LOCUS       NM_001191642            3857 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Rattus norvegicus NLR family, pyrin domain containing 3 (Nlrp3),
            mRNA.
ACCESSION   NM_001191642 XM_220513
VERSION     NM_001191642.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3857)
  AUTHORS   Zhou,Y., Dong,W., Wang,L., Ren,S., Wei,W. and Wu,G.
  TITLE     Cystatin C Attenuates Perihematomal Secondary Brain Injury by
            Inhibiting the Cathepsin B/NLRP3 Signaling Pathway in a Rat Model
            of Intracerebral Hemorrhage
  JOURNAL   Mol Neurobiol 61 (11), 9646-9662 (2024)
   PUBMED   38676809
  REMARK    GeneRIF: Cystatin C Attenuates Perihematomal Secondary Brain Injury
            by Inhibiting the Cathepsin B/NLRP3 Signaling Pathway in a Rat
            Model of Intracerebral Hemorrhage.
REFERENCE   2  (bases 1 to 3857)
  AUTHORS   He,H., Su,H., Chen,X., Chen,X. and Yang,S.
  TITLE     Interference with GPR4 inactivates NLRP3 inflammasome signaling by
            inhibiting LPAR1 expression to ameliorate oxygen-glucose
            deprivation/reoxygenation-induced inflammation and apoptosis of
            cardiomyocytes
  JOURNAL   Prostaglandins Other Lipid Mediat 174, 106863 (2024)
   PUBMED   38936540
  REMARK    GeneRIF: Interference with GPR4 inactivates NLRP3 inflammasome
            signaling by inhibiting LPAR1 expression to ameliorate
            oxygen-glucose deprivation/reoxygenation-induced inflammation and
            apoptosis of cardiomyocytes.
REFERENCE   3  (bases 1 to 3857)
  AUTHORS   Jiang,T. and Li,Y.
  TITLE     25-hydroxycholesterol aggravates oxygen-glucose
            deprivation/reoxygenation-induced pyroptosis through promoting
            activation of NLRP3 inflammasome in H9C2 cardiomyocytes
  JOURNAL   Braz J Med Biol Res 57, e13299 (2024)
   PUBMED   38716981
  REMARK    GeneRIF: 25-hydroxycholesterol aggravates oxygen-glucose
            deprivation/reoxygenation-induced pyroptosis through promoting
            activation of NLRP3 inflammasome in H9C2 cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3857)
  AUTHORS   Cao,W., Zeng,Y., Su,Y., Gong,H., He,J., Liu,Y. and Li,C.
  TITLE     The involvement of oxidative stress and the TLR4/NF-kappaB/NLRP3
            pathway in acute lung injury induced by high-altitude hypoxia
  JOURNAL   Immunobiology 229 (3), 152809 (2024)
   PUBMED   38788361
  REMARK    GeneRIF: The involvement of oxidative stress and the
            TLR4/NF-kappaB/NLRP3 pathway in acute lung injury induced by
            high-altitude hypoxia.
REFERENCE   5  (bases 1 to 3857)
  AUTHORS   Jiang,X.S., Liu,T., Xia,Y.F., Gan,H., Ren,W. and Du,X.G.
  TITLE     Activation of the Nrf2/ARE signaling pathway ameliorates
            hyperlipidemia-induced renal tubular epithelial cell injury by
            inhibiting mtROS-mediated NLRP3 inflammasome activation
  JOURNAL   Front Immunol 15, 1342350 (2024)
   PUBMED   38720901
  REMARK    GeneRIF: Activation of the Nrf2/ARE signaling pathway ameliorates
            hyperlipidemia-induced renal tubular epithelial cell injury by
            inhibiting mtROS-mediated NLRP3 inflammasome activation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3857)
  AUTHORS   Agostini,L., Martinon,F., Burns,K., McDermott,M.F., Hawkins,P.N.
            and Tschopp,J.
  TITLE     NALP3 forms an IL-1beta-processing inflammasome with increased
            activity in Muckle-Wells autoinflammatory disorder
  JOURNAL   Immunity 20 (3), 319-325 (2004)
   PUBMED   15030775
REFERENCE   7  (bases 1 to 3857)
  AUTHORS   O'Connor,W. Jr., Harton,J.A., Zhu,X., Linhoff,M.W. and Ting,J.P.
  TITLE     Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an
            inducible inflammatory mediator with NF-kappa B suppressive
            properties
  JOURNAL   J Immunol 171 (12), 6329-6333 (2003)
   PUBMED   14662828
REFERENCE   8  (bases 1 to 3857)
  AUTHORS   Aksentijevich,I., Nowak,M., Mallah,M., Chae,J.J., Watford,W.T.,
            Hofmann,S.R., Stein,L., Russo,R., Goldsmith,D., Dent,P.,
            Rosenberg,H.F., Austin,F., Remmers,E.F., Balow,J.E. Jr.,
            Rosenzweig,S., Komarow,H., Shoham,N.G., Wood,G., Jones,J.,
            Mangra,N., Carrero,H., Adams,B.S., Moore,T.L., Schikler,K.,
            Hoffman,H., Lovell,D.J., Lipnick,R., Barron,K., O'Shea,J.J.,
            Kastner,D.L. and Goldbach-Mansky,R.
  TITLE     De novo CIAS1 mutations, cytokine activation, and evidence for
            genetic heterogeneity in patients with neonatal-onset multisystem
            inflammatory disease (NOMID): a new member of the expanding family
            of pyrin-associated autoinflammatory diseases
  JOURNAL   Arthritis Rheum 46 (12), 3340-3348 (2002)
   PUBMED   12483741
REFERENCE   9  (bases 1 to 3857)
  AUTHORS   Fiorentino,L., Stehlik,C., Oliveira,V., Ariza,M.E., Godzik,A. and
            Reed,J.C.
  TITLE     A novel PAAD-containing protein that modulates NF-kappa B induction
            by cytokines tumor necrosis factor-alpha and interleukin-1beta
  JOURNAL   J Biol Chem 277 (38), 35333-35340 (2002)
   PUBMED   12093792
REFERENCE   10 (bases 1 to 3857)
  AUTHORS   Hoffman,H.M., Mueller,J.L., Broide,D.H., Wanderer,A.A. and
            Kolodner,R.D.
  TITLE     Mutation of a new gene encoding a putative pyrin-like protein
            causes familial cold autoinflammatory syndrome and Muckle-Wells
            syndrome
  JOURNAL   Nat Genet 29 (3), 301-305 (2001)
   PUBMED   11687797
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jul 17, 2010 this sequence version replaced XM_220513.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887623.3169666.1,
                                           SRR21887623.2121859.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-713               JAXUCZ010000010.1  44828098-44828810
            714-827             JAXUCZ010000010.1  44832892-44833005
            828-2583            JAXUCZ010000010.1  44833973-44835728
            2584-2754           JAXUCZ010000010.1  44837093-44837263
            2755-2925           JAXUCZ010000010.1  44840710-44840880
            2926-3096           JAXUCZ010000010.1  44843447-44843617
            3097-3267           JAXUCZ010000010.1  44851047-44851217
            3268-3438           JAXUCZ010000010.1  44851632-44851802
            3439-3857           JAXUCZ010000010.1  44851948-44852366
FEATURES             Location/Qualifiers
     source          1..3857
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..3857
                     /gene="Nlrp3"
                     /gene_synonym="Cias1"
                     /note="NLR family, pyrin domain containing 3"
                     /db_xref="GeneID:287362"
                     /db_xref="RGD:1308314"
     exon            1..713
                     /gene="Nlrp3"
                     /gene_synonym="Cias1"
                     /inference="alignment:Splign:2.1.0"
     CDS             431..3538
                     /gene="Nlrp3"
                     /gene_synonym="Cias1"
                     /note="cold autoinflammatory syndrome 1 homolog;
                     cryopyrin; PYRIN-containing APAF1-like protein 1; cold
                     autoinflammatory syndrome 1 protein homolog; mast cell
                     maturation-associated-inducible protein 1"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein 3"
                     /protein_id="NP_001178571.1"
                     /db_xref="GeneID:287362"
                     /db_xref="RGD:1308314"
                     /translation="MKMMSVRCKLAQYLEDLEDVDLKKFKMHLEDYPPEKGCVPIPRG
                     QMEKADHLDLATLMIDFNGEEKAWGMAVWIFAAINRRDLWEKAKKDQPEWNDACTSNL
                     SMVCQEDSLEEEWIGLLGYLSRISICKKKKDYCKIYRRHVRSRFYSIKDRNARLGESV
                     DLNRRYTQLQLVKEHPSKQEREHELLTIGRTKMWDRPMSSLKLELLFEPEDEHLEPVH
                     TVVFQGAAGIGKTILARKIMLDWALGKLFKDKFDYLFFIHCREVSLRAPKSLADLIIS
                     CWPDPNPPVCKILCKPSRILFLMDGFDELQGAFDEHIEEVCTDWQKAVRGDILLSSLI
                     RKKLLPKASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSNELQARE
                     AFRLIQENEILFTMCFIPLVCWIVCTGLKQQMETGKSLAQTSKTTTAVYVFFLSSLLQ
                     SRGGIEEHLFSAYLPGLCSLAADGIWNQKILFEECDLRKHGLQKTDVSAFLRMNVFQK
                     EVDCERFYSFSHMTFQEFFAAMYYLLEEEEEGVTVRKGPEGCSDLLNRDVKVLLENYG
                     KFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQVRLELLKWIEVKAKAKKLQRQ
                     PSQLELFYCLYEMQEEDFVQSAMGHFPKIEINLSTRMDHVVSSFCIKNCHRVKTLSLG
                     FLHNSPKEEEEEKRGSQPLDQVQCVFPDPHVACSSRLVNCCLTSSFCRGLFSSLSTNQ
                     SLTELDLSDNTLGDPGMRVLCEALQHPGCNIQRLWLGRCGLTHQCCFNISSVLSSSQK
                     LVELDLSDNALGDFGVRLLCVGLKHLLCNLQKLWLVSCCLTSACCQDLALVLSSNHSL
                     TRLYIGENALGDSGVQVLCEKMKDPQCNLQKLGLVNSGLTSLCCSALTSVLKTNQNLT
                     HLYLRSNALGDMGLKLLCEGLLHPDCKLQMLELDNCSLTSHSCWDLSTILTHNQSLRK
                     LNLSNNDLGDLCVVTLCEVLKQQGCLLQSLQLGEMYLNCETKRTLEALQEEKPELTVV
                     FEISW"
     exon            714..827
                     /gene="Nlrp3"
                     /gene_synonym="Cias1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..2583
                     /gene="Nlrp3"
                     /gene_synonym="Cias1"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2754
                     /gene="Nlrp3"
                     /gene_synonym="Cias1"
                     /inference="alignment:Splign:2.1.0"
     exon            2755..2925
                     /gene="Nlrp3"
                     /gene_synonym="Cias1"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3096
                     /gene="Nlrp3"
                     /gene_synonym="Cias1"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3267
                     /gene="Nlrp3"
                     /gene_synonym="Cias1"
                     /inference="alignment:Splign:2.1.0"
     exon            3268..3438
                     /gene="Nlrp3"
                     /gene_synonym="Cias1"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..3857
                     /gene="Nlrp3"
                     /gene_synonym="Cias1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacgggtccc ggtgaccttg tgtgtgcttg ttctctgcat gccgtatctg gttgtgttaa
       61 tgcctttctt ctttttaatt tctacagagg aactttgctt ccatggctca ggacatgatc
      121 ctggatcaag ctaagagaac tttctaggaa gcctttagct tgctcagctc ttcctaagtc
      181 agagatgacg attcacagaa tcaagtcgta gtttttttcc tttgagtttt tcgagttaag
      241 aaactttaaa aactgtgcca gtctatgggg taccctgaga tgtttcaata ttagcatcta
      301 gtttcctgga tttctgctaa cgccgttttc cggaagtgga gacttttgac tcttttttta
      361 ctcacacgga gttttcattc ctgctctgcc agcgtggatc taagcccaaa gaccctcgca
      421 agaggtgctg atgaagatga tgagtgttcg ctgcaagctg gcccagtatc tagaggacct
      481 ggaagatgtg gacctcaaga aatttaaaat gcatttggaa gattacccac ccgagaaagg
      541 ctgtgttccg atccccaggg gccagatgga gaaggcagat cacttggatc tagccacact
      601 catgattgac ttcaatgggg aggagaaggc gtggggcatg gctgtgtgga tctttgcagc
      661 gatcaacagg cgagacctct gggaaaaagc taagaaggac cagccagagt ggaatgatgc
      721 atgcacgtct aatctctcca tggtgtgcca ggaagacagc cttgaagagg agtggatagg
      781 tttgctggga tatctctccc gcatctcgat ttgtaaaaaa aagaaagatt actgtaagat
      841 atacagaagg catgtgagaa gcaggttcta ctccatcaaa gacaggaatg cacgtctagg
      901 tgagagcgtg gacctcaaca gacgctacac ccagctccaa ctggtcaagg agcatccaag
      961 caagcaggaa agggagcatg aactcttgac cattggcagg actaagatgt gggacaggcc
     1021 catgagctcc cttaagctgg agctgctctt tgagcctgag gatgaacact tggagcccgt
     1081 gcacacagtg gtgttccagg gagcagcagg catcggaaaa acaatcctag ccaggaagat
     1141 tatgttggac tgggccttgg ggaagctctt caaagacaaa tttgattatt tgttctttat
     1201 ccactgtcga gaggtgagcc tcagggcacc aaagagccta gcagatctca ttatcagctg
     1261 ctggcctgac ccaaacccac cagtctgcaa gatcctgtgc aagccttcca ggatcctctt
     1321 cctcatggac ggctttgatg agctgcaggg ggcctttgat gagcacatcg aggaggtctg
     1381 cacagactgg cagaaggctg tgaggggaga cattctgcta agcagcctca tccgaaagaa
     1441 gttgctgcct aaggcctctc tgcttattac gacgaggcca gtagccttgg agaagctgca
     1501 gcatctcctg gaccaccccc gccacgtgga gatcctaggt ttctctgagg ccaaacggaa
     1561 ggagtatttc tttaagtatt tctcaaacga gctgcaggcc agggaggcct tcaggctgat
     1621 ccaagagaat gagatcctgt ttactatgtg cttcatcccc ctggtctgct ggattgtgtg
     1681 cacagggcta aagcagcaga tggagactgg aaagagcttg gcccagacct ccaagaccac
     1741 gactgccgtc tatgtctttt tcctttccag cctgctgcag tcccgggggg gcattgagga
     1801 gcacctcttc tctgcctacc tgccagggct ctgttcattg gctgcggatg gaatttggaa
     1861 ccagaagatc ctatttgaag agtgtgatct gcggaaacac ggcctgcaga agaccgacgt
     1921 ctctgctttc ctgagaatga acgtgttcca gaaggaggtg gactgcgaga gattttacag
     1981 cttcagccac atgactttcc aggagttctt tgcggctatg tactatctgc tagaagagga
     2041 ggaagagggg gtgaccgtga ggaagggacc agaaggctgt tcagaccttc tgaaccgaga
     2101 cgtgaaggtc ctattagaaa attacggcaa gttcgaaaaa ggctatctga tttttgttgt
     2161 acgcttcctc tttggccttg taaaccagga gagaacttct tatttggaga agaagctaag
     2221 ttgcaagatc tctcagcaag tcagactgga gctgctgaag tggatcgaag tgaaagccaa
     2281 ggccaagaag ctgcagaggc agcccagcca gctggaactg ttctactgct tgtacgagat
     2341 gcaggaggaa gactttgtgc agagcgccat gggccacttc cccaaaattg agatcaacct
     2401 ctctaccaga atggaccacg tggtttcttc cttttgcatt aagaattgcc atagggtaaa
     2461 aacactttcc ctgggatttc tccacaactc acccaaggag gaagaagaag agaaaagagg
     2521 aagtcaaccc ttggaccagg tccagtgtgt tttcccagac cctcatgttg cctgttcttc
     2581 cagactggtg aactgctgcc tcacctctag cttctgccga ggtctcttct caagtctcag
     2641 caccaaccag agcctcactg aactggacct cagtgacaat actctagggg atccaggcat
     2701 gagggtgctg tgtgaggcac tccagcaccc aggctgtaac attcagagac tgtggttggg
     2761 gcgctgcgga ctgacccatc aatgctgttt caacatctcc tctgtcctga gcagcagcca
     2821 gaagctggtg gagctggacc tcagtgacaa tgccctgggg gactttggag tcagactgct
     2881 gtgcgtggga ctgaagcatc tgctctgcaa cctgcagaaa ctctggttgg tcagctgctg
     2941 tctcacatct gcgtgttgtc aggatctcgc attggttctg agctccaacc attctctgac
     3001 cagactgtac attggagaaa atgccttggg agactcagga gttcaagttt tgtgtgaaaa
     3061 aatgaaggac ccacagtgta acttgcagaa gctggggttg gtgaattccg gccttacttc
     3121 actgtgctgc tcagctctga cctctgtgct caaaaccaac cagaacctca cacacctgta
     3181 cctacgaagc aatgcccttg gagacatggg actcaagctc ctctgtgagg gacttctgca
     3241 ccccgactgt aagctacaga tgctggagtt agacaactgc agcctcacct cacactcctg
     3301 ctgggatctc tccacaattc tgacccataa ccagagcctc cggaagctga acttgagcaa
     3361 caacgacctg ggcgatctgt gtgtggtgac gctctgtgag gttctgaaac agcagggctg
     3421 cctcctgcag agcctacagt tgggtgaaat gtatttaaat tgtgaaacaa aacgtacctt
     3481 agaagctctc caggaggaaa agcctgagct gactgttgtt tttgagattt cttggtaggt
     3541 gtggaagcag gactgccagg tgccccggtc ccaccccaag ccctactgtt cttcagtgct
     3601 gcaagccctc cttcaccagc aggaccaagc cagggcgctt ttagtgtagg gtctggagca
     3661 aaggcctgtg tgggaacaag tatgctttct ccagggaaga cactgataat acgaaactac
     3721 tagaggacgc ccttcctgtc aggtcctcag tcagcaagtt gttccctctt ggtgacctga
     3781 tgggaccatt ttctagaaaa tgcattttct gtccttttcc tcctcttcct cctcctcttc
     3841 tcccccactt ctctctt
//
