on the basis of molecular recognition theory
  JOURNAL   Nat Med 1 (10), 1074-1081 (1995)
   PUBMED   7489366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 11, 2021 this sequence version replaced NP_599202.3.
            
            Summary: The protein encoded by this gene binds
            arginine-vasopressin and may be involved in the
            arginine-vasopressin-mediated regulation of renal salt-water
            balance. The encoded protein also mediates inflammatory responses
            in the colon to allow recovery from intestinal epithelial damage
            and protects against tumorigenesis and the development of colitis.
            Finally, this protein can increase activation of NF-kappa-B,
            activation of CASP1 through interaction with ASC, and cAMP
            accumulation. [provided by RefSeq, Feb 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ631800.1, SRR26643288.4910.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345331 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..881
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     Protein         1..881
                     /product="NACHT, LRR and PYD domains-containing protein 6"
                     /note="dual angiotensin II/vasopressin receptor; NACHT,
                     leucine rich repeat and PYD containing 6;
                     non-angiotensin-vasopressin receptor; NACHT, LRR and PYD
                     domains-containing protein 6-like"
                     /calculated_mol_wt=98207
     Region          12..>505
                     /region_name="NACHT"
                     /note="Predicted NTPase, NACHT family domain [Signal
                     transduction mechanisms]; COG5635"
                     /db_xref="CDD:444362"
     Region          16..96
                     /region_name="Pyrin_ASC-like"
                     /note="Pyrin Death Domain found in ASC; cd08321"
                     /db_xref="CDD:260033"
     Site            104
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q63035.4)"
     Region          154..175
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63035.4)"
     Region          195..348
                     /region_name="NACHT"
                     /note="NACHT domain; pfam05729"
                     /db_xref="CDD:428606"
     Region          459..484
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63035.4)"
     Region          498..635
                     /region_name="NLRC4_HD2"
                     /note="NLRC4 helical domain HD2; pfam17776"
                     /db_xref="CDD:465499"
     Region          579..611
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63035.4)"
     Region          619..848
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          637..660
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63035.4)"
     Region          749..772
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63035.4)"
     Region          839..863
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63035.4)"
     CDS             1..881
                     /gene="Nlrp6"
                     /gene_synonym="Avr; Nalp6; Navr; Navr/Avr; Non-AVR"
                     /coded_by="NM_134375.5:129..2774"
                     /db_xref="GeneID:171390"
                     /db_xref="RGD:708549"
ORIGIN      
        1 mdaagascss seavarelll aalqdlsqeq lkrfrhklrd apldgrsipw grlehsdavd
       61 ltdkliefya pepavdvtrk ilkkadirdv slrlkeqqlq rlgsssallt vseykkkyre
      121 hvlrqhakvk ernarsvkin krftklliap gsgagedell gtsgepeper arrsdthtfn
      181 rlfrgnddeg prpltvvlqg pagigktmaa kkilydwagg klyhsqvdfa ffmpcgelle
      241 rpgtrsladl ileqcpdrta pvrrilaqph rllfildgad elptlaapea tpcrdpfeat
      301 sglrvlsgll sqellpsarl lvtsrnatlg rlqgrlcspq caevrgfsdk dkkkyffkff
      361 rderkaeray rfvkenetly alcfvpfvcw ivctvllqqm elgrdlsrts ktttsvyllf
      421 itsmlksagt ngprvqgelr mlcrlaregi lkhqaqfsek dlerlklqgs qvqtmflskk
      481 elpgvletvv tyqfidqsfq eflaalsyll daegapgnsa gsvqmllnsd aglrghlalt
      541 trflfgllst erirdignhf gcvvpgrvkq dtlrwvqgqs qpkvatvgae kkdelkdeea
      601 eeeeeeeeee eeelnfglel lyclyetqed dfvrqalssl pemvlervrl trmdlevlsy
      661 cvqccpdgqa lrlvscglva akekkkkkks fmnrlkgsqs tgkqppasll rplceamitq
      721 qcglsiltls hcklpdavcr dlsealkvap slrelgllqn rlteaglrll sqglawpkck
      781 vqtlriqmpg lqevihylvi vlqqspvltt ldlsgcqlpg tvveplcsal khpkcglktl
      841 sltsvelten plrelqavkt lkpdlaiihs klgthpqplk g
//
