LOCUS       NM_001172164            3387 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus NLR family, pyrin domain containing 4 (Nlrp4),
            mRNA.
ACCESSION   NM_001172164
VERSION     NM_001172164.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3387)
  AUTHORS   Lian,Y.G., Zhao,H.Y., Wang,S.J., Xu,Q.L. and Xia,X.J.
  TITLE     NLRP4 is an essential negative regulator of fructose-induced
            cardiac injury in vitro and in vivo
  JOURNAL   Biomed Pharmacother 91, 590-601 (2017)
   PUBMED   28486191
  REMARK    GeneRIF: NLRP4 is an important mediator of cardiac remodeling in
            vitro and in vivo.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Sep 16, 2014 this sequence version replaced NM_001172164.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates and exon combination used
            for the transcript record were based on alignment to full-length
            mouse mRNA AK133284.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                JAXUCZ010000001.1  77156336-77156390   c
            56-398              JAXUCZ010000001.1  77145075-77145417   c
            399-1971            JAXUCZ010000001.1  77138512-77140084   c
            1972-2130           JAXUCZ010000001.1  77137181-77137339   c
            2131-2295           JAXUCZ010000001.1  77136601-77136765   c
            2296-2463           JAXUCZ010000001.1  77133610-77133777   c
            2464-2634           JAXUCZ010000001.1  77127314-77127484   c
            2635-2805           JAXUCZ010000001.1  77124020-77124190   c
            2806-2976           JAXUCZ010000001.1  77122318-77122488   c
            2977-3387           JAXUCZ010000001.1  77118192-77118602   c
FEATURES             Location/Qualifiers
     source          1..3387
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..3387
                     /gene="Nlrp4"
                     /gene_synonym="Nalp4; Nlrp4e; RGD1563529; RGD1564841"
                     /note="NLR family, pyrin domain containing 4"
                     /db_xref="GeneID:499069"
                     /db_xref="RGD:1563529"
     exon            1..55
                     /gene="Nlrp4"
                     /gene_synonym="Nalp4; Nlrp4e; RGD1563529; RGD1564841"
                     /inference="alignment:Splign:2.1.0"
     exon            56..398
                     /gene="Nlrp4"
                     /gene_synonym="Nalp4; Nlrp4e; RGD1563529; RGD1564841"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..3070
                     /gene="Nlrp4"
                     /gene_synonym="Nalp4; Nlrp4e; RGD1563529; RGD1564841"
                     /note="NLR family, pyrin domain containing 4E; NACHT,
                     leucine rich repeat and PYD containing 4"
                     /codon_start=1
                     /product="NLR family, pyrin domain containing 4"
                     /protein_id="NP_001165635.2"
                     /db_xref="GeneID:499069"
                     /db_xref="RGD:1563529"
                     /translation="MASFFSDFGLMWYLEELNKKEFVKFKEFLKQEILQLRLKQISWT
                     KVKKASREDLANLLLKHYEEKQAWDMTFKIFQKMNRKDLIERAGREIAGHSKLYQAHL
                     KKKLTHDYARKFNIKAQDLFKQKFTQDDCDRFENLLVSKATGKKPHMVFLQGVAGIGK
                     SLMLTKLMLAWSEGIVFQNKFSYIFYFCCQDVKQLKRASLAELISREWPNASAPTAEI
                     LSQPEKLLFIIDSLEVMECNMSERESELCDNCTEKQPVSLLLSSLLRRKMLPESSFLI
                     SATPETFEKMEDRIECTNVKIITGFNENNIKMYFRSLFQDKNRTLEAFSLVRENEQLF
                     NVCQVPVLCWMVATCIKKEIEKGRDPVFICRRTTSLYTTHIFNLFTPQNAQYPSKKSQ
                     DQLQGLCSLAAEGMWTDTFVFSEEALRRNGILDSDIPTLLDRRILERSKESESCYIFL
                     HPSLQEVCAAVFYLLKSHLDHPSQDVKSVEALLFTFLKKAKVQWIFLGCFLFGLLHES
                     EQEKLEMFFGHQLSQEIKHQLYQCLETISVNEELQEQIDGMKLFYCLFEMEDEAFLMQ
                     AMNCMEQINFVAKDYSDVIVAAYCLKHCSTLKKLSFSTQNILSEEQEHSYTEKLLICW
                     HHMCSVLISSKDIHVLQVKDTNLNETAFWVLYNHLKYPSCTLKVLVVNNVTFLCDNHL
                     FFELIQNQRLQHLNLSLTFLSHSDVKLLCDVLNQAECNIEKLMIAACNLSPDDCKVFA
                     SVLISSKMLKHLNLSSNNLDKGISSLCKALCHPDCILKHLVLANCSLSEQCWDYLSEV
                     VRRNKTLSHLDISSNDLKDEGLKVLCGALTLPDSGLISLSVRHCLITTSGCQDLAEVL
                     RHNQNLRSLQVSNNKIEDAGVKLLCDAIKQPNCHLENIGLEACELTGACCKDLASAFV
                     HCKTLWGINLLENALDHSGLVVLFEALKQQKCTLHVLGLRITDFDKETQEFLIAEEEK
                     NPYLSILSNV"
     exon            399..1971
                     /gene="Nlrp4"
                     /gene_synonym="Nalp4; Nlrp4e; RGD1563529; RGD1564841"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2130
                     /gene="Nlrp4"
                     /gene_synonym="Nalp4; Nlrp4e; RGD1563529; RGD1564841"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2295
                     /gene="Nlrp4"
                     /gene_synonym="Nalp4; Nlrp4e; RGD1563529; RGD1564841"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2463
                     /gene="Nlrp4"
                     /gene_synonym="Nalp4; Nlrp4e; RGD1563529; RGD1564841"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2634
                     /gene="Nlrp4"
                     /gene_synonym="Nalp4; Nlrp4e; RGD1563529; RGD1564841"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..2805
                     /gene="Nlrp4"
                     /gene_synonym="Nalp4; Nlrp4e; RGD1563529; RGD1564841"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2976
                     /gene="Nlrp4"
                     /gene_synonym="Nalp4; Nlrp4e; RGD1563529; RGD1564841"
                     /inference="alignment:Splign:2.1.0"
     exon            2977..3387
                     /gene="Nlrp4"
                     /gene_synonym="Nalp4; Nlrp4e; RGD1563529; RGD1564841"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttctgccc agtccagctg ccatgtatta aggactaacc tggaagccta gggcgatctc
       61 atcaggttct tactcctgtt actcatctct ctgaagacac atctatcttc cttaagacgc
      121 aatggcatca ttcttttctg attttggcct tatgtggtac ttggaagagt taaacaagaa
      181 agaattcgtg aagtttaagg aattcctcaa acaggagatt ttgcagttga ggctgaaaca
      241 gatttcttgg accaaagtga agaaggcatc tcgggaagac cttgccaact tactgttgaa
      301 acattatgag gagaagcaag cctgggacat gaccttcaaa atcttccaga agatgaacag
      361 gaaggatctc attgagaggg caggaagaga gattgctggt cactcaaagt tatatcaagc
      421 tcatttgaag aagaagctga cccatgatta tgccagaaag tttaacatca aagctcaaga
      481 tctctttaag cagaaattta cccaggatga ctgtgatcgt tttgagaacc ttcttgtatc
      541 aaaggcaact ggaaagaagc cacacatggt gttcctacaa ggagtggcgg gaattggcaa
      601 gtcactgatg ttgacaaagt taatgctggc ctggtcagaa ggcatcgtgt ttcagaacaa
      661 attctcctac atcttctact tctgctgtca agatgtgaag cagttaaaga gagcaagtct
      721 ggcagaactg atctccagag agtggcccaa tgcctcggct cccacagcgg agatcctctc
      781 ccagccggag aaactcttgt ttatcatcga cagcttggaa gtgatggaat gcaatatgtc
      841 cgaacgggaa tcggagctgt gtgataactg cacggagaag cagcccgtga gtttactgct
      901 gagcagtttg ctcaggagga agatgctccc cgaatcctct ttcctcatct ccgctacccc
      961 agagactttt gagaaaatgg aggacaggat tgagtgcacc aatgtgaaaa taataacagg
     1021 attcaatgag aacaatatta agatgtattt ccgcagcttg ttccaagata agaacagaac
     1081 cctggaggcc ttcagtttag tgagagaaaa tgagcagctg ttcaatgtat gtcaggtccc
     1141 tgtgctctgc tggatggtgg ctacctgtat taaaaaggag atagagaagg gaagagaccc
     1201 agtcttcatc tgccgacgta ccacctctct gtacaccact cacatcttca atttgttcac
     1261 tccacaaaat gcccagtatc caagtaagaa aagccaagac cagctgcagg gcttgtgttc
     1321 tctagctgcc gagggcatgt ggaccgacac atttgtgttt agtgaggagg cgctcaggag
     1381 aaatggaatc ctggattctg acatccccac attgctggac agacggatcc ttgaaaggag
     1441 caaggaatct gaaagttgtt acattttcct ccacccatct ctccaggagg tctgtgctgc
     1501 cgtcttttat ctgctaaaga gccacttgga ccaccctagc caggacgtaa agagtgtaga
     1561 ggcactcttg tttacatttc tgaagaaagc caaagtacag tggatctttt taggctgttt
     1621 cctctttggc cttttacatg aatcggaaca agaaaagcta gagatgtttt tcggccacca
     1681 gttgtcccag gaaataaagc atcagctgta tcagtgcctg gaaaccataa gtgtcaatga
     1741 agagcttcaa gaacagatag atggcatgaa gttgttttac tgtctgtttg agatggagga
     1801 tgaagccttc ttaatgcaag caatgaactg tatggagcag attaactttg tggctaagga
     1861 ttattctgat gttattgttg ctgcctactg cttaaaacac tgttctaccc tgaagaaact
     1921 atccttttct acccaaaata tcctgagtga agaacaagaa cacagctata cggaaaagct
     1981 actcatctgt tggcatcata tgtgctctgt gcttataagc agtaaggaca tccacgtact
     2041 ccaagtaaaa gacactaatc tcaatgagac agccttttgg gtcttgtata atcatctgaa
     2101 gtaccccagc tgcaccctta aagtactcgt ggtcaataat gtgaccttcc tgtgtgataa
     2161 ccacctattc tttgagttga ttcagaacca acgtttgcag cacctgaacc tcagcctcac
     2221 gttcctctcc cacagtgatg tgaaactgtt gtgtgatgtc ttgaaccagg ccgagtgcaa
     2281 catagaaaag ctgatgatag cagcctgtaa cctttcccct gatgactgca aggtctttgc
     2341 ctctgtcctg atcagcagca agatgttgaa gcatcttaat ttgtcatcca acaacttgga
     2401 caaagggatc tcctcactgt gcaaggcttt gtgccaccca gactgcattc tgaagcacct
     2461 ggtgttagcc aactgttccc tcagtgagca atgttgggac tatctctcag aagttgttag
     2521 gcggaacaaa accctgagcc acctagacat cagctccaat gacctgaagg atgagggact
     2581 gaaagttctc tgtggagctc tgactctccc agacagtggc ctgatatcac taagtgtgag
     2641 acattgtctc atcaccacta gtggttgcca ggacctggct gaagtcttga ggcacaacca
     2701 gaacctgagg agcctacagg tttcaaacaa taagatcgaa gacgctggtg tgaagctgct
     2761 gtgtgatgct ataaagcaac ccaactgcca cttagagaat attgggttgg aggcctgcga
     2821 gctaactggt gcctgttgta aggatcttgc ttctgctttt gtccactgta aaaccctgtg
     2881 gggtatcaac ctgctagaga acgccttgga ccacagtggg ttggtcgtgc tctttgaggc
     2941 tctgaaacag caaaagtgta ccctgcatgt tcttggactt cgaattactg actttgataa
     3001 ggaaacccag gagttcctga ttgcagagga agagaaaaac ccatatttga gcatcctaag
     3061 caatgtataa acagaaacag aaagcaaggg tggacattct ggtgtaggaa acatggctgt
     3121 attccgactc aaactacctc caaaagaaag agagcaggat ccttaatttg atccattgta
     3181 tacaaaaatt acagaccact aacattccaa cgagatatga tttcttggct ccctgttcag
     3241 atgttttttg caaaatagat atggctttgt tgtttgaact ctagtttcaa acaggccatt
     3301 caaagagatt catgctaaaa tgactggctt gtaatgacat ttttcccaca ctgatatttt
     3361 aagcacccaa taaagtcttt aaatgta
//
