LOCUS       NM_001169142            3441 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus NLR family, pyrin domain containing 12 (Nlrp12),
            mRNA.
ACCESSION   NM_001169142 XM_001066862 XM_218181
VERSION     NM_001169142.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3441)
  AUTHORS   Truax,A.D., Chen,L., Tam,J.W., Cheng,N., Guo,H., Koblansky,A.A.,
            Chou,W.C., Wilson,J.E., Brickey,W.J., Petrucelli,A., Liu,R.,
            Cooper,D.E., Koenigsknecht,M.J., Young,V.B., Netea,M.G.,
            Stienstra,R., Sartor,R.B., Montgomery,S.A., Coleman,R.A. and
            Ting,J.P.
  TITLE     The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold
            against Obesity by Regulating Gut Microbiota Homeostasis
  JOURNAL   Cell Host Microbe 24 (3), 364-378 (2018)
   PUBMED   30212649
REFERENCE   2  (bases 1 to 3441)
  AUTHORS   Allen,I.C., Wilson,J.E., Schneider,M., Lich,J.D., Roberts,R.A.,
            Arthur,J.C., Woodford,R.M., Davis,B.K., Uronis,J.M., Herfarth,H.H.,
            Jobin,C., Rogers,A.B. and Ting,J.P.
  TITLE     NLRP12 suppresses colon inflammation and tumorigenesis through the
            negative regulation of noncanonical NF-kappaB signaling
  JOURNAL   Immunity 36 (5), 742-754 (2012)
   PUBMED   22503542
REFERENCE   3  (bases 1 to 3441)
  AUTHORS   Arthur,J.C., Lich,J.D., Ye,Z., Allen,I.C., Gris,D., Wilson,J.E.,
            Schneider,M., Roney,K.E., O'Connor,B.P., Moore,C.B., Morrison,A.,
            Sutterwala,F.S., Bertin,J., Koller,B.H., Liu,Z. and Ting,J.P.
  TITLE     Cutting edge: NLRP12 controls dendritic and myeloid cell migration
            to affect contact hypersensitivity
  JOURNAL   J Immunol 185 (8), 4515-4519 (2010)
   PUBMED   20861349
REFERENCE   4  (bases 1 to 3441)
  AUTHORS   Jeru,I., Duquesnoy,P., Fernandes-Alnemri,T., Cochet,E., Yu,J.W.,
            Lackmy-Port-Lis,M., Grimprel,E., Landman-Parker,J., Hentgen,V.,
            Marlin,S., McElreavey,K., Sarkisian,T., Grateau,G., Alnemri,E.S.
            and Amselem,S.
  TITLE     Mutations in NALP12 cause hereditary periodic fever syndromes
  JOURNAL   Proc Natl Acad Sci U S A 105 (5), 1614-1619 (2008)
   PUBMED   18230725
REFERENCE   5  (bases 1 to 3441)
  AUTHORS   Lich,J.D., Williams,K.L., Moore,C.B., Arthur,J.C., Davis,B.K.,
            Taxman,D.J. and Ting,J.P.
  TITLE     Monarch-1 suppresses non-canonical NF-kappaB activation and
            p52-dependent chemokine expression in monocytes
  JOURNAL   J Immunol 178 (3), 1256-1260 (2007)
   PUBMED   17237370
REFERENCE   6  (bases 1 to 3441)
  AUTHORS   Williams,K.L., Lich,J.D., Duncan,J.A., Reed,W., Rallabhandi,P.,
            Moore,C., Kurtz,S., Coffield,V.M., Accavitti-Loper,M.A., Su,L.,
            Vogel,S.N., Braunstein,M. and Ting,J.P.
  TITLE     The CATERPILLER protein monarch-1 is an antagonist of toll-like
            receptor-, tumor necrosis factor alpha-, and Mycobacterium
            tuberculosis-induced pro-inflammatory signals
  JOURNAL   J Biol Chem 280 (48), 39914-39924 (2005)
   PUBMED   16203735
REFERENCE   7  (bases 1 to 3441)
  AUTHORS   Williams,K.L., Taxman,D.J., Linhoff,M.W., Reed,W. and Ting,J.P.
  TITLE     Cutting edge: Monarch-1: a pyrin/nucleotide-binding
            domain/leucine-rich repeat protein that controls classical and
            nonclassical MHC class I genes
  JOURNAL   J Immunol 170 (11), 5354-5358 (2003)
   PUBMED   12759408
REFERENCE   8  (bases 1 to 3441)
  AUTHORS   Wang,L., Manji,G.A., Grenier,J.M., Al-Garawi,A., Merriam,S.,
            Lora,J.M., Geddes,B.J., Briskin,M., DiStefano,P.S. and Bertin,J.
  TITLE     PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates
            activation of NF-kappa B and caspase-1-dependent cytokine
            processing
  JOURNAL   J Biol Chem 277 (33), 29874-29880 (2002)
   PUBMED   12019269
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Dec 18, 2009 this sequence version replaced
            XM_001066862.1, XM_218181.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.292.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               JAXUCZ010000001.1  74848222-74848510
            290-370             JAXUCZ010000001.1  74852788-74852868
            371-2051            JAXUCZ010000001.1  74856254-74857934
            2052-2222           JAXUCZ010000001.1  74862302-74862472
            2223-2393           JAXUCZ010000001.1  74863953-74864123
            2394-2564           JAXUCZ010000001.1  74865984-74866154
            2565-2735           JAXUCZ010000001.1  74868189-74868359
            2736-2906           JAXUCZ010000001.1  74870623-74870793
            2907-3077           JAXUCZ010000001.1  74874291-74874461
            3078-3441           JAXUCZ010000001.1  74875978-74876341
FEATURES             Location/Qualifiers
     source          1..3441
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..3441
                     /gene="Nlrp12"
                     /gene_synonym="Nalp12"
                     /note="NLR family, pyrin domain containing 12"
                     /db_xref="GeneID:292541"
                     /db_xref="RGD:1309415"
     CDS             1..3165
                     /gene="Nlrp12"
                     /gene_synonym="Nalp12"
                     /note="NACHT, leucine rich repeat and PYD containing 12"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein
                     12"
                     /protein_id="NP_001162613.1"
                     /db_xref="GeneID:292541"
                     /db_xref="RGD:1309415"
                     /translation="MLPATAKDALHRLSTYLEELEAGELKKFKLYLGIAEELGQDKIP
                     RGRMEMAGPLEMAQLMVAHMGTKEAWLLALSTFERIHRKDLWERGQGEDLVRVTPSNG
                     LCSLESQSTCLSDVSPDAPRKDPQITYKDYVRRKFRLMEDRNARLGECVNLSHRYTRL
                     LLVKEHSNPIWAQQKLLETGWEHSRTRGHQASPIQMETLFEPDEERPEPPRTVVLQGA
                     AGMGKSMLTHKVMLDWADGRLFQDQFDYVFYISCRELNRSHTQCSVHDLLSSCWPEHG
                     APLEDLIRAPDRLLFIIDGFHELHPSFHDVQGPWCHCWEEKRPTELLLGSLIRRLLLP
                     QLSLLITTRPCALEKLHGLLEHPRHVEILGFSEAEREEYFYRYFHNTGQASQVFSFMR
                     DYEPLFTMCFVPMVSWVVCTCLKQQLESGELLRQTSRTTTAVYMFYLLSLMQPKPGTP
                     TFKVPANQRGLVSLAAEGLWNQKILFEEEDLGKHGLDGAEVSTFLNVNIFQKGIKCEK
                     FYSFIHLSFQEFFTAMYCALHGREAVRRALAEYGFSERNFLAHTVRFLFGLLNEEMRC
                     YLERNLGWTISPQVKEEALAWIQNKARSEGSTLQHGSLELLSCLYEIQEEDFIQQALS
                     HFQVVVVRNLSTKMEHVVCSFCARYCRGTEVLHLYGSAYSTGAEDGPPEPPGAQTQST
                     HSQERNILPDIYSAYLSATICTNSNLIELALYRNALGSQGVRLLCQGLRHANCKLQNL
                     RLKRCHISGSACQDLAAAIIANRNLIRLDLSGNSIGVLGLELLCEGLQHPMCRLQMIQ
                     LRKCLLEAAAGRALASVLSNNSHLVELDLTGNPLEDLGLKLLCQGLRHPVCRLRTLWL
                     KICHLGQASCEDLASTLKMNQSLMELDLGLNDLGDSGALLLCEGLRHPDCKLQTLRLG
                     ICRLGSDACAGVASVLQVNTCLRELDLSFNDLGDRGLWLLGEGLRHQTCRLQKLWLDS
                     CGLTSKACEDLSSVLGISQTLNELYLTNNALGDTGVRLLCKRLRHPGCKLRVLWLFGM
                     DLNKVTHRRMAALRVTKPYLDIGC"
     exon            1..289
                     /gene="Nlrp12"
                     /gene_synonym="Nalp12"
                     /inference="alignment:Splign:2.1.0"
     exon            290..370
                     /gene="Nlrp12"
                     /gene_synonym="Nalp12"
                     /inference="alignment:Splign:2.1.0"
     exon            371..2051
                     /gene="Nlrp12"
                     /gene_synonym="Nalp12"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2222
                     /gene="Nlrp12"
                     /gene_synonym="Nalp12"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2393
                     /gene="Nlrp12"
                     /gene_synonym="Nalp12"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2564
                     /gene="Nlrp12"
                     /gene_synonym="Nalp12"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2735
                     /gene="Nlrp12"
                     /gene_synonym="Nalp12"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2906
                     /gene="Nlrp12"
                     /gene_synonym="Nalp12"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..3077
                     /gene="Nlrp12"
                     /gene_synonym="Nalp12"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3441
                     /gene="Nlrp12"
                     /gene_synonym="Nalp12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgttgccag ctacagccaa ggatgccctc catcgactgt ccacctacct ggaagaactt
       61 gaggctgggg aactgaagaa attcaaatta tacctgggga ttgcggagga actgggccag
      121 gacaagatcc ccaggggacg aatggagatg gctggtcctc tggaaatggc ccaattgatg
      181 gtggcccata tggggacaaa ggaggcttgg cttctggctc tcagcacctt tgagaggatc
      241 cacaggaagg acctgtggga gcgaggacag ggagaagacc tggtgagggt gactccaagt
      301 aatggtctat gctctcttga gagccagtca acgtgccttt cggacgtctc tcctgatgct
      361 ccaagaaaag atccccagat aacctacaaa gactatgtcc gaaggaaatt ccggctaatg
      421 gaagaccgca atgcgcgact aggcgaatgt gtgaacttaa gtcatcgtta cactcggctt
      481 ctcctagtaa aggaacactc aaatcctatc tgggcacagc aaaaacttct ggaaacaggg
      541 tgggaacact ccagaaccag gggccaccag gctagcccta tccaaatgga gaccctcttt
      601 gagccagatg aagaacgccc ggagccacca cgcacagtgg tattacaagg ggcagcgggg
      661 atggggaagt ccatgttgac ccacaaagtg atgttggact gggccgatgg gagactcttc
      721 caagaccagt tcgattatgt cttctatatc agctgcaggg agttgaatag aagccacacc
      781 cagtgcagtg tacatgacct cctctccagc tgctggccag agcatggtgc acccctcgag
      841 gacctcatcc gggctcctga tcgtcttcta ttcatcatcg atggcttcca tgagcttcat
      901 ccctctttcc atgacgttca gggtccctgg tgccactgct gggaggagaa acgacccacg
      961 gaactcctcc tcggaagcct gattcggagg ttgcttctgc cccagctctc tttgctcatc
     1021 accacacgac cctgtgcact ggagaagctg cacggcttgt tggaacaccc taggcacgtg
     1081 gagatcctgg gcttctccga ggcagagagg gaggaatatt tctacagata tttccacaac
     1141 actggacaag cgagccaagt gttcagcttc atgagggact atgagcccct ctttaccatg
     1201 tgttttgttc ccatggtgtc ctgggtggtc tgcacctgct taaagcagca gctagaaagt
     1261 ggggagcttt taagacaaac atctaggacc accacagcgg tttatatgtt ctaccttctg
     1321 agcctgatgc agcccaagcc agggacccca accttcaaag tcccagccaa ccagagaggc
     1381 ctggtctctc tggctgcaga gggcctctgg aatcagaaga ttctcttcga ggaagaggat
     1441 cttgggaaac atggcctaga tggagcagag gtctccacct tcctcaacgt gaacatattc
     1501 cagaagggca tcaagtgtga gaaattctac agcttcatcc acctgagttt ccaggaattc
     1561 ttcacagcca tgtactgtgc actgcacggc agagaggcgg tgaggagagc actggctgag
     1621 tatggtttct cagaaaggaa cttcttggcc cacaccgtcc gctttctctt tggcctcctc
     1681 aatgaagaga tgagatgcta cctcgagagg aatctcggct ggaccatctc ccctcaggtc
     1741 aaggaggaag cattggcgtg gatccaaaac aaggctcgaa gtgagggctc caccctgcag
     1801 catggctccc tggagcttct cagctgcttg tacgagatcc aggaggaaga cttcatccag
     1861 caggccctga gccactttca ggtggttgtt gtcagaaacc tctcaacgaa gatggagcac
     1921 gtggtctgct cgttttgtgc gaggtactgc agaggcacag aagtgcttca cttgtatggg
     1981 agtgcctata gtacaggcgc agaggatggc ccgccagaac ctccaggagc ccagacgcag
     2041 tccacacact cacaggaaag gaacatcctt cctgacattt acagtgcata cctctcagca
     2101 accatctgca ccaactcaaa cctgatcgag ctggccttgt atcgaaacgc cttgggcagc
     2161 cagggcgtga ggctgctctg tcaaggcctc cgacatgcaa actgcaagct tcagaacctg
     2221 aggctgaaga ggtgtcacat ctccggatca gcctgccagg atctcgcagc ggctatcatc
     2281 gccaatagga atttaatcag gctggacctc agtggcaaca gcattggagt gctaggccta
     2341 gagctgctct gtgaggggtt acagcacccc atgtgtaggc tgcagatgat ccagctgagg
     2401 aagtgtttgc tggaggctgc ggctggccga gcactggcct ctgttctcag caacaactca
     2461 catcttgtag aactggatct gacaggaaac cccttggagg atttggggct gaagttactg
     2521 tgtcaagggc tgaggcaccc agtctgcagg ctgcggacct tgtggctgaa gatctgccac
     2581 cttggacaag cttcctgtga agatctggct tctactctca aaatgaacca gagcctgatg
     2641 gagctggacc tgggtctgaa tgaccttggg gattctgggg cgcttctgct gtgtgagggc
     2701 ctcaggcatc cagattgcaa actccagacc ctccggctgg gcatttgccg actgggctca
     2761 gacgcgtgtg caggggttgc tagtgtgctc caggtcaaca cgtgcctccg agagctggac
     2821 ctgagcttca atgacttggg agacaggggc ctgtggctgc tgggggaagg actgaggcac
     2881 cagacctgca gactccagaa gctctggctg gacagttgcg gcctcacttc caaagcatgt
     2941 gaggacctgt cttcagtcct gggaatcagt cagaccctga atgagcttta tctgaccaat
     3001 aatgctctgg gggacactgg tgttcgtctg ctgtgcaaga ggctgaggca tccggggtgc
     3061 aagcttcgtg tcctgtggct tttcggaatg gacctgaaca aagtgaccca caggaggatg
     3121 gcggcacttc gagtcacaaa accataccta gatattgggt gctaagcagt aatgcagaat
     3181 ggaccaggtc ttccggatgt ttccggctat gacagaactt taaggcctgt ctctggtata
     3241 tggtgagatg aaggtcatcc ccagaaaccc gctagtgcaa ccctgtcttg aggtcaggag
     3301 gctcagtaag tacaggttga gaaaaattga gacctaaacg ctcaaccttt gatggagctg
     3361 gttgtgtctg atgtagactc catgcagaca aattggctgg ttaggtttga agagcaataa
     3421 atcaagacta cagagaaaac a
//
