LOCUS       NM_001106291            2541 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus NLR family, pyrin domain containing 10 (Nlrp10),
            mRNA.
ACCESSION   NM_001106291 XM_001077301 XM_219247
VERSION     NM_001106291.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2541)
  AUTHORS   Lee SJ and Choi BK.
  TITLE     Involvement of NLRP10 in IL-1alpha induction of oral epithelial
            cells by periodontal pathogens
  JOURNAL   Innate Immun 23 (7), 569-577 (2017)
   PUBMED   28766990
REFERENCE   2  (bases 1 to 2541)
  AUTHORS   Damm A, Giebeler N, Zamek J, Zigrino P and Kufer TA.
  TITLE     Epidermal NLRP10 contributes to contact hypersensitivity responses
            in mice
  JOURNAL   Eur J Immunol 46 (8), 1959-1969 (2016)
   PUBMED   27221772
REFERENCE   3  (bases 1 to 2541)
  AUTHORS   Murphy N, Grehan B and Lynch MA.
  TITLE     Glial uptake of amyloid beta induces NLRP3 inflammasome formation
            via cathepsin-dependent degradation of NLRP10
  JOURNAL   Neuromolecular Med 16 (1), 205-215 (2014)
   PUBMED   24197756
  REMARK    GeneRIF: NLRP10 is bound to ASC protein under resting conditions.
            It decreases with Abeta treatment, both in vitro and in vivo.
            Abeta-induced cathepsin released into the cytosol degrades NLRP10,
            allowing dissociation of NLRP3 and formation of the inflammasome.
REFERENCE   4  (bases 1 to 2541)
  AUTHORS   Su MY, Kuo CI, Chang CF and Chang CI.
  TITLE     Three-dimensional structure of human NLRP10/PYNOD pyrin domain
            reveals a homotypic interaction site distinct from its mouse
            homologue
  JOURNAL   PLoS One 8 (7), e67843 (2013)
   PUBMED   23861819
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2541)
  AUTHORS   Joly S, Eisenbarth SC, Olivier AK, Williams A, Kaplan DH, Cassel
            SL, Flavell RA and Sutterwala FS.
  TITLE     Cutting edge: Nlrp10 is essential for protective antifungal
            adaptive immunity against Candida albicans
  JOURNAL   J Immunol 189 (10), 4713-4717 (2012)
   PUBMED   23071280
REFERENCE   6  (bases 1 to 2541)
  AUTHORS   Lautz K, Damm A, Menning M, Wenger J, Adam AC, Zigrino P, Kremmer E
            and Kufer TA.
  TITLE     NLRP10 enhances Shigella-induced pro-inflammatory responses
  JOURNAL   Cell Microbiol 14 (10), 1568-1583 (2012)
   PUBMED   22672233
REFERENCE   7  (bases 1 to 2541)
  AUTHORS   Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux
            A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz
            LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS and Flavell
            RA.
  TITLE     NLRP10 is a NOD-like receptor essential to initiate adaptive
            immunity by dendritic cells
  JOURNAL   Nature 484 (7395), 510-513 (2012)
   PUBMED   22538615
  REMARK    Erratum:[Nature. 2016 Feb 25;530(7591):504. PMID: 26605525]
            Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473956.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_219247.3, XM_001077301.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN16676808
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2541
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..2541
                     /gene="Nlrp10"
                     /gene_synonym="Nalp10"
                     /note="NLR family, pyrin domain containing 10"
                     /db_xref="GeneID:293426"
                     /db_xref="RGD:1307387"
     exon            1..61
                     /gene="Nlrp10"
                     /gene_synonym="Nalp10"
                     /inference="alignment:Splign:2.1.0"
     exon            62..363
                     /gene="Nlrp10"
                     /gene_synonym="Nalp10"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..2096
                     /gene="Nlrp10"
                     /gene_synonym="Nalp10"
                     /note="NACHT, leucine rich repeat and PYD containing 10"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein
                     10"
                     /protein_id="NP_001099761.1"
                     /db_xref="GeneID:293426"
                     /db_xref="RGD:1307387"
                     /translation="MALARANSPQEALLWALNDLEENSFKTLKFHLRDVTQFHLARGE
                     LEGLSQVDLASKLISMYGAQEAVRVVGRSLQAMNLMELVDYLNQVCLNDYREIYREHV
                     LCLEERQDWGVNSSHNKLLLVATSSSGSLRSPSCSDLEQELDPVHVETLFAPEAESYS
                     TPPIVVMQGSAGTGKTTLVKKLVQDWAKGKLYPGQFDYVFYVSCREVVLLPKCDLPNL
                     ICWCCGDDQAPVTEILRQPERLLFILDGYDELQKSSRAERVLHILMRRREVPCSLLIT
                     TRPPALQSLEPMLGERRHVHVLGFSEEERETYFCSYFMDKEQLRNALEFVQNNAVLYK
                     ACQVPGICWVVCSWLKGKMARGQEVSETPSNSTDIFTAYVSTFLPTDGNGDSSELTRH
                     KVLRGLCSLAAEGMRHQRLLFEEDVLRKHSLDGPSLTAFLNCTDYREGLGIKKLYSFC
                     HISFQEFFYAMSFLVKEDQGQLGEATHKEVAKLVDQENYEEVTLSLQFLFDMLKTDNT
                     LSLGLKFCFKIAPSVRQDLKHFKEQVVAIKYNRSWDLEFSLYDSKIKKLKQGIQMKDV
                     IFNVQHSDEKKSGKKKPFSVTSRFGKGPILETGKSTRKQKKASNGKSRETEEPPAQDG
                     GKSRLASRGKGNKEINDKDGGVYGQEDGEGQEVKKGGEILDEMNG"
     exon            364..2541
                     /gene="Nlrp10"
                     /gene_synonym="Nalp10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaggtgtta ctaagaatct ctggcacagt gacttgggcc ttgagatctg tcatctgtac
       61 agtggctgga ctgaactctg accaccatgg ccttggcaag ggccaacagc ccccaggaag
      121 cgttgctttg ggccttgaac gaccttgagg agaacagttt caagacgctg aagttccact
      181 tacgggatgt gacccaattt catctggccc gaggggaact ggagggtctg agtcaggtgg
      241 acctggcatc aaaactgatt tcaatgtatg gagcacagga agctgtgaga gtggtgggca
      301 ggagcttgca ggccatgaac ttgatggaac ttgtagacta tctcaaccag gtttgtctga
      361 atgattacag agaaatctac cgggagcacg tgctctgctt ggaggagagg caagattggg
      421 gtgtaaacag cagtcacaac aagctgctcc tggtggccac atctagttca gggagtctca
      481 gatcaccttc ctgttctgac ctggaacagg agttggatcc tgtccatgtg gagacattat
      541 ttgctccgga ggcggagtcc tactcaacac cgcccatagt ggtgatgcaa ggatccgccg
      601 gcactggaaa gacaaccctg gtcaaaaaac tggtgcagga ctgggccaaa ggtaagctgt
      661 acccgggcca gtttgattac gttttctacg tgagctgcag agaagtggtc ctgttaccca
      721 agtgtgacct gcccaacctc atctgctggt gttgtgggga tgatcaagcc ccagtcacag
      781 agattctgag gcagcctgag cggctcctgt tcatcctgga tggctatgat gagttacaga
      841 agtccagccg tgccgagcgc gtactacaca ttctgatgag gagaagggag gtaccatgct
      901 ctcttctcat cactacacgg cctccagctt tgcagagtct ggagcccatg ctgggtgaac
      961 ggcgacatgt ccatgtctta ggcttctctg aggaggagag ggagacatat ttctgctcct
     1021 attttatgga taaggagcag ttgagaaacg cccttgagtt tgtgcaaaac aatgctgttc
     1081 tctataaagc atgccaggtt ccaggcattt gctgggtggt ctgctcctgg ctgaagggga
     1141 agatggcgag aggccaggaa gtctctgaga cacctagcaa cagtacagac atcttcactg
     1201 catatgtgtc cacctttctg cccactgatg gcaatgggga cagctctgag cttaccaggc
     1261 acaaggtact gcggggtctg tgctccttgg cagcggaggg gatgcggcac cagaggctgc
     1321 tatttgaaga ggacgtcctc agaaagcaca gcttagatgg ccccagcctt actgctttcc
     1381 tgaactgcac tgactaccga gaggggctcg gcatcaagaa actctacagc ttttgccaca
     1441 ttagcttcca ggaatttttc tatgccatgt ccttccttgt gaaggaggac cagggtcagc
     1501 taggagaggc cacacacaaa gaagtggcaa agctggtaga tcaggagaac tatgaagagg
     1561 tgactctcag tttgcagttc ttatttgaca tgttgaaaac agacaacacc ttgagcttgg
     1621 ggctaaagtt ctgcttcaaa atcgcccctt cggtgaggca ggatctgaag cattttaagg
     1681 aacaagtagt ggccataaag tacaacaggt catgggattt ggaattctct ctctatgatt
     1741 ctaaaataaa gaagctcaaa caaggtatcc agatgaaaga tgtcattttc aatgtgcaac
     1801 attcagatga aaagaaatct ggtaagaaga agccattttc agtgacaagc aggtttggta
     1861 agggtcctat cttggaaact ggtaaaagca caaggaaaca aaagaaggct tctaatggga
     1921 aaagcagaga gacagaggaa ccaccagccc aggacggagg aaagagtagg ctggcaagca
     1981 gaggaaaggg taacaaggag ataaatgata aggatggtgg ggtgtacgga caggaggatg
     2041 gggaaggaca ggaagtcaaa aagggtggag agatactaga tgagatgaat gggtagtaga
     2101 gagagggaag gacaaagaga caaatagaaa agagaattac ataatcaaga ccaggagact
     2161 tagcatagca tctgtaatga acgactcatt ggaagcagcc agctcttacc acagatatct
     2221 gaagtttaac tagttagcat ccctccctct agtagctgtt caatatctcc tgtggtgtga
     2281 agtcactttg agtagcccct tcggtgctaa catccaatga ctaagacttt aattctgaca
     2341 ttagattctt ttctaaataa aacaaactgt ttaaaataag aaagtgagaa tcacatacat
     2401 tctgtaaaat ataggcacat atggaacaca ttatgggcca atgtgtaaag gaaacatgct
     2461 ttggtataat ggaaagtcct gttgactctg tatttgtatt caagtgttgc ttaaataaag
     2521 agtagcttcc cattctttct a
//
